Tag: M.W=300-400

HPLC of Formula: 73590-85-9. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole, is researched, Molecular C17H19N3O2S, CAS is 73590-85-9, about Microbiological production of omeprazole metabolites by Cunninghamella elegans. Author is Pearce, Clive M.; Lushnikova, Marina V..

Incubation of Cunninghamella elegans ATCC 9245 and the anti ulcer drug omeprazole allowed putative fungal metabolites to be isolated in sufficient quantities for structural elucidation. Three metabolites produced by the fungi were isolated using semi-preparative HPLC and their structures identified by a combination of LC/MS(n) and NMR experiments These isolates will be used as reference standards in the confirmatory anal. of mammalian metabolites of this drug.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called A simple and sensitive bioanalytical assay for simultaneous determination of omeprazole and its three major metabolites in human blood plasma using RP-HPLC after a simple liquid-liquid extraction procedure, published in 2006-12-05, which mentions a compound: 73590-85-9, mainly applied to omeprazole metabolite determination blood HPLC, Product Details of 73590-85-9.

A simple, sensitive and specific reverse-phase high-performance liquid chromatog. (HPLC) assay for the simultaneous quant. determination of omeprazole and its three metabolites in human plasma was developed and validated. This method provides excellent chromatog. resolution and peak shape for the four components and the internal standard within a 17 min run time. The simple extraction method results in a clean base line and relatively high extraction efficiency. The method was validated over the range of 2-2000 ng/mL, with 2.0 ng/mL as the lower limit of quantification. Within- and between-day accuracies for five different concentrations ranged from 95 to 102%, and 95 to 114%, resp. Within- and between-day precision ranged from 1.1 to 6.3% and 0.5 to 6.2%, resp. Simplicity and high throughput make this method suitable for clin. pharmacokinetic studies.

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Category: ethers-buliding-blocks. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole, is researched, Molecular C17H19N3O2S, CAS is 73590-85-9, about Development of a validated RP-HPLC method for separation and determination of process-related impurities of omeprazole in bulk drugs. Author is Iuga, Cristina; Bojita, Marius; Leucuta, Sorin E..

A gradient reversed phase liquid chromatog. (RP-LC) method was developed and subsequently validated for the determination of omeprazole and its process-related impurities (noted as: impurity A, B, C, D, G, H). Separation was achieved with a Zorbax Extend C18 column and acetonitrile: water: triethylaminel percent (pH adjusted to 9.5) as eluent, at a flow rate of 0.8 mL/min. UV detection was performed at 280 nm. The described method was linear over a range of 40.6-203 μg/mL for omeprazole, 0.9556-14.334 μg/mL for impurity A, 1.1568-17.352 μg/mL for impurity B, 1.0772-16.158 μg/mL for impurity C, 1.289-19.344 μg/mL for impurity D, and 0.7968-11.952 μg/mL for impurity H. The accuracy of the method was demonstrated at 5 concentration levels in the range of 60-140% of the specification limit and the recovery of impurities was found to be in the range of 90-109%. The method is simple, rapid, selective, accurate, and useful for indicating the stability of omeprazole from dosage forms. The method can be useful in the quality control of bulk manufacturing and pharmaceutical formulations.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole( cas:73590-85-9 ) is researched.Category: ethers-buliding-blocks.Oelschlager, H.; Seeling, A.; Seeling, B.; Westesen, K.; Bunjes, H. published the article 《Selective oxidation of 5-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methylthio]-1-H-benzimidazole to (RS-5-methoxy-2-[[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl]sulfinyl]-1-H-benzimidazole (omeprazole)》 about this compound( cas:73590-85-9 ) in Pharmazie. Keywords: omeprazole preparation decomposition kinetics; pyridylmethylthiobenzimidazole selective oxidation. Let’s learn more about this compound (cas:73590-85-9).

5-Methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methylthio]-1-H-benzimidazole was oxidized with Oxone in diluted EtOH at -5° furnishing omeprazole with an excellent yield. Addnl., decomposition kinetics of omeprazole in aqueous EtOH are presented.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Trivedi, Harshal K.; Patel, Mukesh C. researched the compound: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole( cas:73590-85-9 ).Application In Synthesis of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole.They published the article 《Development and validation of a precise single HPLC method for determination of omeprazole and its related compound in pharmaceutical formulation》 about this compound( cas:73590-85-9 ) in International Journal of ChemTech Research. Keywords: omeprazole determination impurity reversed phase HPLC. We’ll tell you more about this compound (cas:73590-85-9).

A simple reversed-phase high performance liquid chromatog. was developed and employed for the determination of omeprazole and its related substances in bulk material and com. dosage forms. A gradient elution of filtered sample was performed on Zorbax XDB C8 (150 × 4.6), 5μ column with Glacine buffer (pH-8.8) as a mobile phase-A, Acetonitrile : Methanol (83:17) as a mobile phase-B and UV detection at 302 nm. Mobile phase was delivered at flow of 1.2 mL/min and at maintaining the column temperature at 25°C, quantification was achieved with reference to the external standards The active ingredient – omeprazole was successfully separated from its all related substances, including process impurities and other possible impurities of oxidation and decomposition The excipients did not interfere with the determination of omeprazole and its related compound in com. dosage formulations. The method was rapid, simple, accurate and reproducible. It was not only successfully employed for the assay of omeprazole in bulk material and pharmaceutical dosage forms but also for the determination of its related substances. A statistical design of experiments was used for the robustness evaluation of HPLC anal. method. All results were acceptable and confirmed that the method is suitable for its intended use.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Lindberg, Per; Nordberg, Peter; Alminger, Tomas; Braendstroem, Arne; Wallmark, Bjoern researched the compound: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole( cas:73590-85-9 ).Application of 73590-85-9.They published the article 《The mechanism of action of the antisecretory agent omeprazole》 about this compound( cas:73590-85-9 ) in Journal of Medicinal Chemistry. Keywords: omeprazole active metabolite acid decomposition product; sulfenamide omeprazole active metabolite; stomach acid secretion omeprazole. We’ll tell you more about this compound (cas:73590-85-9).

The very potent gastric antisecretory agent omeprazole (I) [73590-58-6], presently under clin. evaluation, has been shown to act via inhibition of the gastric H+, K+-ATPase, the enzyme responsible for pumping of protons into the stomach. I needs acid activation to become an active inhibitor. A tetracyclic sulfenamide (II) was isolated from the acid decomposition of I. This sulfenamide, or, alternatively, the corresponding sulfenic acid, an unstable, probable intermediate in the sulfenamide formation, is the active inhibitor formed in vivo from omeprazole.

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COA of Formula: C17H19N3O2S. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole, is researched, Molecular C17H19N3O2S, CAS is 73590-85-9, about Stability-indicating methods for determining omeprazole and octylonium bromide in the presence of their degradation products. Author is El-Kousy, Naglaa M.; Bebawy, Lories I..

Four stability-indicating assays were developed for determining omeprazole and octylonium bromide. Omeprazole was photodegraded and determined in the presence of its degradation products omeprazole sulfenimide and benzimidazole sulfide by 2 methods. The first method depends on use of first-, second-, and third-derivative spectrophotometry at 290.4, 320.6, and 311.6 nm, resp. The second method was based on applying the charge-transfer technique with chloranil as π acceptor to form a complex with omeprazole, the absorbance of which is measured at 377 nm. These methods determined omeprazole in concentration ranges of 5-20 μg/mL by first-, second-, and third-derivative spectrophotometry and 10-50 μg/mL by charge-transfer complexation with mean accuracies of 99.92, 99.71, 99.64, and 100.24%, resp. Octylonium bromide was determined by a TLC-densitometric method using in the presence of its degradation products p-[2-(n-octyoxy)benzoyl]aminobenzoic acid and diethyl-(2-hydroxyethyl)methylammonium bromide without any interferences. Alternatively, octylonium bromide was evaluated by a colorimetric method using the acid dye Rose Bengal. The ion pair formed was extracted in chloroform at pH 4, and its absorbance was measured at 562 nm. These methods determine octylonium bromide in the presence of its degradation products in concentration ranges of 0.1-0.5 μg/μL by densitometry and 4.5-22.5 μg/mL by colorimetry, with mean accuracies of 100.21 and 99.73%, resp. The suggested methods were used to determine drugs in bulk powder, laboratory-prepared mixtures, and pharmaceutical dosage forms. Results were compared statistically with those obtained with reference methods.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Mechanism of the asymmetric sulfoxidation in the esomeprazole process: effects of the imidazole backbone for the enantioselection, published in 2009-04-30, which mentions a compound: 73590-85-9, mainly applied to mechanism asym sulfoxidation esomeprazole process effect imidazole backbone enantioselection, Computed Properties of C17H19N3O2S.

The asym. sulfoxidation reaction of imidazole-based prochiral sulfides was studied to explore the mechanistic details of the highly efficient esomeprazole process, which is one of the few industrial scale catalytic asym. procedures. The synthetic studies revealed that the smallest subunit governing the selectivity in the esomeprazole process is an imidazole ring. Thus, by using the esomeprazole procedure Me imidazole sulfide could be oxidized as efficiently as its several functionalized derivatives, including pyrmetazol. However, alkylation of the imidazole nitrogen led to a major drop of the enantioselectivity. Our atm. pressure chem. ionization-mass spectrometry (APCI/MS) studies indicate that addition of small amounts of water to the reaction mixture facilitates the formation of mononuclear titanium species, which are the active catalytic intermediates of the selective oxidation reaction. One of the most important features of the esomeprazole procedure is that amine additives increase the enantioselectivity of the oxidation process. The NMR studies of the presumed reaction intermediates show that under catalytic conditions the amines are able to coordinate to titanium and dissociate the coordinated imidazole substrate. The d. functional theory (DFT) modeling studies provided new insights in the mechanism of the asym. induction. It was found that the oxidation requires a lower activation energy if the imidazole sulfide precursor does not coordinate to titanium. Two possible reaction paths were explored for this out of sphere oxidation mechanism. The most important interaction governing the enantioselection is hydrogen bonding between the N-H of the imidazole ring and the chiral tartrate ligand on titanium. Furthermore, the oxidation reaction imposes an important structural constraint to the TS structure involving a linear arrangement of the peroxide oxygens and the sulfur atom. This constraint and the N coordination of imidazole leads to a very strained structure for the inner sphere mechanism of the oxidation, which leads to a much higher activation barrier than the corresponding out of sphere process, and therefore it is unlikely.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole, is researched, Molecular C17H19N3O2S, CAS is 73590-85-9, about Solubility of Omeprazole Sulfide in Different Solvents at the Range of 280.35-319.65 K.Category: ethers-buliding-blocks.

Solubility data were measured for omeprazole sulfide in ethanol, 95 mass-% ethanol, Et acetate, isopropanol, methanol, acetone, n-butanol and n-propanol in the temperature range from 280.35 to 319.65 K by employing the gravimetric method. The solubilities increase with temperature and they are in good agreement with the calculated solubility of the modified Apelblat equation and the λh equation. The exptl. solubility and correlation equation in this work can be used as essential data and model in the purification process of omeprazole sulfide. The thermodn. properties of the solution process, including the Gibbs energy, enthalpy, and entropy were calculated using the van’t Hoff equation.

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Application of 73590-85-9. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole, is researched, Molecular C17H19N3O2S, CAS is 73590-85-9, about Stability-indicating methods for determining omeprazole and octylonium bromide in the presence of their degradation products. Author is El-Kousy, Naglaa M.; Bebawy, Lories I..

Four stability-indicating assays were developed for determining omeprazole and octylonium bromide. Omeprazole was photodegraded and determined in the presence of its degradation products omeprazole sulfenimide and benzimidazole sulfide by 2 methods. The first method depends on use of first-, second-, and third-derivative spectrophotometry at 290.4, 320.6, and 311.6 nm, resp. The second method was based on applying the charge-transfer technique with chloranil as π acceptor to form a complex with omeprazole, the absorbance of which is measured at 377 nm. These methods determined omeprazole in concentration ranges of 5-20 μg/mL by first-, second-, and third-derivative spectrophotometry and 10-50 μg/mL by charge-transfer complexation with mean accuracies of 99.92, 99.71, 99.64, and 100.24%, resp. Octylonium bromide was determined by a TLC-densitometric method using in the presence of its degradation products p-[2-(n-octyoxy)benzoyl]aminobenzoic acid and diethyl-(2-hydroxyethyl)methylammonium bromide without any interferences. Alternatively, octylonium bromide was evaluated by a colorimetric method using the acid dye Rose Bengal. The ion pair formed was extracted in chloroform at pH 4, and its absorbance was measured at 562 nm. These methods determine octylonium bromide in the presence of its degradation products in concentration ranges of 0.1-0.5 μg/μL by densitometry and 4.5-22.5 μg/mL by colorimetry, with mean accuracies of 100.21 and 99.73%, resp. The suggested methods were used to determine drugs in bulk powder, laboratory-prepared mixtures, and pharmaceutical dosage forms. Results were compared statistically with those obtained with reference methods.

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