Tag: M.W=100-150

Grolik, Jaroslaw published the artcileRegioselective synthesis of the 4,5-dialkoxy-2-nitroanilines bearing two different alkoxy substituents, Computed Properties of 91-16-7, the publication is Tetrahedron Letters (2022), 153830, database is CAplus.

This article reported the regioselective and chemoselective synthesis of 4,5-dialkoxy-2-nitroanilines I [R¹ = Me, Et, i-Bu, etc.; R² = Me, i-Pr, n-Bu, etc.] substituted with two alkoxys at C-4 and C-5. Here the optimization protocol of the transetherification reaction used to synthesize 20 new compounds with good to excellent yields (50-92%) was showed. A simple and efficient one-step procedure was described that could be applied to obtain a significant number of pharmacol. active compounds, including antimalarial drug Primaquine analogs.

Tetrahedron Letters published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Computed Properties of 91-16-7.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Senthilkumar, P. published the artcileAntibacterial activity of 26-member [2 + 2] macrocycles: a structure-reactivity study, Safety of 1,2-Dimethoxybenzene, the publication is World Journal of Pharmaceutical Research (2022), 11(1), 1103-1113, database is CAplus.

26 Member [2 + 2] macrocyclic Schiff base compounds were investigated for their antibacterial activity against Gram pos. and Gram neg. bacteria. The recorded data of zone of inhibition showed significant broad activity when compared with standard The structure reactivity correlation of the compounds has been studied. The antibacterial searching suggests that all the synthesized macrocyclic compounds showed moderate to very good activity against the tested organisms. Among the compounds, -COOH substituted compound showed the most promising antibacterial activity. The inhibition zone diameters of these compounds have been correlated with Hammett substituent constants, F and R parameters. From the results of statistical anal., the effects of substituent on the antibacterial activity of compounds have been studied.

World Journal of Pharmaceutical Research published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C17H18N2O6, Safety of 1,2-Dimethoxybenzene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Li, Zhe published the artcileFluorinated triphenylenes and a path to short tailed discotic liquid crystals: synthesis, structure and transport properties, Safety of 1,2-Dimethoxybenzene, the publication is Materials Advances (2022), 3(1), 534-546, database is CAplus.

A new synthetic approach for fluorinated alkoxytriphenylene discotic liquid crystals is presented. This methodol. exploits the previously described photocyclodehydrofluorination (PCDHF) reaction for the preparation of fluorinated triphenylene derivatives coupled with a variety of nucleophilic aromatic substitution (S_NAr) reactions. This particular combination of reactions provides a versatile route to discotic materials with carefully controlled core fluorine and alkoxy tail content. In the course of these studies, new discotic materials with minimal tail content have been revealed. The mesogenic properties of these materials are reported, and their charge transport properties are measured using the time of flight technique.

Materials Advances published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Safety of 1,2-Dimethoxybenzene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Basak, Shubhajit published the artcilePalladium-Catalyzed 2-fold C-H Activation/C-C Coupling for C4-Arylation of Indoles Using Weak Chelation, Application In Synthesis of 91-16-7, the publication is Organic Letters (2022), 24(2), 554-558, database is CAplus and MEDLINE.

Palladium-catalyzed weak chelation-assisted regioselective C4-arylation of indoles was accomplished using a readily available arene at moderate temperature The C4-arylation, weak chelating benzoyl (Bz) directing group, cross-dehydrogenative coupling (CDC), broad substrate scope, and late-stage diversifications were the important practical features.

Organic Letters published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Application In Synthesis of 91-16-7.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Penland, Marine published the artcileBrine salt concentration reduction and inoculation with autochthonous consortia: Impact on Protected Designation of Origin Nyons black table olive fermentations, Related Products of ethers-buliding-blocks, the publication is Food Research International (2022), 111069, database is CAplus and MEDLINE.

Nyons table olives, named after the French city where they are processed, are naturally fermented black table olives. Their specificity relies on the use of the ‘Tanche’ olive variety harvested at full maturity and their slow spontaneous fermentation in 10% salt brine driven by yeast populations. This study aimed at investigating the benefit of inoculating autochthonous consortia to produce Nyons table olives by fermentation in 10% salt brine and in reduced salt conditions (8%). Two strategies were evaluated: inoculation with a defined autochthonous consortium and inoculation by spent brine backslopping. To define the consortium, yeasts were selected among 48 autochthonous isolates and key features included high halotolerance, low pectinolytic and proteolytic activities, however none had β-glucosidase activities. The consortium included eight yeast strains with distinct technol. properties belonging to five dominant species, i.e. Citeromyces nyonsensis, Pichia membranifaciens, Wickerhamomyces anomalus, Zygotorulaspora mrakii and Candida atlantica. Fermentation trials were conducted over a year and compared by evaluating microbial community shifts (16S and ITS metagenetics) and volatile profiles (GC-MS). Regarding fermentations with the defined consortium, four out of five species implanted in early stages while one, Pichia membranifaciens, persisted and largely dominated by the end of the fermentation Altogether, inoculation with the defined consortium did not disrupt microbial shifts compared to traditional fermentations although minor differences were observed in volatile profiles. The backslopping method yielded the highest impact on microbial populations and olive volatile profiles, with higher ester abundances at the end of fermentation Finally, reduced salt in brine gave very promising results as no deleterious effects on microbial communities, volatile dynamics but also safety criteria of the olives were observed compared to traditional fermented olives.

Food Research International published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Ma, Lijuan published the artcileEffect of main taste compounds on the release of methoxyphenolic compounds in Pu-erh tea, Category: ethers-buliding-blocks, the publication is LWT–Food Science and Technology (2022), 113293, database is CAplus.

As a typical Chinese tea, Pu-erh tea attracts much attention due to its unique flavor formed by taste and aroma compounds To study the effects of taste compounds on the aroma release, model solutions containing five typical methoxyphenolic compounds (MCs) and main taste compounds with different concentrations were prepared based on the anal. of Pu-erh tea samples. GC-MS results indicated that the release of five MCs was inhibited by theabrownin, tea polysaccharide, tea polyphenol and catechins. The release of 1,2-dimethoxybenzene, 3,4-dimethoxytoluene and 1,2,3-trimethoxy-5-methyl-benzene was promoted by gallic acid under a low concentration (≤4 mg/g). Statistically, gallic acid had the most significant effect on the release of MCs. Isothermal titration calorimetry suggested that hydrogen bonds and hydrophobic effects had potential contributions to the interaction between taste and aroma compounds This work will provide the research basis for revealing the formation mechanism of tea flavor.

LWT–Food Science and Technology published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Bortolami, Martina published the artcileDesign, synthesis and biological evaluation of a series of iron and copper chelating deferiprone derivatives as new agents active against Candida albicans, SDS of cas: 6850-57-3, the publication is Bioorganic & Medicinal Chemistry Letters (2021), 128087, database is CAplus and MEDLINE.

Candida albicans, in specific conditions, is responsible of severe invasive systemic candidiasis that are related to its ability to produce biofilm on biol. and artificial surfaces. Many studies reported the role of iron in fungal growth and virulence and the ability of metal chelating agents to interfere with C. albicans metabolism, virulence and biofilm formation. Here we report the activity of 3-hydroxy-1,2-dimethyl-4(1H)-pyridinone (deferiprone) derivatives against C. albicans planktonic cells and biofilm. Some of the studied compounds (2b and 3b) were able to chelate Fe(III) and Cu(II), and showed an interesting activity on planktonic cells (MIC50 of 32μg/mL and 16μg/mL resp.) and on biofilm formation (BMIC50 of 32μg/mL and 16μg/mL resp.) in cultured ATCC 10,231C. albicans; this activity was reduced, in a concentration dependent way, by the addition of Fe(III) and Cu(II) to the culture media. Furthermore, the most active compound 3b showed a low toxicity on Galleria mellonella larvae.

Bioorganic & Medicinal Chemistry Letters published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, SDS of cas: 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Pasieka, Anna published the artcileDiscovery of multifunctional anti-Alzheimer’s agents with a unique mechanism of action including inhibition of the enzyme butyrylcholinesterase and γ-aminobutyric acid transporters, Recommanded Product: (2-Methoxyphenyl)methanamine, the publication is European Journal of Medicinal Chemistry (2021), 113397, database is CAplus and MEDLINE.

Looking for an effective anti-Alzheimer’s agent is very challenging; however, a multifunctional ligand strategy may be a promising solution for the treatment of this complex disease. We herein present the design, synthesis and biol. evaluation of novel hydroxyethylamine derivatives displaying unique, multiple properties that have not been previously reported. The original mechanism of action combines inhibitory activity against disease-modifying targets: β-secretase enzyme (BACE1) and amyloid β (Aβ) aggregation, along with an effect on targets associated with symptom relief – inhibition of butyrylcholinesterase (BuChE) and γ-aminobutyric acid transporters (GATs). Among the obtained mols., compound 36 (I) exhibited the most balanced and broad activity profile (eeAChE IC₅₀ = 2.86μM; eqBuChE IC₅₀ = 60 nM; hBuChE IC₅₀ = 20 nM; hBACE1 IC₅₀ = 5.9μM; inhibition of Aβ aggregation = 57.9% at 10μM; mGAT1 IC₅₀ = 10.96μM; and mGAT2 IC₅₀ = 19.05μM). Moreover, we also identified 31 (II) as the most potent mGAT4 and hGAT3 inhibitor (IC₅₀ = 5.01μM and IC₅₀ = 2.95μM, resp.), with high selectivity over other subtypes. Compounds 36 and 31 represent new anti-Alzheimer agents that can ameliorate cognitive decline and modify the progress of disease.

European Journal of Medicinal Chemistry published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Recommanded Product: (2-Methoxyphenyl)methanamine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Andrews, Jonathan A. published the artcileSulfinates from Amines: A Radical Approach to Alkyl Sulfonyl Derivatives via Donor-Acceptor Activation of Pyridinium Salts, Quality Control of 6850-57-3, the publication is Organic Letters (2021), 23(21), 8488-8493, database is CAplus and MEDLINE.

Synthetically versatile alkyl sulfinates RSO₂R¹ (R = cyclobutyl, Bn, pyridin-2-ylmethyl, etc.; R¹ = F, 2-(tert-butoxy)-2-oxoethyl, Ph, Bn, etc.) can be prepared from readily available amines RNH₂, using Katritzky pyridinium salt intermediates I. In a catalyst-free procedure, primary, secondary, and benzylic alkyl radicals are generated by photoinduced or thermally induced single-electron transfer (SET) from an electron donor-acceptor (EDA) complex, and trapped by SO₂ to generate sulfonyl radicals. Hydrogen atom transfer (HAT) from Hantzsch ester gives alkyl sulfinate products, which are used to prepare a selection of medicinal chem. relevant sulfonyl-containing motifs.

Organic Letters published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Quality Control of 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Kanhed, Ashish M. published the artcileIndoloquinoxaline derivatives as promising multi-functional anti-Alzheimer agents, Application In Synthesis of 6850-57-3, the publication is Journal of Biomolecular Structure and Dynamics (2022), 40(6), 2498-2515, database is CAplus and MEDLINE.

To confront a disease like Alzheimer’s disease having complex pathogenesis, development of multitarget-directed ligands has emerged as a promising drug discovery approach. In our endeavor towards the development of multitarget-directed ligands for Alzheimer’s disease, a series of indoloquinoxaline derivatives were designed and synthesized. In vitro cholinesterase inhibition studies revealed that all the synthesized compounds exhibited moderate to good cholinesterase inhibitory activity. 6-(6-(Piperidin-1-yl)hexyl)-6H-indolo[2,3-b]quinoxaline was identified as the most potent and selective BuChE inhibitor (IC₅₀ = 0.96μM, selectivity index = 0.17) that possessed 2 fold higher BuChE inhibitory activity compared to the com. approved reference drug donepezil (IC₅₀ = 1.87μM). Moreover, compound is also endowed with self-induced Aβ1-42 aggregation inhibitory activity (51.24% inhibition at 50μM concentration). Some of the compounds of the series also displayed moderate anti-oxidant activity. To perceive a putative binding mode of the compound, mol. docking studies were carried out, and the results pointed out significant interactions of compound with the enzymes in the binding sites of cholinesterases as well as Aβ1-42. Addnl., compound exhibited favorable in silico ADMET properties. Put together these findings project compound as a potential multitarget-directed ligand in the direction of developing novel anti-AD drugs.Communicated by Ramaswamy H.

Journal of Biomolecular Structure and Dynamics published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Application In Synthesis of 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem