Tag: M.W=300-350

Shaw, Margaret A. published the artcileIsotonic solutions. XIII. Hemolysis of red corpuscles by various substances in the presence of sodium chloride, Safety of 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, the publication is Journal of Pharmaceutical Sciences (1962), 929-31, database is CAplus and MEDLINE.

cf. CA 58, 3735c. An increase in the concentration of NaCl reduced the degree of hemolysis produced in the presence of 0.6% NaCl by procaine-HCl, 2-propoxyprocaine-HCl, NH₄ salicylate, NH₄ benzoate, pramoxine-HCl, benoxinateHCl, hexylcaine-HCl and butacaine sulfate, but increased that produced by phenmetrazine-HCl.

Journal of Pharmaceutical Sciences published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C4H6O3, Safety of 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Mizukami, Daichi published the artcileTandem Macrolactone Synthesis: Total Synthesis of (-)-Exiguolide by a Macrocyclization/Transannular Pyran Cyclization Strategy, Recommanded Product: (+)-B-Methoxydiisopinocampheylborane, the publication is Angewandte Chemie, International Edition (2022), 61(22), e202202549, database is CAplus and MEDLINE.

Tetrahydropyran-containing macrolactones were synthesized by integrating Meyer-Schuster rearrangement, macrocyclic ring-closing metathesis, and transannular oxa-Michael addition under gold and ruthenium catalysis. Single-step access to a variety of 14- to 20-membered macrolactones containing a tetrahydropyran ring was possible from readily available linear precursors in good yields and with moderate to excellent diastereoselectivity. A 13-step synthesis of (-)-exiguolide (I), an anticancer marine macrolide, showcased the feasibility of our tandem reaction sequence for macrolactone synthesis and also demonstrated the power of transannular reactions for rapid assembly of the tetrahydropyran rings of the target natural product.

Angewandte Chemie, International Edition published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, Recommanded Product: (+)-B-Methoxydiisopinocampheylborane.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

White, James D. published the artcileA concise synthesis of the cytotoxic depsipeptide arenastatin A, Name: (+)-B-Methoxydiisopinocampheylborane, the publication is Tetrahedron Letters (1998), 39(48), 8779-8782, database is CAplus.

Arenastatin A (I) (cryptophycin 24) was synthesized by convergence of hydroxy ester II with amino acid derivative III. Two independent and highly efficient routes to II are disclosed.

Tetrahedron Letters published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C4Br2N2O4S, Name: (+)-B-Methoxydiisopinocampheylborane.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Musdal, Yaman published the artcileFDA-approved drugs and other compounds tested as inhibitors of human glutathione transferase P1-1, SDS of cas: 637-58-1, the publication is Chemico-Biological Interactions (2013), 205(1), 53-62, database is CAplus and MEDLINE.

Glutathione transferase P1-1 (GST P1-1) is often overexpressed in tumor cells and is regarded as a contributor to their drug resistance. Inhibitors of GST P1-1 are expected to counteract drug resistance and may therefore serve as adjuvants in the chemotherapy of cancer by increasing the efficacy of cytostatic drugs. Finding useful inhibitors among compounds used for other indications would be a shortcut to clin. applications and a search for GST P1-1 inhibitors among approved drugs and other compounds was therefore conducted. We tested 1040 FDA-approved compounds as inhibitors of the catalytic activity of purified human GST P1-1 in vitro. We identified chlorophyllide, merbromine, hexachlorophene, and ethacrynic acid as the most effective GST P1-1 inhibitors with IC₅₀ values in the low micromolar range. For comparison, these compounds were even more potent in the inhibition of human GST A3-3, an enzyme implicated in steroid hormone biosynthesis. In distinction from the other inhibitors, which showed conventional inhibition patterns, the competitive inhibitor ethacrynic acid elicited strong kinetic cooperativity in the glutathione saturation of GST P1-1. Apparently, ethacrynic acid serves as an allosteric inhibitor of the enzyme. In their own right, the compounds investigated are less potent than desired for adjuvants in cancer chemotherapy, but the structures of the most potent inhibitors could serve as leads for the synthesis of more efficient adjuvants.

Chemico-Biological Interactions published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C17H28ClNO3, SDS of cas: 637-58-1.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Thoma, K. published the artcileColloid association and biological availability of local anesthetics. Part 1. Surface activity studies on critical micelle concentrations, Formula: C17H28ClNO3, the publication is Pharmaceutica Acta Helvetiae (1988), 63(2), 34-9, database is CAplus and MEDLINE.

Surface activities of local anesthetics are reported. The ability to associate to micelles in aqueous solution was found with 9 benzoic acid esters, 3 anilides or acid amides, and for all compounds with ether structures. Twelve of the 29 investigated compounds do not associate to micelles. The critical micelle concentrations (CMC) in 0.9% NaCl solution range from 6.0·10^-5 mol/L for the nonionic polydocanol to 6.6·10^-2 mol/L for cornecaine-HCl. Cyclomethycaine has the lowest CMC (4.3·10^-4 mol/L) of basic local anesthetics.

Pharmaceutica Acta Helvetiae published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C9H12BClO3, Formula: C17H28ClNO3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Thoma, Karl published the artcileStudies to determine the critical micelle concentration of local anesthetics, Name: 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, the publication is Acta Pharmaceutica Fennica (1984), 93(2), 85-96, database is CAplus.

The critical micelle concentrations of local anesthetics such as cyclomethycaine sulfate  [6202-05-7], Psicaine-neu-HCl  [69343-45-9], cocaine-HCl  [53-21-4], etc., were determined by using tensiometry and potentiometry and spectrophotometry of some anesthetics. The nonionic polidocanol  [9002-92-0] had a critical micellar concentrations of 1 × 10^-4 mol/L found both by tensiometry and dye sorption methods. The dissociating local anesthetics show critical micelle concentrations from 0.046-5.5% in aqueous solution

Acta Pharmaceutica Fennica published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C18H34N4O5S, Name: 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Kim, Min published the artcileEffects of drugs on the stability of phospholipid liposomal membranes, Product Details of C17H28ClNO3, the publication is Yakhak Hoechi (1994), 38(6), 637-45, database is CAplus.

The effect of various drugs on the stability of the liposomal membrane of phosphatidylcholine and cholesterol was studied, employing the fluorescence self-quenching method. Calcein was entrapped into the phospholipid small unilamellar vesicles and the leakage of the fluorescence probe was monitored on adding the drug to the system. Phenothiazine derivatives, some potent local anesthetics and surface active agents were very effective in inducing the leakage of calcein from the liposome. The leakage-inducing activity of these drug substances has been ascribed to their surface activity and the pertubation of the liposomal membrane by these substances. On the other hand a drug with low surface activity or without amphiphilic moieties did not show any effect or only a small effect on the leakage of calcein from the liposomes. The effect of lipid concentration on the stability of the liposomes was also investigated to show that the higher concentrations of lipid more drug was required to induce the leakage. The effect of surface charges of vesicles was also studied, and the results showed that the charge on the liposomes enhanced the stability of the liposomes against the leakage-inducing activity of these drug substances.

Yakhak Hoechi published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C17H28ClNO3, Product Details of C17H28ClNO3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Li, Fangzheng published the artcileEfficient Stereoselective Synthesis of a Key Chiral Aldehyde Intermediate in the Synthesis of Picolinamide Fungicides, Formula: C21H37BO, the publication is Organic Process Research & Development (2019), 23(10), 2253-2260, database is CAplus.

A highly stereoselective and efficient synthesis of (4S,5S,6S)-6-(benzyloxy)-5-phenoxy-4-propoxyheptanal, a key intermediate for syntheses of picolinamide fungicides, is described in this report. The synthesis features a scalable allylpropyl ether preparation, an efficient synthesis of the C1-C3 anti,syn-(S,S,S) stereotriad via a highly diastereoselective allylboration, and Cu-catalyzed phenylation of a sterically hindered secondary alc. with BiPh₃(OAc)₂ followed by highly regioselective hydroformylation with the formation of a linear aldehyde. Excellent overall route efficiency was achieved (six steps and 39% yield) starting from readily available and inexpensive (S)-Et lactate.

Organic Process Research & Development published new progress about 99438-28-5. 99438-28-5 belongs to ethers-buliding-blocks, auxiliary class Chiral,Aliphatic cyclic hydrocarbon, name is (+)-B-Methoxydiisopinocampheylborane, and the molecular formula is C21H37BO, Formula: C21H37BO.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Tavlarakis, Panagiotis published the artcileSimultaneous determination of pramoxine HCl and benzalkonium chloride in wound care solutions by HPLC, Name: 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, the publication is Analytical Methods (2010), 2(6), 722-727, database is CAplus.

A simple gradient reversed-phase high performance liquid chromatog. (HPLC) method was developed for the simultaneous determination of total benzalkonium chloride (BAC) and pramoxine HCl in wound care solutions Laboratory formulations were diluted 1:10 with water and injected into a HPLC system equipped with a Phenomenex, Luna CN column (100 Å, 5μm, 250 mm × 4.6 mm) in order for BAC and pramoxine to sep. from other excipients and be detected by a UV detector (λ = 262 nm). The mobile phase was 0.075 mM sodium acetate trihydrate buffer (pH = 5.0) using multi-ramp gradient elution with acetonitrile. Quantitation was achieved by direct comparison of the peaks of BAC and pramoxine HCl of the sample to a reference standard of known concentrations A stress study with acid, base, peroxide, heat, and light indicated no interference from drug product or excipients. The mean recovery results for both pramoxine and benzalkonium chloride at 100% level were 100.5 ± 0.3%, 100.5 ± 0.1% resp. (mean ± SD, n = 6). In this report, the full exptl. results from developing and validating this method are presented.

Analytical Methods published new progress about 637-58-1. 637-58-1 belongs to ethers-buliding-blocks, auxiliary class Inhibitor, name is 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride, and the molecular formula is C9H10O3S, Name: 4-(3-(4-Butoxyphenoxy)propyl)morpholine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Huang, Jing published the artcileDesign, synthesis and evaluation of potent G-protein coupled receptor 40 agonists, Related Products of ethers-buliding-blocks, the publication is Chinese Chemical Letters (2016), 27(1), 159-162, database is CAplus.

GPR40 has emerged as an attractive drug target for the treatment of type 2 diabetes due to its role in the enhancement of insulin secretion with glucose dependency. With the aim to improve the metabolic and safety profiles, a series of novel phenylpropionic acid derivatives were synthesized. Extensive structural optimization led to identification of compounds I and II as potent GPR40 agonists with moderate liver microsomal stability. All the discovery supported further exploration surrounding this scaffold.

Chinese Chemical Letters published new progress about 1823170-17-7. 1823170-17-7 belongs to ethers-buliding-blocks, auxiliary class Fluoride,Boronic acid and ester,Benzene,Ether,Boronate Esters,Boronic Acids,Boronic acid and ester,, name is 2-(4-(Benzyloxy)-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C19H22BFO3, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem