Tag: M.W=50-100

Ethers do have nonbonding electron pairs on their oxygen atoms, 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds. Related Products of 38256-93-8.

Holmes, Jane L.;Almeida, Lynsie;Barlaam, Bernard;Croft, Rosemary A.;Dishington, Allan P.;Gingipalli, Laksmaiah;Hassall, Lorraine A.;Hawkins, Janet L.;Ioannidis, Stephanos;Johannes, Jeffrey W.;McGuire, Thomas M.;Moore, Jane E.;Patel, Anil;Pike, Kurt G.;Pontz, Timothy;Wu, Xiaoyun;Wang, Tao;Zhang, Hai-Jun;Zheng, Xiaolan research published 《 Synthesis of Novel Hydroxymethyl-Substituted Fused Heterocycles》, the research content is summarized as follows. Examples of hydroxymethylated analogs of heteroaryl cores such as quinazolin-4-ones, isoquinolin-1(2H)-ones, pyrido[3,4-d]pyrimidin-4(3H)-ones, chromen-4-ones and pyrrolo[2,1-f][1,2,4]triazin-4(3H)-ones were sparse or non-existent in the scientific literature. Synthesis of such compounds by using standard procedures from readily available raw materials was demonstrated.

Related Products of 38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3. Computed Properties of 38256-93-8.

Hu, Lingling;Yu, Shanshan;Wang, Yachen;Yu, Xiaoqi;Pu, Lin research published 《 Enhanced Fluorescence of 3,3′-Diformyl BINOL by Functional Secondary Amines》, the research content is summarized as follows. Although 3,3′-diformyl-BINOL (S)-I shows little change in its fluorescence when treated with primary amines, its fluorescence can be greatly enhanced by using functional secondary amines including β- and γ-amino alcs. and 1,2- and 1,3-bis(secondary amine) compounds It has been demonstrated that the functional secondary amines react with (S)-I to convert the conjugated aldehyde groups to unconjugated oxazolidines or aminals to turn on the fluorescence.

Computed Properties of 38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers do have nonbonding electron pairs on their oxygen atoms, 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds. Quality Control of 38256-93-8.

Fu, Jiping;Tjandra, Meiliana;Becker, Christopher;Bednarczyk, Dallas;Capparelli, Michael;Elling, Robert;Hanna, Imad;Fujimoto, Roger;Furegati, Markus;Karur, Subramanian;Kasprzyk, Theresa;Knapp, Mark;Leung, Kwan;Li, Xiaolin;Lu, Peichao;Mergo, Wosenu;Miault, Charlotte;Ng, Simon;Parker, David;Peng, Yunshan;Roggo, Silvio;Rivkin, Alexey;Simmons, Robert L.;Wang, Michael;Wiedmann, Brigitte;Weiss, Andrew H.;Xiao, Linda;Xie, Lili;Xu, Wenjian;Yifru, Aregahegn;Yang, Shengtian;Zhou, Bo;Sweeney, Zachary K. research published 《 Potent Nonimmunosuppressive Cyclophilin Inhibitors With Improved Pharmaceutical Properties and Decreased Transporter Inhibition》, the research content is summarized as follows. Nonimmunosuppressive cyclophilin inhibitors have demonstrated efficacy for the treatment of hepatitis C infection (HCV). However, alisporivir, cyclosporin A, and most other cyclosporins are potent inhibitors of OATP1B1, MRP2, MDR1, and other important drug transporters. Reduction of the side chain hydrophobicity of the P4 residue preserves cyclophilin binding and antiviral potency while decreasing transporter inhibition. Representative inhibitor 33 (NIM258) is a less potent transporter inhibitor relative to previously described cyclosporins, retains anti-HCV activity in cell culture, and has an acceptable pharmacokinetic profile in rats and dogs. An X-ray structure of 33 bound to rat cyclophilin D is reported.

Quality Control of 38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers are a class of organic compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine.They have the general formula R–O–R′, where R and R′ represent the alkyl or aryl groups. Application of C4H11NO.

Gabriel, Lars;Gericke, Martin;Heinze, Thomas research published 《 Modular synthesis of non-charged and ionic xylan carbamate derivatives from xylan carbonates》, the research content is summarized as follows. Non-charged and ionic xylan carbamate (XC) derivatives were synthesized in a modular approach from xylan Ph carbonates (XPC) as reactive intermediates. XPC with varying degrees of substitution (DS) from 0.5 to 1.9 were converted with different non-ionic primary and secondary amines in different molar ratio to obtain the corresponding XC with high conversion rates of up to 100%. In a similar way, ionic amines were employed for the aminolysis of XPC to obtain charged XC. The XC were characterized by NMR and IR spectroscopy. XPC were proofed to be highly versatile building blocks for the preparation of ionic xylan derivatives The type and amount of charged groups could be tuned efficiently. DS values of up to 1.4 for cationic and 1.8 for anionic XC derivatives could be achieved, which is higher than reported results obtained by esterification and etherification reactions.

38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., Application of C4H11NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. Ethers do have nonbonding electron pairs on their oxygen atoms, however, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. Quality Control of 38256-93-8.

Gao, Meiping;Teng, Wei;Du, Zhenxia;Nie, Lei;An, Xiaoshuan;Liu, Wenwen;Sun, Xuechun;Shen, Zhengchao;Shi, Aijun research published 《 Source profiles and emission factors of VOCs from solvent-based architectural coatings and their contributions to ozone and secondary organic aerosol formation in China》, the research content is summarized as follows. Volatile organic compounds (VOCs) from solvent-based architectural coatings (SBACs) play an important role in photochem. air pollution with increasing consumption of architectural coatings in China. In this study, we collected 148 typical SBACs of 3 types in China. The TVOC emission factors and source profiles were established, the contributions of SBACs to ozone and secondary organic aerosol (SOA) formation were investigated. The VOC emissions and O₃ and SOA amounts formed in chem. reactions from SBACs in 2017 were estimated Key organic groups and VOC species with high reactivity were identified. According to the results, the TVOC emission factors were 507.17 g L^-1 for solvent-based anticorrosive coatings, 381.34 g L^-1 for solvent-based floor coatings and 459.68 g L^-1 for solvent-based fire-retardant coatings. The VOC emissions were 186,902.11 t, 88,225.41 t and 71,352.32 t; the O₃ amounts formed were 742,001.39 t, 397,896.60 t and 244,738.46 t; the SOA amounts formed were 3934.29 t, 2488.04 t and 1104.61 t, resp., from 3 types of SBACs in 2017. The O₃ production factors were 1781.82 g O₃ (kg paint)^-1, 1457.50 g O₃ (kg paint)^-1 and 1176.63 g O₃ (kg paint)^-1, the SOA production factors were 9.45 g SOA (kg paint)^-1, 9.11 g SOA (kg paint)^-1 and 5.31 g SOA (kg paint)^-1, for 3 types of SBACs. Priority should be given to organic group of aromatics and top 17 VOC species with high reactivity for O₃ and SOA eliminating strategies, especially three xylenes (o-xylene, m-xylene and p-xylene), ethylbenzene, tri-Me benzenes (1,3,5-tri-Me benzene, 1,2,3-Tri-Me benzene) and toluene.

Quality Control of 38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3. Quality Control of 38256-93-8.

George, Sheby Mary;Kim, Hyo-Suk;Oh, Hyun Ji;Lah, Myoung Soo;Jeon, Dong Ju;Park, Bo Keun;Han, Jeong Hwan;Kim, Chang Gyoun;Chung, Taek-Mo research published 《 Heteroleptic strontium complexes stabilized by donor-functionalized alkoxide and β-diketonate ligands》, the research content is summarized as follows. Heteroleptic complexes of strontium (1–7) were prepared by employing β-diketonates and donor-functionalized alkoxides as coordinating ligands. The results illustrate the effect of alkoxide substituent groups on the overall structures of the complexes. The presence of a terminal methoxy group in the alkoxide ligands gives trimeric complexes 1–4, whereas the substituents on the amine nitrogen prove to have less influence in determining the structure. The attempts to increase steric bulkiness of the aminoalkoxide ligands by introducing Et groups on the amine nitrogen and to the alkoxy carbon did not lead to a structural change from the dimeric form in 5–7 but resulted in structurally interesting strontium complexes. In trimeric complexes 2–4, the three strontium atoms were held together by two μ₃-O bonds using alkoxide oxygen atoms and two μ₂-O bonds using a combination of alkoxide and β-diketonate ligand oxygens. The strontium metal centers in these complexes exhibit seven-coordination states in 2 and 4, whereas 3 exhibits one six-coordinated and two seven-coordinated strontium metals in its structure. All of the complexes were characterized using FT-NMR, FTIR, elemental analyses, and thermogravimetric (TG) analyses.

Quality Control of 38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers are a class of organic compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine.They have the general formula R–O–R′, where R and R′ represent the alkyl or aryl groups. COA of Formula: C4H11NO.

Ghoshal, Tanay;Nagar, Vishal;Vutla, Adilakshmi;Kotturi, Sharadsrikar;Kuttappan, Sasikumar research published 《 Synthesis of aminobenzoxazoles via simple, clean and efficient electrochemical redox reactions》, the research content is summarized as follows. An efficient single step process for the construction of pharmaceutically relevant substituted aminobenzoxazoles was described. Various electrodes and electrolytes combinations were carried out to harvest optimum coupling results. The presented C-N bond formation reaction methodol. was applied for the synthesis of biol. active compounds This methodol. saved reaction steps over traditional functionalization reactions.

38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., COA of Formula: C4H11NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3. Synthetic Route of 38256-93-8.

Davoren, Jennifer E.;Claffey, Michelle M.;Snow, Sheri L.;Reese, Matthew R.;Arora, Gaurav;Butler, Christopher R.;Boscoe, Brian P.;Chenard, Lois;DeNinno, Shari L.;Drozda, Susan E.;Duplantier, Allen J.;Moine, Ludivine;Rogers, Bruce N.;Rong, SuoBao;Schuyten, Katherine;Wright, Ann S.;Zhang, Lei;Serpa, Kevin A.;Weber, Mark L.;Stolyar, Polina;Whisman, Tammy L.;Baker, Karen;Tse, Karen;Clark, Alan J.;Rong, Haojing;Mather, Robert J.;Lowe, John A. III research published 《 Discovery of a novel Kv7 channel opener as a treatment for epilepsy》, the research content is summarized as follows. Facilitating activation, or delaying inactivation, of the native Kv7 channel reduces neuronal excitability, which may be beneficial in controlling spontaneous elec. activity during epileptic seizures. In an effort to identify a compound with such properties, the structure-activity relationship (SAR) and in vitro ADME for a series of heterocyclic Kv7.2-7.5 channel openers (I) was explored. PF-05020182 (II) demonstrated suitable properties for further testing in vivo where it dose-dependently decreased the number of animals exhibiting full tonic extension convulsions in response to corneal stimulation in the maximal electroshock (MES) assay. In addition, II significantly inhibited convulsions in the MES assay at doses tested, consistent with in vitro activity measure. The physiochem. properties, in vitro and in vivo activities of II support further development as an adjunctive treatment of refractory epilepsy.

Synthetic Route of 38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3. Synthetic Route of 38256-93-8.

Davoren, Jennifer E.;Claffey, Michelle M.;Snow, Sheri L.;Reese, Matthew R.;Arora, Gaurav;Butler, Christopher R.;Boscoe, Brian P.;Chenard, Lois;DeNinno, Shari L.;Drozda, Susan E.;Duplantier, Allen J.;Moine, Ludivine;Rogers, Bruce N.;Rong, SuoBao;Schuyten, Katherine;Wright, Ann S.;Zhang, Lei;Serpa, Kevin A.;Weber, Mark L.;Stolyar, Polina;Whisman, Tammy L.;Baker, Karen;Tse, Karen;Clark, Alan J.;Rong, Haojing;Mather, Robert J.;Lowe, John A. III research published 《 Discovery of a novel Kv7 channel opener as a treatment for epilepsy》, the research content is summarized as follows. Facilitating activation, or delaying inactivation, of the native Kv7 channel reduces neuronal excitability, which may be beneficial in controlling spontaneous elec. activity during epileptic seizures. In an effort to identify a compound with such properties, the structure-activity relationship (SAR) and in vitro ADME for a series of heterocyclic Kv7.2-7.5 channel openers (I) was explored. PF-05020182 (II) demonstrated suitable properties for further testing in vivo where it dose-dependently decreased the number of animals exhibiting full tonic extension convulsions in response to corneal stimulation in the maximal electroshock (MES) assay. In addition, II significantly inhibited convulsions in the MES assay at doses tested, consistent with in vitro activity measure. The physiochem. properties, in vitro and in vivo activities of II support further development as an adjunctive treatment of refractory epilepsy.

Synthetic Route of 38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., 38256-93-8.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers do have nonbonding electron pairs on their oxygen atoms, 38256-93-8, formula is C4H11NO, Name is 2-Methoxy-N-methylethanamine. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds. Formula: C4H11NO.

Chen, Xinde;Wang, Kai;Xu, Wenwei;Ma, Quanxin;Chen, Minli;Du, Lili;Mo, Mingguang;Wang, Yiping;Shen, Jianhua research published 《 Discovery of Potent and Orally Active Lipoprotein-Associated Phospholipase A₂ (Lp-PLA₂) Inhibitors as a Potential Therapy for Diabetic Macular Edema》, the research content is summarized as follows. Lipoprotein-associated phospholipase A₂ (Lp-PLA₂) is considered to be a promising therapeutic target for several inflammation-associated diseases. Herein, the authors describe the discovery of a series of pyrimidone derivatives as Lp-PLA₂ inhibitors. Systematic structural modifications led to the identification of several pyrimidone compounds with promising in vitro inhibitory potency and pharmacokinetic properties. Compound 2-(4-chloro-3-(trifluoromethyl)phenoxy)-5-(((1-methyl-6-morpholino-2-oxo-1,2-dihydropyrimidin-4-yl)oxy)methyl)benzonitrile (14c), selected for in vivo evaluation, demonstrated decent pharmacokinetic profiles and robust inhibitory potency against Lp-PLA₂ in Sprague-Dawley (SD) rats. Furthermore, (14c) significantly inhibited retinal thickening in STZ-induced diabetic SD rats as a model of diabetic macular edema (DME) after oral dosing for 4 wk. Taken together, these results suggested that (14c) can serve as a valuable lead in the search for new Lp-PLA₂ inhibitors for prevention and/or treatment of DME.

38256-93-8, 2-Methoxy-N-methylethanamine is a useful research compound. Its molecular formula is C4H11NO and its molecular weight is 89.14 g/mol. The purity is usually 95%.
2-Methoxy-N-methylethanamine is a drug that binds to the cannabinoid receptor CB1. It has been shown to be effective in the treatment of cardiac arrhythmia and may also be used as an anti-inflammatory drug. 2MEMEA has been shown to have pharmacokinetic properties that are different from those of other amines, which may be due to its ability to form hydrogen bonds with water molecules. 2MEMEA also has diversified effects on some types of cancer cells, including hyperproliferative and amine-dependent cancers., Formula: C4H11NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem