Tag: M.W=250-300

Wang, Bofei; Zhong, Fangrui published the artcile< Practical and Asymmetric Synthesis of Apremilast Using Ellman's Sulfinamide as a Chiral Auxiliary>, Recommanded Product: (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine, the main research area is apremilast preparation enantioselective imidation.

A new protocol for the asym. synthesis of apremilast using tert-butanesulfinamide as a chiral auxiliary was described. This synthetic route consisted of four steps starting from the com. available 3-hydroxy-4-methoxybenzaldehyde and apremilast was accordingly obtained in an overall 56% yield and with 95.5% ee.

Molbank published new progress about Enantioselective synthesis. 608141-42-0 belongs to class ethers-buliding-blocks, and the molecular formula is C12H19NO4S, Recommanded Product: (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Nahan, Keaton; Sussman, Eric M.; Oktem, Berk; Schultheis, Lester; Wickramasekara, Samanthi published the artcile< Screening for extractables in additive-manufactured acrylonitrile butadiene styrene orthopedic cast>, Related Products of 18312-57-7, the main research area is acrylonitrile butadiene styrene orthopedic cast extractable safety; 3D printing; Acrylonitrile butadiene styrene (ABS); Additive manufacturing; Chemical characterization; Extractables; Medical devices.

The use of additive-manufactured components in medical applications, specifically medical devices (e.g., orthopedic casts), has increased in recent years. Such devices may be fabricated at the point of care using consumer-grade additive manufacturing Limited studies have been conducted to evaluate the extractable substances of these devices. Chem. characterization followed by toxicol. risk assessment is one means of evaluating safety of devices. This study was designed to determine the extractables profile of additive-manufactured materials according to filament grade and post-processing method. Feedstocks for additive manufacturing were tested as filament and manufactured casts, while the cast from consumer-grade filament (CGF) was post-processed. Samples were extracted using three solvents of varying polarities. Extracts were analyzed by gas chromatog./mass spectrometry (GC/MS) and liquid chromatog./mass spectrometry (LC/MS) techniques. In GC/MS anal., isopropanol extracts generated fewer compound identifications for USP Class VI filament (USPF)-based casts (3) compared with the resp. filament (17) while hexane generated the most compound identifications for the finished cast manufactured from CGF. CGF was found to have the highest number of nonvolatile extractables for isopropanol (15) and hexane (34) by pos. ion LC/MS. Addnl., CGF produced more non-polar extractables in hexane than the USPF. A known polymer byproduct and potential genotoxicant, styrene acrylonitrile (SAN) trimer, was one of the compounds identified in both GC/MS and LC/MS at quantities ranging from 19 to 270μg g-1. Overall these results suggested that the extractables profile was affected by the filament material, printing procedure, and post-processing method.

Talanta published new progress about Additive manufacturing. 18312-57-7 belongs to class ethers-buliding-blocks, and the molecular formula is C17H37NO2, Related Products of 18312-57-7.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Popa, Adriana; Davidescu, Corneliu-Mircea; Trif, Radu; Ilia, Gheorghe; Iliescu, Smaranda; Dehelean, Gheorghe published the artcile< Polycationic biocides with pendant quaternary groups. II. Synthesis and antimicrobial activity of ammonium salts grafted on ""gel""-type styrene-divinylbenzene copolymers against Staphylococcus aureus and escherichia coli>, Safety of 2,2′-(Tridecylazanediyl)diethanol, the main research area is quaternary chloromethylated styrene divinylbenzene copolymer antimicrobial agent.

Various ammonium salts grafted on “”gel””-type styrene-divinylbenzene copolymers were prepared and their antimicrobial activity against Staphylococcus aureus and Escherichia coli was assessed by the column system. The antimicrobial activity is strongly dependent on the structure. The length of the alkyl chain has been found to affect significantly the biol. activity.

Revue Roumaine de Chimie published new progress about Antimicrobial agents. 18312-57-7 belongs to class ethers-buliding-blocks, and the molecular formula is C17H37NO2, Safety of 2,2′-(Tridecylazanediyl)diethanol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Bhole, Ritesh P.; Naksakhare, Sachin R.; Bonde, Chandrakant G. published the artcile< A stability indicating HPTLC Method for apremilast and identification of degradation products using MS/MS>, Electric Literature of 608141-42-0, the main research area is apremilast degradation product high performance liquid chromatog pharmaceutical formulation.

Aim: Apremilast is used for treatment of certain types of psoriasis, psoriatic arthritisand plaque psoriasis is a type of skin condition. An extensive literature search revealed that there exist very few methods on RP-HPLC reported and HPTLC method was not reported. This study deals with simple, precise, accurate and economical stability indicating HPTLC method development with validation as per ICH guidelines with application of developed method on in Apremilast pharmaceutical formulations and Identified and Characterization of degradation products using MS/MS. Method: Precoated Silica gels plates were used as stationary phase. Toluene: Et Acetate (4:6; volume/volume) was delivered best separation at 236 nm (Rf 0.55 ± 0.02) by densitometry anal. Degradation anal. was performed as per ICH guidelines (Q2R1). Isolation of degradation product by HPTLC method and identify by MS/MS method. Results: The linearity was 100-600 ng with R2 of 0.997 while, % RSD was in range. LOD and LOQ of Apremilast were found 0.77ng/spot and 2.35ng/spot resp. The recovery of Apremilast was found to be 99.70 ± 0.23%. The % assay of active substance was found in a range 80.62 to 100. HPTLC and MS/MS method revealed possible degradation mechanism of 11 degradant products. Conclusion: The Proposed developed and validated HPTLC method was found to be more sensitive, simple, precise, accurate, cost effective and robust. This method could be applied for anal. of bulk drug and tablet formulation, degradation study. This degradation pathway of drug will help to identify the degradation products of Apremilast.

Journal of Pharmaceutical Sciences and Research published new progress about HPLC. 608141-42-0 belongs to class ethers-buliding-blocks, and the molecular formula is C12H19NO4S, Electric Literature of 608141-42-0.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Wedler, C.; Haage, K.; Herbst, M.; Tischer, H.; Knofe, E. published the artcile< Preparation and some properties of amine oxides derived from defined ethylene oxide adducts>, Recommanded Product: 2,2′-(Tridecylazanediyl)diethanol, the main research area is amine oxide preparation solubility; bishydroxyethylalkylamine oxide preparation solubility; thermal analysis bishydroxyethylalkylamine oxide; addition ethylene oxide amine.

Procedures for the prepn of bis(hydroxyethyl)alkylamine oxides are presented. The solubilities and DTA of a number of amine oxides are also reported.

Abhandlungen der Akademie der Wissenschaften der DDR, Abteilung Mathematik, Naturwissenschaften, Technik published new progress about Addition reaction. 18312-57-7 belongs to class ethers-buliding-blocks, and the molecular formula is C17H37NO2, Recommanded Product: 2,2′-(Tridecylazanediyl)diethanol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Jagannadham, Y.; Ramadevi, B.; Prasanna, B. published the artcile< An improved economical process for preparation of apremilast and identified their impurities>, Related Products of 608141-42-0, the main research area is acetamidophthalic acid ethoxy methoxyphenyl methylsulfonyl ethylamine cyclocondensation; apremilast preparation.

An improved and com. viable process provided for the preparation of apremilast, which was simple, cost effective and non-hazardous. The usage of acetic anhydride and high temperature was avoided. An alternative process using protected 3-aminophthalic acid with acetyl chloride in the presence of triethanolamine as catalyst in dichloromethane solvent at 0 to 5° for 1 h. then followed by condensed with (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamine to get the final apremilast product was reported. Besides, there were two unknown impurities like 3-(amino-1,3-dioxoisoindolin-2-yl)phthalic acid and 4-aminoisobenzofuran-1,3-dione identified by HPLC. A thorough study was under taken to synthesize and characterize these unknown impurities. This improved process has a number of industrial advantages, such as economical material cost and relatively high yield. The structure of the synthesized compounds was elucidated by IR, 1H NMR, 13C NMR, mass spectroscopy and elemental analyses.

Asian Journal of Chemistry published new progress about Cyclocondensation reaction. 608141-42-0 belongs to class ethers-buliding-blocks, and the molecular formula is C12H19NO4S, Related Products of 608141-42-0.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Elhag, Amro S.; Chen, Yunshen; Noguera, Jose; Reddy, Prathima P.; Hirasaki, George J.; Nguyen, Quoc P.; Johnston, Keith P. published the artcile< Switchable amine surfactants for CO2 foams in high temperature enhanced oil recovery>, Electric Literature of 18312-57-7, the main research area is carbon dioxide foam switchable amine surfactant oil recovery.

This paper describes about the switchable amine surfactants for carbon dioxide foams in high temperature enhanced oil recovery.

Preprints – American Chemical Society, Division of Energy & Fuels published new progress about Brines. 18312-57-7 belongs to class ethers-buliding-blocks, and the molecular formula is C17H37NO2, Electric Literature of 18312-57-7.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Lu, Yuting; Shen, Xiaoyue; Hang, Taijun; Song, Min published the artcile< Identification and characterization of process-related substances and degradation products in apremilast: Process optimization and degradation pathway elucidation>, Product Details of C12H19NO4S, the main research area is apremilast degradation product analysis LC MS process optimization; Apremilast; LC–MS; Process optimization; Related substances.

This study aims at investigating the separation, identification and characterization of related substances in apremilast by LC-MS hyphenated techniques, as well as the synthesis optimization and the degradation pathways elucidation. Forced degradation studies were conducted under the ICH prescribed stress conditions. The chromatog. separation was achieved on XBridge C18 column (4.6 mm × 150 mm, 3.5 μm) using a mobile phase consisting of water adjusted to pH 3.0 with formic acid as solvent A and acetonitrile as solvent B in linear gradient elution program. Twelve related substances were detected all together in apremilast and its stress samples. Their structures were identified mainly through pos. ESI high-resolution TOF-MS anal. of the parent ions’ accurate masses and elemental compositions, and the corresponding MS/MS spectra elucidation. There were three process-related substances and nine degradation products, seven of them were first reported. Two degradation products and one process-related substance were further verified by semi-preparation and NMR determination Their origins and formation mechanisms were also discussed, based on which effective approaches for the synthesis optimization were conducted. Therefore, the related substances investigation are valuable for apremilast manufacturing process optimization and quality control.

Journal of Pharmaceutical and Biomedical Analysis published new progress about Chromatography. 608141-42-0 belongs to class ethers-buliding-blocks, and the molecular formula is C12H19NO4S, Product Details of C12H19NO4S.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ma’arif, Burhan; Fitri, Hilwa; Saidah, Nisfatul Lailatus; Najib, Luqman Alfani; Yuwafi, Achmad Hamdan; Atmaja, Ria Ramadhani Dwi; Inayatillah, Fidia Rizkiah; Dianti, Meilina Ratna; Laswati, Hening; Agil, Mangestuti published the artcile< Prediction of compounds with antiosteoporosis activity in Chrysophyllum cainito L. leaves through in silico approach>, Name: 2,2′-(Tridecylazanediyl)diethanol, the main research area is Chrysophyllum antiosteoporosis leaf phytoestrogen; Chrysophyllum cainito L.; antiosteoporosis; in silico; phytoestrogen.

The aims of this study were to analyze the metabolite profiling results of various extract of Chyrsophyllum cainito L. leaves, which contain phytoestrogen, through in silico study against 3OLS protein, an X-ray protein of ERβ, so it can predict the types of the phytoestrogen contents which have antiosteoporosis property. In silico anal. was carried out for the compounds from the metabolite profiling data of C. cainito leaves from our previous study. The structure compounds from metabolite profiling results of various extract of C. cainito leaves were prepared with Avogadro 1.0.1 software, mol. docking was done using PyRx 0.8 software, and Biovia Discovery Studio Visualizer 2016 software was used to visualize the structure of compounds against 3OLS protein. The physicochem. characteristics of the compounds were analyzed using the SwissADME web tool. It was known that there were total 11 compounds in C. cainito leaves that predicted as phytoestrogens which have ERβ agonist properties against 3OLS protein. The ERβ agonist was a compound that has parameters similar to 17β-estradiol in its interaction with 3OLS protein, which has a pharmacophore distance of 10.862 Å, and binding to amino acids His 475 and Glu 305 or Arg 346 at receptor-ligand docking simulation. C. cainito leaves contain 11 compounds that are predicted to be phytoestrogens with ERβ agonist properties, which is responsible for antiosteoporosis activity.

Journal of Basic and Clinical Physiology and Pharmacology published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 18312-57-7 belongs to class ethers-buliding-blocks, and the molecular formula is C17H37NO2, Name: 2,2′-(Tridecylazanediyl)diethanol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Jana, Anupam; Zielinski, Grzegorz Krzysztof; Czarnocka-Sniadala, Sylwia; Grudzien, Krzysztof; Podwysocka, Dominika; Szulc, Marcin; Kajetanowicz, Anna; Grela, Karol published the artcile< Synthesis of Substituted β-Functionalised Styrenes by Microwave-Assisted Olefin Cross-Metathesis and Scalable Synthesis of Apremilast>, HPLC of Formula: 608141-42-0, the main research area is Apremilast scalable synthesis; styryl sulfone diastereoselective preparation; styrene diastereoselective cross metathesis vinyl sulfone microwave irradiation; allylbenzene isomerization deuteration cross metathesis vinyl sulfone.

Preparation of diversely substituted β-functionalized styrenes R1CH:CHR2 (R1 = Ph, 4-BrC6H4, 3-EtO-4-MeOC6H3, etc.; R2 = MeSO2, Et2NSO2, CHO, EtO2C, etc.) by microwave-assisted olefin cross-metathesis of styrenes R1CH:CH2 with functionalized terminal alkenes R2CH:CH2 is described. This method can be also employed in the synthesis of β-deuterated α,β-unsaturated sulfones from inexpensive allylbenzenes though unprecedented one-pot isomerization/deuteration/cross-metathesis sequence. One of such obtained cross-metathesis products has been utilized in a new scalable synthesis of Apremilast, a potent and orally active phosphodiesterase 4 and tumor necrosis factor-α inhibitor. The same strategy was used in synthesis of ent-Apremilast.

ChemCatChem published new progress about Cross-metathesis (stereoselective). 608141-42-0 belongs to class ethers-buliding-blocks, and the molecular formula is C12H19NO4S, HPLC of Formula: 608141-42-0.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem