Tag: M.W=200-250

Ethers can again be classified into two varieties: if the alkyl or aryl groups are the same on both sides of the oxygen atom, 530-59-6, formula is C11H12O5, Name is 3,5-Dimethoxy-4-hydroxycinnamic acid. Then it is a simple or symmetrical ether, whereas if they are different, the ethers are called mixed or unsymmetrical ethers. HPLC of Formula: 530-59-6.

Khan, Palwasha;Akhtar, Naveed research published 《 Phytochemical investigations and development of ethosomal gel with Brassica oleraceae L. (Brassicaceae) extract: An innovative nano approach towards cosmetic and pharmaceutical industry》, the research content is summarized as follows. The study was aimed to develop and characterize plant extract (Brassica oleraceae) loaded ethosomal gel for the valuation of cosmeceutical applications with a credence that botanical extracts have a greater capability to be employed in the formulation of advanced pharmaceuticals. Phytochem. profiling via FT-IR anal., total bioactive contents of different polarity extracts (ethanol, dichloromethane, ethyl-acetate and chloroform) and quantification by using High Performance Liquid Chromatog. (HPLC) assay was carried out. Capabilities against oxidative stress were prodded through 2, 2-Diphenyl-1-picrylhydrazyl (DPPH), reduction potential analyses. Besides this, a correlation amongst total bioactive contents (TPC/TFC) and antioxidant potentials (biol. activities) was studied by multi-variate statistical anal. An augmented ethosomal preparation, after characterization and stability studies was incorporated to the gel matrix of Carbopol-940; Test/ EG (Ethosomal gel) with a Control/NEG (Non-ethosomal gel) formulation. Both formulations were then subjected to in-vitro characterization (organoleptic evaluation, pH, conductivity and rheol.) of 90 days. By permeation studies flux (μg/cm2/h); enhancement ratio was calculated and characterization of release data was done by using different kinetic models. The plant extracts revealed the presence of different functional groups along with 39.6 ± 0.5 mgGAE/g; 26.56 ± 0.4 mgQE/g phenolic and flavonoid contents, resp.; HPLC assay confirmed the existence of Quercetin, Gallic, Caffiec, Benzoic, Syringic and Sinapic Acids with highest antioxidant activity of 87.75% ± 1.18 in hydro-alc. fraction. Optimized ethosomal formulation exhibited entrapment efficiency of 68.57 ± 1.25, smallest vesicle size of 228.6 ± 1.17 nm with – 21.3 ± 0.15, zeta potential and a homogeneous size distribution of 0.233 ± 0.02. Significant results were obtained after in-vitro characterization. Both formulations followed Korsmeyer-peppas model with flux 35.499 and 21.731μg/cm2/h resp. and enhancement ratio 1.63. Thus, a stable ethosomal loaded gel of Brassica oleraceae extract was successfully developed and characterized for cosmeceutical potential.

HPLC of Formula: 530-59-6, Sinapinic acid is a chemical compound that is the dihydroxybenzoic acid derivative of sinapic acid. It has been shown to have anti-inflammatory properties in vitro and in vivo. Sinapinic acid inhibits the activity of various enzymes, such as cyclooxygenase (COX), lipoxygenase (LOX), and 5-lipoxygenase-activating protein (FLAP). It also decreases levels of adhesion molecules and downregulates inflammatory response genes. Sinapinic acid has been shown to reduce inflammation by inhibiting the formation of proinflammatory mediators, such as prostaglandin E2 or leukotriene B4, in endothelial cells and mammary epithelial cells.
Sinapic acid is a phenylpropanoid hydroxycinnamic acid with diverse biological activities. Sinapic acid inhibits collagen-induced human platelet aggregation by up to 70% in vitro (IC50 = 1.03 mM). It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; ) and 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonate) (ABTS) free radicals with IC50 values of 8.3 and 5.4 μg/ml, respectively. Sinapic acid (200 μM) reduces colony formation of SW480 human colon carcinoma cells by 4-fold. It also inhibits colony formation of E. coli, S. enteritidis, and S. aureus on agar (MICs = 2.2, 2, and 1.8 mM, respectively). In vivo, sinapic acid (4 mg/kg, p.o.) increases the time spent in the open arms of the elevated plus maze by approximately 15% in mice, an effect that can be blocked by the GABAA receptor antagonists flumazenil and bicuculline. Sinapic acid is also commonly used as a matrix in protein mass spectrometry.
Sinapic acid analytical standard provided with w/w absolute assay, to be used for quantitative titration.
Sinapic acid is an hydroxycinnamic acid derivative that occurs naturally in Brassicaceae species.
cis-Sinapic acid, also known as cis-sinapate or synapitic acid, belongs to the class of organic compounds known as hydroxycinnamic acids. Hydroxycinnamic acids are compounds containing an cinnamic acid where the benzene ring is hydroxylated. cis-Sinapic acid is considered to be a practically insoluble (in water) and relatively neutral molecule. Within the cell, cis-sinapic acid is primarily located in the cytoplasm. Outside of the human body, cis-sinapic acid can be found in common pea and pulses. This makes cis-sinapic acid a potential biomarker for the consumption of these food products.
Cis-sinapic acid is a 3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoic acid in which the double bond has cis-configuration. It has been isolated from the shoots of alfalfa. It has a role as a plant metabolite., 530-59-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Yamaoka, Yousuke; Yamakawa, Takuro; Tateishi, Kaito; Takasu, Kiyosei published the artcile< Total Synthesis of Cryptopleurine and Its Analogues>, SDS of cas: 190788-60-4, the main research area is total synthesis cryptopleurine analog.

Total synthesis of phenanthroquinolizidine alkaloid (±)-cryptopleurine (I) was achieved in 8 steps from com. available 2-pyridinecarboxaldehyde and the epoxide derived from methyleugenol. The key intermediate vinyl triflate enables the divergent synthesis of cryptopleurine derivatives by late-stage installation of various substituents on the C-ring.

Synthesis published new progress about Oxidative coupling reaction (oxidative biaryl coupling). 190788-60-4 belongs to class ethers-buliding-blocks, and the molecular formula is C13H19BO3, SDS of cas: 190788-60-4.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Xu, Jinhui; Cao, Jilei; Wu, Xiangyang; Wang, Han; Yang, Xiaona; Tang, Xinxin; Toh, Ren Wei; Zhou, Rong; Yeow, Edwin K. L.; Wu, Jie published the artcile< Unveiling Extreme Photoreduction Potentials of Donor-Acceptor Cyanoarenes to Access Aryl Radicals from Aryl Chlorides>, Product Details of C13H19BO3, the main research area is aryl chloride boronate light cyanoarene photoreductive borylation catalyst; arylboronate preparation; phosphine aryl chloride light cyanoarene phosphorylation catalyst; arylphosphonium salt preparation.

Since the seminal work of Zhang in 2016, donor-acceptor cyanoarene-based fluorophores, such as 1,2,3,5-tetrakis(carbazol-9-yl)-4,6-dicyanobenzene (4CzIPN), have been widely applied in photoredox catalysis and used as excellent metal-free alternatives to noble metal Ir- and Ru-based photocatalysts. However, all the reported photoredox reactions involving this chromophore family are based on harnessing the energy from a single visible light photon, with a limited range of redox potentials from -1.92 to +1.79 V vs SCE. Here, we document the unprecedented discovery that this family of fluorophores can undergo consecutive photoinduced electron transfer (ConPET) to achieve very high reduction potentials. One of the newly synthesized catalysts, 2,4,5-tri(9H-carbazol-9-yl)-6-(ethyl(phenyl)amino)isophthalonitrile (3CzEPAIPN), possesses a long-lived (12.95 ns) excited radical anion form, 3CzEPAIPN•-*, which can be used to activate reductively recalcitrant aryl chlorides (Ered ≈ -1.9 to -2.9 V vs SCE) under mild conditions. The resultant aryl radicals can be engaged in synthetically valuable aromatic C-B, C-P, and C-C bond formation to furnish arylboronates, arylphosphonium salts, arylphosphonates, and spirocyclic cyclohexadienes.

Journal of the American Chemical Society published new progress about Aromatic nitriles Role: CAT (Catalyst Use), SPN (Synthetic Preparation), USES (Uses), PREP (Preparation). 190788-60-4 belongs to class ethers-buliding-blocks, and the molecular formula is C13H19BO3, Product Details of C13H19BO3.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Tang, Huiling; Liu, Mengna; Zhu, Meiqi; Cui, Benqiang; Shi, Yanhui; Cao, Changsheng published the artcile< C(sp2)-C(sp2) Suzuki cross-coupling of arylammonium salts catalyzed by a stable Pd-NHC complex>, SDS of cas: 190788-60-4, the main research area is phenylnaphthalene preparation; arylammonium salt phenylboronic acid Suzuki cross coupling palladium catalyst.

The authors developed the Suzuki-Miyaura cross-coupling of aryl ammonium salts via C-N bond activation catalyzed by an easily prepared and bench-stable palladium-N-heterocyclic carbene complex. The reaction proceeded well under mild conditions with phenylboronic acid and pinacol ester or anhydride and provided biaryls Ar1-Ar2 [Ar1 = 1-naphthyl, Ph, 2-pyridyl, etc., Ar2 = Ph, 4-MeC6H4, 4-PhC6H4, etc.] in up to 97% yield with good functional group compatibility. The direct arylation of arylamine could be performed by a two-step, one-pot process and a protocol could be performed on the gram scale.

Tetrahedron published new progress about Biaryls Role: SPN (Synthetic Preparation), PREP (Preparation). 190788-60-4 belongs to class ethers-buliding-blocks, and the molecular formula is C13H19BO3, SDS of cas: 190788-60-4.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Antuganov, Dmitrii; Zykov, Michail; Timofeev, Vasilii; Timofeeva, Ksenija; Antuganova, Yulija; Orlovskaya, Victoriya; Fedorova, Olga; Krasikova, Raisa published the artcile< Copper-Mediated Radiofluorination of Aryl Pinacolboronate Esters: A Straightforward Protocol by Using Pyridinium Sulfonates>, Electric Literature of 190788-60-4, the main research area is aryl pinacolboronate ester radiofluorination copper pyridinium sulfonate catalyst base.

Radiofluorination of arylboronic acids pinacol esters (arylBPin) mediated by copper triflate pyridine complex is one of the more promising synthetic approaches for the direct introduction of nucleophilic [18F]fluoride into non-activated arenes and heteroarenes. However, the application of this method to the production of positron emission tomog. (PET) radiotracers in automated synthesizers remains a challenging task. The choice of phase-transfer catalyst (PTC) and corresponding base used for the generation of reactive [18F]fluoride species has a profound impact on the efficiency of the 18F-fluorination process. Herein the authors report the development of a simple procedure involving trapping of the aqueous [18F]fluoride on a weak anion-exchange resin (WAX) and its release by elution with pyridinium sulfonate in di-Me acetamide. Obtained reactive [18F]fluoride was used as-is in a copper-catalyzed fluorination reaction employing pyridinium salt as both PTC and base. High radiochem. conversion rates (RCCs) achieved for a series of simple arylBPin substrates and 4-[18F]fluoro-D,L-phenylalanine demonstrate the efficiency of this novel 18F-processing approach. Notably, the proposed method obviates conventional azeotropic drying steps, solvents evaporation and/or changeover and can be implemented on com. automated synthesizers.

European Journal of Organic Chemistry published new progress about Esters Role: RCT (Reactant), RACT (Reactant or Reagent) (Aryl Pinacolboronate Esters). 190788-60-4 belongs to class ethers-buliding-blocks, and the molecular formula is C13H19BO3, Electric Literature of 190788-60-4.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Adimurthy, Subbarayappa; Patoliya, Paresh U. published the artcile< N-Bromosuccinimide. A facile reagent for the oxidation of benzylic alcohols to aldehydes>, Quality Control of 17100-64-0, the main research area is benzylic alc oxidation bromosuccinimide reagent; aldehyde aromatic preparation; benzyl bromide preparation.

The oxidation of benzylic alcs. to aldehydes using N-bromosuccinimide (NBS) under ambient conditions without use of a transition-metal catalyst was described.

Synthetic Communications published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 17100-64-0 belongs to class ethers-buliding-blocks, and the molecular formula is C8H9BrO2, Quality Control of 17100-64-0.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Wucher, Philipp; Schwaderer, Judith B.; Mecking, Stefan published the artcile< Solid-Supported Single-Component Pd(II) Catalysts for Polar Monomer Insertion Copolymerization>, Computed Properties of 17100-64-0, the main research area is solid supported palladium catalyst preparation polar monomer insertion copolymerization; polystyrene supported methylpalladium sulfonatophenylphosphine complex preparation crystal mol structure; clay silica physisorbed methylpalladium sulfonatophenylphosphine complex preparation ethylene polymerization; montmorillonite clay supported methylpalladium sulfonatophenylphosphine complex preparation catalyst.

Heterogenized representatives of neutral phosphine sulfonato Pd(II) complexes for polar monomer insertion polymerization were prepared by two different approaches. [{κ2-(P,O)-(2-anisyl)2PC6H4SO2O}Pd(Me)L] (L = pyr, dmso, or Cl) complexes were physisorbed on inorganic substrates, namely, clay or silica. In addition, new phosphine sulfonato complexes bearing hydroxyl linker groups at the nonchelating P-aryl moiety were prepared These complexes were covalently tethered to cross-linked polystyrene. All immobilized palladium complexes are active in ethylene polymerization and ethylene/MA copolymerization without any addnl. cocatalyst. In addition, separation from the polymer solution formed and reutilization for another polymerization were demonstrated for polystyrene-bound complexes.

ACS Catalysis published new progress about Crystal structure. 17100-64-0 belongs to class ethers-buliding-blocks, and the molecular formula is C8H9BrO2, Computed Properties of 17100-64-0.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Varni, Anthony J.; Bautista, Michael V.; Noonan, Kevin J. T. published the artcile< Chemoselective Rhodium-Catalyzed Borylation of Bromoiodoarenes Under Mild Conditions>, Reference of 190788-60-4, the main research area is rhodium catalyst chemoselective borylation bromoiodoarene preparation bromoaryl boronate; aryl bromide boronate trifluoroborate preparation Suzuki coupling polymerization substrate.

A chemoselective rhodium-catalyzed borylation has been developed for the preparation of aryl boronate esters. The reaction proceeds under mild conditions with excellent selectivity for C-I bonds in bromoiodoarenes and exhibits broad functional group tolerance. This procedure can act as a complementary approach toward bifunctional arenes along with other metal-catalyzed borylations. Addnl., the reaction’s utility in the preparation of monomers for metal-catalyzed cross-coupling polymerization is demonstrated.

Journal of Organic Chemistry published new progress about Aryl iodides Role: RCT (Reactant), RACT (Reactant or Reagent). 190788-60-4 belongs to class ethers-buliding-blocks, and the molecular formula is C13H19BO3, Reference of 190788-60-4.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Martin, Adam D.; Easun, Timothy L.; Argent, Stephen P.; Lewis, William; Blake, Alexander J.; Schroder, Martin published the artcile< The effect of carboxylate position on the structure of a metal organic framework derived from cyclotriveratrylene>, Recommanded Product: (4-Bromo-3-methoxyphenyl)methanol, the main research area is cyclotriveratrylene carboxylate cobalt zinc metal organic framework preparation structure; crystal mol structure cyclotriveratrylene carboxylate cobalt zinc MOF.

Two cyclotriveratrylene-based ligands H3L1 and H3L2 have been synthesized using microwave heating and used in the formation of 1 [Zn2(L1)(DMA)2(CH3COO)] and 2 [Zn6(L2)4(DMA)6(H2O)5] (DMA = N,N-dimethylacetamide). 1 Displays an unusual trigonal paddlewheel node geometry, while Zn(II) paddlewheels are observed in 2. However, the stacking of CTV mols. in 1 is replaced by an uncommon mol. capsule structure in 2.

CrystEngComm published new progress about Crystal structure. 17100-64-0 belongs to class ethers-buliding-blocks, and the molecular formula is C8H9BrO2, Recommanded Product: (4-Bromo-3-methoxyphenyl)methanol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Chen, Yixuan; Gu, Yuefei; Meng, Huan; Shao, Qianzhen; Xu, Zhenchuang; Bao, Wenjing; Gu, Yucheng; Xue, Xiao-Song; Zhao, Yanchuan published the artcile< Metal-Free C-H Functionalization via Diaryliodonium Salts with a Chemically Robust Dummy Ligand>, Recommanded Product: 2-(2-Methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, the main research area is unsym iodonium salt preparation; Cross-Coupling; C−H Functionalization; Diaryliodonium Salts; Hypervalent Compounds; Structural Diversification.

A two-step strategy for the transition-metal-free C-H functionalization of arenes using unsym. iodonium salts as versatile synthetic linchpins was presented. The key to the success of this strategy was the identification of the 3,5-dimethyl-4-isoxazolyl (DMIX) group as a superior dummy ligand, which enabled not only site-selective C-H functionalization to afford unsym. iodonium salts I [R = Ph, 2-thienyl, 3,4-di-ClC6H4, etc.; X = OAc, OTs], but also highly selective aryl transfer during the subsequent metal-free coupling reaction. Both electron-rich and moderately electron-deficient arenes could be converted into the iodonium salts through C-H functionalization, allowing for diverse structural elaboration by metal-free C-N, C-C, C-S, and C-O coupling.

Angewandte Chemie, International Edition published new progress about C-H bond activation. 190788-60-4 belongs to class ethers-buliding-blocks, and the molecular formula is C13H19BO3, Recommanded Product: 2-(2-Methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem