Tag: M.W=100-150

Chen, Yefeng published the artcileZ-scheme g-C3N4/Fe₂O₃ for efficient photo-oxidation of benzylamine under mild conditions, Name: (2-Methoxyphenyl)methanamine, the publication is Semiconductor Science and Technology (2021), 36(7), 075004, database is CAplus.

As an important intermediate, imine is widely used in industrial chem. The photocatalytic oxidation of amines to form imines is a green and economical method. But it remains a challenge for the efficient transformation under mild conditions. Herein, a Z-scheme carbon nitride (CM)-Fe₂O₃ heterojunction photocatalyst was synthesized by in-situ preparation of Fe₂O₃ nanoparticles on two-dimensional CM nanosheets. The as-prepared catalyst exhibited efficient photocatalysis activity in selective oxidation of benzylamine to N-benzylidene benzylamine. Under ambient air and room temperature, the selectivity and conversion rate both can reach 99.9%, and the corresponding turnover frequency value reaches up to 9.99 mmol g^-1 h^-1, superior to the most of heterogeneous photocatalysts reported in previous literatures. The excellent catalytic activity of the modified CM material may be due to the enhanced absorption of visible light and the improved photogenerated carrier separation and migration rate, and the Z-scheme mechanism also retains the strong oxidation and reduction ability of the composite material. This work will provide a promising and practical method to promote the photocatalytic conversion of solar-driven organics

Semiconductor Science and Technology published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Name: (2-Methoxyphenyl)methanamine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Sun, Yue published the artcilePolycyclic Aromatic Carbon: A Key Fraction Determining the Light Absorption Properties of Methanol-Soluble Brown Carbon of Open Biomass Burning Aerosols, Related Products of ethers-buliding-blocks, the publication is Environmental Science & Technology (2021), 55(23), 15724-15733, database is CAplus and MEDLINE.

The composition and radiative forcing of light-absorbing brown carbon (BrC) aerosol remain poorly understood. Polycyclic aromatics (PAs) are BrC chromophores with fused benzene rings. Understanding the occurrence and significance of PAs in BrC is challenging due to a lack of standards for many PAs. In this study, we quantified polycyclic aromatic carbon(PAC), defined as the carbon of fused benzene rings, based on mol. markers (benzene polycarboxylic acids, BPCAs). Open biomass burning aerosols (OBBAs) of 22 rainforest plants were successively extracted with water and methanol for the anal. of water- and methanol-soluble PAC (WPAC and MPAC, resp.). PAC is an important fraction of water- and methanol-soluble organic carbon (WSOC and MSOC, resp.). WPAC/WSOC ranged from 0.03 to 0.18, and MPAC/MSOC was even higher (range: 0.16-0.80). The priority polycyclic aromatic hydrocarbons contributed less than 1% of MPAC. The mass absorption efficiency (MAE) of MSOC showed a strong linear correlation with MPAC/MSOC (r = 0.60-0.95, p < 0.01). The absorption Ångström exponent (AAE) of methanol-soluble BrC showed a strong linear correlation with the degree of aromatic condensation of MPAC, which was described by the average number of carboxylic groups of BPCA (r = -0.79, p < 0.01). This result suggested that PAC was a key fraction determining the light absorption properties (i.e., light absorptivity and wavelength dependence) of methanol-soluble BrC in OBBAs.

Environmental Science & Technology published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C11H10O, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Brey, Mary L. published the artcilePreparation and properties of some vinyl and glycidyl fluoro ethers, SDS of cas: 2358-54-5, the publication is Journal of the American Chemical Society (1957), 6533-6, database is CAplus.

KOH (94 g.) in 500 cc. (CH₂OH)₂ in an autoclave chilled with Dry Ice-Me₂CO, treated with approx. 2.5 moles of the appropriate 1,1-difluoronolefin, rocked at room temperature overnight, poured into iced H₂O, and the organic layer washed, dried, and distilled yielded the corresponding glycol monoether; in this manner were prepared the following ROCH₂CH₂OH (R, % yield, b.p./mm., n²⁵_D, d₂₅, and MR_D given): CHClFCF₂, 54, 114-18°/100, 1.3795/21°, -, -; CHCl₂CF₂ (I), 30, 62-3°/2, 1.4245, 1.4905, 33.42; CF₃CHFCF₂, 25, 72-4°/40, 1.3192, 1.5227, 27.57. As a by-product of I was also obtained 18% (CHCl₂CH₂OCH₂)₂, b_2.2 90°, n²⁵_D5 1.4194, d₂₅ 1.5786, MR_D 52.50, hydrolyzed with concentrated H₂SO₄ to 31% (CHCl₂CO₂CH₂)₂, b₃ 148-50°, n²⁵_D 1.4840, d₂₅ 1.5386, MR_D 52.79. KOH (5.0 g.) in 1.5 moles of the appropriate fluoro alc. treated in an autoclave at -78° with 44 g. ethylene oxide, rocked 4 hrs. at 70°, and worked up gave the corresponding glycol monoether; in this manner were prepared the following ROCH₂CH₂OH (same data as above given): CF₃CH₂, 50, 84°/80, 1.3502, 1.2902, 24.04; C₂F₅CH₂, 32, 87°/84, 1.3370, 1.3806, 29.24; C₃F₇CH₂, 62, 91-2°/54, 1.3300/28°, 1.4965/28°, 33.90; CF₃CMe₂, 35, 92°/77, 1.3749/22°, 1.1931/22°, 33.02. The appropriate fluoroalkyl hydroxyethyl ether (about 0.25 mole) treated with stirring with 60 g. PCl₅ in portions, refluxed 20 min., cooled, poured into iced H₂O, washed, dried, and fractionated yielded the corresponding compounds RO(CH₂)₂Cl (II) consistently in 27% yield; when the reaction mixture was diluted with about 100 cc. CHCl₃ the yields were 45-67%. In this manner were prepared the following II (same data given): CHClFCF₂ (III), 27, 85°/100, 1.3882, 1.4471, -; CHCl₂CF₂ (IV), 27, 86-7°/33, 1.4270, 1.4833, 36.95; CF₃CHFCF₂, 27, 46°/37, 1.3349, 1.4749, 32.33; CF₃CH₂, 53, 114-15°/760, 1.3590/27°, 1.3034/27°, 27.46; C₃F₇CH₂, 67, 75°/80, 1.3381, 1.4673, 37.32; CF₃CMe₂, 45, 135°/760, 1.3784, 1.2102, 36.34; C₂F₅CH₂, 49, 120-1°/760, 1.3448/26°, 1.3792/26°, 32.72. Hydrolysis of III yielded 34% CH₂ClCH₂O₂CHClF, b₄₇ 106°, b₄₅ 105°, n²³_D 1.4369, d₂₅ 1.4256, MR_D 32.20; IV gave similarly 36% CHCl₂CO₂(CH₂)₂Cl, b₇₆₀ 207-11°, n²⁵_D 1.4716, d₂₅ 1.4544, MR_D 36.85. The appropriate II (0.20 mole) treated dropwise with stirring and heating with 18 g. KOH in 120 cc. PrOH, the distillate poured into H₂O, and the organic layer washed, dried, and distilled yielded the corresponding compounds ROCH:CH₂ (same data given): CHClFCF₂, 52, 71-3°/760, 1.3531, 1.2408, -; CF₃CH₂, 32, 42-8°/760, 1.3180/27°, 1.118/ 27°, -; C₂F₅CH₂, 21, 54-60°/760, 1.3131/27°, 1.227/27°, 27.92; C₃F₇CH₂, 18, 78-82°/760, 1.3118/26°, 1.343/26°, 31.08. The appropriate fluoro alc. (0.50 mole) and 46 g. epichlorohydrin added to 25 g. NaOH in 300 cc. cold H₂O kept at room temperature overnight, and the organic layer worked up gave mixtures of the epoxy ether and the diether. CF₃CH₂OH gave in this manner 31% CF₃CH₂OCH₂CH.CH₂.O, b₇₆₀ 132-5°, n²⁵_D 1.3560, d₂₅ 1.2666, MR_D 26.93, and 19% (CF₃CH₂OCH₂)₂CHOH, b₁₆ 86°, n²⁵_D 1.3528, d₂₅ 1.3890, MR_D 39.97. C₂F₅CH₂OH gave similarly 19% C₂F₅CH₂OCH₂CH.CH₂.O, b_86-84 81-79°, n²⁵_D 1.3419, d₂₅ 1.3534, MR_D 32.08. C₃F₇CH₂OH gave 23% C₃F₇CH₂OCH₂CH.CH₂.O, b₄₉ 79°, n²⁵_D 1.3350, d₂₅ 1.4429, and 24% (C₃F₇CH₂OCH₂)₂CHOH, b₁₅ 112-15°, n²⁵_D 1.3338, d₂₅ 1.5569, MR_D 60.40. CF₃CH₂OH (100 g.), 185 g. epichlorohydrin, and 2 cc. pyridine heated 12 hrs. with stirring at 80-90° gave 50% CF₃CH₂OCH₂CH(OH)CH₂Cl, b₁₉ 85-6°, n²⁵_D 1.3951, d₂₅ 1.3716, MR_D 1.3716.

Journal of the American Chemical Society published new progress about 2358-54-5. 2358-54-5 belongs to ethers-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-(2,2,2-Trifluoroethoxy)ethanol, and the molecular formula is C4H7F3O2, SDS of cas: 2358-54-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Sakakibara, Shunsaku published the artcileBiological activities of fluorinated nonionic surfactants, Recommanded Product: 2-(2,2,2-Trifluoroethoxy)ethanol, the publication is Nagoya Kogyo Gijutsu Shikensho Hokoku (1991), 40(1), 20-8, database is CAplus.

F(C₂F₄)₃CH₂O[C₂H₄O]_mH (m = 1-19), F(C₂F₄)_lCH₂CH₂O[C₂H₄O]_mH (l = 4, 5; m = 9, 10), H(C₂F₄)_lCH₂O[C₂H₄O]_mH (l = 2-4; m = 1-10), and F(C₂F₄)_lCONHCH₂CH₂NH_2-n[C₂H₄OH]_n (l = 2, 6; n = 0-2) were tested for their biocidal activities. Several surfactants had high insecticidal activity, especially against adult houseflies and carmine mites. These effective compounds showed low surface tension and high HLB values. Their effectiveness was ascribed to suffocation of insects by covering the insect cuticle. There was no relationship between the types of surfactants and insecticidal activity. Few compounds had low herbicidal and fungicidal activities.

Nagoya Kogyo Gijutsu Shikensho Hokoku published new progress about 2358-54-5. 2358-54-5 belongs to ethers-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-(2,2,2-Trifluoroethoxy)ethanol, and the molecular formula is C4H7F3O2, Recommanded Product: 2-(2,2,2-Trifluoroethoxy)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Yan, Penghui published the artcileThe role of Ni sites located in mesopores in the selectivity of anisole hydrodeoxygenation, Application of 1,2-Dimethoxybenzene, the publication is Catalysis Science & Technology (2022), 12(7), 2184-2196, database is CAplus.

A highly dispersed Ni catalyst with an increased number of Ni sites selectively distributed in the mesopores of HBEA has been developed and applied in anisole hydrodeoxygenation (HDO) in a continuous-flow reactor under a high WHSV (2.8 min^-1). The developed catalyst (Ni/BEA-OR-PH) displayed a significantly higher cyclohexane formation rate compared to the catalysts prepared by incipient wetness impregnation (Ni/BEA-IWI) and deposition-precipitation (Ni/BEA-DP) methods, which was attributed to its higher number of accessible active metal sites in mesopores. While the Ni/BEA-DP as well as Ni/BEA-OR-PH exhibited a high dispersion, a higher concentration of Ni species was located in micropores and distributed as charge-compensating cations, leading to a low concentration of high-temperature desorbed H per surface Ni, which facilitates the hydrogenolysis activity but restricts the hydrogenation of aromatics Therefore, a high yield of BTX (benzene, toluene and xylene isomers) products was detected over Ni/BEA-DP.

Catalysis Science & Technology published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C5H10Cl3O3P, Application of 1,2-Dimethoxybenzene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Aranzazu, Sandra-L. published the artcileBF₃-Mediated Acetylation of Pyrazolo[1,5-a]pyrimidines and Other π-Excedent (N-Hetero)arenes, Quality Control of 91-16-7, the publication is Journal of Organic Chemistry (2022), 87(15), 9839-9850, database is CAplus and MEDLINE.

An operably simple microwave-assisted BF₃-mediated acetylation reaction of pyrazolo[1,5-a]pyrimidines and a plausible mechanism based on d. functional theory (DFT) theor. calculations for this transformation are reported. Remarkably, and to the best of authors knowledge, this is the first example of the direct acetylation for the functional pyrazolo[1,5-a]pyrimidine (PP) core. The synthesis of this essential building block is reported in high yields using mild reaction conditions, inexpensive reagents, and even substrates with electron-deficient or highly hindered groups. In addition, one of the new Me ketones was successfully used as a substrate for producing novel and valuable bis-electrophilic compounds with yields of up to 90%. Notably, the discovered acetylation method was successfully applied in other π-excedent (N-hetero)aromatic substrates.

Journal of Organic Chemistry published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Quality Control of 91-16-7.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Xu, Biping published the artcileA Tandem Dehydrogenation-Driven Cross-Coupling between Cyclohexanones and Primary Amines for Construction of Benzoxazoles, HPLC of Formula: 6850-57-3, the publication is Angewandte Chemie, International Edition (2022), 61(30), e202203365, database is CAplus and MEDLINE.

Herein, authors report a transition metal-free, operationally simple, general method for straightforward syntheses of 2-substituted benzoxazoles from readily available cyclohexanones and aliphatic primary amines by an imine α-oxygenation-initiated cascade reaction sequence. The key to achieving high selectivity and excellent functional-group tolerance is the use of TEMPO as a mild oxidant that selectively oxidizes the reaction intermediates through its multiple reactivity modes, thus facilitating the individual steps to proceed in succession. More than 70 substrate combinations are disclosed, demonstrating the reliability of this protocol to synthesize structurally diverse products, including marketed drugs, drug candidate, and natural products that are unattainable by the existing methods.

Angewandte Chemie, International Edition published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C10H9ClN2O, HPLC of Formula: 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Narita, Koichi published the artcileSynthesis and evaluation of trypanocidal activity of derivatives of naturally occurring 2,5-diphenyloxazoles, Synthetic Route of 6850-57-3, the publication is Bioorganic & Medicinal Chemistry (2021), 116253, database is CAplus and MEDLINE.

African trypanosomiasis is a zoonotic protozoan disease affecting the nervous system. Various natural products reportedly exhibit trypanocidal activity. Naturally occurring 2,5-diphenyloxazoles present in Oxytropis lanata, and their derivatives, were synthesized. The trypanocidal activities of the synthesized compounds were evaluated against Trypanosoma brucei brucei, T. b. gambiense, T. b. rhodesiense, T. congolense, and T. evansi. Natural product 1 exhibited trypanocidal activity against all the species/subspecies of trypanosomes, exhibiting half-maximal inhibitory concentrations (IC50) of 1.1-13.5μM. Modification of the oxazole core improved the trypanocidal activity. The 1,3,4-oxadiazole (7) and 2,4-diphenyloxazole (9) analogs exhibited potency superior to that of 1. However, these compounds exhibited cytotoxicity in Madin-Darby bovine kidney cells. The O-methylated analog of 1 (12) was non-cytotoxic and exhibited selective trypanocidal activity against T. congolense (IC50 = 0.78μM). Structure-activity relationship studies of the 2,5-diphenyloxazole analogs revealed aspects of the mol. structure critical for maintaining selective trypanocidal activity against T. congolense.

Bioorganic & Medicinal Chemistry published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Synthetic Route of 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhang, Wenxuan published the artcileEnantioselective Friedel-Crafts Reaction of 2-Alkynyphenols with Aromatic Ethers by Chiral Bronsted Acid Catalysis, Category: ethers-buliding-blocks, the publication is Journal of Organic Chemistry (2022), 87(14), 9100-9111, database is CAplus and MEDLINE.

Herein, authors report chiral strong Bronsted acid-catalyzed enantioselective Friedel-Crafts reaction of 2-alkynyphenols with aromatic ethers. The reaction affords the corresponding axially chiral styrenes in up to 91% yield and 97% ee.

Journal of Organic Chemistry published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C15H24S, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Liu, Zhuqing published the artcilePhIO-Mediated Oxidative C=C Bond Cleavage and Reassembly toward Highly Functionalized Oxazolones, Category: ethers-buliding-blocks, the publication is Organic Letters (2022), 24(6), 1323-1328, database is CAplus and MEDLINE.

An efficient PhIO-mediated oxidative C = C bond cleavage and reassembly of enaminone toward oxazolone I [R¹ = Ph, 3-MeC₆H₄, 4-MeC₆H₄, etc.; R² = Me, Et; R³ = Bn, 2-MeOC₆H₄, CH₂CH₂Ph, etc.] with high regioselectivity was reported. DFT calculations revealed that the reaction proceeded through oxygen atom transfer, C = C bond cleavage, alkylthio migration, and reassembly cascade. This strategy was highlighted by high atom and step economy with formation of five bonds in one pot and generation of high-valued oxazolone skeleton under mild conditions.

Organic Letters published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem