Tag: M.W=300-400

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 70384-51-9, name is Tris(2-(2-methoxyethoxy)ethyl)amine, A new synthetic method of this compound is introduced below., COA of Formula: C15H33NO6

EXAMPLE 61 8-(3,5-Bis-trifluoromethyl-benzoyl)-3-(6-chloro-pyrimidin-4-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one A mixture of 8-(3,5-bis-trifluoromethyl-benzoyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one (0.1 g, 0.21 mmol), potassium carbonate (59 mg, 0.42 mmol), CuCl (2 mg, 0.021 mmol), tris[2-(2-methoxyethoxy)-ethyl]-amine (1.5 muL) and 4,6-dichloropyrimidine (32 mg, 0.21 mmol) in xylene (5 mL) was stirred and boiled for 18 h. The mixture was cooled, washed with water, ammonia in water (10percent) and water again. Evaporation of the solvent yielded a residue which was purified by chromatography on silica gel (ethyl acetate/n-hexane 1:2) to yield the desired product (29 mg, 24percent), m.p. 212-214° C. and MS: m/e=584.1 (M+H+).

The synthetic route of 70384-51-9 has been constantly updated, and we look forward to future research findings.

Electric Literature of 162705-07-9,Some common heterocyclic compound, 162705-07-9, name is (Z)-2-Methoxy-5-(3,4,5-trimethoxystyryl)aniline, molecular formula is C18H21NO4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

3′ CA4-amine (0.11 g, 0.35 mmol) was dissolved in CH2Cl2 (10 mL), and then Fmoc-serine acetate (0.19 g, 0.52 mmol), T3P (0.62 mL, 1.0 mmol), and Et3N (0.073 mL, 0.52 mmol) were added. After stirring for 16 h at room temperature, water (10 mL) was added, and the reactionS3mixture was extracted with CH2Cl2 (3 × 10 mL). The combined organic phase was rinsed with brine, dried with Na2SO4, and concentrated under reduced pressure, and the residue was purified by flash column chromatography using a pre-packed 10 g silica column [solvent A: EtOAc; solvent B: hexanes; gradient: 12%A / 88%B (1 CV), 12%A / 88%B ? 100%A / 0%B (10 CV), 100%A / 0%B (2 CV); flow rate: 36 mL/min; monitored at 254 and 280 nm] affording the desired Fmoc-L-serinamide acetate 47 (0.22 g, 0.32 mmol, 93%) as a white solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (Z)-2-Methoxy-5-(3,4,5-trimethoxystyryl)aniline, its application will become more common.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 162705-07-9 as follows. Computed Properties of C18H21NO4

General procedure: To a solution of substituted benzyl-1H-1,2,3-triazole-4-carboxylic acids (18a-e, 1 mmol) in dry dimethylformamide, EDCI (1.2 mmol) and HOBT (1.2 mmol) were added and the reaction mixture was stirred for 20 min. To the reaction mixture, amino Z-stilbenes (16, 17, 1 mmol) was added and stirred at room temperature for 12 h. The solvent was removed and the residue was dissolved in dichloromethane (50 mL), washed with 5% HCl (2 20 mL), 5% NaHCO3 (2 20 mL), and brine solution (20 mL). The organic layer was separated, dried over anhydrous Na2SO4, filtered, and the solvent was removed to give a crude product which was purified by chromatography (ethyl acetate/hexanes) to givethe desired product (6a-e, 7a-e).

According to the analysis of related databases, 162705-07-9, the application of this compound in the production field has become more and more popular.

Electric Literature of 162705-07-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 162705-07-9, name is (Z)-2-Methoxy-5-(3,4,5-trimethoxystyryl)aniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: DCC (0.47 mmol, 1.2 eq.); the N-Fmoc-protected amino acid (0.472 mmol, 1.2 eq) and HOBt·H2O (0.47 mmol, 1.2 eq) were added to a solution of the 30-aminocombretastatin (0.39 mmol, 1 eq) in anhydrous DMF (1.3 mL). The reaction mixture was stirred under N2 atmosphere for 16 h. Then, it was ltered, and the ltrate was poured into a saturated aqueous NH4Cl solution and then extracted with AcOEt (3×15 mL). The combined organic extracts were washed 2 times with water and brine and dried over anhydrous MgSO4. After ltration and evaporation of the solvent under reduced pressure, the resulting residue was chromatographed on silica gel with Hexanes-AcOEt (6:4) to aord the corresponding N-Fmoc-protected derivatives 7 and 9.

The synthetic route of (Z)-2-Methoxy-5-(3,4,5-trimethoxystyryl)aniline has been constantly updated, and we look forward to future research findings.

Reference of 207226-31-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 207226-31-1, name is 1,3-Dibromo-5-(trifluoromethoxy)benzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

The bromide (3.0 g, 9.38 mmol), tri-nbutyl-l-elhoxyvinyl tin (3.56 g, 9.85 mmol), and PdCl2(Ph3P)2 (0.66 g, 0.94 mmol) were dissolved in toluene and the solution stirred at 95 C for 3 hours. The volatiles were removed in vac, the residue dissolved in 1,4-dioxane (20 mL), aqueous HCl (2 N, 14taunL) added, and the solution stirred rapidly at RT for 1 hour. The mixture was diluted with water (400 mL), followed by aqueous/EtOAc work-up and silica gel chromatography (EtOAc: hexanes (1:19)) to give the titled compound.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,3-Dibromo-5-(trifluoromethoxy)benzene, other downstream synthetic routes, hurry up and to see.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 70627-52-0, name is N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline

The raw material (III) (10 g, 28.0 mmol)And the starting material (IV) (17 g, 55.7 mmol)Was added to a 500 mL three-necked flask,Installed thermometer,Addition funnel and drying tube,Dry methylene chloride (150 mL) was added,The mixture was cooled to -20 C.Diisopropylethylamine (5.8 mL, 33.3 mmol) was added,Temperature control to -30 .Isopropyl titanate (3.0 mL, 10 mmol) was added,Maintaining the temperature at -25 C to -30 C,Titanium tetrachloride (3.3 mL, 30 mmol) was added dropwise.Control temperature <-25 ,The reaction was stirred for 5 hours,The reaction end point was detected by TLC.A mixed solution of slow acetic acid / dichloromethane (10 ml / 10 ml) was added to the reaction mixture,Drop add 2N sulfuric acid 30ml,The temperature was raised to 30 C for 30 minutes,Add water 30ml,Take the organic layer,The aqueous layer was extracted with 50 ml of dichloromethane,Combined organic layer,Followed by water 50ml,Saline 50ml washing,Dried over anhydrous sodium sulfate.After the solvent was distilled off,Add methanol 50ml,Reflux evenly,Standing slowly inside temperature 35 ,filter,The filter cake was washed with methanol 10 ml x 2,The solid was added to 50 ml of methanol,Reflux for 4 hours,Standing slowly cooled to the internal temperature of 40 ~ 45 ,filter,Filter cake with a small amount of methanol washing,Dried to a white solid (11.3 g, 17.1 mmol)Yield 60.9%. According to the analysis of related databases, 70627-52-0, the application of this compound in the production field has become more and more popular.

Application of 2062-98-8, A common heterocyclic compound, 2062-98-8, name is Perfluoro(2-methyl-3-oxahexanoyl) fluoride, molecular formula is C6F12O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 16 Sodium perfluoro-2-methyl-3-oxahexanoate The procedure of Example 1 was followed using perfluoro-2-methyl-3-oxahexanoyl fluoride (16.6 g, 50 mmol), sodium trimethylsilanolate (5.6 g, 50 mmol), dry o-dichlorobenzene (200 mL), and 1 h at room temperature followed by rapid heating to 150. Sodium perfluoro-2-methyl-3-oxahexanoate (13.6 g, 77% yield) was isolated as a white solid: The 19 F NMR data were the same as reported in Example 15.

The synthetic route of 2062-98-8 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2062-98-8, name is Perfluoro(2-methyl-3-oxahexanoyl) fluoride, A new synthetic method of this compound is introduced below., Recommanded Product: Perfluoro(2-methyl-3-oxahexanoyl) fluoride

The same operation as in Example 1-1 was carried out except that the starting materials were changed as shown in Table 1.The GC purity of the recovered crude liquid was 97%.In addition, measurement1the H-NMR and19F.-NMR spectra confirmed the title compound as a main component (fluorine content = 58.5% by mass)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Asahi Glass Co Ltd;; Qing, Shanyuanzhi; Ye, Cunshunping; (28 pag.)CN105492418; (2016); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of 162705-07-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 162705-07-9 as follows.

General procedure: A solution of AmCA-4 (0.7mmol) in THF (5mL/mmol) was cooled at 0C and anhydrous pyridine (1.7mmol) and the corresponding phenyl chloroformate (1.0mmol) were added under inert atmosphere. The resulting mixture was stirred in the dark for 20minat 0C and for 1hat rt. After this time, H2O (3.4mL) and HCl 1M (1.7mL) were added to the reaction mixture, which was then extracted with CH2Cl2 (3¡Á20mL). The organic layer was washed with brine, and then dried on anhydrous Na2SO4. Removal of volatiles under reduced pressure afforded an oily residue which was subjected to column chromatography on silica-gel (Hexanes-EtOAc mixtures as eluant) obtaining the desired products with the yields indicated below. 6.1.2.1 53 Phenyl (Z)-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)carbamate (1) Off-white solid, m. p. 124-126C; 1H NMR (500MHz, CDCl3) delta 8.11 (br s, 1H), 7.52 (br s, 1H, NH), 7.39 (t, J?7.5Hz, 2H), 7.24 (t, J?7.5Hz, 1H), 7.19 (d, ?7.5Hz, 2H), 7.00 (d, J=8.5Hz, 1H), 6.76 (d, J=8.5Hz, 1H), 6.52 (s, 2H), 6.51 (d, J=12Hz, 1H), 6.45 (d, J=12Hz, 1H), 3.89 (s, 3H), 3.81 (s, 3H), 3.70 (s, 6H); 13C NMR (125MHz, CDCl3) delta (C) 152.9 (x 2), 151.3, 150.6, 146.9, 137.2, 132.7, 130.3, 126.9, (CH) 129.5, 129.3 (x 2), 129.2, 125.5, 123.9, 121.6 (x 2), 119.3, 109.6, 106.1 (x 2), (CH3) 60.8, 55.9 (x 2), 55.8; IR numax (cm-1) 3415 (N-H), 1750 (C=O); HR ESMS m/z 458.1588 [M+Na]+. Calc. for C25H25NNaO6, 458.1580.

According to the analysis of related databases, 162705-07-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Conesa-Milian, Laura; Falomir, Eva; Murga, Juan; Carda, Miguel; Meyen, Eef; Liekens, Sandra; Alberto Marco; European Journal of Medicinal Chemistry; vol. 147; (2018); p. 183 – 193;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of 70384-51-9,Some common heterocyclic compound, 70384-51-9, name is Tris(2-(2-methoxyethoxy)ethyl)amine, molecular formula is C15H33NO6, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Synthesis of AMPS-ammonium salt monomer. A nitrogen purged 50 ml schlenk flask was charged with freshly distilled tris[2-(2-methoxyethoxy)-ethyl]amine (1.69 g, 5.24 mmol) and 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS) (1.09 g, 5.24 mmol) and stirred at ambient temperature for 8 hr or until completely dissolved. Total dissolution completes formation of the AMPS-ammonium salt monomer as a transparent light amber oil in a 99percent yield which was used immediately without further purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Tris(2-(2-methoxyethoxy)ethyl)amine, its application will become more common.

Reference:
Patent; The Government of the US, as represented by the Secretary of the Navy; US2008/51605; (2008); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem