Tag: M.W=300-400

Related Products of 2062-98-8, A common heterocyclic compound, 2062-98-8, name is Perfluoro(2-methyl-3-oxahexanoyl) fluoride, molecular formula is C6F12O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The methyl perfluoroalkyl ether carboxylate was prepared by esterfication of perfluorinated ether acid fluoride with methanol. A mixed solution of 41.11 g anhydrous triethylamine (0.40 mol) in 47.5 g anhydrous methanol (1.48 mol) was added dropwise into 185 g perfluoro-2,5-dimethyl-3,6-dioxa-nonanoic acid fluoride (0.37 mol) in a dry three-neck flask under agitation over a period of 2 h at 0 C. The mixture was agitated for another 4 h and the temperature of reaction mass was maintained at room temperature. Subsequently, the reaction mixture was poured into a separating funnel. The fluorocarbon layer was washed with sodium bicarbonate solution and dried over anhydrous sodium sulfate to obtain the crude product. The crude product was distilled to give 178.43 g methyl perfluoro-2,5-dimethyl-3,6-dioxa-nonanoate (yield 94%) boiling at 145 C at 760 mmHg. IR: 2969,1792, 1290, 1237, 1145, 1040, 994 cm-1. 1H-NMR (500 MHz, CDCl3): delta 3.99 (3H, s, CH3). 13C-NMR (125 MHz, CDCl3): delta 54.60 (-CH3-).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Shi, Xiang; Shi, Hongxin; Wu, Hongke; Shen, HaiMin; Research on Chemical Intermediates; vol. 44; 9; (2018); p. 5091 – 5105;,
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Related Products of 2062-98-8,Some common heterocyclic compound, 2062-98-8, name is Perfluoro(2-methyl-3-oxahexanoyl) fluoride, molecular formula is C6F12O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In the implementation of the example 1 on the basis of the, to amplify production test: the full the fluorine is positive n-propyl vinyl ether (PPVE) 1 kg, hexafluoropropylene oxide dimer 1.5 kg, cesium fluoride 120g and diethylene glycol dimethyl ether 2.6L adding 10L in the reactor, the temperature is increased to 95 C, stirring for 2 hours, the reaction pressure will not change the observation, cooling, opening the reaction kettle, separating out the lower liquid product distillation is C11 the re-compounding process 1.95 kg, yield is 87%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Perfluoro(2-methyl-3-oxahexanoyl) fluoride, its application will become more common.

Reference:
Patent; Tianjin Changlu Chemical New Material Co., Ltd; Zhang, Zhijun; Zhao, Xinghua; Xu, Yashuo; Wang, Bo; Xiao, Shan; (5 pag.)CN105503552; (2016); A;,
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Synthetic Route of 13985-15-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13985-15-4, name is 2,3,6,7-Tetramethoxy-9,10-dimethylanthracene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A solution of 2,3,6,7-tetrakis(methoxy)-9, 10-dim-ethylanthracene (10.0 g) obtained from the step 2A-1,sodium dichromate (50 g) and acetic acid (500 ml) wasrefluxed for 60 minutes to obtain 2,3,6,7-tetrakis(methoxy)anthracene-9, 10-dione (2).10336] 2,3,6,7-tetrakis(methoxy) anthracene-9, 1 0-dione:?H NMR (600 MHz, CDC13) oe 7.32 (s, 4H), 4.06 (t, 8H),1.76 (m, 8H), 1.57 (m, 8H), 1.43-1.26 (m, 72H), 0.88 (t,1 2H)

The synthetic route of 2,3,6,7-Tetramethoxy-9,10-dimethylanthracene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY; SUH, Donghack; CHOI, Kyounghwan; (106 pag.)US2019/31586; (2019); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 13985-15-4, name is 2,3,6,7-Tetramethoxy-9,10-dimethylanthracene, A new synthetic method of this compound is introduced below., Safety of 2,3,6,7-Tetramethoxy-9,10-dimethylanthracene

The result of step 2A-1, 2,3,6,7-tetrakis (methoxy) -9,10-dimethyl anthracene(10.0 g), sodium dichromate (50 g),Acetic acid (500 ml) was refluxed for 60 minutes to obtain 2,3,6,7-tetrakis (methoxy) anthracene-9,10-dione (2)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Hanyang University Industry-Academic Cooperation Foundation; Seo Dong-hak; Choi Gyeong-hwan; (85 pag.)KR2018/43221; (2018); A;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 13985-15-4, name is 2,3,6,7-Tetramethoxy-9,10-dimethylanthracene, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C20H22O4

Under an inert N2 atmosphere, 91 (2 g, 6.1 mmol), NBS (4 g, 22.6 mmol) and ABCN (73 mg, 0.3 mmol) were dissolved in anhydrous dichloromethane (150 mL), and the mixture stirred at reflux for 4 hours. The mixture was then cooled to 0 C and filtered. The solid was then dried under high vacuum to afford 92 (2.1 g, 4.3 mmcl, 71%) as a bright yellow solid. 1H NMR (400 MHz, CDCI3) O 4.11 (s, 12H, C(1)H), 5.35 (s, 4H, C(6)H), 7.40 (s, 4H, C(3)H), 13C NMR (100 MHz, CDCI3) 28.7(06), 56.0 (Cl), 101.8(03), 125.7(05), 125.9(04), 150.1 (02).

According to the analysis of related databases, 13985-15-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ZIYLO LIMITED; DAVIS, Anthony; TROMANS, Robert; WILSON, Miriam Ruth; ORCHARD, Michael Glen; CHAPMAN, Andrew Michael; TOMSETT, Michael Roger; MATLOCK, Johnathan Vincent; (320 pag.)WO2018/167503; (2018); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2050-47-7, name is 4,4′-Oxybis(bromobenzene), This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 4,4′-Oxybis(bromobenzene)

All manipulations were performed under an inert atmosphere of nitrogen. A Schlenk flask equipped with a condenser was charged with 4- bromophenylether (3.90 g), carbazole (4.34 g), 18-crown-6 (0.70 g), Cu (1.65 g) and K2CO3 (3.60 g) and 1, 2-dichlorobenzene (150 mL). The resulting mixture was heated to 180 C for four days. After cooling to room temperature, water was added and the mixture was stirred overnight. The organic layer was isolated and the water layer was washed with water. The combined organic layers were dried over MgSO4 and the solvent was evaporated to give a brown oil. The desired product was isolated by crystallization from CH2CI2/MeOH to give an off-white powder in 58% yield (3. 5 g) 1H NMR (CD2CI2, 500 MHz): 6 8.14 (d, 1H), 7. 58 (d, 1H), 7.42 (m, 2H), 7.35 (d, 1H), 7.27 (m, 1H).

According to the analysis of related databases, 2050-47-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; E.I. DUPONT DE NEMOURS AND COMPANY; WO2005/82851; (2005); A2;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 57602-02-5, name is 1,14-Dibromo-3,6,9,12-tetraoxatetradecane, A new synthetic method of this compound is introduced below., Safety of 1,14-Dibromo-3,6,9,12-tetraoxatetradecane

General procedure: Thioacetate 3 (2.2 eq) and dibromide (1eq) were dissolved in dry DMF. DEA was added dropwise and the reaction was stirred for 3 h at room temperature. Then the reaction mixture was washed with 1 M HCl (aq), extracted with CH 2Cl 2, dried with Na 2SO 4. The solution was concentrated and purified by column chromatography.

The synthetic route of 57602-02-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Yang, Yang; He, Yun; Li, Xingzhe; Dinh, Hieu; Iyer, Suri S.; Bioorganic and Medicinal Chemistry Letters; vol. 24; 2; (2014); p. 636 – 643;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2050-47-7, name is 4,4′-Oxybis(bromobenzene), A new synthetic method of this compound is introduced below., Application In Synthesis of 4,4′-Oxybis(bromobenzene)

Bis- (4-bromophenyl) ether (30 g, 0.092 mol), a, a, a-trichlorotoluene (22 ml, 0. 15 mol), aluminum chloride (20 g, 0.15 mol) in dichloromethane (75 ml) were stirred at room temperature for 1 hour. The reaction mixture was poured into water (100 ml) and hexane (300 ml and the suspension was stirred overnight. The mixture was then filtered, washed with water (230 ml) and hexane 400 ml) and dried to give the title compound as a crystalline solid (34.94 g, yield: 88%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; ISIS PHARMACEUTICALS, INC.; WO2005/77966; (2005); A1;,
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Reference of 169247-46-5, These common heterocyclic compound, 169247-46-5, name is 1-(Benzyloxy)-4-bromo-2-(trifluoromethyl)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A 100 mL round bottom flask was charged with EXAMPLE 49B (1.9Og, 5.74 mmol), 4,4,4′,4′,5,5,5′,5′-octamethyl-2,2′-bi(l,3,2-dioxaborolane) (1.75g, 6.89 mmol), [l,r-bis(diphenylphosphino)ferrocene]dichloropalladium(II) dichloromethane (0.234 g, 0.287 mmol), diphenylphosphinoferrocine (0.159g, 0.287 mmol) and potassium acetate (1.689g, 17.21 mmol) in 50 mL dioxane. The mixture was degassed with N2 and heated at 800C overnight, diluted with water, and extracted into ethyl acetate. The organics were washed with brine and dried (MgSO4), filtered, and concentrated. The crude product was purified on silica gel eluting with 0-10percent ethyl acetate/hexane to provide the title compound. MS (DCI(+)) m/e 396 (M+NH4)+; 1H NMR (300 MHz, dimethylsulfoxide- d6) delta ppm 7.64 (dd, 1 H), 7.56-7.16 (m, 7 H), 5.26 (s, 2 H), 1.29 (s, 12 H).

The synthetic route of 169247-46-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ABBOTT LABORATORIES; CLARK, Richard, F.; BELL, Randy, L.; BA-MAUNG, Nwe, Y.; ERICKSON, Scott, A.; FIDANZE, Steve, D.; MANTEI, Robert, A.; SHEPPARD, George, S.; SORENSEN, Bryan, K.; WANG, Gary, T.; WANG, Jieyi; WO2010/138576; (2010); A1;,
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Synthetic Route of 169247-46-5,Some common heterocyclic compound, 169247-46-5, name is 1-(Benzyloxy)-4-bromo-2-(trifluoromethyl)benzene, molecular formula is C14H10BrF3O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Then, 5.10 g of 4-bromo-2-trifluoromethyl-1-benzyloxybenzene, 2.34 g of p-ethoxyphenol, 2.13 g of potassium carbonate, 100 mg of copper and 200 mg of cuprous chloride were charged into a reaction vessel, and stirred at 130° C. to 140° C. for 5 hours. The reaction solution was cooled to room temperature, poured into ice-water and then acidified by adding 10percent hydrochloric acid. The solution was extracted twice with 100 ml of diethyl ether. Then, the ether layers were combined, washed with water, dried over anhydrous magnesium sulfate and concentrated to give a crude product. This crude product was subjected to silica gel chromatography to give 2.50 g of 2-trifluoromethyl-4-(4-ethoxyphenoxy)-1-benzyloxybenzene (yield, 41percent).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-(Benzyloxy)-4-bromo-2-(trifluoromethyl)benzene, its application will become more common.

Reference:
Patent; Sumitomo Chemical Company, Limited; US5530015; (1996); A;,
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