Tag: M.W=100-150

Lin, Xiao-Long; Yu, Yan; Zhang, Liang; Leng, Li-Jing; Xiao, Dong-Rong; Cai, Tian; Luo, Qun-Li published the artcile< Switchable synthesis of 1,4-bridged dihydroisoquinoline-3-ones and isoquinoline-1,3,4-triones through radical oxidation of isoquinolinium salts with phenyliodine(III) diacetate>, Category: ethers-buliding-blocks, the main research area is bridged dihydroisoquinolinone isoquinoline trione preparation stereoselective; isoquinolinium salt hydroxycoumarin radical oxidation annulation.

A metal-free switchable synthesis of 1,4-bridged dihydroisoquinoline-3-ones and isoquinoline-1,3,4-triones through the oxidation of isoquinolinium salts is described. 1,4-Bridged dihydroisoquinolin-3-ones were constructed for the first time via the sequential oxidation/annulation of isoquinolinium salts with 4-hydroxycoumarins. Meanwhile, the iodine(III)-oxidized intermediates of isoquinolinium salt could be converted to isoquinoline-1,3,4-triones in high yields by treatment with tert-Bu hydroperoxide. These site-selective transformations rely on an iodine(III)-mediated dual radical addition/radical coupling strategy and prove that the combination of the bromide anion and phenyliodine(III) diacetate is a useful carrier of relatively stable bromine radicals and highly labile carboxyl radicals.

Organic Chemistry Frontiers published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Category: ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Wei, Jie; Lu, Donghui; Jiang, Cailian; Fang, Dawei; Hu, Xiaohong published the artcile< Experimental determination of viscosity for the binary mixtures of the ether-functionalized ionic liquids [C22O1IM][TfO] with monohydric alcohols>, Computed Properties of 6482-24-2, the main research area is ionic liquid monohydric alc viscosity binary mixture.

In order to apply ionic liquids in various fields, it is necessary to understand their phys. and chem. properties. Viscosity, in particular, is an important parameter of multicomponent solutions and plays a decisive role in mass transfer, heat transfer and fluid flow in industrial process. In this work, the ether-functionalized ionic liquid [C22O1IM][TfO] was synthesized and characterized by 1H NMR, 13C NMR, ESI mass spectrometry and elemental anal. The viscosity of the binary mixture of ionic liquid [C22O1IM][TfO] with ethanol, 1-propanol and 2-propanol in the full concentration range of T = (288.15-318.15) K were measured. The relationships between the viscosity of the binary system and concentration and temperature were investigated. By Vogel-Tamman-Fulcher (VTF) equation and Arrhenius equation, the temperature dependences of the viscosities for the binary system were described and the VTF equation showed better correlation for the binary system. The viscosity deviation that expresses the difference between the actual value and the ideal value of the mixture viscosity, Δη, was calculated At the same time, the Gibbs energy of activation for viscous flow of the relative viscosity for the mixture, ΔG≠r, was also calculated based on the relative viscosity, ηr, and ΔG≠r is neg. that is consistent with the results of, Δη, it means that the interaction between ions becomes weak due to the solvation.

Journal of Molecular Liquids published new progress about Activation energy. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Computed Properties of 6482-24-2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zhao, Xin; Yang, Fang; Zou, Shao-Yu; Zhou, Qian-Qian; Chen, Zi-Sheng; Ji, Kegong published the artcile< Cu-Catalyzed Intermolecular γ-Site C-H Amination of Cyclohexenone Derivatives: The Benefit of Bifunctional Ligands>, Formula: C8H11NO, the main research area is aniline cyclohexenone copper catalyst regioselective amination green chem; amino alc preparation antibacterial antioxidant; cyclohexadienyl oxy silyl ether aniline copper regioselective diastereoselective amination; aminocyclohexenone preparation green chem.

Utilizing 1,10-phenanthroline-type bifunctional ligands, an efficient Cu-catalyzed intermol. site-selective remote C-H amination using cyclohexenone derivatives and anilines was realized. The amide group installed on the bifunctional ligand played a key role in stabilizing the N-centered radical generated in-situ to realize C-N-directed formation. Meanwhile, a useful catalytic system for site-selective intermol. remote γ-C-H amination to p-aminophenols and γ-aminated enones was established. This economical and practical approach using oxygen as the terminal oxidant was mild and environmentally friendly.

ACS Catalysis published new progress about Amination catalysts (stereoselective, regioselective). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Formula: C8H11NO.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Goswami, Lalit N.; Everett, Thomas A.; Khan, Aslam A.; Hawthorne, M. Frederick published the artcile< Rational Design of a Stable Two One-Electron Redox-Active closo-Dodecaalkoxyborane Ion as Biothiol Sensor>, SDS of cas: 6482-24-2, the main research area is biothiol sensor closo alkoxy dodecaborane preparation.

The interest in the incorporation of polyhedral boranes into hybrid mols. has increased tremendously. Most of those efforts have focused on the use of carboranes, as opposed to their all-B counterparts, the polyhedral borane anions. The authors’ efforts have paved the way for the synthesis and application of several inorganic-organic hybrid nanomol. scaffolds derived from closo-dodecaborate ions [B12H12]2- as high payload carriers of drugs and imaging agents. Herein the authors report a significant expansion to the scope of application for these interesting class of mols. A rationally designed water-soluble ether derivative of [B12H12]2-, the [closo-B12(OR)12]2- was synthesized as a highly efficient thiol sensing probe. The thiol sensing mechanism of the probe relies upon the unique two 1-e- redox chem. of the [closo-B12(OR)12]2- ion which is evident by a dramatic color change. This probe is effective over a wide pH range and has the ability to discriminate bio-thiols from common amino acids.

European Journal of Inorganic Chemistry published new progress about Optical biosensors (colorimetric). 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, SDS of cas: 6482-24-2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Yoshii, Kazuki; Uto, Takuya; Tachikawa, Naoki; Katayama, Yasushi published the artcile< The effects of the position of the ether oxygen atom in pyrrolidinium-based room temperature ionic liquids on their physicochemical properties>, Product Details of C3H7BrO, the main research area is methylpyrrolidinium ionic liquid preparation viscosity conductivity conformation cathode potential.

This study investigated, using both exptl. and computational approaches, the effect of ether oxygen atoms on the physicochem. properties of room temperature ionic liquids RTILs consisting of bis(trifluoromethylsulfonyl)amide (TFSA-) with 1-methyl-1-propylpyrrolidinium (MPP+), 1-butyl-1-methylpyrrolidinium (BMP+), 1-methoxymethyl-1-methylpyrrolidinium (MOMMP+), 1-ethoxymethyl-1-methylpyrrolidinium (EOMMP+), and 1-methoxyethyl-1-methylpyrrolidinium (MOEMP+). The viscosity of the RTILs containing the ether oxygen atom was lower than that of the alkyl analogs. Moreover, the viscosity of EOMMPTFSA was lower than that of MOEMPTFSA, albeit EOMMPTFSA and MOEMPTFSA have the same mol. weight with ether oxygen atoms at different positions. Ab initio calculations revealed that the number of methylene groups between nitrogen and oxygen atoms in the cation structure profoundly impacted the local stable structure of the cation. Furthermore, we discussed the relationship between the transport properties and the spatial distribution of ions obtained by MD simulations. This result will be valuable in the design of functionalized RTILs, via the judicious tuning of the conformational flexibility of ether oxygen atoms in related ionic liquids

Physical Chemistry Chemical Physics published new progress about Activation energy. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Product Details of C3H7BrO.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Rianjongdee, Francesco; Atkinson, Stephen J.; Chung, Chun-wa; Grandi, Paola; Gray, James R. J.; Kaushansky, Laura J.; Medeiros, Patricia; Messenger, Cassie; Phillipou, Alex; Preston, Alex; Prinjha, Rab K.; Rioja, Inmaculada; Satz, Alexander L.; Taylor, Simon; Wall, Ian D.; Watson, Robert J.; Yao, Gang; Demont, Emmanuel H. published the artcile< Discovery of a Highly Selective BET BD2 Inhibitor from a DNA-Encoded Library Technology Screening Hit>, Name: 1,3-Dimethoxypropan-2-amine, the main research area is epigenetics chem probe BET BD2 DNA encoded library bromodomains.

Second-generation bromodomain and extra terminal (BET) inhibitors, which selectively target one of the two bromodomains in the BET proteins, have begun to emerge in the literature. These inhibitors aim to help determine the roles and functions of each domain and assess whether they can demonstrate an improved safety profile in clin. settings compared to pan-BET inhibitors. Herein, we describe the discovery of a novel BET BD2-selective chemotype using a structure-based drug design from a hit identified by DNA-encoded library technologies, showing a structural differentiation from key previously reported greater than 100-fold BD2-selective chemotypes GSK620, GSK046, and ABBV-744. Following a structure-based hypothesis for the selectivity and optimization of the physicochem. properties of the series, we identified 60 (GSK040)(I), an in vitro ready and in vivo capable BET BD2-inhibitor of unprecedented selectivity (5000-fold) against BET BD1, excellent selectivity against other bromodomains, and good physicochem. properties. This novel chem. probe can be added to the toolbox used in the advancement of epigenetics research.

Journal of Medicinal Chemistry published new progress about Bromodomain (BD2). 78531-29-0 belongs to class ethers-buliding-blocks, and the molecular formula is C5H13NO2, Name: 1,3-Dimethoxypropan-2-amine.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Mamidala, Ramesh; Biswal, Priyabrata; Subramani, M. Siva; Samser, Shaikh; Venkatasubbaiah, Krishnan published the artcile< Palladacycle-Phosphine Catalyzed Methylation of Amines and Ketones Using Methanol>, Application of C8H11NO, the main research area is amine ketone methylation palladacycle phosphine catalyst methanol.

Methylation of amines and ketones with palladacycle precatalyst was performed using methanol as an environmentally benign reagent. Various ketones and amines undergo methylation reaction to yield monomethylated amines or ketones in moderate to good isolated yields. Moreover, this protocol was tested for the chemoselective methylation of 4-aminobenzenesulfonamide. The scope of the reaction was further extended to the deuteromethylation of ketones.

Journal of Organic Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Application of C8H11NO.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Luridiana, Alberto; Mazzarella, Daniele; Capaldo, Luca; Rincon, Juan A.; Garcia-Losada, Pablo; Mateos, Carlos; Frederick, Michael O.; Nuno, Manuel; Jan Buma, Wybren; Noel, Timothy published the artcile< The Merger of Benzophenone HAT Photocatalysis and Silyl Radical-Induced XAT Enables Both Nickel-Catalyzed Cross-Electrophile Coupling and 1,2-Dicarbofunctionalization of Olefins>, Application of C3H7BrO, the main research area is alkyl bromide bromobenzene nickel catalyst photocatalyst reductive cross coupling; alkene alkylbromide bromobenzene nickel catalyst photocatalyst reductive cross coupling; alkylbenzene preparation.

A strategy for both cross-electrophile coupling and 1,2-dicarbofunctionalization of olefins was developed. Carbon-centered radicals were generated from alkyl bromides by merging benzophenone hydrogen atom transfer (HAT) photocatalysis and silyl radical-induced halogen atom transfer (XAT) and were subsequently intercepted by a nickel catalyst to forge the targeted C(sp3)-C(sp2) and C(sp3)-C(sp3) bonds. The mild protocol was fast and scalable using flow technol., displays broad functional group tolerance and was amenable to a wide variety of medicinally relevant moieties. Mechanistic investigations revealed that the ketone catalyst, upon photoexcitation, was responsible for the direct activation of the silicon-based XAT reagent (HAT-mediated XAT) that furnishes the targeted alkyl radical and was ultimately involved in the turnover of the nickel catalytic cycle.

ACS Catalysis published new progress about Alkylbenzenes Role: SPN (Synthetic Preparation), PREP (Preparation). 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Application of C3H7BrO.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Marro, Nicolas; della Sala, Flavio; Kay, Euan R. published the artcile< Programmable dynamic covalent nanoparticle building blocks with complementary reactivity>, Related Products of 6482-24-2, the main research area is dynamic covalent nanoparticle monolayer complementary reactivity kinetics.

Nanoparticle-based devices, materials and technologies will demand a new era of synthetic chem. where predictive principles familiar in the mol. regime are extended to nanoscale building blocks. Typical covalent strategies for modifying nanoparticle-bound species rely on kinetically controlled reactions optimized for efficiency but with limited capacity for selective and divergent access to a range of product constitutions. In this work, monolayer-stabilized nanoparticles displaying complementary dynamic covalent hydrazone exchange reactivity undergo distinct chemospecific transformations by selecting appropriate combinations of ‘nucleophilic’ or ‘electrophilic’ nanoparticle-bound monolayers with nucleophilic or electrophilic mol. modifiers. Thermodynamically governed reactions allow modulation of product compositions, spanning mixed-ligand monolayers to exhaustive exchange. High-d. nanoparticle-stabilizing monolayers facilitate in situ reaction monitoring by quant. 19F NMR spectroscopy. Kinetic anal. reveals that hydrazone exchange rates are moderately diminished by surface confinement, and that the magnitude of this effect is dependent on mechanistic details: surface-bound electrophiles react intrinsically faster, but are more significantly affected by surface immobilization than nucleophiles. Complementary nanoparticles react with each other to form robust covalently connected binary aggregates.

Chemical Science published new progress about Aggregation. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Related Products of 6482-24-2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zhen, Long; Fan, Hui; Wang, Xiaoji; Jiang, Liqin published the artcile< Synthesis of Thiocarbamoyl Fluorides and Isothiocyanates Using CF3SiMe3 and Elemental Sulfur or AgSCF3 and KBr with Amines>, Recommanded Product: 2-Methoxy-N-methylaniline, the main research area is thiocarbamoyl fluoride isothiocyanate preparation amine sulfur trifluoromethyl trimethylsilane.

Reactions of thiocarbonyl fluoride derived from cheap, readily available, and widely used CF3SiMe3, elemental sulfur, and KF with secondary amines and primary amines at room temperature in THF provided a wide variety of thiocarbamoyl fluorides and isothiocyanates in moderate to excellent yields, resp. The two reactions show broad substrate scope and good functional group tolerance. Moreover, AgSCF3 reacts with secondary/primary amines under KBr at room temperature, affording quant. thiocarbamoyl fluorides/isothiocyanates, which feature late-stage application.

Organic Letters published new progress about Fluorides Role: SPN (Synthetic Preparation), PREP (Preparation) (thiocarbamoyl). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Recommanded Product: 2-Methoxy-N-methylaniline.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem