Tag: M.W=150-200

He, Xinxin published the artcileBis-selenonium Cations as Bidentate Chalcogen Bond Donors in Catalysis, Safety of 2-Methoxynaphthalene, the publication is ACS Catalysis (2021), 11(20), 12632-12642, database is CAplus.

Hydrolytically stable bidentate Lewis acid catalysts derived from selenonium dicationic centers were developed. The bis-selenonium catalysts were employed in the activation of imine and carbonyl groups in various transformations with good yields and selectivity. Lewis acidity of the bis-selenonium salts was found to be stronger than that of the monoselenonium systems, attributed to the synergistic effect of the two cationic selenonium centers. In addition, the bis-selenonium catalysts were not inhibited by strong bases or moisture.

ACS Catalysis published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C11H10O, Safety of 2-Methoxynaphthalene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Li, Yang published the artcileTrifluoromethyl Selenoxides: Electrophilic Reagents for C-H Trifluoromethylselenolation of (Hetero)Arene, Safety of 2-Methoxynaphthalene, the publication is Organic Letters (2022), 24(16), 3009-3013, database is CAplus and MEDLINE.

Herein, designed and synthesized the new electrophilic trifluoromethylselenolation reagents, trifluoromethyl selenoxides I [X = H, CF₃, CN], which were easy to prepare and easy-to-handle and were not moisture or air sensitive. The selenoxides are successfully applied to metal-free C-H trifluoromethylselenolation of a series of (hetero)arenes to gave ((trifluoromethyl)selanyl)aryl ArSeCF₃ [Ar = 4-HOC₆H₄, 1H-indol-3-yl, (5-methoxycarbonyl-1H-pyrrol-3-yl), etc.].

Organic Letters published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C11H10O, Safety of 2-Methoxynaphthalene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Gao, Anjiang published the artcileVolatile-char interactions during biomass pyrolysis: Reactor design toward product control, Name: 4-Hydroxy-3,5-dimethoxybenzaldehyde, the publication is Renewable Energy (2022), 1-7, database is CAplus.

This paper proposes a novel reactor featuring controllable adjustment of volatile-char interactions to investigate the pyrolysis of poplar wood and corresponding products. Controllable adjustment of volatile-char interactions enables the selective production of pyrolysis products. The oxygen content in biochar nearly disappears with the reduction of volatile-char interactions and the pore structure of biochar is improved after the interactions being intensified. Moreover, as the interactions reduce, the bio-oil yield increases by 1.23 times, and the outputs of acetic acid and phenols in the bio-oil exhibit decreasing trends, while that of levoglucosan is improved by nearly 4.5 times. Furthermore, the average mol. weight of bio-oil decreases from 786 to 322 g/mol with the continuous intensification of volatile-char interactions. It concludes that the controllable adjustment of volatile-char interactions plays a vital role in regulating the distribution of pyrolysis products and is of great importance to the production of light oil.

Renewable Energy published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Name: 4-Hydroxy-3,5-dimethoxybenzaldehyde.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Wu, Zhuo published the artcilePd-Catalyzed ipso,meta-Dimethylation of ortho-Substituted Iodoarenes via a Base-Controlled C-H Activation Cascade with Dimethyl Carbonate as the Methyl Source, HPLC of Formula: 93-04-9, the publication is Journal of the American Chemical Society (2021), 143(12), 4524-4530, database is CAplus and MEDLINE.

A Me group can have a profound impact on the pharmacol. properties of organic mols. Hence, developing methylation methods and methylating reagents is essential in medicinal chem. We report a palladium-catalyzed dimethylation reaction of ortho-substituted iodoarenes using di-Me carbonate as a Me source. In the presence of K₂CO₃ as a base, iodoarenes are dimethylated at the ipso- and meta-positions of the iodo group, which represents a novel strategy for meta-C-H methylation. With KOAc as the base, subsequent oxidative C(sp³)-H/C(sp³)-H coupling occurs; in this case, the overall transformation achieves triple C-H activation to form three new C-C bonds. These reactions allow expedient access to 2,6-dimethylated phenols, 2,3-dihydrobenzofurans, and indanes, which are ubiquitous structural motifs and essential synthetic intermediates of biol. and pharmacol. active compounds

Journal of the American Chemical Society published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C38H24F4O4P2, HPLC of Formula: 93-04-9.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Xu, Ren-Rui published the artcilePalladium-catalyzed cascade Heck-type cyclization and reductive aminocarbonylation for the synthesis of functionalized amides, Application In Synthesis of 93-04-9, the publication is Organic & Biomolecular Chemistry (2022), 20(13), 2605-2608, database is CAplus and MEDLINE.

A palladium-catalyzed Heck/carbonylative cyclization process was explored for the synthesis of functionalized amides. By using nitroarenes as readily accessible nitrogen sources, a variety of amide products, e.g., I (Ar = 4-MeC₆H₄, 2-ClC₆H₄, 1-naphthyl, 2-thienyl, 8-quinolinyl, etc.), was obtained from the corresponding o-iodoaryl alkenes, e.g., II, in moderate to excellent yields with good functional group compatibility. Furthermore, a late-stage modification of a natural mol. was also achieved by this protocol.

Organic & Biomolecular Chemistry published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C13H14N2O, Application In Synthesis of 93-04-9.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Wu, Rui-Qing published the artcileExtracts from Cinnamomum cassia leaf residues display antioxidant and anti-inflammatory activities, Name: 4-Hydroxy-3,5-dimethoxybenzaldehyde, the publication is Journal of Food Processing and Preservation (2022), 46(4), e16454, database is CAplus.

In order to explore the potential utilization value of Cinnamomum cassia leaf residues (CcLRs), the extracts of CcLRs and their biol. activities were investigated in this study. The results showed that Et acetate (EA) fraction of CcLRs’ crude extract had the highest total phenolic content (361.53 ± 19.24 mg GAE/g extract) and total flavonoid content (652.48 ± 9.91 mg RE/g extract), and its antioxidant capacity was 1.2- to 1.4-fold higher than that of the crude extract and other fractions. The in vitro NO inhibition rate of the EA fraction was up to 92.25% at concentration of 200μg/mL. The in vivo study showed that the EA fraction significantly improved the total antioxidant capacity (T-AOC) in D-galactose-induced aging mice by enhancing the total superoxide dismutase (T-SOD) and glutathione peroxidase (GSH-Px) activities, as well as inhibited the inflammatory response by reducing the induced nitrogen monoxide synthase (iNOS) activity. Thus, the extract from CcLRs possesses excellent antioxidant and anti-inflammatory activities, and has potential as a new dietary supplement in the food industry.

Journal of Food Processing and Preservation published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C8H6F3NO, Name: 4-Hydroxy-3,5-dimethoxybenzaldehyde.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Mirk, Daniela published the artcileOxidative coupling of alkylated anisole derivatives using MoCl₅, COA of Formula: C10H14O, the publication is Synlett (2004), 1970-1974, database is CAplus.

Despite the Lewis acidic character of MoCl₅ it can be employed for the selective oxidative coupling reaction of alkylated anisole derivatives without transalkylation or de-tert-butylation of the substrates. The spatial demand close to the donor function seemed to be beneficial.

Synlett published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, COA of Formula: C10H14O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Liu, Bin published the artcileIonic liquid/boronic acid system enabled deuteration with D₂O, COA of Formula: C11H10O, the publication is Tetrahedron Letters (2022), 153968, database is CAplus.

The development of transition-metal free systems for multi-sites deuteration is important for the preparation of deuterium-labeled drugs and intermediates e.g, d-agomelatine. The ionic liquid [bmim]PF₆, which was able to promote highly efficient deuterodeborylation of boronic acids RB(OH)₂ [R = thianthren-1-yl, 1-benzothiophen-2-yl, 4-formyl-2-methoxyphenyl, etc.] with D₂O was reported. The ionic liquid/boronic acid system was successfully applied to the selective H/D exchange at various sp²/sp³ C-H positions. Moreover, unusual nucleophilic behaviors of nitrogen-containing heteroaromatics in ionic liquid were observed

Tetrahedron Letters published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C11H10O, COA of Formula: C11H10O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Li, Yan published the artcileComparison analysis of widely-targeted metabolomics revealed the variation of potential astringent ingredients and their dynamic accumulation in the seed coats of both Carya cathayensis and Carya illinoinensis, Category: ethers-buliding-blocks, the publication is Food Chemistry (2022), 131688, database is CAplus and MEDLINE.

Pecan and hickory nuts are two of consumers favorite ones. Pecan seeds can be eaten fresh, while hickory ones must remove astringency before eating. Here, we reported that total phenols, flavonoids and condensed tannins of hickory seeds were reduced after de-astringent treatments. They gradually increased with development, showing higher levels in hickory seed coat at mid-late periods than that in pecans. Widely-targeted metabonomics anal. of developing testa identified 424 kinds of components, including 101, 38, 58, 27 classes of flavonoids, tannins, phenolic acids, organic acids and others, showing 16 different changing trends. Notably, most kinds of flavonoids, hydrolysable tannins and phenolic acids at maturity were more than that of pecans, while oligomeric condensed tannins were opposite. Gene expression anal. provided further explanations for their dynamic accumulation. These results unraveled potential astringent components in hickory testa and preliminary mol. mechanisms of their dynamic changes, offering theor. basis for the targeted de-astringency.

Food Chemistry published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Gao, Hailian published the artcileEnhanced oxidative depolymerization of lignin in cooperative imidazolium-based ionic liquid binary mixtures, Recommanded Product: 4-Hydroxy-3,5-dimethoxybenzaldehyde, the publication is Bioresource Technology (2022), 127333, database is CAplus and MEDLINE.

The aerobic oxidation of lignin model 2-phenoxyacetophenone (2-PAP) in cooperative ionic liquid mixtures (CoILs) with 1-ethyl-3-methylimidazolium acetate ([C₂C₁i.m.]OAc) and 1-benzyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ([B_ZC₁i.m.]NTf₂) was investigated. Complete degradation of 2-PAP was achieved with [C₂C₁i.m.]OAc/[B_ZC₁i.m.]NTf₂ molar ratio (R_IL) of 1/1 and 1/2 at 100 °C for 2 h. The conversion and product yields from CoILs were higher than those in pure ILs, indicating the cooperative effects of [C₂C₁i.m.]OAc/[B_ZC₁i.m.]NTf₂ on cleaving aryl-ether bonds. [C₂C₁i.m.]OAc promoted the catalytic cleavage of aryl-ether bonds and solvation, and [B_ZC₁i.m.]NTf₂ induced the formation of alkyl radicals and enhanced the product selectivity. Accordingly, the highest conversion of alkali lignin (79.8%) was obtained with RIL of 5/1 at 100 °C for 2 h, and phenol monomers (306 mg/g) were selectively produced. The CoILs exhibited good catalytic capacities for oxidative depolymerization of lignin, which strongly depends on the changes in intermol. interactions and structural organization with varying RIL.

Bioresource Technology published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Recommanded Product: 4-Hydroxy-3,5-dimethoxybenzaldehyde.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem