Tag: M.W=300-350

Yadav, J. S. published the artcileStereoselective total synthesis of (+)-sapinofuranone B, Related Products of ethers-buliding-blocks, the publication is Tetrahedron (2011), 67(25), 4620-4627, database is CAplus.

Two approaches for the total synthesis of (+)-sapinofuranone B have been described. The first strategy utilizes the methodol. developed earlier in our group to get the chiral propargyl alc. and the second strategy involves generation of threo-1,2-diol derivative by diastereoselective and enantioselective addition of [(Z)-γ-methoxymethoxyallyl]diisopinocampheylborane onto aldehyde and cross metathesis as the key steps.

Tetrahedron published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C6H4ClNO2, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Weinberger, R. published the artcileHigh-pressure liquid chromatographic analysis of pramoxine hydrochloride in high lipoid aerosol foam dosage form, Related Products of ethers-buliding-blocks, the publication is Journal of Pharmaceutical Sciences (1980), 69(4), 475-7, database is CAplus and MEDLINE.

A rapid and quant. method for the determination of pramoxine-HCl (I) [637-58-1] by high-pressure liquid chromatog. is presented. The drug is extracted as the salt from a preparation with a high lipoid composition by partitioning it to the aqueous phase of an Et₂O-MeOH-H₂O-AcOH system. The extract is chromatographed on an octadecylsilane bonded packing with MeOH-H₂O-AcOH-MeSO₃H mobile phase. The time required for each separation is âˆ? min. Anal. recoveries of 100.4 ± 1.5% were obtained.

Journal of Pharmaceutical Sciences published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C9H9NO, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Varkuti, Boglarka H. published the artcileHigh-Throughput Small Molecule Screen Identifies Modulators of Mitochondrial Function in Neurons, Name: 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, the publication is iScience (2020), 23(3), 100931, database is CAplus and MEDLINE.

We developed a high-throughput assay for modulators of mitochondrial function in neurons measuring inner mitochondrial membrane potential (ΔΨ_m) and ATP production The assay was used to screen a library of small mols., which led to the identification of structural/functional classes of mitochondrial modulators such as local anesthetics, isoflavones, COXII inhibitors, adrenergic receptor blockers, and neurotransmitter system effectors. Our results show that some of the isolated compounds promote mitochondrial health, enhance oxygen consumption rate, and protect neurons against toxic insults found in the cellular environment of Alzheimer disease. These studies offer a set of compounds that may provide efficacy in protecting the mitochondrial system in neurodegenerative disorders.

iScience published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C4H8Cl2S2, Name: 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Fliri, Anton F. published the artcileDrug effects viewed from a signal transduction network perspective, Related Products of ethers-buliding-blocks, the publication is Journal of Medicinal Chemistry (2009), 52(24), 8038-8046, database is CAplus and MEDLINE.

Understanding how drugs affect cellular network structures and how resulting signals are translated into drug effects holds the key to the discovery of medicines. Herein we examine this cause-effect relationship by determining protein network structures associated with the generation of specific in vivo drug-effect patterns. Medicines having similar in vivo pharmacol. have been identified by a comparison of drug-effect profiles of 1320 medicines. Protein network positions reached by these medicines were ascertained by examining the coinvestigation frequency of these medicines and 1179 protein network constituents in millions of scientific investigations. Interestingly, medicine associations obtained by comparing by drug-effect profiles mirror those obtained by comparing drug-protein coinvestigation frequency profiles, demonstrating that these drug-protein reachability profiles are relevant to in vivo pharmacol. By using protein associations obtained in these investigations and independent, curated protein interaction information, drug-mediated protein network topol. models can be constructed. These protein network topol. models reveal that drugs having similar pharmacol. profiles reach similar discrete positions in cellular protein network systems and provide a network view of medicine cause-effect relationships.

Journal of Medicinal Chemistry published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C17H28ClNO3, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Beraki, Simret published the artcileA pharmacological screening approach for discovery of neuroprotective compounds in ischemic stroke, SDS of cas: 637-58-1, the publication is PLoS One (2013), 8(7), e69233, database is CAplus and MEDLINE.

With the availability and ease of small mol. production and design continuing to improve, robust, high-throughput methods for screening are increasingly necessary to find pharmacol. relevant compounds amongst the masses of potential candidates. Here, we demonstrate that a primary oxygen glucose deprivation assay in primary cortical neurons followed by secondary assays (i.e. post-treatment protocol in organotypic hippocampal slice cultures and cortical neurons) can be used as a robust screen to identify neuroprotective compounds with potential therapeutic efficacy. In our screen about 50% of the compounds in a library of pharmacol. active compounds displayed some degree of neuroprotective activity if tested in a pre-treatment toxicity assay but just a few of these compounds, including Carbenoxolone, remained active when tested in a post-treatment protocol. When further examined, Carbenoxolone also led to a significant reduction in infarction size and neuronal damage in the ischemic penumbra when administered six hours post middle cerebral artery occlusion in rats. Pharmacol. testing of Carbenoxolone-related compounds, acting by inhibition of 11-β-hydroxysteroid dehydrogenase-1 (11β-HSD1), gave rise to similarly potent in vivo neuroprotection. This indicates that the increase of intracellular glucocorticoid levels mediated by 11β-HSD1 may be involved in the mechanism that exacerbates ischemic neuronal cell death and inhibiting this enzyme could have potential therapeutic value for neuroprotective therapies in ischemic stroke and other neurodegenerative disorders associated with neuronal injury.

PLoS One published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C17H28ClNO3, SDS of cas: 637-58-1.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhang, Wei published the artcileResearch progress of apratoxin A: a marine cyclic-depsipeptide with significant anticancer activity, Recommanded Product: (+)-B-Methoxydiisopinocampheylborane, the publication is Youji Huaxue (2014), 34(3), 475-484, database is CAplus.

Apratoxin A, a marine natural cyclic-depsipeptide bearing novel and complex structure, showed significant antiproliferative activity against several cancer cell lines. A brief introduction on the research progress of this natural product including total synthesis, structure-activity relationship, pharmacol. studies, and biosynthetic pathway was summarized.

Youji Huaxue published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C10H12O5, Recommanded Product: (+)-B-Methoxydiisopinocampheylborane.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Gui, Honggang published the artcileCross-metathesis approach for stereocontrolled synthesis of the C1-C15 fragment of rhizopodin, COA of Formula: C21H37BO, the publication is Synlett (2014), 25(1), 138-142, database is CAplus.

The C1-C15 fragment of rhizopodin was synthesized through either Suzuki coupling reaction of vinyl iodide and vinyl boronate or cross-metathesis of a terminal olefin and a diene adduct in the presence of Hoveyda-Grubbs II catalyst.

Synlett published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, COA of Formula: C21H37BO.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Wang, Li published the artcileDetermination of content of compound pramoxine hydrochloride cream by HPLC, SDS of cas: 637-58-1, the publication is Xibei Daxue Xuebao, Ziran Kexueban (2007), 37(1), 52-54, database is CAplus.

The paper established an HPLC method for the determination of content of compound pramoxine hydrochloride cream. A CLC-ODS C₁₈ column (150 mm × 4.6 mm, 5 μm) and acetonitrile-phosphate buffer solution (55:45) as the mobile phase (adjusted to pH 7.5) were used for the determination with the detection wavelength of 224 nm and the column temperature of 40°. The flow rate was 1.0 mL/min. Results showed that a linear relationship was obtained within the range of 0.2120-0.9035 mg/mL (r = 0.9999). The average recovery was 99.63% (RSD = 0.53%). In conclusion, the method was simple, sensitive, accurate and suitable for the quant. control of compound pramoxine hydrochloride cream.

Xibei Daxue Xuebao, Ziran Kexueban published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C18H26ClN3O, SDS of cas: 637-58-1.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Stockdale, Tegan P. published the artcileA synthesis-enabled relative configurational assignment of the C31-C46 region of hemicalide, HPLC of Formula: 99438-28-5, the publication is Chemical Communications (Cambridge, United Kingdom) (2022), 58(38), 5729-5732, database is CAplus and MEDLINE.

Herein, through the targeted synthesis of configurationally defined fragments, as well as “encoded” mixtures of diastereomers, the stereochem. elucidation of the C31-C46 region of hemicalide I was achieved. Detailed NMR spectroscopic anal. of candidate fragments and comparison with the related hemicalide data strongly supported a 31,32-syn, 32,36-anti and 42,46-anti relationship. In combination with previous work on hemicalide, this reduced the number of possible structural permutations down to a more manageable eight diastereomers.

Chemical Communications (Cambridge, United Kingdom) published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C15H12O6, HPLC of Formula: 99438-28-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Helberger, Johann Heinrich published the artcileOrganic sulfonic acids. V. Syntheses of 1,4-butanesultone, Related Products of ethers-buliding-blocks, the publication is Justus Liebigs Annalen der Chemie (1954), 158-64, database is CAplus.

To 216 g. O.CH₂.CH₂.CH₂.CH₂ and 1.5 Zn dust was added slowly 237 g. AcCl; the mixture warmed initially at 40°, later at 60°, allowed to stand overnight, and heated 4 hrs. at 100°, giving 330 g. AcO(CH₂)₃CH₂Cl, b₁₅ 85°, 300 g. of which, refluxed 28 hrs. under N with 262 g. Na₂SO₃ in 1 l. H₂O, followed by concentration in vacuo, addition of 0.51. concentrated HCl, saturation with HCl gas, addition of MeOH, filtration, and concentration gave 280 g. HOCH₂(CH₂)₃SO₃H. Heating this acid 1.5 hrs. at 120-30°/16 mm., distilling, and removing dissolved SO₂ by N yielded 221 g. CH₂.(CH₂)₃.SO₂.O (I), b₁₃ 149-50°, large plates, m. 14.5°, nearly insoluble in cold. H₂O and CCl₄ soluble in Et₂O, CHCl₃, C₆H₆, and EtOH, hydrolyzed quantitatively to the sulfonic acid by boiling 1.5 hrs. with H₂O. [Cl(CH₂)₄]₂O (198 g.) heated and stirred under N 58 hrs. with 264 g. Na₂SO₃ in 1 l. H₂O, filtered, treated with BaCl₂, refiltered, and evaporated to dryness in vacuo gave [NaO₃SCH₂(CH₂)₃]₂O, which with saturated HCl and MeOH gave 92.3% of the corresponding free acid (II), uncrystallizable sirup. The Na salt of II, with PCl₅ and CCl₄ gave 78% acid chloride, oil, which, in Et₂O at -50° with liquid NH₃, formed [H₂NO₂S(CH₂)₄]₂O, needles, m. 104.5° (from H₂O). II (76 g.), heated 10 hrs. at 120-5°/6 mm., gave 66.8 g. I, b₅ 135-6°. As in previous publications, I gave the following hygroscopic sulfobetaines in excellent yields: (from pyridine) C₉H₁₃O₃NS, m. 249-50° (decomposition); (from PhNMe₂) C₁₂H₁₉O₃NS, m. 272-3° (decomposition); (from PhNH₂, noncrystalline glass. EtOH (15 cc.) saturated with NH₃ at 0° and heated with 1.36 g. I at 60-5° gave 1.45 g. H₂N(CH₂)₄SO₃H, m. 222-3° (decomposition) (from MeOH). The following crystalline adducts of I were also formed in 92-96% yields, by heating I with the appropriate salts or phenolates in suitable solvents: NC(CH₂)₄SO₃K, SN C(CH₂)₄SO₃K, I(CH₂)₄SO₃K, PhOCH₂(CH₂)₃SO₂Na, PhSCH₂(CH₂)₃SO₃Na, and (from K phthalimide). o-C₆H₄(CO)₂N(CH₂)₄SO₃K.

Justus Liebigs Annalen der Chemie published new progress about 183278-30-0. 183278-30-0 belongs to ethers-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain,Ether, name is Sodium 4,4′-oxybis(butane-1-sulfonate), and the molecular formula is C8H16Na2O7S2, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem