Tag: M.W=100-150

Karmakar, Ujjwal; Hwang, Ho Seong; Lee, Yunjeong; Cho, Eun Jin published the artcile< Photocatalytic para-Selective C-H Functionalization of Anilines with Diazomalonates>, Synthetic Route of 10541-78-3, the main research area is photocatalytic para selective alkylation aniline diazomalonate.

Visible-light-induced para-selective C-H functionalization of anilines over N-H insertion was developed using diazomalonates with the help of an Ir(III) photocatalyst. The para-selective radical-radical cross coupling proceeded via C-centered radical intermediates generated from both anilines and diazomalonates. The photochem. of anilines could be extended to other N-heterocycles, such as indole and carbazole. The reaction pathway for the selective C-C coupling was validated by electrochem. and photophys. experiments as well as computational studies.

Organic Letters published new progress about Alkylation, regioselective (photocatalytic). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Synthetic Route of 10541-78-3.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Li, Rui; Gong, Zhong-Liang; Zhu, Qijian; Sun, Meng-Jia; Che, Yanke; Yao, Jiannian; Zhong, Yu-Wu published the artcile< A pre-organized monomer-reservoir strategy to prepare multidimensional phosphorescent organoplatinum nanocrystals and suprastructures>, SDS of cas: 6482-24-2, the main research area is phosphorescent organoplatinum nanocrystal suprastructure.

The preparation of multidimensional nano- and micro structures, in particular suprastructures with well-defined morphol. and bright emissions, is a challenging task in supramol. assembly. For this purpose, a new type of amphiphilic diplatinum complexes is presented as an excellent building block to assemble into highly phosphorescent nanofibers by supramol. Pt···Pt interactions. These organoplatinum supramol. fibers are further used as a pre-organized monomer reservior for the metal ion-triggered post-transformation into crystalline nanoneedles, nanorods, nanobunches, microplates, and microflowers with controllable morphol. and bright phosphorescence. A reverse transformation of the obtained nanorods into nanofibers is demonstrated with the aid of ethylenediamine tetraacetic acid. In contrast, the direct treatment of diplatinum complexes with different metal ions fails to give well-defined nano and microstructures, suggestive of the pre-organized role of nanofibers for the morphol. transformation. Preliminary applications of these nano- and suprastructures in sensing temperature and organic vapors by emission signal changes are demonstrated. In contrast to the conventional hierarchical assembly, the pre-organized monomer-reservoir strategy disclosed in this study offers a versatile method for the synthesis of organic nano and suprastructures with multidimensional morphol. and controllable emission properties.

Science China: Chemistry published new progress about Crystallinity. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, SDS of cas: 6482-24-2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Xin, Zhili; Himmelbauer, Martin K.; Jones, J. Howard; Enyedy, Istvan; Gilfillan, Rab; Hesson, Thomas; King, Kristopher; Marcotte, Douglas J.; Murugan, Paramasivam; Santoro, Joseph C.; Gonzalez-Lopez de Turiso, Felix published the artcile< Discovery of CNS-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors>, Computed Properties of 6482-24-2, the main research area is preparation CNS penetrant apoptosis signal regulating kinase inhibitor.

Apoptosis signal-regulating kinase 1 (ASK1) is a key mediator in the apoptotic and inflammatory cellular stress response. To investigate the therapeutic value of modulating this pathway in neurol. disease, we have completed medicinal chem. studies to identify novel CNS-penetrant ASK1 inhibitors starting from peripherally restricted compounds reported in the literature. This effort led to the discovery of 21, a novel ASK1 inhibitor with good potency (cell IC50 = 138 nM), low clearance (rat Cl/Clu = 0.36/6.7 L h-1 kg-1) and good CNS penetration (rat Kp,uu = 0.38).

ACS Medicinal Chemistry Letters published new progress about Apoptosis. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Computed Properties of 6482-24-2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Shinohara, Koichi; Tsurugi, Hayato; Mashima, Kazushi published the artcile< N-Methylation of Aniline Derivatives with CO2 and Phenylsilane Catalyzed by Lanthanum Hydridotriarylborate Complexes bearing a Nitrogen Tridentate Ligand>, Product Details of C8H11NO, the main research area is methyl aniline preparation; aniline methylation phenylsilane lanthanum hydridotriarylborate complex nitrogen tridentate ligand; lanthanum hydridotriarylborate complex nitrogen tridentate ligand preparation.

A lanthanum amide complex, La(L)[N(SiHMe2)2](thf) (L = N,N””-bis(pentafluorophenyl)diethylenetriamine dianion), upon activation with B(3,4,5-F2C6H2)3, showed excellent catalytic activity for N-methylation of N-alkylaniline derivatives with CO2 in the presence of PhSiH3. A catalytically active lanthanum hydridotriarylborate complex, [La(L)(thf)2][HB(3,4,5-F3C6H2)3], was generated via hydride abstraction from the Si-H moiety by moderate Lewis acid B(3,4,5-F2C6H2)3 in THF. DFT studies of the CO2 hydrosilylation step clarified the following multiple noncovalent interactions as key factors for locating the HB(3,4,5-F2C6H2)3 anion and B(3,4,5-F3C6H2)3 near the lanthanum center in the transition states of CO2 reduction and Si-O bond formation: (1) π-π interaction between the electron-deficient C6F5 ring on ligand L and the 3,4,5-F3C6H2 ring of the HB(3,4,5-F3C6H2)3 anion and (2) C-H···F hydrogen bonds between the ortho-C-H bond of B(3,4,5-F3C6H2)3 and the fluorine atoms of L.

ACS Catalysis published new progress about Anilines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Product Details of C8H11NO.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Feng, Shao-Ping; Huang, Kun published the artcile< Enhanced separation of Pd(II) and Pt(IV) from hydrochloric acid aqueous solution using 2-((2-methoxyethyl)thio)-1H-benzimidazole>, Synthetic Route of 6482-24-2, the main research area is palladium platinum separation extraction methoxyethyl thiobenzimidazole.

Separation of palladium (Pd) and platinum (Pt) by solvent extraction is difficult because of their extremely similar physicochem. properties. Development of new extractants with a high extraction efficiency and excellent separation selectivity is the primary focus for enhancing the separation of Pd and Pt by solvent extraction In this study, a new extractant, 2-((2-methoxyethyl)thio)-1H-benzimidazole (MOBI), which contains N, S, and O atoms, was synthesized and used to sep. Pd(II) and Pt(IV) from a hydrochloric acid aqueous solution The exptl. results revealed that Pd(II) and Pt(IV) were effectively separated under the optimal conditions: MOBI concentration of 0.005 mol·L-1, HCl concentration of 0.2 mol·L-1, organic/aqueous (O/A) phase ratio of 1.0, and contact time of 15 min. The separation coefficient between Pd(II) and Pt(IV) was 1246.40, which indicates that MOBI has a higher selectivity for Pd(II) than Pt(IV). In addition, the mechanism of coordination between Pd(II) and MOBI was demonstrated through the slope method, Fourier transform IR spectroscopy (FTIR), hydrogen-1 NMR spectroscopy (1H NMR), and carbon-13 NMR spectroscopy (13C NMR). The results revealed that MOBI could coordinate with Pd(II) via the N atom in the benzimidazole ring of MOBI mols. to form [Pd(MOBI)2Cl2](O).

Rare Metals (Beijing, China) published new progress about Extraction (stripping). 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Synthetic Route of 6482-24-2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Gu, Lijun; Jin, Cheng; Guo, Junming; Zhang, Lizhu; Wang, Wei published the artcile< A novel strategy for the construction of substituted benzoxazoles via a tandem oxidative process>, Name: 2-Amino-3-methoxyphenol, the main research area is toluene aminophenol tandem oxidative cyclization iron bromide catalyst; benzoxazole preparation.

A practical and simple synthesis of benzoxazoles from easily available substrates was developed. The protocol is triggered by an iron-catalyzed tandem oxidative process from simple toluene derivatives and 2-aminophenols. This method represents a straightforward approach to access substituted benzoxazoles.

Chemical Communications (Cambridge, United Kingdom) published new progress about Alkylarenes Role: RCT (Reactant), RACT (Reactant or Reagent). 40925-69-7 belongs to class ethers-buliding-blocks, and the molecular formula is C7H9NO2, Name: 2-Amino-3-methoxyphenol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zhou, Ning; Wang, Yufeng; Zhou, Yang; Shen, Jinyou; Zhou, Yong; Yang, Yong published the artcile< Star-shaped multi-arm polymeric ionic liquid based on tetraalkylammonium cation as high performance gel electrolyte for lithium metal batteries>, COA of Formula: C3H7BrO, the main research area is polymerized ionic liquid starshaped lithium metal battery gel electrolyte.

Star-shaped polymeric ionic liquids (PIL-3 and PIL-4) based on poly(2-(dimethyl-ethyl-amino)ethyl methacrylate) bis(trifluoromethylsulfonyl)imide (P(EtDMAEMA-TFSI)) with three-arm and four-arm architectures were prepared through atom transfer radical polymerization (ATRP) and ion exchange. Subsequently, gel polymer electrolytes (GPEs) comprising PIL host, N,N-diethyl-N-methyl-N-(2-methoxyethyl)ammonium bis(trifluoromethylsulfonyl)imide (DEME-TFSI) ionic liquid (IL) plasticizer with the same anion unit and LiTFSI salt were obtained. Compared with the linear PIL possessing the same elements, the increase of branches for PIL decreases the crystallity and glass transition temperature (Tg) of the corresponding GPEs. Accordingly, the ionic conductivity, electrochem. window and ion transport number of three-arm and four-arm PILs based GPEs (PIL-GPE-3 and PIL-GPE-4) are obviously superior to the linear contrastive sample. Among lithium metal batteries assembled by linear, three-arm and four-arm PILs based GPEs, Li/PIL-GPE-4/LiFePO4 presents the best performance. The specific discharge capacity attains 151 mAh g-1 at 0.1 C, the capacity retention ratio achieves 93.6% after 100 cycles at 60 °C, and the coulombic efficiency is around 99%. The outstanding compatibility between PIL-4 and IL and the resulted interfacial stability between PIL-GPE-4 and electrodes both contribute to the excellent performance.

Electrochimica Acta published new progress about Atom transfer radical polymerization. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, COA of Formula: C3H7BrO.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Shenghur, Abraham; Weber, Kevin H.; Nguyen, Nhan D.; Sontising, Watit; Tao, Fu-Ming published the artcile< Theoretical Study of the Hydrogen Abstraction of Substituted Phenols by Nitrogen Dioxide as a Source of HONO>, Name: 2-Amino-3-methoxyphenol, the main research area is nitrogen dioxide hydrogen abstraction phenol nitrous acid formation.

The mild yet promiscuous reactions of nitrogen dioxide (NO2) and phenolic derivatives to produce nitrous acid (HONO) have been explored with d. functional theory calculations The reaction is found to occur via four distinct pathways with both proton coupled electron transfer (PCET) and hydrogen atom transfer (HAT) mechanisms available. While the parent reaction with phenol may not be significant in the gas phase, electron donating groups in the ortho and para positions facilitate the reduction of nitrogen dioxide by electronically stabilizing the product phenoxy radical. Hydrogen bonding groups in the ortho position may addnl. stabilize the nascent resonantly stabilized radical product, thus enhancing the reaction. Catechol (ortho-hydroxy phenol) has a predicted overall free energy change ΔG0 = -0.8 kcal mol-1 and electronic activation energy Ea = 7.0 kcal mol-1. Free amines at the ortho and para positions have ΔG0 = -3.8 and -1.5 kcal mol-1; Ea = 2.3 and 2.1 kcal mol-1, resp. The results indicate that the hydrogen abstraction reactions of these substituted phenols by NO2 are fast and spontaneous. Hammett constants produce a linear correlation with bond dissociation energy (BDE) demonstrating that the BDE is the main parameter controlling the dark abstraction reaction. The implications for atm. chem. and ground-level nitrous acid production are discussed.

Journal of Physical Chemistry A published new progress about Abstraction reaction enthalpy. 40925-69-7 belongs to class ethers-buliding-blocks, and the molecular formula is C7H9NO2, Name: 2-Amino-3-methoxyphenol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Siddiqui, Sheema; Bhawar, Ramesh; Geetharani, K. published the artcile< Iron-Based Catalyst for Borylation of Unactivated Alkyl Halides without Using Highly Basic Organometallic Reagents>, Safety of 1-Bromo-2-methoxyethane, the main research area is alkyl halide unactivated borylation catalyst iron amide complex; alkylboronate preparation borylation unactivated alkyl halide iron hexamethyldisilazide catalyst.

The mild borylation of alkyl bromides and chlorides with bis(neopentylglycolato)diborane (B2neop2) mediated by iron-bis amide is described. The reaction proceeds with a broad substrate scope and good functional group compatibility. Moreover, sufficient catalytic activity was obtained for primary and secondary alkyl halides. Mechanistic studies indicate that the reaction proceeds through a radical pathway.

Journal of Organic Chemistry published new progress about Amines Role: CAT (Catalyst Use), USES (Uses) (amido complexes). 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Safety of 1-Bromo-2-methoxyethane.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

McPherson, Andrew K.; Capaldi, Daniel; Chen, Lijian; Olsen, Philip published the artcile< An Improved Process for the Manufacture of 5'-O-(4,4'-Dimethoxytrityl)-N2-isobutyryl-2'-O-(2-methoxyethyl)guanosine>, Category: ethers-buliding-blocks, the main research area is alkylation aminopurine riboside bromomethoxyethane nucleoside nucleotide preparation enzymic.

A revised, optimized process for the manufacture of 5′-O-(4,4′-dimethoxytrityl)-N2-isobutyryl-2′-O-(2-methoxyethyl)guanosine (MOE G PNS) that controls critical impurities to less than 0.2% was developed. The 2′-O-alkylation of 2,6-diaminopurine riboside (DAPR) with 1-bromo-2-methoxyethane (MOE-Br) in DMSO was examined using a DOE approach, which lead to the selection of LiOH as the optimal base choice. DMSO was removed with a solid-phase extraction using SP-207 resin, affording the desired 2′-O-(2-methoxyethyl)-2,6-diaminopurine riboside (MOE DAPR) in an aqueous solution in 53% yield. The methylbromide impurity commonly found in bulk source MOE-Br was controlled using a co-distillation with MEK, thereby controlling the resulting critical 2′-O-Me nucleoside impurity. The aqueous solution was telescoped into the enzymic conversion of MOE-DAPR to 2′-O-(2-methoxyethyl)guanosine (MOE G) using adenosine deaminase. MOE G purity is enhanced at this step due to enzymic selectivity and crystallization from the reaction mixture, which together significantly reduce levels of the 3′ MOE G isomer. The improved process was carried out at production-scale to afford 59 kg of MOE G PNS with no critical impurity over 0.2% in an overall yield of 26%.

Organic Process Research & Development published new progress about Alkylation. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Category: ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem