Tag: M.W=300-350

Hammarlund, E. R. published the artcileMethods of preparing isotonic solutions by means of graphs or tables on the basis of experimentally found iso-osmotic values, Recommanded Product: 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, the publication is Pharmaceutica Acta Helvetiae (1960), 593-607, database is CAplus.

Four graphical and three tabular methods for preparing isotonic aqueous solutions are described. New exptl. data is presented for 353 compounds to be used for the recommended and most practical of the methods studied for isotonicity adjustment. All the methods described may be used in practical pharmacy. The graphical methods are more accurate but consume more space than the tabular methods.

Pharmaceutica Acta Helvetiae published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C17H28ClNO3, Recommanded Product: 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Mukherjee, Sumit published the artcileApplication of Tandem Ring-Closing Enyne Metathesis: Formal Total Synthesis of (-)-Cochleamycin A, Application of (+)-B-Methoxydiisopinocampheylborane, the publication is Organic Letters (2009), 11(13), 2916-2919, database is CAplus and MEDLINE.

A tandem ring-closing metathesis of a silaketal-based dienyne substrate proceeded efficiently to provide a bicyclic siloxane, which upon removal of the silicon tether afforded an (E,Z)-1,3-dienediol. Further manipulation of this key functional motif rendered synthesis of the entire C1-C19 linear skeleton of (-)-cochleamycin A (I) , a late-stage intermediate employed in the previous total synthesis of (+)-cochleamycin A by Roush and co-workers.

Organic Letters published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, Application of (+)-B-Methoxydiisopinocampheylborane.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Habrant, Damien published the artcileTowards the total synthesis of calyculin C: preparation of the C₉-C₂₅ spiroketal-dipropionate unit, Computed Properties of 99438-28-5, the publication is Organic & Biomolecular Chemistry (2010), 8(19), 4364-4373, database is CAplus and MEDLINE.

An asym. synthesis of the C₉-C₂₅ spiroketal fragment of calyculin C is described. Key steps include two crotylation reactions using successively Brown’s reagent and (Z)-crotyltrifluorosilane for the formation of the anti, anti, anti stereo-tetrad, ynone formation by a Pd-catalyzed coupling of a thiol ester with a terminal alkyne and a double intramol. hetero-Michael addition for the stereoselective construction of the spiroketal framework.

Organic & Biomolecular Chemistry published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, Computed Properties of 99438-28-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Karisalmi, Kaisa published the artcileStereoselective synthesis of the C₉-C₁₉ lactone-dipropionate fragment of calyculin C, Computed Properties of 99438-28-5, the publication is Tetrahedron Letters (2004), 45(44), 8245-8248, database is CAplus.

A highly diastereoselective synthesis of the title fragment (I) of calyculin C has been developed based on an internal asym. induction between a chiral aldehyde and Z-crotyl trifluorosilane.

Tetrahedron Letters published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, Computed Properties of 99438-28-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

White, James D. published the artcileTotal Synthesis of Phorboxazole A. 1. Preparation of Four Subunits, Category: ethers-buliding-blocks, the publication is Organic Letters (2006), 8(26), 6039-6042, database is CAplus and MEDLINE.

Four subunits (I–IV) of the potent antitumor agent phorboxazole A were constructed. Fragments C20-C32 (I) and C9-C19 (II) containing tetrahydropyrans A and B, resp., were assembled using palladium-catalyzed intramol. alkoxycarbonylation.

Organic Letters published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C14H18BClO4, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Son, Jung Beom published the artcileEnantioselective total synthesis of (-)-clavosolide A and B, Category: ethers-buliding-blocks, the publication is Bulletin of the Korean Chemical Society (2010), 31(3), 653-663, database is CAplus.

Enantioselective total synthesis of proposed and revised structure of (-)-clavosolide A and B by a convergent approach, where syn-selective aldol, hydroxy-directed cyclopropanation, Mitsunobu inversion, Schmidt-type glycosylation, and macrolactonization reactions were utilized as key reactions. The relative and absolute stereochem. of the natural products were confirmed unambiguously by comparing the optical rotation values and ¹H and ¹³C NMR spectra of them.

Bulletin of the Korean Chemical Society published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C9H5ClO2, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Wang, Pengfei published the artcileSynthesis of the Potent Immunostimulatory Adjuvant QS-21A, Formula: C21H37BO, the publication is Journal of the American Chemical Society (2005), 127(10), 3256-3257, database is CAplus and MEDLINE.

QS-21A is one of the most promising new adjuvants for immune response potentiation and dose-sparing in vaccine therapy, given its exceedingly high level of potency and its favorable toxicity profile. Melanoma, breast cancer, small cell lung cancer, prostate cancer, HIV-1, and malaria are among the numerous maladies targeted in more than 80 recent and ongoing clin. trials involving QS-21A as a critical component for immune response augmentation in microgram doses. Herein is reported the first synthesis and structure verification of QS-21A_api, applying novel glycosylation methodologies in the convergent modular construction of this rare and potent natural product immunostimulant (no biol. data).

Journal of the American Chemical Society published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C15H21BO3, Formula: C21H37BO.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Denmark, Scott E. published the artcileTotal synthesis of (+)-papulacandin D, Name: (+)-B-Methoxydiisopinocampheylborane, the publication is Tetrahedron (2010), 66(26), 4745-4759, database is CAplus and MEDLINE.

A total synthesis of (+)-papulacandin D (I) was achieved in 31 steps, in a 9.2% overall yield from com. available materials. The synthetic strategy divided the mol. into two nearly equal sized subunits, i.e. the spirocyclic C-arylglycopyranoside and the polyunsaturated fatty acid side-chain. The C-arylglycopyranoside was prepared in 11 steps in a 30% overall yield from triacetoxyglucal. The fatty acid side-chain was also prepared in 11 steps in a 30% overall yield from geraniol. The key strategic transformations in the synthesis were a palladium-catalyzed organosilanolate-based cross-coupling reaction of a dimethylglucal-silanol with an electron-rich and sterically hindered aromatic iodide and a Lewis-base catalyzed enantioselective allylation reaction of a dienal and allyltrichlorosilane. A critical element in the successful execution of the synthesis was the development of a suitable protecting group strategy that satisfied a number of stringent criteria.

Tetrahedron published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, Name: (+)-B-Methoxydiisopinocampheylborane.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Tan, Choon-Hong published the artcileStereochemical assignment of the C21-C38 portion of the desertomycin/oasomycin class of natural products by using universal NMR databases: Proof, Quality Control of 99438-28-5, the publication is Angewandte Chemie, International Edition (2000), 39(23), 4282-4284, database is CAplus and MEDLINE.

We have predicted the stereochem. of the C21-C38 portion of the desertomycin/oasomycin class of natural products and have proven the predicted stereochem. by a stereoselective synthesis of the C21-C38 degradation product.

Angewandte Chemie, International Edition published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C5H4N4, Quality Control of 99438-28-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Varga, Janos M. published the artcileMechanism of allergic cross-reactions. I. Multispecific binding of ligands to a mouse monoclonal anti-DNP IgE antibody, Quality Control of 637-58-1, the publication is Molecular Immunology (1991), 28(6), 641-54, database is CAplus and MEDLINE.

A recently developed solid-phase binding assay was used to investigate the specificity of ligand binding to a mouse monoclonal anti-dinitrophenyl IgE (I). All DNP-amino acids, that were tested inhibited the binding of the radio-labeled I to DNP covalently attached to polystyrene microplates; however, the concentration for 50% inhibition varied within four orders of magnitude, DNP-L-serine being the most and DNP-L-proline the least potent inhibitor. In addition to DNP analogs, a large number of drugs and other compounds were tested for their ability to compete with DNP for the binding site of I. At the concentration used for screening, 59% of compounds had no significant inhibition; 19% inhibited the binding of I more than 50%. Several families of compounds (tetracyclines, polymyxins, phenothiazines, salicylates, and quinones) that were effective competitors were found. Within these families, changes in the functional groups attached to the family stem had major effects on the affinity of ligand binding. The occurrence frequencies of interactions of ligands with I is in good agreement with the semi-empirical model for multispecific antibody-ligand interactions.

Molecular Immunology published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C7H13ClNNaO5S, Quality Control of 637-58-1.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem