Tag: M.W=300-350

Vafai, Yassaman published the artcilePrenatal medication use in a prospective pregnancy cohort by pre-pregnancy obesity status, Category: ethers-buliding-blocks, the publication is Journal of Maternal-Fetal & Neonatal Medicine, database is CAplus and MEDLINE.

The association between obesity (body mass index (BMI) ≥ 30 kg/m2) and pattern of medication use during pregnancy in the United States is not well-studied. Higher pre-pregnancy BMI may be associated with increases or decreases in medication use across pregnancy as symptoms (e.g. reflux) or comorbidities (e.g. gestational diabetes) requiring treatment that may be associated with higher BMI could also change with advancing gestation. To determine whether prenatal medication use, by the number and types of medications, varies by pre-pregnancy obesity status. In a secondary data anal. of a racially/ethnically diverse prospective cohort of pregnant women with low risk for fetal abnormalities enrolled in the first trimester of pregnancy and followed to delivery (singleton, 12 United States clin. sites), free text medication data were obtained at enrollment and up to five follow-up visits and abstracted from medical records at delivery. In 436 women with obesity and 1750 women without obesity (pre-pregnancy BMI, 19-29.9 kg/m2), more than 70% of pregnant women (77% of women with and 73% of women without obesity) reported taking at least one medication during pregnancy, resp. (adjusted risk ratio (aRR)=1.10, 95% confidence interval (CI)=1.01, 1.20), with 81% reporting two and 69% reporting three or more. A total of 17 classes of medications were identified. Among medication classes consumed by at least 5% of all women, the only class that differed between women with and without obesity was hormones and synthetic substitutes (including steroids, progesterone, diabetes, and thyroid medications) in which women with obesity took more medications (11 vs. 5%, aRR = 1.9, 95% CI = 1.38, 2.61) compared to women without obesity. Within this class, a higher percentage of women with obesity took diabetes medications (2.3 vs. 0.7%) and progesterone (3.4 vs. 1.3%) than their non-obese counterparts. Similar percentages of women with and without obesity reported consuming medications in the remaining medication classes including central nervous system agents (50 and 46%), gastrointestinal drugs (43 and 40%), anti-infective agents (23 and 21%), antihistamines (20 and 17%), autonomic drugs (10 and 9%), and respiratory tract agents (7 and 6%), resp. (p > 0.05 for all adjusted comparisons). There were no differences in medication use by obesity status across gestation. Since the study exclusion criteria limited the non-obese group to women without thyroid disease, in a sensitivity anal. we excluded all women who reported thyroid medication intake and still a higher proportion of women with obesity took the hormones and synthetic substitutes class compared to women without obesity. Our findings suggest that pre-pregnancy obesity in otherwise healthy women is associated with a higher use of only selected medications (such as diabetes medications and progesterone) during pregnancy, while the intake of other more common medication types such as analgesics, antibiotics, and antacids does not vary by pre-pregnancy obesity status. As medication safety information for prenatal consumption is insufficient for many medications, these findings highlight the need for a more in-depth examination of factors associated with prenatal medication use.

Journal of Maternal-Fetal & Neonatal Medicine published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C19H14N2, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Wang, Xiao-Dan published the artcileSynthesis and configurations of YF-0200R A and B, HPLC of Formula: 99438-28-5, the publication is Tetrahedron (2016), 72(23), 3177-3184, database is CAplus.

Two natural unsaturated fatty acids, YF-0200R A (I, R¹ = H) and B (I, R¹ = OH), with aspargyl protease inhibition activity were synthesized for the first time. The stereogenic centers were installed by using Brown asym. allylation or chiral building blocks derived from D-glucose, resp. The conjugate diene unit was introduced via an HWE reaction. The geometry of the C-C double bonds was clearly shown to be (E) by ¹H NMR in C₆D₆. The spectroscopic data for the synthetic samples were in excellent consistency with those reported for the corresponding natural ones. The optical rotations were also compatible with those for the natural ones. The absolute configurations for natural YF-0200R A and B thus could be reliably assigned as (8S) and (8S,10S), resp.

Tetrahedron published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C9H17NO, HPLC of Formula: 99438-28-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Fuwa, Haruhiko published the artcileTotal Synthesis and Complete Stereostructure of a Marine Macrolide Glycoside, (-)-Lyngbyaloside B, Name: (+)-B-Methoxydiisopinocampheylborane, the publication is Chemistry – A European Journal (2016), 22(20), 6815-6829, database is CAplus and MEDLINE.

We have described in detail the total synthesis of both the proposed and correct structures of (-)-lyngbyaloside B, which facilitated the elucidation of the complete stereostructure of this natural product. Our study began with the total synthesis of 13-demethyllyngbyaloside B, in which an esterification/ring-closing metathesis strategy was successfully used for the efficient construction of the macrocycle. We also established reliable methods for the introduction of the conjugated diene side chain and the L-rhamnose residue onto the macrocyclic framework. However, the esterification/Ring Closure Metathesis strategy proved ineffective for the parent natural product because of the difficulties in acylating the sterically encumbered C-13 tertiary alc.; macrolactonization of a seco-acid was also extensively investigated under various conditions without success. We finally completed the total synthesis of the proposed structure of (-)-lyngbyaloside B by means of a macrolactonization that involves an acyl ketene as the reactive species. However, the NMR spectroscopic data of our synthetic material did not match those of the authentic material, which indicated that the proposed structure must be re-examined Inspection of the NMR spectroscopic data of the natural product and mol. mechanics calculations led us to postulate that the configuration of the C-10, C-11, and C-13 stereogenic centers had been incorrectly assigned in the proposed structure. Finally, our revised structure of (-)-lyngbyaloside B was unambiguously verified through total synthesis.

Chemistry – A European Journal published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, Name: (+)-B-Methoxydiisopinocampheylborane.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Weeks, Kellie L. published the artcileA three-step enantioselective synthesis of (+)- and (-)-α-thujone, Formula: C21H37BO, the publication is Organic & Biomolecular Chemistry (2021), 19(37), 8018-8020, database is CAplus and MEDLINE.

The stereocontrolled three-step synthesis of either enantiomer of α-thujone from com. available 3-methyl-1-butyne is described. The enantioselectivity originates from a Brown crotylation which is then conferred to the all-carbon quaternary center via chirality transfer in a gold-catalyzed cycloisomerization. The route is highly atom economical and requires no protecting groups or redox manipulations.

Organic & Biomolecular Chemistry published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C5H5NO3S, Formula: C21H37BO.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhu, Shijun published the artcileSynthesis and Configuration of Neomaclafungin A, Product Details of C21H37BO, the publication is Chemistry – An Asian Journal (2017), 12(17), 2211-2215, database is CAplus and MEDLINE.

The relative and absolute configuration of neomaclafungins were impossible to establish by spectroscopic analyses alone because of the lack of exploitable ¹H-¹H couplings and NOEs between the upper and the lower subunits. This very difficult task now is finally completed by an enantioselective total synthesis of neomaclafungin A (revised) and its diastereomer (reported). The results also provided a key reference for the complete structures for other neomaclafungins and the long-known closely related natural product maclafungin.

Chemistry – An Asian Journal published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C18H24N6O6S4, Product Details of C21H37BO.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Sokolsky, Alexander published the artcileSpirastrellolide E: synthesis of an advanced C(1)-C(24) southern hemisphere, Product Details of C21H37BO, the publication is Tetrahedron Letters (2015), 56(23), 3160-3164, database is CAplus and MEDLINE.

The synthesis of a C(1)-C(24) advanced southern hemisphere fragment (I) towards the total synthesis of spirastrellolide E has been achieved. Highlights of the route include a highly convergent Type I Anion Relay Chem. (ARC) tactic for fragment assembly, in conjunction with a directed, regioselective gold-catalyzed alkyne functionalization to generate the central unsaturated [6,6]-spiroketal.

Tetrahedron Letters published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C9H9F5Si, Product Details of C21H37BO.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Thompson, W. E. published the artcileIdentification of primary, secondary, and tertiary pharmaceutical amines by the infrared spectra of their salts, Safety of 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, the publication is Journal of Pharmaceutical Sciences (1965), 54(12), 1819-21, database is CAplus.

The spectra of 80 pharmaceutically active amine salts have been analyzed in the range of 4000-2000 cm.^-1 The amine salts have characteristic absorption bands in this region. The wave numbers at which these absorption bands occur are specific for each given class of amine. Spectra and structure correlations and assignments of these bands are given and discussed.

Journal of Pharmaceutical Sciences published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C14H12O2, Safety of 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Kim, Yong-Jae published the artcileSynthetic Studies of Complex Immunostimulants from Quillaja saponaria: Synthesis of the Potent Clinical Immunoadjuvant QS-21A_api, Synthetic Route of 99438-28-5, the publication is Journal of the American Chemical Society (2006), 128(36), 11906-11915, database is CAplus and MEDLINE.

QS-21 is one of the most promising new adjuvants for immune response potentiation and dose-sparing in vaccine therapy given its exceedingly high level of potency and its favorable toxicity profile. Melanoma, breast cancer, small cell lung cancer, prostate cancer, HIV-1, and malaria are among the numerous maladies targeted in more than 80 recent and ongoing vaccine therapy clin. trials involving QS-21 as a critical adjuvant component for immune response augmentation. QS-21 is a natural product immunostimulatory adjuvant, eliciting both T-cell- and antibody-mediated immune responses with microgram doses. Herein is reported the synthesis of QS-21A_api in a highly modular strategy, applying novel glycosylation methodologies to a convergent construction of the potent saponin immunostimulant. The chem. synthesis of QS-21 offers unique opportunities to probe its mode of biol. action through the preparation of otherwise unattainable nonnatural saponin analogs.

Journal of the American Chemical Society published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, Synthetic Route of 99438-28-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Paterson, Ian published the artcileStudies in marine macrolide synthesis: synthesis of a C₁₆-C₂₈ subunit of spongistatin 1 (altohyrtin A) incorporating the CD-spiroacetal moiety, Formula: C21H37BO, the publication is Tetrahedron Letters (1997), 38(51), 8911-8914, database is CAplus.

The C₁₆-C₂₈ ketone I, containing the CD-spiroacetal of spongistatin 1, was prepared in 17 steps from the aldehyde Me₃CSiMe₂OCH₂CH₂CHO. Both thermodn. and kinetic conditions were explored for controlling the CD-acetal configuration.

Tetrahedron Letters published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, Formula: C21H37BO.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Winefordner, J. D. published the artcileThe use of rigid ethanolic solutions for the phosphorimetric investigation of organic compounds of pharmacological interest, Recommanded Product: 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, the publication is Analytica Chimica Acta (1964), 31(3), 239-45, database is CAplus.

cf. CA 59 13102h; 60, 8605e. The phosphorescence excitation (mμ) and emission maximum (mμ), lifetime (sec.) and limit of detection (γ/ml.) of EtOH solutions at 77°K. of phenobarbital (I), Mebaral, Rutonal, atropine, benzocaine, procaine-HCl, p-aminobenzoic acid, butacaine sulfate, Cyclaine-HCl, Metycaine-HCl, PhCO₂H, cocaine-HCl, quinidine sulfate, quinine-HCl, lidocaine, caffeine, ephedrine, phenylephrinc-HCl, Tronothane-HCl, cinchophen, physostigmine sulfate, and chlortetracycline, are, resp., 240, 380, 1.8, 0.1; 240,380, 2.2, 0.01; 240, 380, 2.5, 0.02; 240,380, 2.1, 0.1; 310, 430, 5.3, 0.007; 310, 430, 3.5, 0.01; 310, 430, 3.2, 0.004; 310, 430, 5.7, 0.05; 240, 400, 2.4, 0.006; 240, 400, 2.7, 0.006; 240, 400, 2.3, 0.005; 240, 400, 2.7, 0.01; 340, 500, 1.3, 0.05; 340, 500, 1.3, 0.04; 265, 400, 1.1, 1.2; 285, 440, 2.0, 0.2; 225, 390, 3.6, 0.2; 290,390, 2.4, 0.01; 300, 410, 1.2, 0.02; 350, 520, 0.8, 0.02; 315, 420, 3.6, 0.03; 280, 410, 2.7, 0.05

Analytica Chimica Acta published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C19H17N3O, Recommanded Product: 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem