Tag: M.W=300-350

Lu, Hai-Hua published the artcileSynthesis and Biological Evaluation of Paleo-Soraphens, Application In Synthesis of 99438-28-5, the publication is Angewandte Chemie, International Edition (2013), 52(51), 13549-13552, database is CAplus and MEDLINE.

Possible natural product precursors of soraphen A [(1R,2S,5S,10S,11R,12E,14S,15S,16S,17S,18R)-1,17-dihydroxy-10,11,18-trimethoxy-2,14,16-trimethyl-5-phenyl-4,19-dioxabicyclo[13.3.1]nonadec-12-en-3-one] (I) were prepared The synthesis of the target compounds was achieved by a multistep process. The title compounds thus formed included a precursor for soraphen A (II) and a precursor for soraphen B (III). The title compounds were evaluated against Pythium debaryanum, Mucor hiemalis, Botrytis cinerea (fungal pathogens, antifungal agents) and against animal cell line L-929 (mouse connective tissue fibroblast cell line), animal cell line KB-3-1, human cervical carcinoma cell line (anticancer agents, antitumor agents). The compounds were evaluated as deoxyribonucleate topoisomerase I inhibitors.

Angewandte Chemie, International Edition published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, Application In Synthesis of 99438-28-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Grujic-Vasic, J. published the artcileThin-layer chromatographic separation and colorimetric determination of some local anesthetics and tropane alkaloids, HPLC of Formula: 637-58-1, the publication is Glasnik Hemicara i Tehnologa Bosne i Hercegovine (1970), 41-6, database is CAplus.

Tropane alkaloids and local anesthetics can be separated by thin-layer chromatog. on cellulose powder D impregnated with a borate/phosphate buffer at pH 6.6, using n-butanol saturated with H2O. Quant. determination is carried out by the method of Decker, et al. (1965).

Glasnik Hemicara i Tehnologa Bosne i Hercegovine published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C17H28ClNO3, HPLC of Formula: 637-58-1.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Brown, Gerbert C. published the artcileChiral synthesis via organoboranes. 26. An efficient synthesis of isoprenyl derivatives of borane. Valuable reagents for the isoprenylboration of aldehyde. A convenient route to both enantiomers of ipsenol and ipsdienol in high optical purity, COA of Formula: C21H37BO, the publication is Tetrahedron (1990), 46(13-14), 4463-72, database is CAplus.

Preparation of B-isoprenyldialkylboranes is achieved by adopting the Brandsma modification of the Schlosser procedure, namely metalation of isoprene with potassium 2,2,5,5-tetramethylpiperidide followed by sequential treatment with B-methoxydialkylborane and boron trifluoride-etherate. These reagents are used for the convenient isoprenylation of aldehydes. Reaction of isovaleraldehyde and β,β-dimethylacrolein with B-2′-isoprenyldiisopinocampheylborane (I) provides both ipsenol (II) and ipsdienol (III), resp. in 65% yields and 96% ee.

Tetrahedron published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, COA of Formula: C21H37BO.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Brown, Herbert C. published the artcileB-2′-Isoprenyldiisopinocampheylborane: an efficient reagent for the chiral isoprenylation of aldehydes. A convenient route to both enantiomers of ipsenol and ipsdienol, Related Products of ethers-buliding-blocks, the publication is Tetrahedron Letters (1990), 31(4), 455-8, database is CAplus.

B-2′-Isoprenyldiisopinocampheylborane is prepared by metalation of isoprene with potassium 2,2,5,5-tetramethylpiperidide followed by sequential treatment with B-methoxydiisopinocampheylborane and boron trifluoride-etherate. Condensation of this reagent with aldehydes provides isoprenylated chiral alcs. This methodol. is utilized for an efficient one-pot synthesis of both enantiomers of the pheromones of the bark beetle Ips paraconfusus Lanier, ipsenol (I) and ipsdienol (II) in 96% ee and 65% isolated yield.

Tetrahedron Letters published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Park, Sei-Kyoung published the artcileInhibition of Aβ42 oligomerization in yeast by a PICALM ortholog and certain FDA approved drugs, HPLC of Formula: 637-58-1, the publication is Microbial Cell (2016), 3(2), 53-64, database is CAplus and MEDLINE.

The formation of small Aβ42 oligomers has been implicated as a toxic species in Alzheimer disease (AD). In strong support of this hypothesis we found that overexpression of Yap1802, the yeast ortholog of the human AD risk factor, phosphatidylinositol binding clathrin assembly protein (PICALM), reduced oligomerization of Aβ42 fused to a reporter in yeast. Thus we used the Aβ42-reporter system to identify drugs that could be developed into therapies that prevent or arrest AD. From a screen of 1,200 FDA approved drugs and drug-like small compounds we identified 7 drugs that reduce Aβ42 oligomerization in yeast: 3 antipsychotics (bromperidol, haloperidol and azaperone), 2 anesthetics (pramoxine HCl and dyclonine HCl), tamoxifen citrate, and minocycline HCl. Also, all 7 drugs caused Aβ42 to be less toxic to PC12 cells and to relieve toxicity of another yeast AD model in which Aβ42 aggregates targeted to the secretory pathway are toxic. Our results identify drugs that inhibit Aβ42 oligomers from forming in yeast. It remains to be determined if these drugs inhibit Aβ42 oligomerization in mammals and could be developed as a therapeutic treatment for AD.

Microbial Cell published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C17H28ClNO3, HPLC of Formula: 637-58-1.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Nikolic, Kosta published the artcileElectro-analytical determination of some compounds from a group of synthetic local anesthetics, SDS of cas: 637-58-1, the publication is Arhiv za Farmaciju (1977), 27(1), 37-43, database is CAplus.

Amylocaine-HCl [532-59-2], butanilcaine-HCl [6027-28-7], dibucaine-HCl [61-12-1], falicaine [1155-49-3], cornecaine [3686-68-8], pramoxine-HCL [637-58-1], and tetracaine-HCl [136-47-0] in DMSO were determined by conductometric titration with KOH. The standard deviations were 0.2, 0.2, 0.1, 0.3, 0.3, 0.1 and 0.2, reps.

Arhiv za Farmaciju published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C17H28ClNO3, SDS of cas: 637-58-1.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Wang, Xiang published the artcileTotal Synthesis of the Salicylate Enamide Macrolide Oximidine II, Synthetic Route of 99438-28-5, the publication is Journal of the American Chemical Society (2003), 125(20), 6040-6041, database is CAplus and MEDLINE.

The asym. synthesis of the salicylate enamide macrolide oximidine II (I) is reported. The synthesis involves a highly regio- and stereoselective ring-closing metathesis of a bis-diene substrate to construct the macrocyclic triene core. Copper(I)-mediated amidation of a (Z)-vinyl iodide was employed to attach the enamide side chain.

Journal of the American Chemical Society published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C5H5F3O2, Synthetic Route of 99438-28-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Ramachandran, P. Veeraraghavan published the artcilePreparative-scale synthesis of both antipodes of B-γ,γ-dimethylallyldiisopinocampheylborane: application for the synthesis of C₁-C₆ subunit of epothilone, HPLC of Formula: 99438-28-5, the publication is Tetrahedron Letters (2004), 45(5), 1011-1013, database is CAplus.

A preparative-scale synthesis of B-γ,γ-dimethylallyldiisopinocampheylborane starting from prenyl alc. has been described. This reagent, upon reaction with various aldehydes, provides the corresponding α,α-dimethylhomoallylic alcs. in high enantioselectivities. The application of this reagent has been demonstrated for the synthesis of C₁-C₆ subunit of epothilone.

Tetrahedron Letters published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, HPLC of Formula: 99438-28-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Brown, Herbert C. published the artcileChiral synthesis via organoboranes. 9. Crystalline chelates from borinic and boronic esters. A simple procedure for upgrading borinates and boronates to materials approaching 100% optical purity, Recommanded Product: (+)-B-Methoxydiisopinocampheylborane, the publication is Journal of Organic Chemistry (1986), 51(24), 4526-30, database is CAplus.

The synthesis of crystalline chelates from borinate and boronate esters was explored as a means of upgrading the optical purities of intermediates from asym. hydroboration. B-Methoxy-9-borabicyclo[3.3.1]nonane and Me dicyclohexyl- and diisopinocampheylborinate react with various amino alcs. to form the corresponding chelates. Crystallization of 2-pyrrolidinylmethyl isopinocampheyl exo-norbornylborinate of 83% enantiomeric excess (e.e.) gives a product approaching 100% e.e. Treating di-Me cyclopentyl-, exo-norbornyl- and siamylboronate with various amino diols gave the corresponding boronates. The formation of the B←N bond depends on both steric and electronic factors. The corresponding boronates (2:1 derivatives) derived from these typical di-Me boronates and tetrols were also prepared The chelate derived from di-Et 3-tetrahydropyranylboronate of 83% e.e. and (HOCH₂CH₂)₂NCH₂CH₂N(CH₂CH₂OH)₂ yields a product of optical purity ≤100% e.e. upon crystallization

Journal of Organic Chemistry published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, Recommanded Product: (+)-B-Methoxydiisopinocampheylborane.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Yang, Mingze published the artcileTotal Synthesis of Dysoxylactam A, SDS of cas: 99438-28-5, the publication is Organic Letters (2020), 22(5), 1776-1779, database is CAplus and MEDLINE.

The total synthesis of a potent multi-drug-resistant reverser, dysoxylacatam A (1), was achieved in a highly efficient and stereocontrolled fashion. The highlights of the strategy enlisted an iterative combination of lithiation-borylation tactics including Aggarwal homologation and Matteson homologation, Brown crotylation, Krische allylation, and ring-closing metathesis to forge the macrocycle.

Organic Letters published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C8H10O2, SDS of cas: 99438-28-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem