Tag: M.W=150-200

Bruzik, K. published the artcileThiono-thiolo rearrangement and solvolysis of the secondary alkyl phosphorothionates. 3, Synthetic Route of 2944-47-0, the publication is Journal of Organic Chemistry (1981), 46(8), 1618-24, database is CAplus.

The protic acid-catalyzed thiono-thiolo (O→S) migration of secondary alkyl groups R in title esters I occurs in a complex fashion. Anal. of product distribution, stereochem., and D-incorporation experiments supports an ion pair-type intermediate (e.g., II.CF₃CO₂^–R⁺) as being responsible for the entire process. Nucleophilic attack by I on the ion pair initiates the chain reaction leading to III. In CF₃CO₂H, inversion of configuration (96%) at the C atom of the migrating EtCHMe group was observed A high concentration of I promotes this mode of rearrangement. However, the overall stereospecificity of EtCHMe migration is much lower, owing to an elimination process leading to the dialkyl H phosphorothioate II and an intermediate olefin which after protonation in acidic medium returns to the ion pair. The latter process is responsible for the nonstereospecific formation of part of the rearrangement product III and contributes to the lower stereospecificity of the trifluoroacetolysis process. The role of the acidity of the medium is discussed.

Journal of Organic Chemistry published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Synthetic Route of 2944-47-0.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Mierina, Inese published the artcileA green and effective route leading to antiradical agents with 3-arylmethyl 4-hydroxyquinolin-2(1H)-one moiety, Category: ethers-buliding-blocks, the publication is Tetrahedron Letters (2022), 153847, database is CAplus.

A new, green, convenient, cost- and atom effective route leading to 3-arylmethyl 4-hydroxyquinolin-2(1H)-ones from arylaldehydes and 1,3-dicarbonyl compounds in tri-Et ammonium formate in good to excellent yield was presented. The provided method foresaw the Knoevenagel condensation between a 4-hydroxyquinolin-2(1H)-one and an aromatic aldehyde followed by in-situ trapping of the arylidene intermediate with the hydride ion. All synthesized compounds were tested for their antiradical activity against DPPH and GO free radicals. The antiradical activity of the 3-arylmethyl 4-hydroxyquinolin-2(1H)-ones was comparable to or even higher than that of some com. widely used antioxidants like BHT, TBHQ, or α-tocopherol.

Tetrahedron Letters published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Dethe, Dattatraya H. published the artcileSc(OTf)₃-Catalyzed Synthesis of Symmetrical Dithioacetals and Bisarylmethanes Using Nitromethane as a Methylene Source, Product Details of C11H10O, the publication is Organic Letters (2020), 22(15), 5778-5782, database is CAplus and MEDLINE.

Use of nitromethane as an electrophilic methylene source for the synthesis of sym. dithioacetals and bisarylmethanes has been showcased using Sc(OTf)₃ as a catalyst. The procedure allows straightforward access to densely functionalized dithioacetals and bisarylmethanes under mild conditions. Addnl., the method has been applied for the synthesis of antimalarial tetra-Me mellotojaponin C and anticancer dimeric phloroglucinol derivative

Organic Letters published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C11H10O, Product Details of C11H10O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Vorobyova, Victoria published the artcilePotential of Tomato Pomace Extract as a Multifunction Inhibitor Corrosion of Mild Steel, Application In Synthesis of 134-96-3, the publication is Waste and Biomass Valorization (2022), 13(7), 3309-3333, database is CAplus.

The aim of this paper is to investigate tomato pomace extract (TPE) as a multifunctional ‘green’ vapor phase corrosion inhibitor for prevention from the atm. corrosion of mild steel and as a corrosion inhibitor in neutral media of 0.5 M NaCl solution TPE would be an effective inhibitor with the efficiency of around 98% in both corrosive conditions. The chem. profile of the TPE was analyzed using gas chromatog. mass spectrometry (GC-MS) and high-performance liquid chromatog. anal. (HPLC-DAD-MS). The major volatile constituents identified in tomato pomace extract were alcs. (12.5%), fatty acids (23.78%), aldehydes (41.6%), ketones (8.65%), and terpenoids (9.11%). The predominant semi-volatile and high mol. weight chem. components in tomato pomace extract were phenolic acids and flavanols [caffeic acid (2.03 0.3μg/g), chlorogenic acid (37.23 ± 0.80μg/g), gallic acid (10.2 ±0.80μg/g)]. The corrosion protection properties of the TPE as multifunctional corrosion inhibitor were studied using accelerated corrosion tests (weight loss method) and electrochem. methods [polarization curves and linear polarization technique (LPR)]. The mechanism of steel inhibition by TPE formulations was studied with the help of SEM (SEM) and at. force microscopy (AFM) observations. TPE acts as a “pro-inhibitor” of the steel corrosion in neutral solution The anal. confirmed that the growth of inhibitory properties is prolonged and corrosion rate is reduced after 40-48 h of exposure. The inhibition efficiency increases with increasing exposure time and reaches 98% after 48 h. Quantum-chem. calculations were used to predict the adsorption/inhibition properties of some of the main compounds of the extract and compounds formed as a result of chem. conversion. This work to contributes interpretation/explanation and understanding of the mechanism of action of green corrosion inhibitors in neutral solution

Waste and Biomass Valorization published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C6H13NO2, Application In Synthesis of 134-96-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Vorobyova, Viktoria published the artcileA New Combination Inhibitor Based on Tomato Pomace Extract and Organosilane for Enhanced Anticorrosion Performance of Steel, Product Details of C9H10O4, the publication is Chemistry Africa (2022), 5(4), 997-1014, database is CAplus.

The study aims to assess the effect of extract based inhibiting mixture, i.e., tomato pomace and organosilanes (Vinyltrimethoxysilane (VS)) against corrosion of steel in atm. environment. Such compositions can be used as polymer-type corrosion inhibitors for steel. The developed blend VCI based on tomato pomace extract (TPE) and organosilane provide a long-term protection from corrosion processes under the model conditions of carbon steel. The results show that the protection efficiency of the film reaches 96.97%. The tomato pomace extract chem. composition was analyzed by Head Space-Solid Phase Micro Extraction-Gas Chromatog.-Mass Spectrometry (HS-SPME-GC-MS). The major volatile compounds ot the TPE include alcs., esters, aldehydes, ketones and terpene compounds as described by panelists of HS-SPME-GC-MS. Electrochem. studies reveal decreased corrosion current densities from 4.29 x 10-4 to 0.65 x 10-4 A cm^-2 and increased polarization resistance under the conditions of periodic moisture condensation. FT-IR absorption peak obtained at 954, 1142, 1230 cm^-1 revealed the formation of Fe-O-Si, Si-O-Si and Si-O-C bonds. The protective film consesed of silane and extract offered the highest corrosion resistance since the corrosion protective barrier minimized the oxygen access and prevented corrosion of mild steel to a greater extent where the EDX anal. showed a high intense signal of Si and C. The mixture of phytochem. extract and organosilane were incorporated in a paint coating. The addition of additive increases the inhibitory properties of the final coating while keeping the barrier properties of the coating.

Chemistry Africa published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C10H11NO4, Product Details of C9H10O4.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhao, Lanxiao published the artcileCalcium-Catalyzed Dehydrogenative Silylation of Aromatic Ethers with Hydrosilane, Quality Control of 93-04-9, the publication is ACS Catalysis (2021), 11(4), 2041-2046, database is CAplus.

The catalytic regioselective C-H silylation of a wide range of alkoxy-substituted benzene derivatives with primary hydrosilane was achieved using scorpionate-supported Ca benzyl complex [(Tp^Ad,iPr)Ca(p-CH₂C₆H₄Me)(THP)] (1) (Tp^Ad,iPr = hydrotris(3-adamantyl-5-isopropylpyrazolyl)borate, THP = tetrahydropyran) as the precatalyst. This protocol offers an atom-efficient and straightforward method for the synthesis of a variety of silyl-substituted aromatic ether derivatives without a H acceptor and free of transition metal. Ca anisyl complexes [(Tp^Ad,iPr)Ca(o-MeO-m-Br-C₆H₃)] (5) and [(Tp^Ad,iPr)Ca(o-Me-OCH₂C₆H₄)] (6), proposed as the catalytic reaction intermediates, were isolated and structurally characterized.

ACS Catalysis published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C13H16O2, Quality Control of 93-04-9.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Komakech, Richard published the artcileGC-MS and LC-TOF-MS profiles, toxicity, and macrophage-dependent in vitro anti-osteoporosis activity of Prunus africana (Hook f.) Kalkman Bark, Application In Synthesis of 134-96-3, the publication is Scientific Reports (2022), 12(1), 7044, database is CAplus and MEDLINE.

Osteoporosis affects millions of people worldwide. As such, this study assessed the macrophage-dependent in vitro anti-osteoporosis, phytochem. profile and hepatotoxicity effects in zebrafish larvae of the stem bark extracts of P. africana. Mouse bone marrow macrophages (BMM) cells were plated in 96-well plates and treated with P. africana methanolic bark extracts at concentrations of 0, 6.25, 12.5, 25, and 50 μg/mL for 24 h. The osteoclast tartrate-resistant acid phosphatase (TRAP) activity and cell viability were measured. Lipopolysaccharides (LPS) induced Nitrite (NO) and interleukin-6 (IL-6) production inhibitory effects of P. africana bark extracts (Methanolic, 150 μg/mL) and β-sitosterol (100 μM) were conducted using RAW 264.7 cells. Addnl., inhibition of IL-1β secretion and TRAP activity were determined for chlorogenic acid, catechin, naringenin and β-sitosterol. For toxicity study, zebrafish larvae were exposed to different concentrations of 25, 50, 100, and 200 μg/mL P. africana methanolic, ethanolic and water bark extracts DMSO (0.05%) was used as a neg. control and tamoxifen (5 μM) and dexamethasone (40 μM or 80 μM) were pos. controls. The methanolic P. africana extracts significantly inhibited (p < 0.001) TRAP activity at all concentrations and at 12.5 and 25 μg/mL, the extract exhibited significant (p < 0.05) BMM cell viability. NO production was significantly inhibited (all p < 0.0001) by the sample. IL-6 secretion was significantly inhibited by P. africana methanolic extract (p < 0.0001) and β-sitosterol (p < 0.0001) and further, chlorogenic acid and naringenin remarkably inhibited IL-1β production The P. africana methanolic extract significantly inhibited RANKL-induced TRAP activity. The phytochem. study of P. africana stem bark revealed a number of chem. compounds with anti-osteoporosis activity. There was no observed hepatocyte apoptosis in the liver of zebrafish larvae. In conclusion, the stem bark of P. africana is non-toxic to the liver and its inhibition of TRAP activity makes it an important source for future anti-osteoporosis drug development.

Scientific Reports published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Application In Synthesis of 134-96-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Hashimoto, Toru published the artcileCross-Coupling Reactions of Aryl Halides with Primary and Secondary Aliphatic Alcohols Catalyzed by an O,N,N-Coordinated Nickel Complex, Synthetic Route of 93-04-9, the publication is Advanced Synthesis & Catalysis (2021), 363(6), 1625-1630, database is CAplus.

A synthesis of alkyl aryl ethers was achieved via the cross-coupling of aryl halides with primary and secondary aliphatic alcs. catalyzed by a bench-stable nickel complex supported by a monoanionic O,N,N-tridentate ligand. This nickel-catalyzed reaction proceeds smoothly in the absence of a phosphine ligand, affording alkyl aryl ethers in moderate to good yields.

Advanced Synthesis & Catalysis published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C11H10O, Synthetic Route of 93-04-9.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Dahiya, Amit published the artcileBase-Mediated Direct C-H Germylation of Heteroarenes and Arenes, Synthetic Route of 93-04-9, the publication is Organic Letters (2021), 23(15), 6010-6013, database is CAplus and MEDLINE.

The direct C-H germylation of heteroarenes, arenes, and benzylic C-H bonds promoted by lithium tetramethylpiperidide (LiTMP) is reported. The method is rapid, selective, and operationally simple, consisting of direct addition of all reagents at room temperature (one-pot procedure). The synthetic utility of these newly accessed aryl germanes as viable coupling partners in Pd catalysis is also showcased.

Organic Letters published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C11H10O, Synthetic Route of 93-04-9.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Burmaoglu, Serdar published the artcileSyntheses and evaluation of multicaulin and miltirone-like compounds as antituberculosis agents, Product Details of C10H14O, the publication is Journal of Enzyme Inhibition and Medicinal Chemistry (2017), 32(1), 878-884, database is CAplus and MEDLINE.

Four multicaulin and miltirone-like phenanthrene derivatives were synthesized and evaluated as antituberculosis agents. The crucial step of the synthesis was Pschorr coupling of 4-(3-isopropyl-4-methoxyphenyl)-2-(2-aminophenyl)ethane to give 2-isopropyl-3-methoxy-9,10-dihydrophenanthrene and 4-isopropyl-3-methoxy-9,10-dihydrophenanthrene. 2-Isopropyl-3-methoxy-9,10-dihydrophenanthrene was converted to multicaulin and miltirone-like phenanthrene derivatives by further reactions. The best antituberculosis activity was exhibited by 2-isopropylphenanthrene-3-ol.

Journal of Enzyme Inhibition and Medicinal Chemistry published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Product Details of C10H14O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem