Tag: M.W=300-400

Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. 73724-45-5, formula is C18H17NO5, Name is Fmoc-Ser-OH. Ethers do have nonbonding electron pairs on their oxygen atoms, however, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. Product Details of C18H17NO5.

Wang, Zhuoer;Hao, Aiyou;Xing, Pengyao research published 《 Helical secondary structures and supramolecular tilted chirality in N-terminal aryl amino acids with diversified optical activities》, the research content is summarized as follows. Helix structures at at./mol. level have not been found in self-assembled peptide sequence with less than three residues. As β-sheet supramol. secondary structures have been discovered in solid-state amino acids, we here report the conjugation of simple N-terminal aryl protecting group could give rise to helical supramol. secondary structures in solid-state, which determines the optical activities of the adjacent aryl groups. The carboxylic acid-involved asym. H-bonds in N-terminal aryl amino acids induce the emergence of super-helical structures of amino acid residues and aryl groups. In most cases, supramol. tilted chirality of aryl groups is opposite to that of amino acid sequences, of which handedness and helical pitch are determined by the H-bond modalities. Determining correlation between supramol. tilted chirality of aryl segments and their chiroptical activities is firstly unveiled, which was verified by the computational results based on d. functional theory. Most aryl amino acids self-assembled by nanopptn. method via crystallization induced self-assembly into rigid one-dimensional microstructures with ultra-high Young’s modulus. This study reveals the generic existence of chiral supramol. structures in aggregated amino acid derivatives and gives an in-depth investigation into the structural-property relationships, which could guide the rational design and screening of chiroptical supramol. materials.

73724-45-5, Fmoc-Ser-OH, also known as Fmoc-Ser-OH, is a useful research compound. Its molecular formula is C18H17NO5 and its molecular weight is 327.3 g/mol. The purity is usually 95%.
Fmoc-L-Ser-OH is a synthetic peptide that belongs to the group of glycopeptides. It is used as a model for such compounds and has been shown to have antimicrobial activity in vitro against gram-positive bacteria, especially Staphylococcus epidermidis. This compound was synthesized from 3-mercaptopropionic acid and chloride in the presence of hydroxyl groups and epidermal growth factor. The synthetic pathway can be divided into three steps: (1) condensation of 3-mercaptopropionic acid with hydrochloric acid to yield 3-mercaptoacrylic acid; (2) esterification of 3-mercaptoacrylic acid with glycine to form Fmoc-L-Ser; and (3) deprotection of Fmoc protecting group., Product Details of C18H17NO5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers are a class of organic compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. 73724-45-5, formula is C18H17NO5, Name is Fmoc-Ser-OH.They have the general formula R–O–R′, where R and R′ represent the alkyl or aryl groups. Electric Literature of 73724-45-5.

Traboulsi, Hassan;Khedr, Mohammed A.;Al-Faiyz, Yasair S. S.;Elgorashe, Rafea;Negm, Amr research published 《 Structure-Based Epitope Design: Toward a Greater Antibody-SARS-CoV-2 RBD Affinity》, the research content is summarized as follows. Efficient COVID-19 vaccines are widely acknowledged as the best way to end the global pandemic. SARS-CoV-2 receptor-binding domain (RBD) plays fundamental roles related to cell infection. Antibodies could be developed to target RBD and represent a potential approach for the neutralization of the virus. Epitopes used to produce antibodies are generally linear peptides and thus possess multiple confirmations that do not reflect the actual topol. of the targeted part in the native protein. On the other hand, macrocyclic epitopes could constitute closer mimics of the native protein topol. and, as such, could generate superior antibodies. We demonstrated the vital effect of the size and the 3-dimensional shape of epitopes on the activity of the developed antibodies against the RBD of SARS-CoV-2. The mol. dynamics studies showed the greater stability of the cyclic epitopes compared with the linear counterparts, which was reflected in the affinity of the produced antibodies. The antibodies developed using macrocyclic epitopes showed superiority with respect to binding to RBD compared to antibodies formed from linear peptides. This study constitutes a roadmap for developing superior antibodies that could be used to inhibit the activity of SARS-CoV-2.

Electric Literature of 73724-45-5, Fmoc-Ser-OH, also known as Fmoc-Ser-OH, is a useful research compound. Its molecular formula is C18H17NO5 and its molecular weight is 327.3 g/mol. The purity is usually 95%.
Fmoc-L-Ser-OH is a synthetic peptide that belongs to the group of glycopeptides. It is used as a model for such compounds and has been shown to have antimicrobial activity in vitro against gram-positive bacteria, especially Staphylococcus epidermidis. This compound was synthesized from 3-mercaptopropionic acid and chloride in the presence of hydroxyl groups and epidermal growth factor. The synthetic pathway can be divided into three steps: (1) condensation of 3-mercaptopropionic acid with hydrochloric acid to yield 3-mercaptoacrylic acid; (2) esterification of 3-mercaptoacrylic acid with glycine to form Fmoc-L-Ser; and (3) deprotection of Fmoc protecting group., 73724-45-5.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers do have nonbonding electron pairs on their oxygen atoms, 73724-45-5, formula is C18H17NO5, Name is Fmoc-Ser-OH. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds. Application of C18H17NO5.

Tran, Kien;Van Den Hauwe, Robin;Sainsily, Xavier;Couvineau, Pierre;Cote, Jerome;Simard, Louise;Echevarria, Marco;Murza, Alexandre;Serre, Alexandra;Theroux, Lea;Saibi, Sabrina;Haroune, Lounes;Longpre, Jean-Michel;Lesur, Olivier;Auger-Messier, Mannix;Spino, Claude;Bouvier, Michel;Sarret, Philippe;Ballet, Steven;Marsault, Eric research published 《 Constraining the Side Chain of C-Terminal Amino Acids in Apelin-13 Greatly Increases Affinity, Modulates Signaling, and Improves the Pharmacokinetic Profile》, the research content is summarized as follows. Side-chain-constrained amino acids are useful tools to modulate the biol. properties of peptides. In this study, we applied side-chain constraints to apelin-13 (Ape13) by substituting the Pro12 and Phe13 positions, affecting the binding affinity and signaling profile on the apelin receptor (APJ). The residues 1Nal, Trp, and Aia were found to be beneficial substitutions for Pro12, and the resulting analogs displayed high affinity for APJ (K_i 0.08-0.18 nM vs Ape13 K_i 0.7 nM). Besides, constrained (D-Tic) or α,α-disubstituted residues (Db_zg; D-α-Me-Tyr(OBn)) were favorable for the Phe13 position. Compounds 47 (Pro12-Phe13 replaced by Aia-Phe, K_i 0.08 nM) and 53 (I) (Pro12-Phe13 replaced by 1Nal-Db_zg, K_i 0.08 nM) are the most potent Ape13 analogs activating the Gα₁₂ pathways (53, EC₅₀ Gα₁₂ 2.8 nM vs Ape13, EC₅₀ 43 nM) known to date, displaying high affinity, resistance to ACE2 cleavage as well as improved pharmacokinetics in vitro (t_1/2 5.8-7.3 h in rat plasma) and in vivo.

73724-45-5, Fmoc-Ser-OH, also known as Fmoc-Ser-OH, is a useful research compound. Its molecular formula is C18H17NO5 and its molecular weight is 327.3 g/mol. The purity is usually 95%.
Fmoc-L-Ser-OH is a synthetic peptide that belongs to the group of glycopeptides. It is used as a model for such compounds and has been shown to have antimicrobial activity in vitro against gram-positive bacteria, especially Staphylococcus epidermidis. This compound was synthesized from 3-mercaptopropionic acid and chloride in the presence of hydroxyl groups and epidermal growth factor. The synthetic pathway can be divided into three steps: (1) condensation of 3-mercaptopropionic acid with hydrochloric acid to yield 3-mercaptoacrylic acid; (2) esterification of 3-mercaptoacrylic acid with glycine to form Fmoc-L-Ser; and (3) deprotection of Fmoc protecting group., Application of C18H17NO5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers are a class of organic compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. 73724-45-5, formula is C18H17NO5, Name is Fmoc-Ser-OH.They have the general formula R–O–R′, where R and R′ represent the alkyl or aryl groups. Formula: C18H17NO5.

Tyrikos-Ergas, Theodore;Gim, Soeun;Huang, Jhih-Yi;Pinzon Martin, Sandra;Varon Silva, Daniel;Seeberger, Peter H.;Delbianco, Martina research published 《 Synthetic phosphoethanolamine-modified oligosaccharides reveal the importance of glycan length and substitution in biofilm-inspired assemblies》, the research content is summarized as follows. Bacterial biofilm matrixes are nanocomposites of proteins and polysaccharides with remarkable mech. properties. Efforts understanding and tuning the protein component have been extensive, whereas the polysaccharide part remained mostly overlooked. The discovery of phosphoethanolamine (pEtN) modified cellulose in E. coli biofilms revealed that polysaccharide functionalization alters the biofilm properties. To date, the pattern of pEtN cellulose and its mode of interactions with proteins remains elusive. Herein, we report a model system based on synthetic epitomes to explore the role of pEtN in biofilm-inspired assemblies. Nine pEtN-modified oligosaccharides were synthesized with full control over the length, degree and pattern of pEtN substitution. The oligomers were co-assembled with a representative peptide, triggering the formation of fibers in a length dependent manner. We discovered that the pEtN pattern modulates the adhesion of biofilm-inspired matrixes, while the peptide component controls its stiffness. Unnatural oligosaccharides tune or disrupt the assembly morphol., revealing interesting targets for polysaccharide engineering to develop tunable bio-inspired materials.

Formula: C18H17NO5, Fmoc-Ser-OH, also known as Fmoc-Ser-OH, is a useful research compound. Its molecular formula is C18H17NO5 and its molecular weight is 327.3 g/mol. The purity is usually 95%.
Fmoc-L-Ser-OH is a synthetic peptide that belongs to the group of glycopeptides. It is used as a model for such compounds and has been shown to have antimicrobial activity in vitro against gram-positive bacteria, especially Staphylococcus epidermidis. This compound was synthesized from 3-mercaptopropionic acid and chloride in the presence of hydroxyl groups and epidermal growth factor. The synthetic pathway can be divided into three steps: (1) condensation of 3-mercaptopropionic acid with hydrochloric acid to yield 3-mercaptoacrylic acid; (2) esterification of 3-mercaptoacrylic acid with glycine to form Fmoc-L-Ser; and (3) deprotection of Fmoc protecting group., 73724-45-5.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers are a class of organic compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. 73724-45-5, formula is C18H17NO5, Name is Fmoc-Ser-OH.They have the general formula R–O–R′, where R and R′ represent the alkyl or aryl groups. Name: Fmoc-Ser-OH.

Volpina, Olga M.;Koroev, Dmitriy O.;Serebryakova, Marina V.;Volkova, Tatyana D.;Kamynina, Anna V.;Bobkova, Natalia V. research published 《 Proteolytic degradation patterns of the receptor for advanced glycation end products peptide fragments correlate with their neuroprotective activity in Alzheimer’s disease models》, the research content is summarized as follows. The receptor for advanced glycation end products (RAGE) plays an essential role in Alzheimer’s disease (AD). We previously demonstrated that a fragment (60-76) of RAGE improved the memory of olfactory bulbectomized (OBX) and Tg 5 x FAD mice – animal models of AD. The peptide analog (60-76) with protected N- and C-terminal groups was more active than the free peptide in Tg 5 x FAD mice. This study investigated proteolytic cleavage of the RAGE fragment (60-76) and its C- and N-terminally modified analog by blood serum using HPLC and mass spectrometry. The modified peptide was proteolyzed slower than the free peptide. Degrading the protected analog resulted in shortened fragments with memory-enhancing effects, whereas the free peptide yielded inactive fragments. After administering the different peptides to OBX mice, their performance in a spatial memory task revealed that the ED of the modified peptide was five times lower than that of the free peptide. HPLC and mass spectrometry anal. of the proteolytic products allowed us to clarify the differences in the neuroprotective activity conferred by administering these two peptides to AD animal models. The current study suggests that the modified RAGE fragment is more promising for the development of anti-AD therapy than its free analog.

73724-45-5, Fmoc-Ser-OH, also known as Fmoc-Ser-OH, is a useful research compound. Its molecular formula is C18H17NO5 and its molecular weight is 327.3 g/mol. The purity is usually 95%.
Fmoc-L-Ser-OH is a synthetic peptide that belongs to the group of glycopeptides. It is used as a model for such compounds and has been shown to have antimicrobial activity in vitro against gram-positive bacteria, especially Staphylococcus epidermidis. This compound was synthesized from 3-mercaptopropionic acid and chloride in the presence of hydroxyl groups and epidermal growth factor. The synthetic pathway can be divided into three steps: (1) condensation of 3-mercaptopropionic acid with hydrochloric acid to yield 3-mercaptoacrylic acid; (2) esterification of 3-mercaptoacrylic acid with glycine to form Fmoc-L-Ser; and (3) deprotection of Fmoc protecting group., Name: Fmoc-Ser-OH

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. 73724-45-5, formula is C18H17NO5, Name is Fmoc-Ser-OH. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3. Computed Properties of 73724-45-5.

Soerensen, Kasper K.;Mishra, Narendra K.;Paprocki, Maciej P.;Mehrotra, Amit;Jensen, Knud J. research published 《 High-Performance Reversed-Phase Flash Chromatography Purification of Peptides and Chemically Modified Insulins》, the research content is summarized as follows. Preparative reversed-phase HPLC is the established method for the purification of peptides, but has significant limitations. We systematically investigated the use of high-performance reversed-phase flash chromatog. (HPFC) to rapidly purify laboratory-scale quantities of crude, synthetic peptides and chem. modified insulins. We demonstrated these methods for a diverse set of peptides, including short, medium, and long peptides. Depending on the purity profile of the peptide, HPFC can be used either as the sole purification method, or as a pre-purification method prior to final HPLC purification Furthermore, HPFC is suitable for the purification of peptides that are not fully in solution We provide guidelines for the HPFC of synthetic peptides and small proteins, including the choice of columns, eluents, and gradients. We believe that HPFC is a valuable alternative to HPLC purification of peptides and small proteins.

Computed Properties of 73724-45-5, Fmoc-Ser-OH, also known as Fmoc-Ser-OH, is a useful research compound. Its molecular formula is C18H17NO5 and its molecular weight is 327.3 g/mol. The purity is usually 95%.
Fmoc-L-Ser-OH is a synthetic peptide that belongs to the group of glycopeptides. It is used as a model for such compounds and has been shown to have antimicrobial activity in vitro against gram-positive bacteria, especially Staphylococcus epidermidis. This compound was synthesized from 3-mercaptopropionic acid and chloride in the presence of hydroxyl groups and epidermal growth factor. The synthetic pathway can be divided into three steps: (1) condensation of 3-mercaptopropionic acid with hydrochloric acid to yield 3-mercaptoacrylic acid; (2) esterification of 3-mercaptoacrylic acid with glycine to form Fmoc-L-Ser; and (3) deprotection of Fmoc protecting group., 73724-45-5.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers are a class of organic compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. 73724-45-5, formula is C18H17NO5, Name is Fmoc-Ser-OH.They have the general formula R–O–R′, where R and R′ represent the alkyl or aryl groups. Related Products of 73724-45-5.

Takayama, Kentaro;Hitachi, Keisuke;Okamoto, Hideyuki;Saitoh, Mariko;Odagiri, Miki;Ohfusa, Rina;Shimada, Takahiro;Taguchi, Akihiro;Taniguchi, Atsuhiko;Tsuchida, Kunihiro;Hayashi, Yoshio research published 《 Development of Myostatin Inhibitory D-Peptides to Enhance the Potency, Increasing Skeletal Muscle Mass in Mice》, the research content is summarized as follows. Myostatin is a key neg. regulator of skeletal muscle growth, and myostatin inhibitors are attractive tools for the treatment of muscular atrophy. Previously, we reported a series of 14-29 mer peptide myostatin inhibitors, including a potent derivative MIPE-1686, a 16-mer N-terminal-free L-peptide with three unnatural amino acids and a propensity to form β-sheets. However, the biol. stability in vivo of MIPE-1686 is a concern for its development as a drug. In the present study, to develop a more stable myostatin inhibitory D-peptide (MID), various retro-inverso versions of a 16-mer peptide were synthesized. Among these, an arginine-containing derivative, MID-35 shows a potent and equivalent in vitro myostatin inhibitory activity equivalent to that of MIPE-1686 and considerable stability against biodegradation The in vivo potency of MID-35 to increase tibialis anterior muscle mass in mice is significantly enhanced over that of MIPE-1686 and MID-35 can serve as a new entity for the prolonged inactivation of myostatin in skeletal muscle.

73724-45-5, Fmoc-Ser-OH, also known as Fmoc-Ser-OH, is a useful research compound. Its molecular formula is C18H17NO5 and its molecular weight is 327.3 g/mol. The purity is usually 95%.
Fmoc-L-Ser-OH is a synthetic peptide that belongs to the group of glycopeptides. It is used as a model for such compounds and has been shown to have antimicrobial activity in vitro against gram-positive bacteria, especially Staphylococcus epidermidis. This compound was synthesized from 3-mercaptopropionic acid and chloride in the presence of hydroxyl groups and epidermal growth factor. The synthetic pathway can be divided into three steps: (1) condensation of 3-mercaptopropionic acid with hydrochloric acid to yield 3-mercaptoacrylic acid; (2) esterification of 3-mercaptoacrylic acid with glycine to form Fmoc-L-Ser; and (3) deprotection of Fmoc protecting group., Related Products of 73724-45-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. 73724-45-5, formula is C18H17NO5, Name is Fmoc-Ser-OH. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3. Formula: C18H17NO5.

Sgorbati, Clara;Lo Presti, Eliana;Bergamaschi, Greta;Sani, Monica;Volonterio, Alessandro research published 《 Solid-phase synthesis of Gly-Ψ[CH(CF₃)NH]-peptides》, the research content is summarized as follows. The solid-phase synthesis of Gly-Ψ[CH(CF₃)NH]-peptides is presented. In order to achieve this goal, the synthesis of Gly-Ψ[CH(CF₃)NH]-dipeptides having the C-terminus unprotected, the N-terminus protected as Fmoc- or Teoc-, and possibly side chain functionalities protected with acid-labile protecting groups has been developed. A selected small library of six peptidomimetics, encompassing analogs of biol. relevant peptides, have been obtained in high purity.

73724-45-5, Fmoc-Ser-OH, also known as Fmoc-Ser-OH, is a useful research compound. Its molecular formula is C18H17NO5 and its molecular weight is 327.3 g/mol. The purity is usually 95%.
Fmoc-L-Ser-OH is a synthetic peptide that belongs to the group of glycopeptides. It is used as a model for such compounds and has been shown to have antimicrobial activity in vitro against gram-positive bacteria, especially Staphylococcus epidermidis. This compound was synthesized from 3-mercaptopropionic acid and chloride in the presence of hydroxyl groups and epidermal growth factor. The synthetic pathway can be divided into three steps: (1) condensation of 3-mercaptopropionic acid with hydrochloric acid to yield 3-mercaptoacrylic acid; (2) esterification of 3-mercaptoacrylic acid with glycine to form Fmoc-L-Ser; and (3) deprotection of Fmoc protecting group., Formula: C18H17NO5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. 73724-45-5, formula is C18H17NO5, Name is Fmoc-Ser-OH. Ethers do have nonbonding electron pairs on their oxygen atoms, however, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. Product Details of C18H17NO5.

Shimada, Naoyuki;Ohse, Naoki;Takahashi, Naoya;Urata, Sari;Koshizuka, Masayoshi;Makino, Kazuishi research published 《 Direct synthesis of N-protected serine- and threonine-derived Weinreb amides via diboronic acid anhydride-catalyzed dehydrative amidation: Application to the concise synthesis of Garner’s aldehyde》, the research content is summarized as follows. An efficient method for the direct synthesis of Weinreb amides derived from serine and threonine derivatives via diboronic acid anhydride-catalyzed hydroxy-directed amidation is described. This is the first successful example of the synthesis of serine- or threonine-derived Weinreb amides using catalytic dehydrative amidations. The methodol. could be applied to the concise synthesis of Garner’s aldehyde.

73724-45-5, Fmoc-Ser-OH, also known as Fmoc-Ser-OH, is a useful research compound. Its molecular formula is C18H17NO5 and its molecular weight is 327.3 g/mol. The purity is usually 95%.
Fmoc-L-Ser-OH is a synthetic peptide that belongs to the group of glycopeptides. It is used as a model for such compounds and has been shown to have antimicrobial activity in vitro against gram-positive bacteria, especially Staphylococcus epidermidis. This compound was synthesized from 3-mercaptopropionic acid and chloride in the presence of hydroxyl groups and epidermal growth factor. The synthetic pathway can be divided into three steps: (1) condensation of 3-mercaptopropionic acid with hydrochloric acid to yield 3-mercaptoacrylic acid; (2) esterification of 3-mercaptoacrylic acid with glycine to form Fmoc-L-Ser; and (3) deprotection of Fmoc protecting group., Product Details of C18H17NO5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers do have nonbonding electron pairs on their oxygen atoms, 73724-45-5, formula is C18H17NO5, Name is Fmoc-Ser-OH. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds. HPLC of Formula: 73724-45-5.

Simov, Vladimir;Altman, Michael D.;Bianchi, Elisabetta;DelRizzo, Sonia;DiNunzio, Edward N.;Feng, Guo;Goldenblatt, Peter;Ingenito, Raffaele;Johnson, Scott A.;Mansueto, My Sam;Mayhood, Todd;Mortison, Jonathan D.;Serebrov, Victor;Sondey, Christopher;Sriraman, Venkat;Tucker, Thomas J.;Walji, Abbas;Wan, Hui;Yue, Yingzi;Stoeck, Alexander;DiMauro, Erin F. research published 《 Discovery and characterization of novel peptide inhibitors of the NRF2/MAFG/DNA ternary complex for the treatment of cancer》, the research content is summarized as follows. Pathway activating mutations of the transcription factor NRF2 and its neg. regulator KEAP1 are strongly correlative with poor clin. outcome with pemetrexed/carbo(cis)platin/pembrolizumab (PCP) chemo-immunotherapy in lung cancer. Despite the strong genetic support and therapeutic potential for a NRF2 transcriptional inhibitor, currently there are no known direct inhibitors of the NRF2 protein or its complexes with MAF and/or DNA. Herein we describe the design of a novel and high-confidence homol. model to guide a medicinal chem. effort that resulted in the discovery of a series of peptides that demonstrate high affinity, selective binding to the Antioxidant Response Element (ARE) DNA and thereby displace NRF2-MAFG from its promoter, which is an inhibitory mechanism that to our knowledge has not been previously described. In addition to their activity in electrophoretic mobility shift (EMSA) and TR-FRET-based assays, we show significant dose-dependent ternary complex disruption of NRF2-MAFG binding to DNA by SPR, as well as cellular target engagement by thermal destabilization of HiBiT-tagged NRF2 in the NCI-H1944 NSCLC cell line upon digitonin permeabilization, and SAR studies leading to improved cellular stability. We report the characterization and unique profile of lead peptide (1), [(Ac-DELRAKALHIPFPVEKIINLPVVDFNEMMSKEQFN-EAQLALIRDIRRRGKNKVAAQNSRKRKLENIVELEQDLDHLKDEKEKGGhPraA-GSSG-K(DBCO-Cy5)-CONH₂)-(Ac-NGTSLTDEELVTMSVRELNQHLRGLSKEEIVQLKQRRRTLKNRGYAASSRVKRVTQKEELEKQKAELQQEVEKGGDabA-CONH₂)] which we believe to be a useful in vitro tool to probe NRF2 biol. in cancer cell lines and models, while also serving as an excellent starting point for addnl. in vivo optimization toward inhibition of NRF2-driven transcription to address a significant unmet medical need in non-small cell lung cancer (NSCLC).

73724-45-5, Fmoc-Ser-OH, also known as Fmoc-Ser-OH, is a useful research compound. Its molecular formula is C18H17NO5 and its molecular weight is 327.3 g/mol. The purity is usually 95%.
Fmoc-L-Ser-OH is a synthetic peptide that belongs to the group of glycopeptides. It is used as a model for such compounds and has been shown to have antimicrobial activity in vitro against gram-positive bacteria, especially Staphylococcus epidermidis. This compound was synthesized from 3-mercaptopropionic acid and chloride in the presence of hydroxyl groups and epidermal growth factor. The synthetic pathway can be divided into three steps: (1) condensation of 3-mercaptopropionic acid with hydrochloric acid to yield 3-mercaptoacrylic acid; (2) esterification of 3-mercaptoacrylic acid with glycine to form Fmoc-L-Ser; and (3) deprotection of Fmoc protecting group., HPLC of Formula: 73724-45-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem