Tag: M.W=100-150

Amanchukwu, Chibueze V.; Yu, Zhiao; Kong, Xian; Qin, Jian; Cui, Yi; Bao, Zhenan published the artcile< A New Class of Ionically Conducting Fluorinated Ether Electrolytes with High Electrochemical Stability>, Quality Control of 6482-24-2, the main research area is ionically conducting fluorinated ether electrolyte high electrochem stability.

Increasing battery energy d. is greatly desired for applications such as portable electronics and transportation. However, many next-generation batteries are limited by electrolyte selection because high ionic conductivity and poor electrochem. stability are typically observed in most electrolytes. For example, ether-based electrolytes have high ionic conductivity but are oxidatively unstable above 4 V, which prevents the use of high-voltage cathodes that promise higher energy densities. In contrast, hydrofluoroethers (HFEs) have high oxidative stability but do not dissolve lithium salt. In this work, we synthesize a new class of fluorinated ether electrolytes that combine the oxidative stability of HFEs with the ionic conductivity of ethers in a single compound We show that conductivities of up to 2.7 x 10-4 S/cm (at 30°C) can be obtained with oxidative stability up to 5.6 V. The compounds also show higher lithium transference numbers compared to typical ethers. Furthermore, we use NMR (NMR) and mol. dynamics (MD) to study their ionic transport behavior and ion solvation environment, resp. Finally, we demonstrate that this new class of electrolytes can be used with a Ni-rich layered cathode (NMC 811) to obtain over 100 cycles at a C/5 rate. The design of new mols. with high ionic conductivity and high electrochem. stability is a novel approach for the rational design of next-generation batteries.

Journal of the American Chemical Society published new progress about Battery cathodes. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Quality Control of 6482-24-2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Wang, Xiaomei; Qian, Jianqiang; Zhu, Peng; Hua, Rong; Liu, Ji; Hang, Jiaying; Meng, Chi; Shan, Wenpei; Miao, Jiefei; Ling, Yong published the artcile< Novel Phenylmethylenecyclohexenone Derivatives as Potent TrxR Inhibitors Display High Antiproliferative Activity and Induce ROS, Apoptosis, and DNA Damage>, Related Products of 6482-24-2, the main research area is Phenylmethylenecyclohexenone derivative TrxR inhibitor ROS antiproliferative DNA damage anticancer; Antiproliferative activities; Aqueous solubility; DNA damage; Phenylmethylenecyclohexenone; Reactive oxygen species; Thioredoxin reductase.

The natural product piperlonguminine (PL) has been shown to exert potential anticancer activity against several types of cancer via elevation of reactive oxidative species (ROS). However, the application of PL has been limited due to its poor water solubility and moderate activity. To improve PL′s potency, we designed and synthesized a series of 17 novel phenylmethylenecyclohexenone derivatives and evaluated their pharmacol. properties. Most of them exerted antiproliferative activities against four cancer cell lines with IC50 values lower than PL. Among these, compound 10 e not only showed good water solubility and exerted the most potent antiproliferative activity against HGC27 cells (IC50=0.76 μM), which was 10-fold lower than PL (IC50=7.53 μM), but also exhibited lower cytotoxicity in human normal gastric epithelial cells GES-1 compared with HGC27 cells. Mechanistically, compound 10 e inhibited thioredoxin reductase (TrxR) activity, increased ROS levels, and diminished mitochondrial transmembrane potential (MTP) in HGC27 cells. Furthermore, 10 e also induced G2/M cell-cycle arrest, and triggered cancer cell apoptosis through the regulation of apoptotic proteins. Finally, 10 e promoted DNA damage in HGC27 cells via the activation of the H2AX(S139ph) and p53 signaling. In conclusion, 10 e, with prominent tumor selectivity and water solubility, could be a promising candidate for the treatment of cancer and, as such, warrants further investigation.

ChemMedChem published new progress about Antiproliferative agents. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Related Products of 6482-24-2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Nie, Xiao-Di; Han, Xiao-Li; Sun, Jian-Ting; Si, Chang-Mei; Wei, Bang-Guo; Lin, Guo-Qiang published the artcile< Nickel-Catalyzed Regioselective Hydroamination of Ynamides with Secondary Amines>, Electric Literature of 10541-78-3, the main research area is ethene diamine preparation regioselective diastereoselective; secondary amine ynamide preparation hydroamination nickel catalyst.

The first Ni(OTf)2-catalyzed hydroamination of ynamides e.g., N-benzyl-4-methyl-N-(2-phenylethynyl)benzene-1-sulfonamide was developed by reacting with secondary amines e.g., N-methylaniline. This protocol features excellent regioselectivity, a broad substrate scope of secondary aryl amines, and good functional group tolerance for ynamides. Using this method, a variety of substituted ethene-1,1-diamine compounds e.g., I were prepared in moderate to excellent yields with high regioselectivities.

Journal of Organic Chemistry published new progress about Alkynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (amides). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Electric Literature of 10541-78-3.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Dombrowski, Amanda W.; Gesmundo, Nathan J.; Aguirre, Ana L.; Sarris, Katerina A.; Young, Jonathon M.; Bogdan, Andrew R.; Martin, M. Cynthia; Gedeon, Shasline; Wang, Ying published the artcile< Expanding the Medicinal Chemist Toolbox: Comparing Seven C(sp2)-C(sp3) Cross-Coupling Methods by Library Synthesis>, HPLC of Formula: 6482-24-2, the main research area is carbon cross coupling library synthesis medicinal chemist synthetic toolbox.

Despite recent advances in the field of C(sp2)-C(sp3) cross-couplings and the accompanying increase in publications, it can be hard to determine which method is appropriate for a given reaction when using the highly functionalized intermediates prevalent in medicinal chem. Thus a study was done comparing the ability of seven methods to directly install a diverse set of alkyl groups on “”drug-like”” aryl structures via parallel library synthesis. Each method showed substrates that it excelled at coupling compared with the other methods. When analyzing the reactions run across all of the methods, a reaction success rate of 50% was achieved. Whereas this is promising, there are still gaps in the scope of direct C(sp2)-C(sp3) coupling methods, like tertiary group installation. The results reported herein should be used to inform future syntheses, assess reaction scope, and encourage medicinal chemists to expand their synthetic toolbox.

ACS Medicinal Chemistry Letters published new progress about Combinatorial library. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, HPLC of Formula: 6482-24-2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zheng, Yunlong; Zhang, Sainan; Guo, Jinbiao; Shi, Ruixuan; Yu, Jiangyue; Li, Kaipeng; Li, Ning; Zhang, Zhenjie; Chen, Yao published the artcile< Green and Scalable Fabrication of High-Performance Biocatalysts Using Covalent Organic Frameworks as Enzyme Carriers>, Product Details of C3H7BrO, the main research area is biocatalyst covalent organic framework stability; Biocatalysts; Chiral Catalysis; Covalent Organic Frameworks; Enzyme Immobilization; Porous Materials.

Enzyme immobilization is essential to the com. viability of various critical large-scale biocatalytic processes. However, challenges remain for the immobilization systems, such as difficulties in loading large enzymes, enzyme leaching, and limitations for large-scale fabrication. Herein, we describe a green and scalable strategy to prepare high-performance biocatalysts through in situ assembly of enzymes with covalent organic frameworks (COFs) under ambient conditions (aqueous solution and room temperature). The obtained biocatalysts have exceptional reusability and stability and serve as efficient biocatalysts for important industrial reactions that cannot be efficiently catalyzed by free enzymes or traditional enzyme immobilization systems. Notably, this versatile enzyme immobilization platform is applicable to various COFs and enzymes. The reactions in an aqueous solution occurred within a short timeframe (ca. 10-30 min) and could be scaled up readily (ca. 2.3 g per reaction).

Angewandte Chemie, International Edition published new progress about Adsorption. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Product Details of C3H7BrO.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Wu, Liangying; Song, Yang; Li, Zhanchong; Guo, Jiabao; Yao, Xiaoquan published the artcile< Copper(II)-Catalyzed Aerobic Oxidative Coupling of Arylamines with Hexafluoroisopropanol: An Alternative Methodology for Constructing Fluorinated Compounds>, Formula: C8H11NO, the main research area is fluoroalkylated arylamine green preparation regioselective; arylamine hexafluoroisopropanol oxidative coupling copper catalyst.

The selective functionalization of arylamine derivatives with hexafluoroisopropanol through copper(II)-catalyzed aerobic oxidative coupling was developed to generate various fluoroalkylated arylamines RC(OH)(CF3)2 [R = 4-MeNHC6H4, 1,2,3,4-tetrahydroquinolin-6-yl, 4-Et2NC6H4, etc.] under mild conditions. This method had a wide substrate scope with excellent functional group tolerance and provided the fluorinated products in good to excellent yields. Furthermore, preliminary studies indicated that this reaction occurred via a radical mechanism. This protocol, which uses atm. O2 as an oxidant, provided an alternative green route for constructing fluorinated compounds

Advanced Synthesis & Catalysis published new progress about Aromatic amines Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Formula: C8H11NO.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Katayama, Shintaro; Nishino, Hiroshi published the artcile< Manganese(III)-Based Oxidative Cyclization of N -Aryl-2-oxocycloalkane-1-carboxamides: Synthesis of Spiroindolinones>, Application In Synthesis of 10541-78-3, the main research area is aryl oxocycloalkane carboxamide oxidative cyclization; spiro cycloalkane indoline dione preparation.

The Mn(III)-based oxidative cyclization of twenty-five N-aryl-2-oxocycloalkane-1-carboxamides was investigated. The reactions progressed efficiently to give the desired spiro[cycloalkane-1,3′-indoline]-2,2′-diones in high to quant. yields. The easy conversion of the carbonyl functional group of one of the indoline products, 1′-methylspiro[cyclohexane-1,3′-indoline]-2,2′-dione, was also demonstrated.

Synthesis published new progress about Amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Application In Synthesis of 10541-78-3.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Jones, J. Howard; Xin, Zhili; Himmelbauer, Martin; Dechantsreiter, Michael; Enyedy, Istvan; Hedde, Joseph; Fang, Terry; Coomaraswamy, Janaky; King, Kristopher W.; Murugan, Paramasivam; Santoro, Joseph C.; Hesson, Thomas; Walther, Dirk M.; Wei, Ru; Zheng, Fengmei; Marcotte, Douglas J.; Spilker, Kerri; Kumar, P. Rajesh; Liu, Ying; Gilfillan, Rab; Gonzalez-Lopez de Turiso, Felix published the artcile< Discovery of Potent, Selective, and Brain-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors that Modulate Brain Inflammation In Vivo>, Electric Literature of 6482-24-2, the main research area is ASK1 inhibitor brain inflammation pharmacokinetic penetration.

Apoptosis signal-regulating kinase 1 (ASK1) is one of the key mediators of the cellular stress response that regulates inflammation and apoptosis. To probe the therapeutic value of modulating this pathway in preclin. models of neurol. disease, we further optimized the profile of our previously reported inhibitor 3. This effort led to the discovery of 32, a potent (cell IC50 = 25 nM) and selective ASK1 inhibitor with suitable pharmacokinetic and brain penetration (rat Cl/Clu = 1.6/56 L/h/kg and Kp,uu = 0.46) for proof-of-pharmacol. studies. Specifically, the ability of 32 to inhibit ASK1 in the central nervous system (CNS) was evaluated in a human tau transgenic (Tg4510) mouse model exhibiting elevated brain inflammation. In this study, transgenic animals treated with 32 (at 3, 10, and 30 mg/kg, BID/PO for 4 days) showed a robust reduction of inflammatory markers (e.g., IL-1β) in the cortex, thus confirming inhibition of ASK1 in the CNS.

Journal of Medicinal Chemistry published new progress about Anti-inflammatory agents. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Electric Literature of 6482-24-2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Verma, Piyush Kumar; Prasad, K. Sujit; Varghese, Dominic; Geetharani, K. published the artcile< Cobalt(I)-Catalyzed Borylation of Unactivated Alkyl Bromides and Chlorides>, Recommanded Product: 1-Bromo-2-methoxyethane, the main research area is cobalt catalyzed borylation unactivated alkyl bromide chloride diboron reagent; alkyl boronic ester preparation.

A Co-complex-catalyzed borylation of a wide range of alkyl halides with a diboron reagent (B2pin2 or B2neop2) was developed under mild reaction conditions, demonstrating the 1st Co-mediated cross-coupling with alkyl electrophiles. This protocol allows alkyl boronic esters to be accessed from alkyl halides, including alkyl chlorides, which were used rarely as coupling partners. Mechanistic studies reveal the possible involvement of an alkyl radical intermediate in this Co-mediated catalytic cycle.

Organic Letters published new progress about Boronic acids, esters Role: SPN (Synthetic Preparation), PREP (Preparation) (alkyl boronic esters). 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Recommanded Product: 1-Bromo-2-methoxyethane.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Bonnefoy, Clemence; Chefdeville, Emmanuel; Tourvieille, Christian; Panossian, Armen; Hanquet, Gilles; Leroux, Frederic; Toulgoat, Fabien; Billard, Thierry published the artcile< Study of Carbamoyl Fluoride: Synthesis, Properties and Applications>, Recommanded Product: 2-Methoxy-N-methylaniline, the main research area is carbamoyl fluoride preparation stability; amine fluorocarbonylation dinitrotrifluoromethoxybenzene; radiolabeled carbamoyl fluoride preparation; carbamoyl fluorides; dinitrotrifluoromethoxybenzene; fluorine; radiochemistry; trifluoromethoxide.

In this study, the little-explored carbamoyl fluorides have been studied in order to bring relevant information for their application to the community of chemists. A new easy, safe, inexpensive, and metal-free synthesis method is also described. Finally, a potential use in radiochem. through a 18F/19F isotopic exchange is demonstrated.

Chemistry – A European Journal published new progress about Acid fluorides Role: SPN (Synthetic Preparation), PREP (Preparation). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Recommanded Product: 2-Methoxy-N-methylaniline.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem