Tag: M.W=100-150

Ethers can again be classified into two varieties: if the alkyl or aryl groups are the same on both sides of the oxygen atom, 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. Then it is a simple or symmetrical ether, whereas if they are different, the ethers are called mixed or unsymmetrical ethers. Safety of Diethylene Glycol Monoethyl Ether.

Ha, Eun-Sol;Park, Heejun;Lee, Seon-Kwang;Jeong, Ji-Su;Kim, Jeong-Soo;Kim, Min-Soo research published 《 Solubility, solvent effect, and modelling of oxcarbazepine in mono-solvents and N-methyl-2-pyrrolidone + water solvent mixtures at different temperatures and its application for the preparation of nanosuspensions》, the research content is summarized as follows. A solid-liquid equilibrium technique was used to measure the solubility of oxcarbazepine in a mono-solvent and a solvent mixture in the temperature range of 288.15-308.15 K under atm. pressure. Oxcarbazepine in N-methyl-2-pyrrolidone (NMP) showed the highest solubility The KAT-LSER model was applied to determine solvent effect on the solubility of oxcarbazepine in mono-solvents at 298.15 K; the dipolarity-polarizability and cohesive energy d., as the Hildebrand solubility parameter, of the solvent had a greater effect on oxcarbazepine solubility than other parameters. The solubility results of oxcarbazepine in the mono-solvents and mixed (NMP + water) solvents were correlated by applying various models. The oxcarbazepine dissolution in the mono-solvents and mixed (NMP + water) solvents was endothermic and spontaneous. Oxcarbazepine nanosuspensions were prepared based on these solubility results of oxcarbazepine in a mono-solvent and mixed (NMP + water) solvent; the average particle size of all oxcarbazepine nanosuspensions was smaller than 200 nm. The exptl. and calculated solubility results of oxcarbazepine may be utilized in drug development through the application of solubilization techniques to increase the bioavailability of poorly water-soluble drugs.

111-90-0, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., Safety of Diethylene Glycol Monoethyl Ether

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers can again be classified into two varieties: if the alkyl or aryl groups are the same on both sides of the oxygen atom, 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. Then it is a simple or symmetrical ether, whereas if they are different, the ethers are called mixed or unsymmetrical ethers. Application In Synthesis of 111-90-0.

Haq, Nazrul;Alghaith, Adel F.;Alshehri, Sultan;Shakeel, Faiyaz research published 《 Solubility and Thermodynamic Data of Febuxostat in Various Mono Solvents at Different Temperatures》, the research content is summarized as follows. This study examines the solubility and thermodn. of febuxostat (FBX) in a variety of mono solvents, including “water, methanol (MeOH), ethanol (EtOH), isopropanol (IPA), 1-butanol (1-BuOH), 2-butanol (2-BuOH), ethylene glycol (EG), propylene glycol (PG), polyethylene glycol-400 (PEG-400), Et acetate (EA), Transcutol-HP (THP), and DMSO (DMSO)” at 298.2-318.2 K and 101.1 kPa. The solubility of FBX was determined using a shake flask method and correlated with “van’t Hoff, Buchowski-Ksiazczak λh, and Apelblat models”. The overall error values for van’t Hoff, Buchowski-Ksiazczak λh, and Apelblat models was recorded to be 1.60, 2.86, and 1.14%, resp. The maximum mole fraction solubility of FBX was 3.06 × 10^-2 in PEG-400 at 318.2 K, however the least one was 1.97 × 10^-7 in water at 298.2 K. The FBX solubility increased with temperature and the order followed in different mono solvents was PEG-400 (3.06 × 10^-2) > THP (1.70 × 10^-2) > 2-BuOH (1.38 × 10^-2) > 1-BuOH (1.37 × 10^-2) > IPA (1.10 × 10^-2) > EtOH (8.37 × 10^-3) > EA (8.31 × 10^-3) > DMSO (7.35 × 10^-3) > MeOH (3.26 × 10^-3) > PG (1.88 × 10^-3) > EG (1.31 × 10^-3) > water (1.14 × 10^-6) at 318.2 K. Compared to the other combinations of FBX and mono solvents, FBX-PEG-400 had the strongest solute-solvent interactions. The apparent thermodn. anal. revealed that FBX dissolution was “endothermic and entropy-driven” in all mono solvents investigated. Based on these findings, PEG-400 appears to be the optimal co-solvent for FBX solubility

111-90-0, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., Application In Synthesis of 111-90-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers do have nonbonding electron pairs on their oxygen atoms, 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds. Safety of Diethylene Glycol Monoethyl Ether.

Hassan, Ahmad;Sahni, Jasjeet Kaur;Ali, Javed research published 《 Development and evaluation of oral nanoemulsion for the bioavailability enhancement of telmisartan》, the research content is summarized as follows. The present study aimed at developing an optimal oral nanoemulsion of telmisartan and evaluating its stability, pharmacodynamic and pharmacokinetic potential. Solubility of telmisartan was determined in various oils, surfactants & cosurfactants. Formulations were selected from the o/w nanoemulsion region from the help of pseudoternary phase diagrams and were subjected to various thermodn. stability and dispersibility tests. Optimized formulations were characterized for their percentage transmittance, refractive index, viscosity, droplet size and zeta potential & TEM. Release rate of optimized formulations was determined using an in vitro dissolution test. The formulation used for lowering of induced hypertension contained Soyabean oil (10%, volume/volume), Tween 20 (22.50%, volume/volume), Transcutol HP (7.5%, volume/volume) & double distilled water (60% volume/volume). The release of drug from the nanoemulsion formulations was highly significant (p < 0.01) in comparison to the drug suspension. More than 40% of the drug was released in the initial 1 h of the dissolution study in comparison to the drug suspension. The lowering of blood pressure in the group administered with the formulation F2 was highly significant (p < 0.01) with respect to the group administered with the marketed formulation. The plasma concentration time profile of telmisartan from oral nanoemulsion represented greater improvement of drug absorption than the marketed formulation. The shelf life of the nanoemulsion was found to be 1.5 years at room temperature The present study established oral nanoemulsion formulation to be one of the possible alternatives to traditional oral formulations of telmisartan to improve its bioavailability.

Safety of Diethylene Glycol Monoethyl Ether, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., 111-90-0.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3. Category: ethers-buliding-blocks.

Hu, Qing;Lin, Han;Wang, Yanfang;Wang, Xiaoqin;Yao, Jiayi;Fu, Xiaoling;Yu, Xiangbin research published 《 Design, optimization and evaluation of a microemulsion-based hydrogel with high malleability for enhanced transdermal delivery of levamisole》, the research content is summarized as follows. The objective of the present study was to prepare and evaluate a microemulsion-based hydrogel with high malleability as a transdermal delivery carrier for levamisole (LMS). A pseudo-ternary phase diagram and D-optimal mixture design were utilized to screen and optimize the microemulsion, and the formulation comprised 7.5% MaisineTM35-1, 33% Smix and 59.5% water. The microemulsion was phys. stable with an average size of 19.3 ± 0.1 nm and zeta potential of -3.84 ± 0.05 mV. Moreover, a highly malleable alginate-boronic acid (alginate-BA) gel was prepared and could come into close contact with highly curved skin. The optimized microemulsion was loaded into alginate-BA gel and subjected to ex vivo and in vivo investigation. The microemulsion-based gel had desirable characterization, good stability and negligible skin irritation. The results of ex vivo permeation study showed that LMS achieved a significantly higher cumulative amount from the LMS-loaded microemulsion-based gel than that from the LMS-gel. The pharmacokinetic study showed a twofold increase in relative bioavailability compared to the com. liniment. These results provide insight into the capability of the developed malleable microemulsion-based gel to enhance the transdermal permeation and bioavailability of LMS.

Category: ethers-buliding-blocks, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., 111-90-0.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3. HPLC of Formula: 111-90-0.

Gao, Haoshi;Jia, Haoyue;Dong, Jie;Yang, Xinggang;Li, Haifeng;Ouyang, Defang research published 《 Integrated in silico formulation design of self-emulsifying drug delivery systems》, the research content is summarized as follows. The drug formulation design of self-emulsifying drug delivery systems (SEDDS) often requires numerous experiments, which are time- and money-consuming. This research aimed to rationally design the SEDDS formulation by the integrated computational and exptl. approaches. 4495 SEDDS formulation datasets were collected to predict the pseudo-ternary phase diagram by the machine learning methods. Random forest (RF) showed the best prediction performance with 91.3% for accuracy, 92.0% for sensitivity and 90.7% for specificity in 5-fold cross-validation. The pseudo-ternary phase diagrams of meloxicam SEDDS were exptl. developed to validate the RF prediction model and achieved an excellent prediction accuracy (89.51%). The central composite design (CCD) was used to screen the best ratio of oil-surfactant-cosurfactant. Finally, mol. dynamic (MD) simulation was used to investigate the mol. interaction between excipients and drugs, which revealed the diffusion behavior in water and the role of cosurfactants. In conclusion, this research combined machine learning, central composite design, mol. modeling and exptl. approaches for rational SEDDS formulation design. The integrated computer methodol. can decrease traditional drug formulation design works and bring new ideas for future drug formulation design.

111-90-0, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., HPLC of Formula: 111-90-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers do have nonbonding electron pairs on their oxygen atoms, 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds. Quality Control of 111-90-0.

Gao, Siliang;Tang, Wencheng;Zhao, Ming;Qie, Siyuan;Pang, Weiwei;Tian, Longsheng research published 《 Extractive distillation of benzene, toluene, and xylenes from pyrolysis gasoline using methylsulfonylethane as a cosolvent》, the research content is summarized as follows. Highly efficient separation of benzene, toluene, and xylenes (BTXs) from pyrolysis gasoline is very important in petrochem. industries. Though the extractive distillation (ED) process is simpler and consumes less energy compared with liquid-liquid extraction process, it is difficult for a single solvent, for example, sulfolane, to achieve both high purity and high yield of BTXs. In this work, methylsulfonylethane (MSE) was chosen as a cosolvent to improve the selectivity of sulfolane after solvent screening, and factors that may affect the selectivity of the composite solvent were fully investigated, such as the content of cosolvent, solvent to feed ratio, the composition of the feed, and temperature Furthermore, 240 h of continuous extractive distillation and solvent recovery experiment was carried out using sulfolane (85 wt%)-MES (15 wt%) mixture as solvent. The purity of mixed aromatics obtained was 99.83%, and the yield was as high as 99.7%.

Quality Control of 111-90-0, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., 111-90-0.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers do have nonbonding electron pairs on their oxygen atoms, 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds. Recommanded Product: Diethylene Glycol Monoethyl Ether.

Goh, Andrea Shi’en;Ningtyas, Dian Widya;Bhandari, Bhesh;Prakash, Sangeeta research published 《 Investigating phytosterol as a potential functional component in milk through textural, flavour and oral perception study》, the research content is summarized as follows. Phytosterols (PS) are functional ingredients capable of providing health benefits. This study investigated the potential of incorporating different levels of PS ester (0.8, 1.2, 1.6 and 2.0 g/100 g) into skim milk (0.1 g/100 mL milk fat) to replace the milk fat. PS-enriched milk were analyzed for its phys. characteristics (color, viscosity, tribol., particle size and microstructure) and compared to com. milk (0.1, 1.3, 2 g/100 mL fat, and 1.3 g/100 mL fat with 0.3 g/100 mL PS). Furthermore, the flavor profiles and sensory acceptability of the PS-enriched milk were evaluated. All samples exhibited a characteristic shear-thinning flow behavior, with 2 g/100 g PS ester milk displaying the highest viscosity (4.46 ± 1.93 mPa s) at 50/s shear rate and 35°C. Confocal images and particle size distribution suggest fat coalescence resulting in larger fat globules (0.53 ± 0.14μm) in 2 g/100 g PS ester milk. In general, the addition of PS ester increased the fatty acid and aldehyde compounds of PS-enriched milk, providing comparable lubrication properties and whiteness to com. milk with the same fat levels. Sensory evaluation revealed that the PS-enriched milk did not possess any off-flavor and milk with 1.6 g/100 g PS ester were the most preferred.

Recommanded Product: Diethylene Glycol Monoethyl Ether, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., 111-90-0.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers are a class of organic compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether.They have the general formula R–O–R′, where R and R′ represent the alkyl or aryl groups. Synthetic Route of 111-90-0.

Goo, Yoon Tae;Sa, Cheol-Ki;Kim, Min Song;Sin, Gi Hyeong;Kim, Chang Hyun;Kim, Hyeon Kyun;Kang, Myung Joo;Lee, Sangkil;Choi, Young Wook research published 《 Enhanced dissolution and bioavailability of revaprazan using self-nanoemulsifying drug delivery system》, the research content is summarized as follows. A self-nanoemulsifying drug delivery system (SNEDDS) was developed to enhance the dissolution and oral bioavailability (BA) of revaprazan (RVP). Various SNEDDSs containing 200 mg of RVP were formulated using Capmul MCM, Tween 80, and Brij L4, and they were characterized according to their size, polydispersity index, and dissolution behavior. Dissolution rates of all SNEDDS formulations significantly (p < 0.05) improved with the formation of nanoemulsion with monodispersity. Formulation D resulted in RVP dissolution exceeding 70% at 2 h. Compared to raw RVP, SNEDDS exhibited a 4.8- to 7.4-fold improved effective permeability coefficient (Peff) throughout the intestine in the in situ single pass intestinal permeability study and a 5.1-fold increased oral BA in the in vivo oral absorption assessment in rats. To evaluate the degree of lymphatic uptake, cycloheximide (CYC), a chylomicron flowing blocker, was pretreated prior to the experiment This pretreatment barely affected the absorption of raw RVP; however, it greatly influenced the absorption of SNEDDS, resulting in an approx. 40% reduction in both the Peff value and oral BA representing lymphatic transport. Thus, we suggest that the SNEDDS formulation is a good candidate for improving oral absorption of RVP through enhanced lymphatic uptake.

Synthetic Route of 111-90-0, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., 111-90-0.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers do have nonbonding electron pairs on their oxygen atoms, 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds. Name: Diethylene Glycol Monoethyl Ether.

Gorle, Ashish;Ahire, Kalpesh;Shende, Rutuja research published 《 Design, development and characterization of nanoemulsion developed by High Pressure Homogenization (HPH) method containing antifungal drug》, the research content is summarized as follows. Nanoemulsion is one the most attractive drug delivery for researchers to treat fungal diseases and getting interested in increasing the solubility of low soluble drugs. The objective of this research was to develop a topical nanoemulsion formulation of Posaconazole drug with the intention to enhance its aqueous solubility and local action. By employing High Pressure Homogenization (HPH) method, oil in water nanoemulsion was formulated with 0.2% cinnamon oil as lipid phase, 0.4% tween-80 and poloxamer-188 as surfactants, 0.2% transcutol as a co-surfactant. The phys. characteristics of formulations were found to be stable after thermodn. stability testing. In-vitro diffusion study for optimized nanoemulsion was performed using a dialysis bag membrane and cumulative % drug release was determined Viscosity and percent drug content was observed to be 0.0593 cps and 90.21 ± 0.23% resp. The optimized nanoemulsion formulation (F8) was evaluated to be transparent and thermodynamically stable, with -9.46 zeta potential, 78.79 nm particle size, 0.315 polydispersity index. The optimized Nanoemulsion was stable for 3 mo in three different temperature conditions. The result from the release study was indicative of improved solubility of Posaconazole, which may serve to boost up the action of the drug for the treatment of fungal diseases.

Name: Diethylene Glycol Monoethyl Ether, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., 111-90-0.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers do have nonbonding electron pairs on their oxygen atoms, 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds. Application of C6H14O3.

Daryab, Mahshid;Faizi, Mehrdad;Mahboubi, Arash;Aboofazeli, Reza research published 《 Preparation and characterization of lidocaine-loaded, microemulsion-based topical gels》, the research content is summarized as follows. Microemulsion-based gels (MBGs) were prepared for transdermal delivery of lidocaine and evaluated for their potential for local anesthesia. Lidocaine solubility was measured in various oils, and phase diagrams were constructed to map the concentration range of oil, surfactant, cosurfactant, and water for oil-in-water (o/w) microemulsion (ME) domains, employing the water titration method at different surfactant/cosurfactant weight ratios. Refractive index, elec. conductivity, droplet size, zeta potential, pH, viscosity, and stability of fluid o/w MEs were evaluated. Carbomer 940 was incorporated into the fluid drug-loaded MEs as a gelling agent. Microemulsion-based gels were characterized for spreadability, pH, viscosity, and in-vitro drug release measurements, and based on the results obtained, the best MBGs were selected and subsequently subjected to ex-vivo rat skin permeation anesthetic effect and irritation studies. Data indicated the formation of nano-sized droplets of MEs ranging from 20-52 nm with a polydispersity of less than 0.5. In-vitro release and ex-vivo permeation studies on MBGs showed significantly higher drug release and permeation in comparison to the marketed topical gel. Developed MBG formulations demonstrated greater potential for transdermal delivery of lidocaine and advantage over the com. available gel product, and therefore, they may be considered as potential vehicles for the topical delivery of lidocaine.

111-90-0, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., Application of C6H14O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem