Tag: M.W=100-200

Beiginejad, Hadi; Nematollahi, Davood; Varmaghani, Fahimeh; Bayat, Mehdi published an article about the compound: 4-(Piperazin-1-yl)phenol( cas:56621-48-8,SMILESS:OC1=CC=C(N2CCNCC2)C=C1 ).COA of Formula: C10H14N2O. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:56621-48-8) through the article.

Electrochem. oxidation of some p-aminophenol derivatives (1-5) in acidic solutions was studied both exptl. and theor. to provide insight into the influence of some factors on the hydrolysis reaction rate. The result of this work shows that the electrogenerated p-quinoneimines participate in the hydrolysis reaction and are converted to the p-benzoquinone. The hydrolysis reaction rate strongly depends on the structure of the p-aminophenols and solution’s pH. The observed homogeneous rate constants of hydrolysis (kobshyd) of p-quinoneimines were determined using digital simulation technique. The effect of different parameters such as: change of Gibbs free energy (ΔG) of the electrochem. oxidation of para-aminophenol derivatives (1-5), charge of reaction site, N-C4 bond order (Wiberg Bond Indexes, WBIs) and the nature of substituted group, on the hydrolysis rate constant were also studied. All calculations were performed using D. Functional Theory (DFT) both BP86 and B3LYP levels of theory and 6-311G (p,d) basis set. The N-C4 bond order and charge on the reaction site play significant roles in hydrolysis reaction’s rate.

Although many compounds look similar to this compound(56621-48-8)COA of Formula: C10H14N2O, numerous studies have shown that this compound(SMILES:OC1=CC=C(N2CCNCC2)C=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

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Ether – Wikipedia,
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Safety of 4-(Piperazin-1-yl)phenol. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 4-(Piperazin-1-yl)phenol, is researched, Molecular C10H14N2O, CAS is 56621-48-8, about Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors. Author is Neves, Gilda; Menegatti, Ricardo; Antonio, Camila B.; Grazziottin, Luiza R.; Vieira, Renan O.; Rates, Stela M. K.; Noel, Francois; Barreiro, Eliezer J.; Fraga, Carlos A. M..

The authors described herein the design, synthesis, and pharmacol. evaluation of N-phenylpiperazine heterocyclic derivatives as multi-target compounds potentially useful for the treatment of schizophrenia. The isosteric replacement of the heterocyclic ring at the biaryl motif generating pyrazole, 1,2,3-triazole, and 2-methylimidazole[1,2-a]pyridine derivatives resulted in 21 analogs with different substitutions at the para-biaryl and para-phenylpiperazine positions. Among the compounds prepared, 4 (LASSBio-579) and 10 (LASSBio-664) exhibited an adequate binding profile and a potential for schizophrenia pos. symptoms treatment without cataleptogenic effects. Structural features of this mol. scaffold are discussed regarding binding affinity and selectivity for D2-like, 5-HT1A, and 5-HT2A receptors.

Although many compounds look similar to this compound(56621-48-8)Safety of 4-(Piperazin-1-yl)phenol, numerous studies have shown that this compound(SMILES:OC1=CC=C(N2CCNCC2)C=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 4-(Piperazin-1-yl)phenol( cas:56621-48-8 ) is researched.Reference of 4-(Piperazin-1-yl)phenol.Ryu, Eun Kyoung; Choe, Yearn Seong; Kim, Dong Hyun; Ko, Bong-Ho; Choi, Yong; Lee, Kyung-Han; Kim, Byung-Tae published the article 《In vitro metabolism studies of 18F-labeled 1-phenylpiperazine using mouse liver S9 fraction》 about this compound( cas:56621-48-8 ) in Nuclear Medicine and Biology. Keywords: radiolabeled fluorine 18 phenylpiperazine metabolism liver S9 fraction. Let’s learn more about this compound (cas:56621-48-8).

The in vitro metabolism of 1-(4-[18F]fluoromethylbenzyl)-4-phenylpiperazine ([18F]1) and 1-(4-[18F]fluorobenzyl)-4-phenylpiperazine ([18F]2) was investigated using mouse liver S9 fraction. Results were compared to those of in vivo metabolism using mouse blood and bone and to in vitro metabolism using mouse liver microsomes. Defluorination was the main metabolic pathway for [18F]1 in vitro and in vivo. Based on TLC, HPLC and LC-MS data, [18F]fluoride ion and less polar radioactive metabolites derived from aromatic ring oxidation were detected in vitro, and the latter metabolites were rapidly converted into the former with time, whereas only the [18F]fluoride ion was detected in vivo. Similarly, the in vitro metabolism of [18F]2 using either S9 fraction or microsomes showed the same pattern as the in vivo method using blood; however, the radioactive metabolites derived from aromatic ring oxidation were not detected in vivo. These results demonstrate that liver S9 fraction can be widely used to investigate the intermediate radioactive metabolites and to predict the in vivo metabolism of radiotracers.

Although many compounds look similar to this compound(56621-48-8)Reference of 4-(Piperazin-1-yl)phenol, numerous studies have shown that this compound(SMILES:OC1=CC=C(N2CCNCC2)C=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Recommanded Product: 4-(Piperazin-1-yl)phenol. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 4-(Piperazin-1-yl)phenol, is researched, Molecular C10H14N2O, CAS is 56621-48-8, about Modifications to five-substituted 3,3-diethyl-4,5-dihydro-2(3H)-furanones en route to novel muscarinic receptor ligands. Author is Bhandare, Richie R.; Canney, Daniel J..

Lead lactone-based ligands with modest affinity for muscarinic receptors were modified based on structure-activity relationship data in the literature to provide a new series of 5-substituted 4,5-dihydro-2(3H)-furanones. The modifications included the addition of various nitrogen-containing heterocycles attached to substituted and unsubstituted aromatic rings. The target compounds, e.g. I, were synthesized in modest yields and evaluated in preliminary muscarinic binding assays. A lactone-based ligand containing a diphenylmethylpiperazine moiety was identified as a nonselective muscarinic ligand with IC50 of 340 nM. The design of future ligands will be based, in part, on structure-activity data reported herein.

In some applications, this compound(56621-48-8)Recommanded Product: 4-(Piperazin-1-yl)phenol is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Category: ethers-buliding-blocks. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 4-(Piperazin-1-yl)phenol, is researched, Molecular C10H14N2O, CAS is 56621-48-8, about Dependence of mechanisms to thermodynamics in the electrochemical study of different electrophiles in the presence of some sulfur nucleophiles. Author is Beiginejad, Hadi; Rafiee, Zeinab.

Abstract: Electrochem. study of different electrophiles in the presence of p-toluenesulfinic acid and 2-mercaptobenzothiazole as sulfur nucleophiles was investigated. Mechanistic study of the electrochem. reactions indicates that the electrochem. oxidation of some species in the presence of the sulfur groups has different mechanisms, but some other species in the presence of both sulfur nucleophiles have the same mechanism. To explain the reason for this difference, the computational study was used. Thermodn. investigation shows that when ΔGtot of the electrochem. oxidation of products are less than that of initial species, the electrochem. produced species can be oxidized during controlled-potential coulometry. The results of this work indicate that the computational study can be used to justify the reaction mechanisms. Cyclic voltammetry, linear sweep voltammetry, and controlled-potential coulometry were used to obtain the exptl. results. Also, by the use of BP86 level of theory and 6-31 + G(d,p) basis set, the theor. data were obtained.

In some applications, this compound(56621-48-8)Category: ethers-buliding-blocks is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electric Literature of C10H14N2O. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 4-(Piperazin-1-yl)phenol, is researched, Molecular C10H14N2O, CAS is 56621-48-8, about Electrochemical oxidation of 4-(piperazin-1-yl)phenol in the presence of aryl sulfinic acids. Author is Nematollahi, Davood; Khazalpour, Sadegh; Amani, Amene.

Electrochem. oxidation of 4-(piperazin-1-yl)phenol was studied in the presence of aryl sulfinic acids as nucleophiles in EtOH/H2O mixture (10/90) using cyclic voltammetry and controlled-potential coulometry methods. The electrochem. generated p-quinone-imine participates in Michael type addition reaction with aryl sulfinic acids and via an EC mechanism converts to the new 2-(phenylsulfonyl)-4-(piperazin-1-yl)phenol derivatives The present work led to the development of a facile and environmentally friendly electrochem. method for the synthesis of some new 2-(phenylsulfonyl)-4-(piperazin-1-yl)phenol derivatives under green conditions.

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 4-(Piperazin-1-yl)phenol( cas:56621-48-8 ) is researched.Formula: C10H14N2O.Hayatshahi, Hamed S.; Luedtke, Robert R.; Taylor, Michelle; Chen, Peng-Jen; Blass, Benjamin E.; Liu, Jin published the article 《Factors Governing Selectivity of Dopamine Receptor Binding Compounds for D2R and D3R Subtypes》 about this compound( cas:56621-48-8 ) in Journal of Chemical Information and Modeling. Keywords: dopamine receptor selectivity D2R D3R ligand binding. Let’s learn more about this compound (cas:56621-48-8).

Targeting the D3 dopamine receptor (D3R) is a promising pharmacotherapeutic strategy for the treatment of many disorders. The structure of the D3R is similar to the D2 dopamine receptor (D2R), especially in the transmembrane spanning regions that form the orthosteric binding site, making it difficult to identify D3R selective pharmacotherapeutic agents. Here, the authors examine the mol. basis for the high affinity D3R binding and D3R vs. D2R binding selectivity of substituted phenylpiperazine thiopheneamides. Removing the thiophenearylamide portion of the ligand consistently decreases the affinity of these ligands at D3R, while not affecting their affinity at the D2R. The authors’ long (>10μs) mol. dynamics simulations demonstrated that both dopamine receptor subtypes adopt two major conformations that the authors refer to as closed or open conformations, with D3R sampling the open conformation more frequently than D2R. The binding of ligands with conjoined orthosteric-allosteric binding moieties causes the closed conformation to populate more often in the trajectories. Also, significant differences were observed in the extracellular loops (ECL) of these two receptor subtypes leading to the identification of several residues that contribute differently to the ligand binding for the two receptors that could potentially contribute to ligand binding selectivity. The authors’ observations also suggest that the displacement of ordered water in the binding pocket of D3R contributes to the affinity of the compounds containing an allosteric binding motif. These studies provide a better understanding of how a bitopic mode of engagement can determine ligands that bind selectively to D2 and D3 dopamine receptor subtypes.

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Indian Journal of Heterocyclic Chemistry called Synthesis of substituted 2-aminobenzothiazoles as non-acidic antiinflammatory agents, Author is Velingkar, V. S.; Ahire, D. C.; Koihe, N. S.; Shidore, M. S., which mentions a compound: 56621-48-8, SMILESS is OC1=CC=C(N2CCNCC2)C=C1, Molecular C10H14N2O, COA of Formula: C10H14N2O.

The title compounds were synthesized and characterized by spectral anal. (IR, 1H NMR, mass spectroscopy). The effect of the synthesized compounds on inflammation, using the carrageenan induced mouse paw edema model was studied. In general, the compounds were found to be potent antiinflammatory agents. Antiinflammatory activity was influenced by some structural characteristics of the synthesized compounds

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 4-(Piperazin-1-yl)phenol( cas:56621-48-8 ) is researched.Application In Synthesis of 4-(Piperazin-1-yl)phenol.Neves, Gilda; Menegatti, Ricardo; Antonio, Camila B.; Grazziottin, Luiza R.; Vieira, Renan O.; Rates, Stela M. K.; Noel, Francois; Barreiro, Eliezer J.; Fraga, Carlos A. M. published the article 《Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors》 about this compound( cas:56621-48-8 ) in Bioorganic & Medicinal Chemistry. Keywords: heterocyclic phenylpiperazine preparation D2 HT1A receptor ligand antipsychotic. Let’s learn more about this compound (cas:56621-48-8).

The authors described herein the design, synthesis, and pharmacol. evaluation of N-phenylpiperazine heterocyclic derivatives as multi-target compounds potentially useful for the treatment of schizophrenia. The isosteric replacement of the heterocyclic ring at the biaryl motif generating pyrazole, 1,2,3-triazole, and 2-methylimidazole[1,2-a]pyridine derivatives resulted in 21 analogs with different substitutions at the para-biaryl and para-phenylpiperazine positions. Among the compounds prepared, 4 (LASSBio-579) and 10 (LASSBio-664) exhibited an adequate binding profile and a potential for schizophrenia pos. symptoms treatment without cataleptogenic effects. Structural features of this mol. scaffold are discussed regarding binding affinity and selectivity for D2-like, 5-HT1A, and 5-HT2A receptors.

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of 4-(Piperazin-1-yl)phenol. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 4-(Piperazin-1-yl)phenol, is researched, Molecular C10H14N2O, CAS is 56621-48-8, about Synthesis and bioevaluation of 4,5,6,7-tetrahydrobenzo[d]isoxazole derivatives as melanogenesis inhibitors. Author is Song, Jiho; Lee, Kiho; Kim, Doran; Kim, Jongmin; Lee, Seul; Shin, Jun Seob; Kim, Dong-Seok; Min, Kyung Hoon.

A series of 4,5,6,7-tetrahydrobenzo[d]isoxazole derivatives I [R1 = H, tert-butyl; R2 = 4-OH, 4-OMe, 2-OMe, 4-CF3, 4-F] was prepared via amide coupling of arylpiperazines with corresponding 4,5,6,7-tetrahydrobenzo[d]isoxazole carboxylic acid chlorides. Addnl., 4,5,6,7-tetrahydrobenzo[d]isoxazole derivative I [R1 = H; R2 = 4-OEt] was synthesized by O-alkylation of compound I [R1 = H; R2 = 4-OH] using iodoethane. The synthesized compounds were tested for their melanogenesis inhibiting activity through potential down-regulation of tyrosinase expression. Among the tested compounds, compounds I [R1 = H; R2 = 4-OMe, 2-OMe, 4-CF3] displayed better melanogenesis inhibiting activity than well-known compounds Arbutin and Kojic acid, without intrinsic cytotoxicity.

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem