Tag: M.W=300-400

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2062-98-8, name is Perfluoro(2-methyl-3-oxahexanoyl) fluoride, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C6F12O2

In a three-port glass reaction flask with a stirring and condenser in a volume of 0.25L,First add 80g of dioxane, 10g of sodium borohydride, stir and mix.After heating to 50 C, 83 g of perfluoro-2-methyl-3-oxa-hexanoyl fluoride was added dropwise, and the reaction was continued for 2 hours after the addition, and the material was distilled off after the reaction.The crude material was collected by freezing to obtain 96 g. The content of 2-perfluoropropoxy-2,3,3,3-tetrafluoropropanol in the crude material was 75%, and the product yield was 91%.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2062-98-8.

Reference:
Patent; Zhejiang Lantian Environmental Protection Gao Technology Co., Ltd.; Sinochem Lantian Group Co., Ltd.; Han Guoqing; Xiang Wenqin; Chen Mingyan; Sheng Nan; (5 pag.)CN108264451; (2018); A;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 70627-52-0, name is N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline, This compound has unique chemical properties. The synthetic route is as follows., Formula: C20H16FNO

To a solution of [RhCl(cod)]2(2 mol %) and N-(4-(benzyloxy)benzylidene)-4-fluoroaniline(1B, 0.5 mmol) in THF (1.25 mL) at room temperature was added BF3·Et2O (0.6 mmol), andthen it stirred for 30 min at the same temperature. Subsequently, 5,6-dihydro-2H-pyran-2-one (2h, 0.6 mmol) was added to the suspension mixture, and then 1.0 M Et2Zn in hexane (1.5 mmol, 1.5 mL) was gradually added to the mixture and stirred for 24 h. The mixture was quenched with sat. NH4Cl and extracted with AcOEt. The AcOEt layer was washed with sat. NaCl and dried over MgSO4. The solvent was removed in vacuo, and the residue was purified by column chromatography (AcOEt/hexane = 4:6) and anti diastereomer was obtained in 46% (93.3 mg) [2].

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 70627-52-0.

Reference:
Article; Isoda, Motoyuki; Sato, Kazuyuki; Kunugi, Yurika; Tokonishi, Satsuki; Tarui, Atsushi; Omote, Masaaki; Minami, Hideki; Ando, Akira; Beilstein Journal of Organic Chemistry; vol. 12; (2016); p. 1608 – 1615;,
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Synthetic Route of 207226-31-1, These common heterocyclic compound, 207226-31-1, name is 1,3-Dibromo-5-(trifluoromethoxy)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 1,3-dibromo-5-(trifluoromethoxy)benzene (25 g, 78.15 mmol, 1 eq) in i-Pr2O (50 mL) was added n-BuLi (2.5 M, 32 mL, 1.02 eq) at -78C for 0.5 h, then acetone (7.9 g, 136 mmol, 10 mL, 1.74 eq) was added. The mixture was stirred at 20C for 2 h. The reaction mixture was poured into 100 mL of aqueous NH4Cl and the resulting mixture was stirred for 15 min. The organic phase was separated, dried over anhydrous Na2SO4, filtered and evaporated in vacuo to give a residue. The residue was purified by flash silica gel chromatography (ISCO; 80 g SepaFlash Silica Flash Column, Eluent of 0~1% Ethylacetate/Petroleum ethergradient 50 mL/min). The title compound (8 g, 26.75 mmol, 34% yield) was obtained as a yellow liquid. 1H NMR (400 MHz, DMSO-d6) delta ppm 1.94 (s, 6 H), 5.90 (s, 1 H), 7.91 – 8.01 (m, 2 H), 8.19 – 8.25 (m, 1 H).

The synthetic route of 207226-31-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SAINT LOUIS UNIVERSITY; INDALO THERAPUETICS, INC.; RUMINSKI, Peter, G.; GRIGGS, David, W.; SEIWERT, Scott; (155 pag.)WO2018/132268; (2018); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 162705-07-9, name is (Z)-2-Methoxy-5-(3,4,5-trimethoxystyryl)aniline, This compound has unique chemical properties. The synthetic route is as follows., Formula: C18H21NO4

General procedure: DCC (0.47 mmol, 1.2 eq.); the N-Fmoc-protected amino acid (0.472 mmol, 1.2 eq) and HOBt·H2O (0.47 mmol, 1.2 eq) were added to a solution of the 30-aminocombretastatin (0.39 mmol, 1 eq) in anhydrous DMF (1.3 mL). The reaction mixture was stirred under N2 atmosphere for 16 h. Then, it was ltered, and the ltrate was poured into a saturated aqueous NH4Cl solution and then extracted with AcOEt (3×15 mL). The combined organic extracts were washed 2 times with water and brine and dried over anhydrous MgSO4. After ltration and evaporation of the solvent under reduced pressure, the resulting residue was chromatographed on silica gel with Hexanes-AcOEt (6:4) to aord the corresponding N-Fmoc-protected derivatives 7 and 9.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 162705-07-9.

Reference:
Article; Agut, Rauel; Alberto Marco, J.; Carda, Miguel; Falomir, Eva; Gil-Edo, Raquel; Martin-Beltran, Celia; Murga, Juan; Pla, Alberto; Molecules; vol. 25; 3; (2020);,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2062-98-8, name is Perfluoro(2-methyl-3-oxahexanoyl) fluoride, A new synthetic method of this compound is introduced below., Quality Control of Perfluoro(2-methyl-3-oxahexanoyl) fluoride

EXAMPLE 1; Example of production of monomer (1M); EXAMPLE 1-1: Esterification reaction; [] 2-Tetrahydrofurfuryl alcohol (20 g) and (CH3CH2)3N (21.8 g) were put in a flask and stirred under cooling with ice. While keeping the temperature in the flask to at most 10C, FCOCF(CF3)OCF2CF2CF3 (71.5 g) was dropwise added over a period of 1 hour. After completion of the dropwise addition, stirring was further carried out at 25C for 2 hours. Then, while keeping the temperature in the flask to at most 15C, water (50 mL) was added to obtain a reaction liquid which was separated into two layers. The reaction liquid was separated, and the lower layer was washed with water (50 mL) twice and dried over magnesium sulfate, followed by filtration to obtain a crude liquid. By distillation under reduced pressure, an aimed ester compound (66.3 g) was obtained as a fraction of 88 to 89C/2.7 kPa (absolute pressure). The GC purity was 98%. Formation of compound (A-20) was confirmed by NMR analysis. 1H-NMR (300.4 MHz, CDCl3, TMS) delta (ppm) : 1.60 to 1.73 (m, 1H), 1.86 to 2.10 (m,3H), 3.76 to 3.91 (m,2H), 4.14 to 4.22 (m, 1H), 4.28 to 4.47 (m,2H). 19F-NMR (282.7 MHz, CDCl3, CFCl3) delta (ppm): -79.9 (1F), -81.3 (3F), -82.1 (3F), -86.4 (1F), -129.5 (2F), -131.5 (1F).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; ASAHI GLASS COMPANY LTD.; EP1548014; (2005); A1;,
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Ether | (C2H5)2O – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 105404-89-5, name is 2,7-Dibromo-3,6-dimethoxynaphthalene, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 2,7-Dibromo-3,6-dimethoxynaphthalene

Sodium (0.21 g, 8.6 mmol) was added portionwise to anhydrous methanol (30 mL) stirred under an argon atmosphere. Upon complete dissolution, copper(I) iodide (1.65 g, 8.64 mmol), 3,6-dibromo-2,7-dimethoxynaphthalene (7, 1.50 g, 4.32 mmol) and anhydrous DMF (5 mL), were added to the reaction mixture and brought to reflux for 24 h. Additional copper(I) iodide (0.83 g, 4.32 mmol) and satd sodium methoxide (20 mL) were added to regenerate the catalyst and stirred at reflux for an additional 12 h. The reaction was quenched by the addition of water (10 mL) and extracted with DCM (2*25 mL), washed successively with 10% HCl (2*10 mL), water (2*10 mL), dried (MgSO4) and concentrated in vacuo to afford a crude solid, which was recrystallized from ethanol to afford the title compound (0.75 g, 70%). Mp 255-256 C (lit. 23 mp>200 C). 1H NMR (300 MHz, CDCl3) delta 7.04 (s, 4H), 3.98 (s, 12H); 13C NMR (75 MHz, CDCl3) delta 148.1, 124.1, 55.8; IR (ATR) (cm-1) 3064, 3003, 2964, 2937, 2887, 1669, 1608, 1528, 1510. HRMS (EI+, 70 eV); m/z: [M]+ calcd for C14H16O4 248.1049, found 248.1048.

According to the analysis of related databases, 105404-89-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Tate, Daniel J.; Abdelbasit, Mohamed; Kilner, Colin A.; Shepherd, Helena J.; Warriner, Stuart L.; Bushby, Richard J.; Tetrahedron; vol. 70; 1; (2014); p. 67 – 74;,
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Ether | (C2H5)2O – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 162705-07-9, name is (Z)-2-Methoxy-5-(3,4,5-trimethoxystyryl)aniline, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 162705-07-9

General procedure: DCC (0.47 mmol, 1.2 eq.); the N-Fmoc-protected amino acid (0.472 mmol, 1.2 eq) and HOBt·H2O (0.47 mmol, 1.2 eq) were added to a solution of the 30-aminocombretastatin (0.39 mmol, 1 eq) in anhydrous DMF (1.3 mL). The reaction mixture was stirred under N2 atmosphere for 16 h. Then, it was ltered, and the ltrate was poured into a saturated aqueous NH4Cl solution and then extracted with AcOEt (3×15 mL). The combined organic extracts were washed 2 times with water and brine and dried over anhydrous MgSO4. After ltration and evaporation of the solvent under reduced pressure, the resulting residue was chromatographed on silica gel with Hexanes-AcOEt (6:4) to aord the corresponding N-Fmoc-protected derivatives 7 and 9.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 162705-07-9.

Reference:
Article; Agut, Rauel; Alberto Marco, J.; Carda, Miguel; Falomir, Eva; Gil-Edo, Raquel; Martin-Beltran, Celia; Murga, Juan; Pla, Alberto; Molecules; vol. 25; 3; (2020);,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2062-98-8, name is Perfluoro(2-methyl-3-oxahexanoyl) fluoride, A new synthetic method of this compound is introduced below., Computed Properties of C6F12O2

A mixture of ethanolamine (13 g, 28 mmol) and ether (30 mL) was cooled to 15C. Perfluoro-2-methyl-3-oxahexanoyl fluoride (33 g in ether 50 mL) was added dropwise to keep the reaction temperature below 25C. After the addition, the reaction mixture was stirred at room temperature for one hour. The solid was removed by filtration and the filtrate was washed with hydrochloric acid (0.5N, 30 mL), water (2 times 30 mL), sodium hydrogen carbonate solution (0.5N, 20 mL), water (30 mL), and sodium chloride solution (saturated, 20 mL). It was then concentrated and dried in vacuum over night at room temperature to give a white solid 35 g, yield 95%. The product was analyzed using ^HNMR and the structure confirmed as is N-(perfluoro-2-methyl-3-oxahexanoyl)-2-aminoethanol, C3F7OCF(CF3)CONHCH2CH2OH.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; E. I. DU PONT DE NEMOURS AND COMPANY; MURPHY, Peter, Michael; HEWAT, Tracy; WO2010/2623; (2010); A2;,
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Synthetic Route of 162705-07-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 162705-07-9 as follows.

General procedure: DCC (0.47 mmol, 1.2 eq.); the N-Fmoc-protected amino acid (0.472 mmol, 1.2 eq) and HOBt·H2O (0.47 mmol, 1.2 eq) were added to a solution of the 30-aminocombretastatin (0.39 mmol, 1 eq) in anhydrous DMF (1.3 mL). The reaction mixture was stirred under N2 atmosphere for 16 h. Then, it was ltered, and the ltrate was poured into a saturated aqueous NH4Cl solution and then extracted with AcOEt (3×15 mL). The combined organic extracts were washed 2 times with water and brine and dried over anhydrous MgSO4. After ltration and evaporation of the solvent under reduced pressure, the resulting residue was chromatographed on silica gel with Hexanes-AcOEt (6:4) to aord the corresponding N-Fmoc-protected derivatives 7 and 9.

According to the analysis of related databases, 162705-07-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Agut, Rauel; Alberto Marco, J.; Carda, Miguel; Falomir, Eva; Gil-Edo, Raquel; Martin-Beltran, Celia; Murga, Juan; Pla, Alberto; Molecules; vol. 25; 3; (2020);,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

162705-07-9, name is (Z)-2-Methoxy-5-(3,4,5-trimethoxystyryl)aniline, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: ethers-buliding-blocks

General procedure: DCC (0.47 mmol, 1.2 eq.); the N-Fmoc-protected amino acid (0.472 mmol, 1.2 eq) and HOBt·H2O (0.47 mmol, 1.2 eq) were added to a solution of the 30-aminocombretastatin (0.39 mmol, 1 eq) in anhydrous DMF (1.3 mL). The reaction mixture was stirred under N2 atmosphere for 16 h. Then, it was ltered, and the ltrate was poured into a saturated aqueous NH4Cl solution and then extracted with AcOEt (3×15 mL). The combined organic extracts were washed 2 times with water and brine and dried over anhydrous MgSO4. After ltration and evaporation of the solvent under reduced pressure, the resulting residue was chromatographed on silica gel with Hexanes-AcOEt (6:4) to aord the corresponding N-Fmoc-protected derivatives 7 and 9.

The synthetic route of 162705-07-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Agut, Rauel; Alberto Marco, J.; Carda, Miguel; Falomir, Eva; Gil-Edo, Raquel; Martin-Beltran, Celia; Murga, Juan; Pla, Alberto; Molecules; vol. 25; 3; (2020);,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem