Tag: M.W=150-200

Tang, Shouchu published the artcileApplication of a Domino Friedel-Crafts Acylation/Alkylation Reaction to the Formal Syntheses of (±)-Taiwaniaquinol B and (±)-Dichroanone, Recommanded Product: 2-Isopropylanisole, the publication is Organic Letters (2008), 10(9), 1855-1858, database is CAplus and MEDLINE.

An efficient acid-promoted domino Friedel-Crafts (FC) acylation/alkylation reaction has been developed for the construction of the core 6,5,6-ABC tricyclic skeleton (e.g. I) of taiwaniaquinoids. The formal total syntheses of diterpenoids (±)-taiwaniaquinol B and (±)-dichroanone based on this strategy have been achieved.

Organic Letters published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C38H74Cl2N2O4, Recommanded Product: 2-Isopropylanisole.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Hong, Kai published the artcileVarietal differences in the phytochemical components’ accumulation and aroma profile of three Humulus lupulus cultivars, Formula: C9H10O4, the publication is Food Control (2022), 108499, database is CAplus.

Humulus lupulus (hop) cone is a key ingredient in beer, which determines its taste and aroma. The impact of ripening on the bitter acids, aroma compounds, and polyphenols of hops has been reported sep., there is no systematic study on all three components. Here, three hop varieties in China were sampled to investigate the correlation between the harvest maturity and these three components, which indicated that polyphenols synthesized earlier than hop bitter acids, followed by the aroma compounds Variety differences of the hop cultivars prompted the obvious separation in the partial least-squares discriminant anal. (PLS-DA). Among three hop cultivars. TP1 with the highest contents of aroma compounds contributed to flower aroma, and with higher contents of bitter acids which contributed to bitter taste. In contrast, TP2 has been reported to be rich in caffeic acid, salicylic acid, syringaldehyde, (+)-catechin, and (-)-epicatechin. To analyze the hop aroma characteristics, two matrixes of hop tea and late-hopped beer were prepared and used for sensory evaluation. Compared to TP2 and QTF, the hop tea with TP1 scored best for strong (P < 0.01), herbal (P < 0.05) and citrus (P < 0.01). While the ‘strong’ and ‘herbal’ characteristics from terpene compounds receded in the late-hopped beer, the ‘citrus’ and ‘fruity’ notes from terpenol compounds remained noticeable.

Food Control published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Formula: C9H10O4.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Deng, Jiazhu published the artcilePreparation of a cost-effective Ni-Ag bimetallic catalyst for hydrodehalogenation of aryl halides under mild conditions, Recommanded Product: 2-Methoxynaphthalene, the publication is New Journal of Chemistry (2022), 46(25), 12169-12176, database is CAplus.

Cost-effective Ni-Ag bimetallic nanoparticles were prepared using an aqueous-phase surfactant-aided co-reduction process and used as catalysts for the hydrodehalogenation of aryl halides CAr-X (X = F, Cl, Br). CAr-X could be easily converted at 60°C by using water as a solvent, with a CAr-H yield higher than 90%. This catalyst was widely applicable in the hydrodehalogenation of halogenated aromatics with various functional groups (more than 40 examples), including the high concentration solution of aryl fluorides, polyhalogenated phenol, environmental pollutants like 2,4-dichlorophenoxyacetic acid (2,4-D) and triclosan. Furthermore, it could be easily recycled and reused, providing a green and cost-effective method for the degradation of polyhalogenated aromatic pollutants and synthesis of important structural units through hydrodehalogenation reactions.

New Journal of Chemistry published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C11H10O, Recommanded Product: 2-Methoxynaphthalene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Katariya, Ashishkumar P. published the artcileAn Efficient and Green Synthesis of Tetrahydrobenzo[b]pyran Derivatives Using [(EMIM)Ac] at Room Temperature, SDS of cas: 134-96-3, the publication is ChemistrySelect (2022), 7(15), e202104184, database is CAplus.

An efficient, expedient, clean, and environmentally benign synthesis of twenty tetrahydrobenzo[b]pyran derivatives I (R = 4-H₂NC₆H₄, 3-MeOC₆H₄, 2-furyl, 2-HOC₆H₄, etc.), is reported via a one-pot three-component condensation reaction of various benzaldehydes with dimedone and malononitrile in the presence of ionic liquid [(EMIM)Ac] as a catalyst at ambient temperature in ethanol. Advantages of this reaction follow the principle of green chem., which includes operational simplicity, shorter reaction times, and mild reaction conditions with high yield (78-98%) products.

ChemistrySelect published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, SDS of cas: 134-96-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Baker, Sarah I. published the artcileEnhanced Reactivity for Aromatic Bromination via Halogen Bonding with Lactic Acid Derivatives, HPLC of Formula: 93-04-9, the publication is Journal of Organic Chemistry (2022), 87(13), 8492-8502, database is CAplus and MEDLINE.

Herein, a new method for regioselective aromatic bromination using lactic acid derivatives as halogen bond acceptors with N-bromosuccinimide (NBS) is reported. Several structural analogs of lactic acid affected the efficiency of aromatic brominations, presumably via Lewis acid/base halogen-bonding interactions. Rate comparisons of aromatic brominations demonstrated the reactivity enhancement available via catalytic additives capable of halogen bonding. Computational results demonstrated that Lewis basic additives interact with NBS to increase the electropos. character of bromine prior to electrophilic transfer. An optimized procedure using catalytic mandelic acid under aqueous conditions at room temperature has been developed to promote aromatic bromination on a variety of arene substrates with complete regioselectivity.

Journal of Organic Chemistry published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C11H10O, HPLC of Formula: 93-04-9.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Al Qahtani, Hayfa W. S. published the artcileChemical Profile, Antioxidant and Enzyme Inhibition Activities of Natural Saudi Sidr and Talh Honeys, HPLC of Formula: 134-96-3, the publication is Chemistry & Biodiversity (2022), 19(7), e202200227, database is CAplus and MEDLINE.

Honey is used since ancient time as a food and to cure many diseases. The present study investigated the chem. constituents, antioxidant and enzyme inhibition activities of natural Saudi Sidr (SH) and Talh (TH) honeys. Beside entire honey samples, Et acetate, ethanol and water extracts were prepared The total polyphenolic content of SH, TH and their extracts was in the range of 2.86-7.21 and 3.80-17.33 mg gallic acid equivalent/g, resp. and the total flavonoids content was in the range of 0.05-1.17 and 0.18-2.38 mg rutin equivalent/g, resp. Out of the 53 standards analyzed by HPLC, 27 compounds were detected with highest number of compounds identified in the Et acetate extract of TH (45%, 24/53) and SH (26%, 14/53), resp. Quinic acid was dominant compound identified in all honey samples with the highest content determined in TH ethanol extract (4454μg/g). The majority of tested samples possessed considerable anti-radicals and reducing ions capacity with the Et acetate extract from TH exerted significantly (p<0.05) the highest activity. All honey samples did not show chelating iron metal property. Honey samples revealed variable enzyme inhibition activity with TH (entire and/or Et acetate extract) showed significantly (p<0.05) the highest acetylcholinesterase, butyrylcholinesterase, tyrosinase and α-amylase inhibition activity. In conclusion, Et acetate is the best solvent for extraction of bioactive mols. from the two honey types. Moreover, the dark-colored TH contained the highest number of mols. and consequently exerted the best antioxidant and enzyme inhibition activities in most assays.

Chemistry & Biodiversity published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, HPLC of Formula: 134-96-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Kinoshita, Hidenori published the artcileDiisobutylaluminum hydride-promoted cyclization of silylated 1,3-dien-5-ynes: Application to total synthesis of a 20-norabietane derivative, Application of 2-Isopropylanisole, the publication is Tetrahedron Letters (2017), 58(16), 1607-1610, database is CAplus.

The diisobutylaluminum hydride (DIBAL-H)-promoted benzocyclization, recently developed by this group, was adopted for the synthesis of a natural product containing a 9,10-dihydrophenanthrene skeleton to demonstrate its synthetic utility. One of the extracts from the roots of Salvia hydrangea DC. ex Bentham (Lamiaceae), a 20-norabietane derivative (I), was selected as the target mol. The key step forming the 9,10-dihydrophenanthrene skeleton was achieved by the DIBAL-H-promoted cyclization of a silylated 1,3-dien-5-yne easily accessible from a substituted α-tetralone.

Tetrahedron Letters published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Application of 2-Isopropylanisole.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Wang, Zhifan published the artcileC(sp³)-H 1,3-diamination of cumene derivatives catalyzed by a dirhodium(II) catalyst, Application of 2-Isopropylanisole, the publication is Organic Chemistry Frontiers (2022), 9(12), 3274-3280, database is CAplus.

The simultaneous and direct amination of multiple inert Csp³-H bonds is a challenging method for C-N bond formation. Here, a radical sequential reaction mediated by a dirhodium(II) catalyst was developed for the successful one-step synthesis of 1,3-diamines via the interaction of cumene derivatives with N-fluorobenzenesulfonimide (NFSI). Mechanistic studies revealed that the reaction underwent an iterative radical polar crossover and desaturation activation procedure to achieve the activation of three adjacent C-H bonds. The synthesized diamine compounds were converted into useful functional mols. by further removal of phenylsulfonyl groups.

Organic Chemistry Frontiers published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C18H23N3O4S, Application of 2-Isopropylanisole.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhang, Dejin published the artcileAn efficient method to prepare aryl acetates by the carbonylation of aryl methyl ethers or phenols, COA of Formula: C10H14O, the publication is New Journal of Chemistry (2021), 45(5), 2683-2687, database is CAplus.

A method of preparing aryl acetates ROC(O)CH₃ (R = Ph, 2-(propan-2-yl)phenyl, 4-fluorophenyl, 2,3,5-trimethylphenyl, etc.) by the carbonylation of aryl Me ethers ROCH₃ or phenols ROH under low CO pressure was developed. Good to excellent yields of aryl acetates were obtained using different substrates, and a possible reaction mechanism was proposed by conducting a series of control experiments This method may provide a potential way for the utilization of lignin.

New Journal of Chemistry published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H2F12NiO4, COA of Formula: C10H14O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Gao, Yang published the artcilePractical synthesis of 3-aryl anthranils via an electrophilic aromatic substitution strategy, Formula: C11H10O, the publication is Chemical Science (2022), 13(7), 2105-2114, database is CAplus and MEDLINE.

A practical route for the synthesis of valuable 3-aryl anthranils from readily available anthranils and simple arenes by using the classical electrophilic aromatic substitution (EAS) strategy was reported. This transformation goes through an electrophilic substitution and rearomatisation sequence by employing Tf₂O as an effective activator. A wide range of arenes were compatible in this transformation, delivering various structurally diversified 3-aryl anthranils in good yields and high regioselectivity. In addition, a variety of readily available feedstocks such as olefins, alkenyl triflates, silyl enolethers, carbonyl compounds, thiophenols and thiols could also participate in the reaction to achieve the C3 alkenylation, alkylation and thioetherification of anthranils. Of note, the synthesized 3-aryl anthranils proved to be a highly robust platform to access a series of biol. active compounds, drug derivatives and organic optoelectronic materials.

Chemical Science published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C11H10O, Formula: C11H10O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem