Tag: M.W=100-150

Zhang, Jinhong published the artcileStudy on the Staged and Direct Fast Pyrolysis Behavior of Waste Pine Sawdust Using High Heating Rate TG-FTIR and Py-GC/MS, Application In Synthesis of 91-16-7, the publication is ACS Omega (2022), 7(5), 4245-4256, database is CAplus and MEDLINE.

To understand the fast pyrolysis kinetics and product evolution of waste pine sawdust, high heating rate thermogravimetry-Fourier transform IR (TG-FTIR) was used to obtain the kinetic parameters and the chem. groups formed during the pyrolysis process, while pyrolysis-gas chromatog./mass spectrometry (Py-GC/MS) was used to investigate the detailed compositions of products under the staged (seven stages from 300 to 600°C) and direct fast pyrolysis process. Spectral bands were identified for acids, alcs., aldehydes, aromatics, esters, ethers, hydrocarbons, ketones, phenols, and sugars. Research found that the apparent activation energy for fast pyrolysis is much higher than that of slow pyrolysis. The evolution of CO₂ is the major deoxygenation route. Cracking mainly occurred at the 450°C stage with phenols, ketones, aldehydes, and sugars as the main products. The product distributions for different stages are significantly different; the selectivity of aldehydes decreased, while phenols showed an upward trend with an increase in pyrolysis temperature Ketones and sugars reached their peak values at 450°C. The changes in the mol. composition of each stage helped to understand the pyrolysis process. Compared with the staged pyrolysis, the direct pyrolysis process had higher selectivity of acids, aldehydes, esters, and sugars and lower selectivity of phenols, ketones, and alcs.

ACS Omega published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C13H26N2, Application In Synthesis of 91-16-7.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Huang, Ying published the artcileDiscovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies, Application In Synthesis of 6850-57-3, the publication is Journal of Medicinal Chemistry (2022), 65(7), 5317-5333, database is CAplus and MEDLINE.

Polycomb Repressive Complex 2 (PRC2) plays an important role in transcriptional regulation during animal development and in cell differentiation, and alteration of PRC2 activity has been associated with cancer. On a mol. level, PRC2 catalyzes methylation of histone H3 lysine 27 (H3K27), resulting in mono-, di-, or trimethylated forms of H3K27, of which the trimethylated form H3K27me3 leads to transcriptional repression of polycomb target genes. Previously, we have shown that binding of the low-mol.-weight compound EED226 to the H3K27me3 binding pocket of the regulatory subunit EED can effectively inhibit PRC2 activity in cells and reduce tumor growth in mouse xenograft models. Here, we report the stepwise optimization of the tool compound EED226 toward the potent and selective EED inhibitor MAK683 (compound 22) and its subsequent preclin. characterization. Based on a balanced PK/PD profile, efficacy, and mitigated risk of forming reactive metabolites, MAK683 has been selected for clin. development.

Journal of Medicinal Chemistry published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Application In Synthesis of 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Chandrashekhar, Vishwas G. published the artcileSilica-supported Fe/Fe-O nanoparticles for the catalytic hydrogenation of nitriles to amines in the presence of aluminium additives, Computed Properties of 6850-57-3, the publication is Nature Catalysis (2022), 5(1), 20-29, database is CAplus.

The hydrogenation of nitriles to amines represents an important and frequently used industrial process due to the broad applicability of the resulting products in chem. and life sciences. Despite the existing portfolio of catalysts reported for the hydrogenation of nitriles, the development of iron-based heterogeneous catalysts for this process is still a challenge. Here, we show that the impregnation and pyrolysis of iron(II) acetate on com. silica produces a reusable Fe/Fe-O@SiO₂ catalyst with a well-defined structure comprising the fayalite phase at the Si-Fe interface and α-Fe nanoparticles, covered by an ultrathin amorphous iron(III) oxide layer, growing from the silica matrix. These Fe/Fe-O core-shell nanoparticles, in the presence of catalytic amounts of aluminum additives, promote the hydrogenation of all kinds of nitriles, including structurally challenging and functionally diverse aromatic, heterocyclic, aliphatic and fatty nitriles, to produce primary amines under scalable and industrially viable conditions.

Nature Catalysis published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Computed Properties of 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Wang, Chao published the artcileCopper-Catalyzed Three-Component Cascade Reaction of Benzaldehyde with Benzylamine and Hydroxylamine or Aniline: Synthesis of 1,2,4-Oxadiazoles and Quinazolines, Safety of (2-Methoxyphenyl)methanamine, the publication is Advanced Synthesis & Catalysis (2021), 363(11), 2825-2833, database is CAplus.

The analogous three-component synthesis strategy for substituted 1,2,4-oxadiazoles and quinazolines derivatives from readily available benzaldehydes, benzylamines and hydroxylamine or anilines was developed. Both the cascade reaction sequences involved nucleophilic addition of C-N bond, introduction a halogen donor, nucleophilic substitution and Cu(II)-catalyzed aerobic oxidation This synthesis methodol. demonstrated good yields, broad substrate scope and oxygen as a green oxidant. Thus, this synthesis protocol provided strategies for the construction of substituted 1,2,4-oxadiazole and quinazolines from readily and simple starting materials.

Advanced Synthesis & Catalysis published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C13H15NO6S, Safety of (2-Methoxyphenyl)methanamine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Tasnim, Tarannum published the artcileRadical Perfluoroalkylation Enabled by a Catalytically Generated Halogen Bonding Complex and Visible Light Irradiation, Safety of 1,2-Dimethoxybenzene, the publication is Organic Letters (2022), 24(1), 446-450, database is CAplus and MEDLINE.

Exploiting charge-transfer complexes in visible light-promoted single-electron redox reactions is a promising route for opening novel synthetic pathways, and catalytic approaches to complex formation are critical for facilitating this chem. This report describes the use of a substituted hydroquinone catalyst to promote radical perfluoroalkylation reactions. Mechanistic studies indicate that the reaction is initiated through formation of a visible light-absorbing halogen bonding complex between the hydroquinone catalyst and the perfluoroalkyl halide radical precursor.

Organic Letters published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C39H35N5O8, Safety of 1,2-Dimethoxybenzene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Macsari, Istvan published the artcilePhenyl isoxazole voltage-gated sodium channel blockers: Structure and activity relationship, Recommanded Product: 2-(2,2,2-Trifluoroethoxy)ethanol, the publication is Bioorganic & Medicinal Chemistry Letters (2011), 21(13), 3871-3876, database is CAplus and MEDLINE.

Blocking of certain sodium channels is considered to be an attractive mechanism to treat chronic pain conditions. Ph isoxazole carbamate (I) was identified as a potent and selective Na_V1.7 blocker. Structural analogs of I, both carbamates, ureas and amides, were proven to be useful in establishing the structure-activity relation and improving ADME related properties. Amide II showed a good overall in vitro profile, that translated well to rat in vivo PK.

Bioorganic & Medicinal Chemistry Letters published new progress about 2358-54-5. 2358-54-5 belongs to ethers-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-(2,2,2-Trifluoroethoxy)ethanol, and the molecular formula is C4H7F3O2, Recommanded Product: 2-(2,2,2-Trifluoroethoxy)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Ma, Yiming published the artcileSelective production of 2-(tert-butyl)-3-methylphenol from depolymerization of enzymatic hydrolysis lignin with MoS₂ catalyst, Product Details of C8H10O2, the publication is Catalysis Today, database is CAplus.

Low selectivity and complex product distribution are the main challenges for the utilization of lignin. Herein, the selective production of 2-(tert-butyl)-3-methylphenol (TBC), an antioxidant in the polymer industry, from depolymerization of enzymic hydrolysis lignin (EHL) on a hydrothermally synthesized MoS₂ catalyst is studied. The total aromatic monomer yield is 124.1 mg/g EHL and the selectivity of TBC is up to 40.3 wt% in methanol at 280 °C under 2 MPa H₂ for 6 h. The FT-IR anal. of products reveals that MoS₂ has a high activity for demethylation, dehydroxylation and alkylation, and the dimer conversions reveal that C-O and C-C bonds in EHL are broken with MoS₂. The guaiacol and its derivatives are identified as the intermediate for formation of TBC in EHL depolymerization according to the effect of time on product distribution and monomer conversion.

Catalysis Today published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Product Details of C8H10O2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

De la Rosa, Jose M. published the artcileImpact of Biochar Amendment on Soil Properties and Organic Matter Composition in Trace Element-Contaminated Soil, Synthetic Route of 91-16-7, the publication is International Journal of Environmental Research and Public Health (2022), 19(4), 2140, database is CAplus and MEDLINE.

The application of biochar as an organic amendment in polluted soils can facilitate their recovery by reducing the availability of contaminants. In the present work, the effect of biochar application to acid soils contaminated by heavy metal spillage is studied to assess its effect on the quantity and composition of soil organic matter (SOM), with special attention given to soil humic acids (HAs). This effect is poorly known and of great importance, as HA is one of the most active components of SOM. The field experiment was carried out in 12 field plots of fluvisols, with moderate and high contamination by trace elements (called MAS and AS, resp.), that are located in the Guadiamar Green Corridor (SW Spain), which were amended with 8 Mg·ha-1 of olive pit biochar (OB) and rice husk biochar (RB). The results indicate that 22 mo after biochar application, a noticeable increase in soil water holding capacity, total organic carbon content, and soil pH were observed The amounts of oxidisable carbon (C) and extracted HAs in the soils were not altered due to biochar addition Thermogravimetric analyses of HAs showed an increase in the abundance of the most thermostable OM fraction of the MAS (375-650°C), whereas the HAs of AS were enriched in the intermediate fraction (200-375°C). Spectroscopic and chromatog. analyses indicate that the addition of biochar did not alter the composition of the organic fraction of HAs, while Cu, Fe, and as were considerably accumulated at HAs.

International Journal of Environmental Research and Public Health published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Synthetic Route of 91-16-7.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Fraga, Gabriel published the artcileRole of Catalyst Support’s Physicochemical Properties on Catalytic Transfer Hydrogenation over Palladium Catalysts, COA of Formula: C8H10O2, the publication is ChemCatChem (2021), 13(24), 5191-5202, database is CAplus.

Catalytic transfer hydrogenation (CTH) is a promising reaction for valorisation of bio-based feedstocks via hydrogenation without needing to use H₂. Unlike standard hydrogenation, CTH occurs via dehydrogenation (DHD) of a hydrogen donor (H-donor) and hydrogenation (HYD) of a substrate. Therefore, the “ideal” CTH catalyst must balance the catalysis of both reactions to maximize the hydrogen transfer between H-donor and substrate with minimal H₂ loss to gas (high atom efficiency). Addnl., the H-donor must be highly stable to prevent secondary reactions with the substrate. Herein we study the impact of the catalyst’s properties on CTH of guaiacol using bicyclohexyl, a liquid organic hydrogen carrier, as a H-donor. The reaction was promoted by palladium dispersed on three typical support materials (γ-Al₂O₃, MgO, and SiO₂). The performance of these catalysts in the conversion of bicyclohexyl and guaiacol was evaluated, allowing to estimate the H-transfer efficiency, as well as the potential for recycling the spent H-donor (bicyclohexyl). The apparent activation energies for DHD of bicyclohexyl and HYD of guaiacol revealed that slow DHD combined with fast HYD, as is the case with Pd/MgO, favors hydrogen transfer efficiency and selectivity towards hydrogenated products. In addition, an investigation of the DHD of bicyclohexyl and HYD of guaiacol independently showed that the affinity between the organic mols. and the support significantly impacts CTH. Indeed, Pd/SiO₂ was highly active for both reactions individually and almost inactive for CTH. Consequently, these findings highlight the importance of the interaction between solvent-substrate-support in designing catalysts for transfer hydrogenation.

ChemCatChem published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, COA of Formula: C8H10O2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Sarkate, A. P. published the artcileConvenient Microwave-Assisted Chlorosulfonic Acid-Catalyzed Synthesis of Some Quinazolinones from 2-Phenylindole, Quality Control of 6850-57-3, the publication is Russian Journal of Organic Chemistry (2022), 58(3), 428-432, database is CAplus.

A new convenient method was developed for the synthesis of quinazolinones from 2-phenyl-1H-indole and substituted amines under catalysis by chlorosulfonic acid. The target quinazolinones were synthesized through a coupling reaction of 2-phenyl-1H-indole and different amines using chlorosulfonic acid and hydrogen peroxide in DMSO on heating at 100°C, as well as under microwave irradiation at 80°C. The microwave-assisted synthesis provided excellent yields in 8 min compared to 4-5 h under conventional heating. The developed method is flexible and economical, and it has major importance in industry and academics.

Russian Journal of Organic Chemistry published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Quality Control of 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem