Tag: M.W=150-200

Nantaba, Florence published the artcileTemporal dynamics and ecotoxicological risk assessment of personal care products, phthalate ester plasticizers, and organophosphorus flame retardants in water from Lake Victoria, Uganda, COA of Formula: C11H16O2, the main research area is ecotoxicol risk assessment water pollution Lake Victoria Uganda; East africa; Flame retardants; Lake victoria; Personal care products; Plasticizers; Risk assessment.

For the first time the occurrence of 25 organic micropollutants (OMPs) including, eleven personal care products (PCPs), six phthalate ester plasticizers (PEPs) and eight organophosphorus flame retardants (OPFRs) was investigated in 72 water samples obtained from five bays in the Uganda sector of Lake Victoria. In addition, an assessment of the potential ecotoxic risk of the target OMPs to aquatic organisms was conducted. Water samples were analyzed for the target OMPs using gas chromatog. coupled with GC/MS. All the target PCPs were found in all the water samples with the exception of musk ketone and 2,6-di-tert-butylphenol. Triclosan, benzophenone, and 4-methylbenzylidine camphor were the most predominant PCPs. All the six plasticizers were found in all the water samples with di-Bu phthalate, and bis-(2-ethylhexyl) phthalate detected at the highest concentrations Tricresyl phosphate, tris-(2-chloroethyl) phosphate and tri-Ph phosphate were the most dominant OPFRs. The highest concentrations of OMPs were recorded in Murchison and Thurston Bays, presumably due to industrial wastewater effluents from the highly industrialized localities of the two Bays. Ecotoxicol. risk assessment showed that PCPs (triclosan, musk ketone, and 4-MBC), plasticizers (di-Bu phthalate, bis-(2-ethylhexyl) adipate and bis-(2-ethylhexyl) phthalate) and OPFRs (tricresyl phosphate, tri-Ph phosphate and tris-(2-chloroethyl) phosphate) pose a high ecotoxic risk to lives of aquatic organisms.

Chemosphere published new progress about Alkalinity. 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, COA of Formula: C11H16O2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Hu, Xiaomei published the artcileModification of thionucleobases in ionic liquids, SDS of cas: 622-86-6, the main research area is ionic liquid catalyst thioalkylation nucleobase preparation thionucleobase.

A simple method was established for the preparation of thio-substituted thionucleobases using room temperature ionic liquids (RTILs) such as 1-butyl-3-methylimidazolium trifluoroacetate [BMIM]+[CF3COO]- and 1-methoxyethyl-3-methylimidazolium trifluoroacetate [MeOEtMIM]+[CF3COO]- as solvents and catalysts without any other catalyst. These reactions proceeded efficiently in RTILs with excellent yield of products. RTILs can be recycled and reused effectively without further purification

Journal of Chemistry published new progress about Alkylation. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, SDS of cas: 622-86-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Demuner, Antonio Jacinto published the artcileThe Fungal Phytotoxin Alternariol 9-Methyl Ether and Some of Its Synthetic Analogues Inhibit the Photosynthetic Electron Transport Chain, SDS of cas: 127972-00-3, the main research area is Alternaria phytotoxin alternariol methyl ether analog preparation inhibition photosynthesis.

Alternariol and monomethylalternariol are natural phytotoxins produced by some fungal strains, such as Nimbya and Alternaria. These substances confer virulence to phytopathogens, yet no information is available concerning their mode of action. Here it is shown that in the micromolar range alternariol 9-Me ether is able to inhibit the electron transport chain (IC50 = 29.1 ± 6.5 μM) in isolated spinach chloroplasts. Since its effectiveness is limited by poor solubility in water, several alternariol analogs were synthesized using different aromatic aldehydes. The synthesized 6H-benzo-[c]-cromen-6-ones, 5H-chromene-[4,3-b]-pyridin-5-one, and 5H-chromene-[4,3-c]-pyridin-5-one also showed inhibitory properties, and three 6H-benzo-[c]-cromen-6-ones were more effective (IC50 = 12.8-22.8 μM) than the lead compound Their addition to the culture medium of a cyanobacterial model strain was found to inhibit algal growth, with a relative effectiveness that was consistent with their activity in vitro. In contrast, the growth of a nonphotosynthetic plant cell culture was poorly affected. These compounds may represent a novel lead for the development of new active principles targeting photosynthesis.

Journal of Natural Products published new progress about Alternaria. 127972-00-3 belongs to class ethers-buliding-blocks, name is 2-Methoxy-5-methylphenylboronic acid, and the molecular formula is C8H11BO3, SDS of cas: 127972-00-3.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Rausaria, Smita published the artcileManganese(III) Complexes of Bis(hydroxyphenyl)dipyrromethenes Are Potent Orally Active Peroxynitrite Scavengers, SDS of cas: 127972-00-3, the main research area is manganese chelate biscyclohexano fused bishydroxyphenyldipyrromethene preparation crystal structure; oral analgesic activity manganese chelate biscyclohexano fused bishydroxyphenyldipyrromethene; peroxynitrite scavenger manganese chelate biscyclohexano fused bishydroxyphenyldipyrromethene.

The authors report biscyclohexano-fused Mn(III) complexes of bis(hydroxyphenyl)dipyrromethenes, complexes I (R1 = H, Me, or F, 4a-c, resp.,) as potent and orally active peroxynitrite scavengers. Complexes 4a-c reduce peroxynitrite through a two-electron mechanism, thereby forming the corresponding Mn(V)O species, which were characterized by UV, NMR, and LC-MS methods. Mn(III) complex 4b and its strained boron (BODIPY) analog 9b were analyzed by x-ray crystallog. Finally, complex 4a is an orally active and potent analgesic in a model carrageenan-induced hyperalgesia known to be driven by the over-production of peroxynitrite.

Journal of the American Chemical Society published new progress about Analgesics. 127972-00-3 belongs to class ethers-buliding-blocks, name is 2-Methoxy-5-methylphenylboronic acid, and the molecular formula is C8H11BO3, SDS of cas: 127972-00-3.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Yang, Huibin published the artcileDesign and synthesis of thiazolylhydrazone derivatives as inhibitors of chitinolytic N-acetyl-β-D-hexosaminidase, Related Products of ethers-buliding-blocks, the main research area is thiazolylhydrazone derivative acetylhexosaminidase inhibitor mol docking.

N-acetyl-β-D-hexosaminidase (Hex) is potential target for pesticide design. Here, a series of thiazolylhydrazone derivatives were designed, synthesized and evaluated as competitive inhibitors of OfHex1, a Hex from the agricultural pest Ostrinia furnacalis. The derivative 3k, with a (benzyloxy)methyl group at the N3 atom, demonstrated greater potency with a Ki of 10.2 μM. Mol. docking anal. indicated that the (benzyloxy)methyl group of 3k was bound to a previously unexplored pocket formed by Loop 478-496. Then further optimization around naphthalene ring led to find the more potency substituent Ph. The derivative 7, with phenoxyethyl group at R1 and a Ph group at R2, demonstrated an augmented potency with a Ki of 2.1 μM. Mol. docking anal. indicated that 7 was bound to the active pocket of OfHex1 more favorably than 3k. This work suggests a novel scaffold for developing specific Hex inhibitors.

Bioorganic & Medicinal Chemistry published new progress about Drug design. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Related Products of ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ram, Siya published the artcileSynthesis of potential antifilarial agents. 2. Methyl 2-substituted purine 8-carbamates and related compounds, Quality Control of 622-86-6, the main research area is purinecarbamate preparation inactive filaricide; methoxycarbonylthioureidopyrimidine preparation inactive filaricide.

Purinecarbamates I [R = (un)substituted alkyl, benzyl] were prepared from 2-mercapto-4,5-pyrimidinediamine. Some methoxycarbonylthioureidopyrimidines were also prepared The compounds were tested against the filarial infection, Brugia pahangi, in Meriones ungericulatus malis. None of the compounds demonstrated antifilarial activity.

Journal of Heterocyclic Chemistry published new progress about Filaricides. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Quality Control of 622-86-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Bolton, Roger published the artcileSulfuryl chloride as an electrophile. IV. Steric hindrance to activation by the methoxy-group, Category: ethers-buliding-blocks, the publication is Journal of the Chemical Society [Section] B: Physical Organic (1970), 1770-2, database is CAplus.

The rates of reactions of sulfuryl chloride with a number of aromatic ethers have been studied in chlorobenzene solution The additivity principle, which holds in a number of examples of this reactions, fails when 2 substituents are placed ortho to the methoxyl group in anisole. 2,3,4,6-Tetramethylanisole substitutes Cl at a similar rate to that of 3-methylanisole, its calculated rate coefficient being 2000 times the exptl. value. Neither increasing the size of the alkyl group attached to the O atom nor using only 1 ortho substituent brought about any detectable effect due to steric factors.

Journal of the Chemical Society [Section] B: Physical Organic published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Demir, Hulya published the artcileEvaluation of the chemical profiling, total phenolic composition, the antioxidant and antimicrobial properties of the essential oils of Mentha piperita L., Salvia officinalis L., and Thymus vulgaris L, Application of 2-Isopropylanisole, the publication is Journal of Food Science and Engineering (2018), 8(6), 263-270, database is CAplus.

The purpose of this study was to determine the chem. composition, total phenolic composition, the antioxidant and antimicrobial properties of the essential oils (EOs) of Mentha piperita L., Salvia officinalis L., and Thymus vulgaris L. The essential oils of M. piperita L., S. officinalis L., and T. vulgaris L. were analyzed by means of gas chromatog.-mass spectrometry (GC-MS) to demonstrate their chem. composition The antioxidant properties of the EOs were evaluated with the 2,2-diphenyl-picrylhydrazyl (DDPH) free radical scavenging assay, their total phenolic compound contents were determined by the Folin Ciocalteau method, and their antimicrobial activities were evaluated by the disk diffusion assay. The major compounds in the contents of the essential oils of M. piperita L., S. officinalis L., and T. vulgaris L. were found to be eucalyptol, 1R-α-pinene, and o-cymene, resp. In the 2,2-diphenyl-picrylhydrazyl (DDPH) assay, the EO of M. piperita L. (8,930.01 μMTE/g) demonstrated the highest antioxidant activity, followed by the activities of the EOs of T. vulgaris L. (157.76 μMTE/g) and S. officinalis L. (115.54 μMTE/g). The total phenolic compound contents of M. piperita L., T. vulgaris L., and S. officinalis L. were measured as 135.074, 0.242, and 0.221 mMGAE/g. All essential oils showed antioxidant activities and antimicrobial activities. The highest antimicrobial activity against S. aureus, A. nigeris, and C. albicans was determined in the EO of M. piperita L. within diameters of 42, 32, and 28 mm, resp. These properties of essential oils are used in the pharmaceutical and food industries. The essential oils are approved as official medications in many countries and take place in their pharmacopoeias.

Journal of Food Science and Engineering published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Application of 2-Isopropylanisole.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Poole, Colin F. published the artcileSelection of calibration compounds for selectivity evaluation of siloxane-bonded silica columns for reversed-phase liquid chromatography by the solvation parameter model, Recommanded Product: 2-Methoxynaphthalene, the publication is Journal of Chromatography A (2020), 461652, database is CAplus and MEDLINE.

For the faster evaluation of selectivity in reversed-phase liquid chromatog. of siloxane-bonded silica columns using the solvation parameter model a minimal set of calibration compounds is described suitable for mobile phase composition from 20-70% (volume/volume) methanol-, acetonitrile-, or tetrahydrofuran-water. The Kennard-Stone uniform mapping algorithm is used to select the calibration compounds from a larger database of compounds with known retention properties used earlier for column selectivity evaluation. Thirty-five compounds are shown to be necessary to minimize the standard deviation of the system constants and to minimize the difference between the system constants determined by conventional calibration and the values obtained for the reduced calibration compounds The models for SunFire C₁₈ with methanol-, acetonitrile- and tetrahydrofuran-water mobile phase compositions and XBridge Shield RP18, XBridge C₈, XBridge Ph and Discovery HS F5 with methanol- and acetonitrile-water mobile phase compositions had an average coefficient of determination of 0.996 (standard deviation = 0.003, n = 11) and average standard error of the estimate 0.025 (standard deviation = 0.005, n = 11) for the reduced calibration compounds Some octadecylsiloxane-bonded silica stationary phases with a high bonding d. and methanol-water mobile phase compositions containing ≤ 30% (volume/volume) methanol exhibit extreme retention factors (log k > 2.5) for the low-polarity, two-ring aromatic compounds in the thirty-five compound calibration set. Alternative calibration compounds with more favorable retention properties are suggested as replacements in these cases. The predictive capability of the calibration models is validated using external test sets characterized by the average error, average absolute error and root mean square error of prediction. For the thirty-five calibration compounds sets the average absolute error 0.026 (standard deviation = 0.009, n = 11) and root mean square error of prediction 0.032 (standard deviation = 0.010, n = 11) confirm the suitability of the calibration models for column selectivity evaluation. System maps for XBridge Shield RP18 for 20-70% (volume/volume) methanol-water and Synergi Hydro-RP and 50% (volume/volume) methanol-water at temperatures from 25-65°C together with a correlation diagram for XBridge Shield RP18 and SunFire C₁₈ are presented as representative applications of the reduced calibration compounds for column selectivity evaluation.

Journal of Chromatography A published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C11H10O, Recommanded Product: 2-Methoxynaphthalene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Poole, Colin F. published the artcileEvaluation of the solvation parameter model as a quantitative structure-retention relationship model for gas and liquid chromatography, Related Products of ethers-buliding-blocks, the publication is Journal of Chromatography A (2020), 461308, database is CAplus and MEDLINE.

The Wayne State University (WSU) exptl. descriptor database is utilized to bench mark the current capability of the solvation parameter model for use as a quant. structure-retention relationship tool for estimating retention in gas and reversed-phase liquid chromatog. The prediction error for the retention factors of varied compounds on six open-tubular columns for gas chromatog. (Rtx-5 SIL MS, DB-35 ms, RtxCLPesticides, HP-88, HP-INNOWAX and SLB-IL76) and three packed columns for reversed-phase liquid chromatog. (SunFire C₁₈, XBridge Shield RP₁₈, and XBridge Phenyl) is used to establish expectations related to current practices. Each column data set was divided into a training set for calibration and a test set for validation employing a roughly 1 to 2 split, such that each test set contained about 40 to 80 varied compounds The average absolute error for the prediction of retention factors by gas chromatog. varied from about 0.1 to 0.4 on the retention factor scale with the larger error typical of stationary phases ranked as the most polar (or cohesive). For reversed-phase liquid chromatog. the average error for the prediction of retention factors was 0.3 to 0.5 and generally larger than for gas chromatog. Statistical filters where utilized to identify a group of polycyclic aromatic compounds without hydrogen-bonding functional groups with a larger prediction error on the SunFire C₁₈ column than for other compounds of smaller size, flexible structure or containing hydrogen-bonding functional groups. The heterogeneity of the retention mechanism is speculated to be the main contribution to the prediction error for both gas and liquid chromatog. using the solvation parameter model.

Journal of Chromatography A published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C11H10O, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem