Tag: M.W=300-350

Brown, Herbert C. published the artcileChiral synthesis via organoboranes. XVI. Boroxazolidones derived from α-amino acids and borinic or boronic esters. A simple procedure for upgrading borinates and boronates to materials of high optical purity, Category: ethers-buliding-blocks, the publication is Journal of Organometallic Chemistry (1988), 341(1-3), 73-81, database is CAplus.

The synthesis of boron heterocycles from borinic and boronic esters with α-amino acids was explored as a means of upgrading the optical purities of intermediates from asym. hydroboration. B-Methoxy-9-borabicyclo[3.3.1]nonane, Me dicyclohexylborinate, and (+)- and (-)-Me diisopinocampheylborinate react with various α-amino acids to form the corresponding crystalline chelates. Recrystallization of the chelates derived from Me trans-2-phenylcyclopentylisopinocampheylborinate of 85% enantiomeric excess (ee) with L-phenylalanine, Me isopinocampheyl-exo-norbornylborinate of 83% ee with L-proline, and both optical isomers of Me diisopinocampheylborinate of 92% ee with L-proline yield the corresponding products with optical purities approaching 100% ee. Di-Me cyclopentylboronate, di-Me exo-norbornylboronate, and di-Me isopinocampheylboronate upon treatment with iminodiacetic acid and N-methyliminodiacetic acid form the corresponding bicyclic boronates. Recrystallization of the chelate derived from di-Et 3-tetrahydropyranylboronate and iminodiacetic acid yields a product of essentially 100% ee. Consequently, formation of boroxazolidones of asym. hydroboration products provides one possible route to upgrade such products to materials of high optical purity.

Journal of Organometallic Chemistry published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Tsuruda, Takeshi published the artcileStereoselective Synthesis of the C1-C29 Part of Amphidinol 3, Quality Control of 99438-28-5, the publication is Journal of Organic Chemistry (2015), 80(2), 859-871, database is CAplus and MEDLINE.

Stereoselective synthesis of the C1-C29 part (I) of amphidinol 3 (AM3) was achieved. The C1-C20 part was assembled from three building blocks via regioselective cross metathesis to form the C4-C5 double bond and addition of an alkenyllithium and a lithium acetylide to two Weinreb amides followed by asym. reduction to form the C9-C10 and C14-C15 bonds, resp. The C21-C29 part was synthesized via successive cross metathesis and oxa-Michael addition sequence to construct the 1,3-diol system at C25 and C27 and Brown asym. crotylation to introduce the stereogenic centers at C23 and C24. Coupling of the C1-C20 and C21-C29 parts was achieved by Julia-Kocienski olefination and regio- and stereoselective dihydroxylation of the C20-C21 double bond in the presence of the C4-C5 and C8-C9 double bonds to afford the C1-C29 part of AM3.

Journal of Organic Chemistry published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C3H5BN2O2, Quality Control of 99438-28-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Hassfeld, Jorma published the artcileSynthesis of the C1-C17 macrolactone of tedanolide, Related Products of ethers-buliding-blocks, the publication is Synthesis (2005), 1183-1199, database is CAplus.

The vinylogous Mukaiyama aldol reaction is a useful method to build up complex polyketide structures. It is successfully employed in the synthesis of the C1-C17 macrolactone of tedanolide, a highly cytotoxic marine natural product. These studies present a practical approach toward the total synthesis of tedanolide; it is pursued using the appropriate C13-C23 segment that is introduced by a pivotal aldol reaction to join both hemispheres.

Synthesis published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Ibrahim, Fawzia published the artcileComparative study of two different chromatographic approaches for quantitation of hydrocortisone acetate and pramoxine hydrochloride in presence of their impurities, Formula: C17H28ClNO3, the publication is Journal of Food and Drug Analysis (2018), 26(3), 1160-1170, database is CAplus and MEDLINE.

In the present study, we compare the performance of two reversed-phase liquid chromatog. approaches using different eluents either conventional hydro-organic eluent or micellar one for simultaneous estimation of hydrocortisone acetate and pramoxine hydrochloride in presence of their degradants and process-related impurities; hydrocortisone and 4-butoxyphenol, resp. For conventional reversed-phase liquid chromatog. (RPLC), separation of the studied compounds was completed on an Inertsil ODS 3-C18 column (150 mm × 4.6 mm, 5μm particle size) with a mobile phase consists of 50 mM phosphate buffer (pH 5.0): acetonitrile (50: 50, volume/volume). For micellar liquid chromatog. (MLC), an Eclipse XDB-C8 column (150 mm × 4.6 mm, 5μm particle size) was chosen for the separation with a green mobile phase consists of 0.15 M sodium dodecyl sulfate, 0.3% triethylamine and 10% n-butanol in 20 mM orthophosphoric acid (pH 5.0). Both methods were extended to analyze hydrocortisone acetate and pramoxine hydrochloride in their co-formulated cream. RPLC was superior to MLC with regard to sensitivity for the estimation of impurities. While, MLC represents an eco-friendly, less hazardous and biodegradable approach. Furthermore, the direct injection of the cream to the system without the need to laborious samples pretreatment, excessive amount of anal. time and/or use of large amount of toxic organic solvents is one of the outstanding advantages of MLC.

Journal of Food and Drug Analysis published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C17H28ClNO3, Formula: C17H28ClNO3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Reddy, Y. Krishna published the artcileAsymmetric Total Synthesis of (+)-Fostriecin, Recommanded Product: (+)-B-Methoxydiisopinocampheylborane, the publication is Organic Letters (2002), 4(6), 969-971, database is CAplus and MEDLINE.

(+)-Fostriecin (I), a potent protein phosphatase inhibitor and anticancer agent, was prepared by an efficient, multi-convergent asym. synthesis. Key transformations include a ring forming olefin metathesis leading to the α,β-unsaturated lactone II and creation of the triene moiety via Suzuki cross-coupling.

Organic Letters published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, Recommanded Product: (+)-B-Methoxydiisopinocampheylborane.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Della Sala, Giorgio published the artcileTowards the biosynthesis of the aromatic products of the Mediterranean mollusc Scaphander lignarius: isolation and synthesis of analogues of lignarenones, Category: ethers-buliding-blocks, the publication is Tetrahedron (2007), 63(30), 7256-7263, database is CAplus.

Secondary metabolites of the Mediterranean mollusc Scaphander lignarius from different collection sites have been investigated, proving the constant presence of a number of minor metabolites correlated to the already known lignarenones. Complete characterization of the new metabolites has been supported by enantioselective synthesis. The data are consistent with the origin of this unique class of ω-phenyloctanoids from a common polyketide pathway.

Tetrahedron published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Megemont, C. published the artcileComparative activities of some local anesthetics in modifying the effect of acetylcholine in presence of the isolated ventricle of Helix pomatia and the denervated dorsal muscle of Hirudo medicinalis, Application of 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, the publication is Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales (1960), 64-6, database is CAplus.

In low concentrations all of 11 diverse local anesthetics augmented the neg. chronotropic and inotropic effects of acetylcholine on the isolated snail ventricle, and all but 2 antagonized the effect of acetylcholine on the denervated leech muscle.

Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C17H28ClNO3, Application of 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zampella, Angela published the artcileStereoselective synthesis of (2R,3R,4R)-3-hydroxy-2,4,6-trimethylheptanoic acid and determination of the absolute stereochemistry of the natural product from callipeltin A, Quality Control of 99438-28-5, the publication is Tetrahedron: Asymmetry (2002), 13(12), 1237-1239, database is CAplus.

A revised stereostructure of 3-hydroxy-2,4,6-trimethylheptanoic acid, the β-hydroxy acid that acylates the N-terminus of callipeltin A, is proposed on the basis of anal. of J-coupling in the ¹H NMR spectrum of the acetonide derivative obtained from the acid hydrolyzate of callipeltin A. The proposed structure was definitively confirmed by enantioselective synthesis.

Tetrahedron: Asymmetry published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C7H13NO2, Quality Control of 99438-28-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Delbeke, F. T. published the artcileDetection of some local anesthetics in horse urine and plasma by gas-liquid chromatography, COA of Formula: C17H28ClNO3, the publication is Journal of Chromatography (1981), 206(3), 594-9, database is CAplus and MEDLINE.

A gas-liquid chromatog. (GLC) method using a N specific detector is described for the screening of several local anesthetics in horse plasma and urine. The glass columns used were: 5% OV-101, 3% OV-7, and 3% OV-25 on Chromosorb W (80-100 mesh). Blank plasma or urine samples were spiked with the local anesthetics, echothiophate iodide was added followed by NH₄⁺/NH₃ buffer (pH 9.4) and the mixture extracted with cyclohexane. The residue from the organic layer was used for GLC anal. Detection limits and percentage recoveries for the 11 anesthetics studied are given for urine and plasma.

Journal of Chromatography published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C17H28ClNO3, COA of Formula: C17H28ClNO3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Kim, Hak Joong published the artcileChemoenzymic Synthesis of Spinosyn A, COA of Formula: C21H37BO, the publication is Angewandte Chemie, International Edition (2014), 53(49), 13553-13557, database is CAplus and MEDLINE.

Following the biosynthesis of polyketide backbones by polyketide synthases (PKSs), post-PKS modifications result in a significantly elevated level of structural complexity that renders the chem. synthesis of these natural products challenging. We report herein a total synthesis of the widely used polyketide insecticide spinosyn A by exploiting the prowess of both chem. and enzymic methods. As more polyketide biosynthetic pathways are characterized, this chemoenzymic approach is expected to become readily adaptable to streamlining the synthesis of other complex polyketides with more elaborate post-PKS modifications.

Angewandte Chemie, International Edition published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, COA of Formula: C21H37BO.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem