Tag: M.W=300-350

Tuesley, Sidney P. published the artcileDevelopment and evaluation of a sampling device for the analysis of pharmaceutical aerosols, Safety of 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, the publication is Journal of Pharmaceutical Sciences (1968), 57(3), 488-93, database is CAplus and MEDLINE.

Various devices and techniques were studied in an attempt to obtain suitable samples of material from aerosol products. Generally accepted sampling procedures cannot be used since the aerosol product contains propellants that are extremely volatile. Several of these methods were investigated and used as the basis for assaying various aerosol products. A sampling device was developed and evaluated. The sampling device was designed in a manner that made available a sample of aerosol product that could then be assayed directly in the chamber. Openings were fitted with specially designed valves that allow for transfer of the contents without loss of volatile propellant or active ingredients. Various samples of aerosol products containing local anesthetics, steroids, and amines, were assayed by this method and gave acceptable results. In all cases, the amount of active ingredient contained in each product could be accurately determined The device makes possible a technique applicable to the anal. of most pharmaceutical aerosols. This method, which can be carried out with ease in a relatively short period of time, produced accurate results when used in the manner described.

Journal of Pharmaceutical Sciences published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C19H14Cl2, Safety of 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Barrett, Anthony G. M. published the artcileThe use of B-[(E)-3-(diphenylamino)allyl]diisopinocampheylborane as a reagent for the stereoselective synthesis of anti-β-diphenylamino alcohols and trans-1-diphenylamino-2-(1-hydroxylalkyl)cyclopropanes, Formula: C21H37BO, the publication is Tetrahedron (1993), 49(36), 7857-70, database is CAplus.

Anti-β-Amino alcs., e.g. (3R,4S)-4-(diphenylamino)-1,5-hexadien-3-ol (I), and trans-1-amino-2-(1-hydroxyalkyl)cyclopropanes, e.g. II, were prepared with high relative and absolute stereocontrol in a simple one-pot process via the reaction of aldehydes with B-[(E)-3-(diphenyamino)allyl]-diisopinocampheylborane and a subsequent alk. hydrogen peroxide work-up. The crystal structures of Mosher ester of I and cyclopropane II were determined

Tetrahedron published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, Formula: C21H37BO.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Barrett, Anthony G. M. published the artcileB-[(E)-3-(Diphenylamino)allyl]diisopinocampheylborane: an excellent reagent for the stereoselective synthesis of anti-β-diphenylamino alcohols, Category: ethers-buliding-blocks, the publication is Journal of the Chemical Society, Chemical Communications (1993), 339-41, database is CAplus.

Anti-β-Amino alcs. have been produced with high relative and absolute stereochem. control in a simple one-pot process via the reaction of aldehydes with B-[(E)-3-(diphenylamino)allyl]diisopinocampheylborane and alk. hydrogen peroxide work-up.

Journal of the Chemical Society, Chemical Communications published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Schmidt, A. C. published the artcileCrystal polymorphism of local anesthetic drugs. Part I: Pramocaine base in comparison with pramocaine hydrochloride, Application In Synthesis of 637-58-1, the publication is Journal of Thermal Analysis and Calorimetry (2003), 73(2), 397-408, database is CAplus.

Crystal polymorphs of pramocaine hydrochloride (PRCNC) and pramocaine (PRCN) free base were produced and characterized by means of thermomicroscopy, differential scanning calorimetry (DSC), FTIR- and FT-Raman-spectroscopy as well as x-ray-powder diffractometry. The relative thermodn. stabilities of all forms were determined and are represented in semi-schematic energy/temperature diagrams. PRCN, which is a viscous liquid at room temperature and insoluble in water, was found to exist in two different crystal forms with the m.ps. 23.5° (mod. I°) and 12.5° (mod. II). The water-soluble PRCNC crystallizes in three different crystal modifications. Mod. II° is the thermodynamically stable form at room temperature and is present in com. products. This form is obtained by crystallization from solvents and transforms on heating at about 95° into the high temperature form mod. I which melts at 171.0°. Both compounds show conformational polymorphism with forms of low kinetic stability.

Journal of Thermal Analysis and Calorimetry published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C17H28ClNO3, Application In Synthesis of 637-58-1.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Wipf, Peter published the artcileSynthesis and Biological Evaluation of Structurally Highly Modified Analogues of the Antimitotic Natural Product Curacin A, Computed Properties of 99438-28-5, the publication is Journal of Medicinal Chemistry (2002), 45(9), 1901-1917, database is CAplus and MEDLINE.

Structure-activity relationship anal. of synthetic analogs of curacin A revealed the lack of activity of traditional heterocyclic replacements of the thiazoline ring or cyclopropyl analogs of the core diene segment. The significance of the C(3)-C(4)-(Z)-alkene geometry was established, and a novel oxime analog was designed that displays biol. properties that are a close match of the natural product lead. The much less lipophilic, structurally simplified oxime I was only slightly weaker at inhibiting the growth of cultured human tumor cells than the natural product and was found to be more potent than curacin A at inhibiting the assembly of purified tubulin. Accordingly, the oxime moiety is likely to serve as a novel bioisostere of the (Z)-alkene group.

Journal of Medicinal Chemistry published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C3H6O2, Computed Properties of 99438-28-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Gao, Xuguang published the artcileTotal synthesis of the putative structure of the proposed Banyasin A, COA of Formula: C21H37BO, the publication is Frontiers in Chemistry (Lausanne, Switzerland) (2015), 1-7, database is CAplus and MEDLINE.

The first total synthesis of four possible isomers of a mol. possessing the configuration proposed for Banyasin A is described. The structure synthesized appears to be different from that of the natural product.

Frontiers in Chemistry (Lausanne, Switzerland) published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, COA of Formula: C21H37BO.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhang, Yuan published the artcileTotal Synthesis of Brevenal, Name: (+)-B-Methoxydiisopinocampheylborane, the publication is Journal of the American Chemical Society (2011), 133(9), 3208-3216, database is CAplus and MEDLINE.

This Article describes the total synthesis of the marine ladder toxin brevenal (I) utilizing a convergent synthetic strategy. Critical to the success of this work was the use of olefinic-ester cyclization reactions and the utilization of glycal epoxides as precursors to C-C and C-H bonds.

Journal of the American Chemical Society published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C7H5ClN2S, Name: (+)-B-Methoxydiisopinocampheylborane.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Huh, Chan Woo published the artcileHighly Stereoselective and Modular Syntheses of 10-Hydroxytrilobacin and Three Diastereomers via Stereodivergent [3 + 2]-Annulation Reactions, Category: ethers-buliding-blocks, the publication is Organic Letters (2008), 10(15), 3371-3374, database is CAplus and MEDLINE.

A convergent synthesis of the annonaceous acetogenin, 10-hydroxytrilobacin (I), was accomplished by using the [3+2]-annulation reaction of tetrahydrofuranyl carboxaldehyde II and allylsilane III. The stereodivergency of the [3+2]-annulation reaction made it possible to achieve modular, highly stereoselective syntheses of three 10-hydroxytrilobacin diastereomers from the same precursors by using simple modifications of reaction conditions.

Organic Letters published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Sun, Huikai published the artcileSynthesis of (+)-B-allyldiisopinocampheylborane and its reaction with aldehydes, Application In Synthesis of 99438-28-5, the publication is Organic Syntheses (2011), 87-101, database is CAplus and MEDLINE.

(+)-B-allyldiisopinocampheylborane (I) was prepared from (+)-B-methoxydiisopinocampheylborane and allylmagnesium bromide. Allylboration of achiral aldehydes by I gave secondary homoallylic alcs. stereoselectively. E.g., reaction of I and MeCHO gave 74% alc. (II). Allylboration of chiral aldehydes was also studied.

Organic Syntheses published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C28H41N2P, Application In Synthesis of 99438-28-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Paterson, Ian published the artcileSynthetic studies towards iriomoteolide 1a: stereocontrolled construction of C1-C9 and C11-C23 segments using lactate aldol chemistry, HPLC of Formula: 99438-28-5, the publication is Synlett (2010), 571-574, database is CAplus.

Nonracemic undecenal I (TES = Et₃Si) and nonracemic butenyldihydropyranone II (PMB = 4-MeOC₆H₄CH₂), C13-C23 and C1-C9 segments of the cytotoxic macrolide iriomoteolide 1a III, are prepared using stereoselective boron-mediated aldol additions (using both enantiomers of a nonracemic lactate-derived ketone) and a Suzuki-Miyaura cross-coupling reaction as the key steps.

Synlett published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, HPLC of Formula: 99438-28-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem