Tag: M.W=300-350

Terwilliger, Daniel W. published the artcileSelective Synthesis of Divergolide I, Recommanded Product: (+)-B-Methoxydiisopinocampheylborane, the publication is Journal of the American Chemical Society (2018), 140(8), 2748-2751, database is CAplus and MEDLINE.

Divergolide I (I) is a naphthoquinone ansamycin that exhibits broad antibacterial activity. Its tetracyclic ring system is believed to be biosynthetically assembled via ring-contraction of a macrocyclic precursor (proto-divergolide) that is both a macrolactone and a macrolactam. We here report a convergent and enantioselective synthesis that delivers the target mol. in less than 20 linear steps. Our work establishes the absolute configuration of divergolide I, confirms its relative configuration, and demonstrates that the biomimetic cyclization of a proto-divergolide can be surprisingly selective.

Journal of the American Chemical Society published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C7H7BrN2O2, Recommanded Product: (+)-B-Methoxydiisopinocampheylborane.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Meissner, Andreas published the artcileStereocontrolled synthesis of the macrolactone core of neopeltolide, Category: ethers-buliding-blocks, the publication is Tetrahedron Letters (2019), 60(5), 432-434, database is CAplus.

A stereoselective synthesis of the macrolactone core I of neopeltolide is described. The tetrahydropyran moiety was constructed via the intramol. allylation of an α-acetoxy ether. A late-stage macrolactonization provided a known synthetic intermediate of neopeltolide.

Tetrahedron Letters published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Frein, Jeffrey D. published the artcileNew Sources of Chemical Diversity Inspired by Biosynthesis: Rational Design of a Potent Epothilone Analog, Safety of (+)-B-Methoxydiisopinocampheylborane, the publication is Organic Letters (2009), 11(15), 3186-3189, database is CAplus and MEDLINE.

A concise total synthesis of (14S)-14-methoxyepothilone D (I) was accomplished. (14S)-14-Methoxyepothilone D represents a conceptually novel example of polyketide analog design based on an alternative biogenetic pattern of extender units. The significant biol. activity observed for this compound provides a foundation to support studies designed to prepare derivatives of this type through fermentation of genetically engineered organisms expressing the epothilone PKS gene cluster.

Organic Letters published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, Safety of (+)-B-Methoxydiisopinocampheylborane.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Tanaka, Nobuhiro published the artcileTotal synthesis of rhoiptelol B, Related Products of ethers-buliding-blocks, the publication is Heterocycles (2018), 97(2), 1157-1164, database is CAplus.

A stereoselective total synthesis of rhoiptelol B, a diarylheptanoid isolated from the fruits of Rhoiptelea chiliantha, is described. The tetrahydropyran ring was constructed via an intramol. allylation methodol.

Heterocycles published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C6H12O2, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Dinh, Tam Q. published the artcileAnalogs Incorporating trans-4-Hydroxy-L-proline That Reverse Multidrug Resistance Better than Hapalosin, Recommanded Product: (+)-B-Methoxydiisopinocampheylborane, the publication is Journal of Organic Chemistry (1997), 62(4), 790-791, database is CAplus.

Hydroxyproline-containing hapalosin analogs I [R = H, CH₂C₆H₄OMe (PMB); R¹ = H, CONHCH₂Ph] were prepared in several steps starting from trans-4-hydroxy-L-proline. Whereas the PMB ether of hapalosin possesses substantially lower lower anti-multidrug resistance activity than hapalosin, analogs I (R = PMB, R¹ = H; R = H, R¹ = CONHCH₂Ph) reverse multidrug resistance better than hapalosin, while I (R = = R¹ = H; R = PMB, R¹ = CONHCH₂Ph) were less effective that hapalosin. These results suggest that a free hydroxyl and an aromatic group may be important in the multidrug resistance activity of hapalosin and its analogs.

Journal of Organic Chemistry published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, Recommanded Product: (+)-B-Methoxydiisopinocampheylborane.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Leonardi, G. published the artcileInteraction between pharmaceuticals and sodium poly(ethylenesulfonate), Category: ethers-buliding-blocks, the publication is Journal of Pharmaceutical Sciences (1966), 55(5), 526-8, database is CAplus.

The interaction of several drugs, mainly local anesthetics, with Na poly(ethylenesulfonate) was studied by means of membrane equilibrium dialysis measurements. Data on equilibrium constants of the association between the drugs considered, as hydrochlorides, and the polyelectrolyte are reported.

Journal of Pharmaceutical Sciences published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C17H28ClNO3, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

De Rosa, Margherita published the artcileA three-step and enantioselective synthesis of (-)-(S)- or (+)-(R)-2-(furan-3-yl)-3,6-dihydro-2H-pyrans, HPLC of Formula: 99438-28-5, the publication is Tetrahedron Letters (2000), 41(10), 1593-1596, database is CAplus.

Enantiomerically enriched (3-furyl)-2-pyran derivatives, e.g. I, key-intermediates in the synthesis of the pharmacophoric pyranofuranone system of the bioactive natural products manoalide and cacospongionolide B, are easily accessible by a rapid sequence involving a chiral allylation and a ring closing metathesis reaction.

Tetrahedron Letters published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, HPLC of Formula: 99438-28-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Hirner, Sebastian published the artcileMicrowave-assisted rearrangement of vinylaziridines to 3-pyrrolines: formal synthesis of (-)-anisomycin, Safety of (+)-B-Methoxydiisopinocampheylborane, the publication is Synlett (2005), 3099-3102, database is CAplus.

An efficient microwave-assisted rearrangement of activated vinylaziridines to 3-pyrrolines is described. The rearrangement proceeds in good to excellent yields and is mediated by NaI or LiI in MeCN at elevated temperatures The synthetic utility of this reaction is shown in an efficient formal total synthesis of the antibiotic (-)-anisomycin.

Synlett published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, Safety of (+)-B-Methoxydiisopinocampheylborane.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Bates, Roderick W. published the artcileTetrahydropyran synthesis by intramolecular conjugate addition to enones: synthesis of the clavosolide tetrahydropyran ring, Recommanded Product: (+)-B-Methoxydiisopinocampheylborane, the publication is Synthesis (2010), 2935-2942, database is CAplus.

The synthesis of a tetrahydropyran intermediate for clavosolide A is reported, employing a combination of cross-metathesis and intramol. oxa-Michael addition The intramol. oxa-Michael addition to α,β-unsaturated esters requires the use of strong bases and can result in either modest yields or stereo-isomeric mixtures, and can be highly variable according to the substrate structure. In contrast, the corresponding ketones cyclize under very mild conditions to give the 2,6-cis-isomers directly. The use of appropriately substituted ketones allows efficient conversion into esters.

Synthesis published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, Recommanded Product: (+)-B-Methoxydiisopinocampheylborane.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Gohil, Vishal M. published the artcileNutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis, Related Products of ethers-buliding-blocks, the publication is Nature Biotechnology (2010), 28(3), 249-255, database is CAplus and MEDLINE.

Most cells have the inherent capacity to shift their reliance on glycolysis relative to oxidative metabolism, and studies in model systems have shown that targeting such shifts may be useful in treating or preventing a variety of diseases ranging from cancer to ischemic injury. However, we currently have a limited number of mechanistically distinct classes of drugs that alter the relative activities of these two pathways. We screen for such compounds by scoring the ability of >3500 small mols. to selectively impair growth and viability of human fibroblasts in media containing either galactose or glucose as the sole sugar source. We identify several clin. used drugs never linked to energy metabolism, including the antiemetic meclizine, which attenuates mitochondrial respiration through a mechanism distinct from that of canonical inhibitors. We further show that meclizine pretreatment confers cardioprotection and neuroprotection against ischemia-reperfusion injury in murine models. Nutrient-sensitized screening may provide a useful framework for understanding gene function and drug action within the context of energy metabolism

Nature Biotechnology published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C17H28ClNO3, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem