Tag: M.W=100-150

Chen, Yuan; Lu, Fo-Yun; Li, Rui-Xue; Guan, Zhi; He, Yan-Hong published the artcile< Visible-light-mediated Synthesis of Bromo-containing Azaspirotrienediones from N-phenylpropynamides>, Product Details of C8H11NO, the main research area is bromo azaspirotrienedione preparation photochem green chem; phenylpropynamide tandem radical addition ipsocyclization oxidation photocatalyst.

A visible-light-mediated reaction of N-phenylpropynamides 2-R1-3-R2C6H3N(R3)C(=O)CCR4 (R1 = H, Me, OMe; R2 = H, Me, CF3, Cl, F, Br; R1R2 = -CH=CHCH=CH-; R3 = Me, Et, i-Pr, Bn; R4 = Ph, 3-MeOC6H4, 4-MeOC6H4, 4-MeC6H4, 4-CF3C6H4, 4-FC6H4, 4-ClC6H4, 4-BrC6H4) and 1-(3,4-dihydro-1(2H)-quinolinyl)-3-phenyl-2-propyn-1-one with di-Et 2,2-dibromomalonate for the synthesis of bromo-substituted azaspirotrienediones I and II has been developed. This method allows the formation of C-Br, C-C and C=O bonds in one pot via a cascade radical addition/ipso-cyclization/oxidation process. A possible radical mechanism involving single electron transfer and energy transfer processes is proposed based on control experiments, cyclic voltammetry determination and Stern-Volmer quenching experiments

Asian Journal of Organic Chemistry published new progress about Bond formation (C-Br, C-C, C=O). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Product Details of C8H11NO.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Wang, Ning; Chi, Zhuomin; Wang, Xinchao; Gao, Zezhong; Li, Shangda; Li, Gang published the artcile< Formal C-H/C-I Metathesis: Site-Selective C-H Iodination of Anilines Using Aryl Iodides>, Application In Synthesis of 10541-78-3, the main research area is iodinated aniline preparation regioselective; aniline iodination palladium catalyst.

Protocols for the meta- and ortho-C-H iodination of aniline derivatives via formal C(sp2)-H/C(sp2)-I metathesis using 2-nitrophenyl iodides as mild iodinating reagents were reported herein. These protocols led to the production of a range of valuable iodinated aniline derivatives These results demonstrated the potential of developing novel site-selective C-H activation reactions with electron-rich compounds, since mild reagents can often been utilized in functional group metathesis reactions.

Organic Letters published new progress about Anilines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Application In Synthesis of 10541-78-3.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ma, Jiaoli; Li, Jing; Guo, Penghu; Liao, Xincheng; Cheng, Huicheng published the artcile< Synthesis and antitumor activity of novel indole derivatives containing α-aminophosphonate moieties>, Recommanded Product: 2-Methoxy-N-methylaniline, the main research area is aminophosphonate moiety indole derivative antitumor activity.

A series of novel indole derivatives containing α-aminophosphonate moieties were synthesized as antitumor agents. The in vitro cytotoxic activity of the compounds was evaluated against human hepatoma cells (HepG2) and human gastric cancer cells (MGC-803) by MTT assay, revealing that most of target compounds exhibited moderate to high antitumor activities. Among them, compound C5 (IC50 = 34.2 μM) demonstrated superior inhibitory activities against HepG2 compared with 5-fluorouracil (IC50 = 78.7 μM). It is noteworthy that compound B7 (IC50 = 35.7 μM) displayed higher inhibitory activities against MGC-803 than that of 5-fluorouracil (IC50 = 82.0 μM).

Arabian Journal of Chemistry published new progress about Antiproliferative agents. 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Recommanded Product: 2-Methoxy-N-methylaniline.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Li, Jing; Shi, Qiang; Han, Ying; Chen, Chuan-Feng published the artcile< Complexation of 2,6-helic[6]arene and its derivatives with 1,1'-dimethyl-4,4'-bipyridinium salts and protonated 4,4'-bipyridinium salts: an acid-base controllable complexation>, Name: 1-Bromo-2-methoxyethane, the main research area is helicarene preparation inclusion compound formation constant crystal mol structure; 4,4′-bipyridinium salts; complexation; helic[6]arene; hydrogen bond; macrocycles; macrocyclic arene.

2,6-Helic[6]arene and its derivatives I [R = H, Me, (CH2)3, (CH2)2OCH3, (CH2)2OH] were synthesized, and their complexation with 1,1′-dimethyl-4,4′-bipyridinium and protonated 4,4′-bipyridinium salts were investigated in detail. It was found that the helic[6]arene and its derivatives could all form 1:1 complexes with both 1,1′-dimethyl-4,4′-bipyridinium salts and protonated 4,4′-bipyridinium salts II (R1 = H, Me; X = PF6, tetrakis[3,5-bis(trifluoromethyl)phenyl]boranuide) in solution and in the solid state. Especially, the helic[6]arene and its derivatives I [R = (CH2)2OCH3, (CH2)2OH] exhibited stronger complexation with the guests than the other helic[6]arene derivatives for the addnl. multiple hydrogen bonding interactions between the hosts and the guests, which were evidenced by 1H NMR titrations, X-ray crystal structures and DFT calculations Moreover, it was also found that the association constants (Ka) of the complexes could be significantly enhanced with larger counteranions of the guests and in less polar solvents. Furthermore, the switchable complexation between the helic[6]arene and protonated 4,4′-bipyridinium salt could be efficiently controlled by acids and bases.

Beilstein Journal of Organic Chemistry published new progress about Acid-base titration. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Name: 1-Bromo-2-methoxyethane.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Gao, Xinpei; Wu, Fanglin; Mariani, Alessandro; Passerini, Stefano published the artcile< Concentrated Ionic-Liquid-Based Electrolytes for High-Voltage Lithium Batteries with Improved Performance at Room Temperature>, Reference of 6482-24-2, the main research area is concentration ionic liquid electrolyte lithium battery room temperature viscosity; Li-rich cathode; asymmetric anions; ether-functionalized cations; high concentrated electrolytes; ionic liquids.

Ionic liquids (ILs) have been widely explored as alternative electrolytes to combat the safety issues associated with conventional organic electrolytes. However, hindered by their relatively high viscosity, the electrochem. performances of IL-based cells are generally assessed at medium-to-high temperature and limited cycling rate. A suitable combination of alkoxy-functionalized cations with asym. imide anions can effectively lower the lattice energy and improve the fluidity of the IL material. The Li/Li1.2Ni0.2Mn0.6O2 cell employing N-N-diethyl-N-methyl-N-(2-methoxyethyl)ammonium (fluorosulfonyl)(trifluoromethanesulfonyl)imide (DEMEFTFSI)-based electrolyte delivered an initial capacity of 153 mAh g-1 within the voltage range of 2.5-4.6 V, with a capacity retention of 65.5 % after 500 cycles and stable coulombic efficiencies exceeding 99.5 %. Moreover, preliminary battery tests demonstrated that the drawbacks in terms of rate capability could be improved by using Li-concentrated IL-based electrolytes. The improved room-temperature rate performance of these electrolytes was likely owing to the formation of Li+-containing aggregate species, changing the concentration-dependent Li-ion transport mechanism.

ChemSusChem published new progress about Activation energy. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Reference of 6482-24-2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Jiang, Lei; Zhang, Xiaoyan; Wang, Yinran; Guo, Fang; Hou, Zhaomin published the artcile< N-Monomethylation of Amines with Methanol by Syndiotactic Poly(aminostyrene)-supported Palladium Nanoparticle Catalyst>, Recommanded Product: 2-Methoxy-N-methylaniline, the main research area is methyl amine preparation green chem; primary amine methanol monomethylation syndiotactic polyaminostyrene support palladium nanocatalyst.

Palladium nanocatalyst supported on dimethylamino-functionalized syndiotactic polystyrene (Pd@sPSNMe2) showed high activity and selectivity for the N-monomethylation of various primary amines RNH2 (R = Ph, cyclohexyl, 3-(morpholin-4-yl)propyl, 2-(1H-indol-3-yl)ethyl, etc.) using methanol as methylation reagent under air to prepare monomethylated amines RNH(CH3), 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole and N-methyl-1H-benzo[d]imidazole. The excellent catalytic performance could be associated with the ultrafine palladium nanoparticles and high amine-adsorbing capacity of the catalyst. The Pd@sPS-NMe2 catalyst was highly robust, and could be easily recovered by filtration and reused more than ten times without decrease in activity and selectivity.

Asian Journal of Organic Chemistry published new progress about Amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Recommanded Product: 2-Methoxy-N-methylaniline.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Song, Tangqiumei; Morales-Collazo, Oscar; Brennecke, Joan F. published the artcile< Solubility and Diffusivity of Oxygen in Ionic Liquids>, Reference of 6482-24-2, the main research area is oxygen solubility diffusivity ionic liquid gravimetry.

The solubility of O2 was measured gravimetrically in 16 ionic liquids (ILs) containing piperidinium, pyrrolidinium, ammonium, tetrahydrothiophenium, methyltriazabicyclodecene, or guanidinium cations paired with bis(trifluoromethanesulfonyl)imide, bis(perfluoroethylsulfonyl)imide, or perfluoropropanoyl(trifluoromethylsulfonyl)imide anions. The temperature dependence of the solubility was determined for eight of the ILs. Henry’ law constants were determined from the solubility data as well as standard enthalpies and entropies of absorption for systems with temperature-dependent data. Knowledge of these thermodn. properties is essential in guiding the structural design of ionic liquids for different applications involving O2. The O2 solubility did not follow any obvious trend with regard to IL structure or molar volume; instead, the dipole-quadrupole interactions are the primary driving forces for O2 dissolution in ionic liquids, as demonstrated by neg. standard enthalpies of absorption for all of the ILs. In addition, diffusion coefficients of O2 in the ILs as a function of temperature (293, 313, and 333 K) and applied O2 pressure (1, 3, and 5 MPa) were obtained by fitting the time-dependent absorption data to a widely used mass diffusion model. The diffusion coefficients of O2 in ionic liquids at 293 K and 1 MPa roughly correlate inversely with the pure IL viscosity, likely due to the relatively low and similar O2 solubilities under these conditions. As expected, O2 diffusivities increase with increasing temperature However, they also increase with increasing pressure, likely due to decreasing solution viscosity with increasing gas solubility

Journal of Chemical & Engineering Data published new progress about Absorption. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Reference of 6482-24-2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Frank, Aziza; Hamidi, Negar; Xue, Fengtian published the artcile< Regioselective alkylation of 2,4-dihydroxybenzyaldehydes and 2,4-dihydroxyacetophenones>, Name: 1-Bromo-2-methoxyethane, the main research area is alkoxy hydroxybenzaldehyde regioselective preparation; dihydroxybenzaldehyde alkyl bromide alkylation cesium bicarbonate; hydroxyacetophenone alkoxy regioselective preparation; dihydroxyacetophenone alkylation alkyl bromide cesium bicarbonate; Alkylation; Cesium bicarbonate; Regioselective; Scalable.

A cesium bicarbonate-mediated alkylation of 2,4-dihydroxybenzaldehyde and 2,4-dihydroxyacetophenone to generate 4-alkylated 2-hydroxybenzaldehydes/2-hydroxyacetophenones I [R = Br, Me, OMe, etc.; R1 = H, Me] in acetonitrile at 80°C with excellent regioselectivity, up to 95% isolated yields, and broad substrate scope was reported.

Tetrahedron Letters published new progress about Acetophenones Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (o-hydroxy). 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Name: 1-Bromo-2-methoxyethane.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Nishimura, Rodolfo H. V.; dos Santos, Thiago; Murie, Valter E.; Furtado, Luciana C.; Costa-Lotufo, Leticia V.; Clososki, Giuliano C. published the artcile< Efficient N-arylation of 4-chloroquinazolines en route to novel 4-anilinoquinazolines as potential anticancer agents>, COA of Formula: C8H11NO, the main research area is halophenyl anilinoquinazoline preparation microwave irradiation green chem antitumor human; chloroquinazoline aniline arylation; 4-anilinoquinazoline; 4-chloroquinazoline; N-arylation; anticancer agents; microwave irradiation.

Microwave-mediated N-arylation of 4-chloroquinazolines in THF/H2O rapidly and efficiently afforded a library of novel 6-halo-2-phenyl-substituted 4-anilinoquinazolines. The methodol. was compatible with numerous ortho-, meta-, and para-substituted N-methylanilines as well as substituted anilines and furnished the corresponding 4-anilinoquinazolines in good yields. Preliminary screening of the synthesized compounds against tumor cells (HCT-116 and T98G) showed promising antiproliferative properties.

Beilstein Journal of Organic Chemistry published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, COA of Formula: C8H11NO.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Spadaro, Angelo; Rao, Marco; Lorenti, Miriam; Romano, Mario Rosario; Augello, Antonio; Eandi, Chiara Maria; Platania, Chiara Bianca Maria; Drago, Filippo; Bucolo, Claudio published the artcile< New brilliant blue G derivative as pharmacological tool in retinal surgery>, Formula: C3H7BrO, the main research area is alkyl brilliant blue inner limiting membrane retina vitreoretinal surgery; Brilliant Blue G; drug design; inner limiting membrane; pucker; retina; vitreoretinal surgery.

Our study was aimed at assessing the retinal binding of a new synthetic Brilliant Blue G (BBG) derivative (pure benzyl-Brilliant Blue G; PBB) ophthalmic formulation, to improve vitreoretinal surgery procedure. Protein affinity of the new mol. was evaluated in vitro (cell-free assay) and in silico. Furthermore, an ex vivo model of vitreoretinal surgery was developed by using porcine eyes to assess the pharmacol. profile of PBB, compared to com. formulations based on BBG and methyl-BBG (Me-BBG). PBB showed a higher affinity for proteins (p < 0.05), compared to BBG and Me-BBG. In vitro and in silico studies demonstrated that the high selectivity of PBB could be related to high lipophilicity and binding affinity to fibronectin, the main component of the retinal internal limiting membrane (ILM). The PBB staining capabilities were evaluated in porcine eyes in comparison with BBG and Me-BBG. Forty microliters of each formulation were slowly placed over the retinal surface and removed after 30 s. After that, ILM peeling was carried out, and the retina collected. BBG, Me-BBG, and PBB quantification in ILM and retina tissues was carried out by HPLC anal. PBB levels in the ILM were significantly (p < 0.05) higher compared to BBG and Me-BBG formulations. On the contrary, PBB showed a much lower (p < 0.05) distribution in retina (52 ng/mg tissue) compared to BBG and Me-BBG, in particular PBB levels were significantly (p < 0.05) lower. Therefore, the new synthetic Brilliant Blue derivative (PBB) showed a great ILM selectivity in comparison to underneath retinal layers. In conclusion, these findings had high translational impact with a tangible improving in ex vivo model of retinal surgery, suggesting a future use during surgical practice. Frontiers in Pharmacology published new progress about Bovine serum albumin Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Formula: C3H7BrO.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem