Tag: M.W=100-150

Ethers are a class of organic compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether.They have the general formula R–O–R′, where R and R′ represent the alkyl or aryl groups. HPLC of Formula: 111-90-0.

Khalilollah, Parandis;Shokri, Javad;Ahmadi, Seyedehzahra;Monajjemzadeh, Farnaz research published 《 Effects of transcutol p and precirol ATO-5 on percutaneous absorption of flutamide from emulgels》, the research content is summarized as follows. Flutamide is a non-steroidal anti-androgenic agent which is not only used in treating prostate cancer but also can be effective in some disorders such as androgenic alopecia and male pattern baldness. Several serious side effects for systemic administration of flutamide can be overcome by emulgel dosage form. Absorption enhancers can promote permeation of flutamide through skin. Percutaneous absorption of Flutamide emulgels with different concentrations of Transcutol P and Precirol ATO5 was studied. Various emulgel formulations using different concentrations of Transcutol P and Precirol ATO5 with 0.5 to 5% weight/weight were prepared Percutaneous absorption was tested with standard Franz Diffusion Cell equipment using full thickness rat skin. Drug concentrations in the samples were analyzed by High-Performance Liquid Chromatog. (HPLC) equipped with UV-Vis detector at 305 nm. The percutaneous absorption of flutamide emulgels formulated with enhancers was higher than control formulations. The enhancement ratio increased from 1.218 to 3.670 and 1.346 to 3.900 for Precirol ATO5 and Transcutol P, resp. The area under the Curve (AUC) increased by increasing the enhancers’ concentration and a significant upsurge was seen in the concentration 1% for both enhancers. The flutamide emulgel containing 1% Transcutol P showed more appropriate percutaneous absorption through the skin compared to others.

111-90-0, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., HPLC of Formula: 111-90-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers do have nonbonding electron pairs on their oxygen atoms, 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds. Recommanded Product: Diethylene Glycol Monoethyl Ether.

Khandelwal, Mukul K.;Srinivasan, Bharath;Kumari, Kabita;Jayaraman, Anbu;Rajamanickam, Deveswaran research published 《 Peroral delivery of risedronate sodium for treatment of osteoporosis》, the research content is summarized as follows. Oral route of administration is considered as most widely accepted route which is a potential site for drug delivery, direct access to systemic circulation and site of action. Bisphosphonates are the class of drugs which have been approved for clin. use in osteoporosis and other bone diseases. Bisphosphonates are very poorly absorbed from the GI tract and have limited bioavailability of less than 1% with adverse gastrointestinal effects in humans. The present work aimed to develop sublingual spray formulation using Risedronate sodium with combination of Pullulan gum and HPMC E5. Formulation of sublingual spray was developed by employing optimization technique. The optimized formulation was selected and evaluated for various pharmaco-tech. parameters such as viscosity, spray angle, drug content per actuation, In-vitro drug diffusion study, Ex-vivo permeation study and In-vivo pharmacodynamics study by glucocorticoid induced model in rats. Pharmaco-tech. parameter results of optimized formulation showed satisfactory results. Comparative In-vitro drug permeation and ex-vivo permeation studies showed maximum drug release of 85% for optimized formulation incorporated with permeation enhance transcutol. In-vivo pharmacodynamic study showed better efficacy in treatment animals with optimized formulation and thus newly developed risedronate sodium sublingual spray proved to be effective used in treatment of osteoporosis.

111-90-0, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., Recommanded Product: Diethylene Glycol Monoethyl Ether

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ethers do have nonbonding electron pairs on their oxygen atoms, 111-90-0, formula is C6H14O3, Name is Diethylene Glycol Monoethyl Ether. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds. Recommanded Product: Diethylene Glycol Monoethyl Ether.

Khoa Huynh, Nguyen Anh;Do, Thi Hong Tuoi;Le, Xuan Loc;Huynh, Truc Thanh Ngoc;Nguyen, Duc Hanh;Tran, Ngoc Khue;Tran, Cao Thuy Ha Lan;Nguyen, Dai Hai;Truong, Cong Tri research published 《 Development of softgel capsules containing cyclosporine a encapsulated pine essential oil based self-microemulsifying drug delivery system》, the research content is summarized as follows. In this study, a new self-microemulsifying drug delivery system (SMEDDS) based on pine essential oil has been designed and successfully developed to load cyclosporine A (CsA), a poorly water-soluble immunosuppressant, for oral CsA softgel manufacturing SMEDDS were prepared from pine essential oil and Capmul MCM as oily phases, Kolliphor RH 40 as surfactant, polyethylen glycol 400 as co-surfactant/co-solvent and none volatized co-solvent utilizing the pseudo-ternary phase diagrams. CsA SMEDDS loading 9.09% of CsA, dispersed in aqueous environments (water, pH 1.2, 4.5 and 6.8 buffers), presented an average droplet size of about 160 nm with polydispersity index (PdI) below 0.25, and were stable after 6 h of self-emulsification. Cytotoxicity of CsA SMEDDS on LLC-PK1 cells demonstrated that CsA SMEDDS had an IC50 value greater than that of the reference product, suggesting product safety against nephrotoxicity. CsA SMEDDS was filled into oval-5 soft gelatin capsules (softgels) containing 0.5% glycine which could avoid the crosslinking process. Addnl., CsA SMEDDS softgels presented the in vitro release profiles equivalent to that of Sandimmun Neoral at pH 1.2, 4.5 and 6.8. Therefore, the pine essential oil based SMEDDS was considered to be potential and suitable for developing softgels to enhance the oral bioavailability of CsA.

111-90-0, Diethylene glycol monoethyl ether appears as a colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.
Diethylene glycol monoethyl ether is a primary alcohol that is ethanol substituted by a 2-ethoxyethoxy group at position 2. It has a role as a protic solvent. It is a diether, a primary alcohol and a hydroxypolyether. It derives from a diethylene glycol., Recommanded Product: Diethylene Glycol Monoethyl Ether

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Sun, Wei; Raimbach, William A. T.; Elliott, Luke D.; Booker-Milburn, Kevin I.; Harrowven, David C. published the artcile< New approaches to ondansetron and alosetron inspire a versatile, flow photochemical method for indole synthesis>, Product Details of C8H11NO, the main research area is aryl amino cycloalkenone iodine catalyst oxidative photocyclization; tetrahydro cycloalkaindolone preparation; arylamino alkenone iodine catalyst oxidative photocyclization; indolyl alkenone preparation.

An oxidative photocyclization of N-arylenaminones to indoles was described, that mirrored the Fischer indole synthesis but used anilines in place of arylhydrazines. Its value was exemplified with new approaches to the WHO-listed APIs ondansetron and alosetron.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aromatic amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Product Details of C8H11NO.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Iijima, Daisuke; Sugama, Hiroshi; Awai, Nobumasa; Takahashi, Yoichi; Togashi, Yuko; Takebe, Tohru; Xie, Jianshu; Shen, Jingkang; Ke, Ying; Akatsuka, Hidenori; Kawaguchi, Takayuki; Takedomi, Kei; Kashima, Akiko; Nishio, Masashi; Inui, Yosuke; Yoneda, Hikaru; Xia, Guangxin; Iijima, Toru published the artcile< Discovery of Novel 2-Carbamoyl Morpholine Derivatives as Highly Potent and Orally Active Direct Renin Inhibitors>, Electric Literature of 6482-24-2, the main research area is carbamoyl morpholine derivative preparation oral renin inhibitor hypertension.

The renin-angiotensin-aldosterone system (RAAS) plays a key role in the regulation of blood pressure. Renin, the first and rate-limiting enzyme of the RAAS, is an attractive target for the treatment of hypertension and cardiovascular/renal diseases. Therefore, various direct renin inhibitors (DRIs) have been researched over recent decades; however, most exhibited poor pharmacokinetics and oral bioavailability due to the peptidomimetic or nonpeptidomimetic structures with a mol. weight (MW) of >600, and only aliskiren is approved. This study introduces a novel class of DRIs comprised of a 2-carbamoyl morpholine scaffold. These compounds have a nonpeptidomimetic structure and a MW of <500. The representative compound 26 was highly potent despite not occupying S1′-S2′ sites or the opened flap region used by other DRIs and exerted a significant antihypertensive efficacy via oral administration on double transgenic mice carrying both the human angiotensinogen and the human renin genes. ACS Medicinal Chemistry Letters published new progress about Antihypertensives. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Electric Literature of 6482-24-2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Chen, Yan; Bian, Yuemin; Wang, Jian-Wei; Gong, Ting-Ting; Ying, You-Min; Ma, Lie-Feng; Shan, Wei-Guang; Xie, Xiang-Qun; Zhan, Zha-Jun published the artcile< Effects of α-Mangostin Derivatives on the Alzheimer's Disease Model of Rats and Their Mechanism: A Combination of Experimental Study and Computational Systems Pharmacology Analysis>, Application of C8H11NO, the main research area is mangostin derivative preparation Alzheimer’s neuroprotectant memory learning cognition.

α-Mangostin (α-M) is a natural xanthone from the pericarp of fruit Garcinia mangostana and possesses versatile biol. activities. α-M has a therapeutic potential to treat Alzheimer’s disease (AD) because of its anti-inflammatory, antioxidative, and neuroprotective activities. However, the use of α-M for AD treatment is limited due to its cytotoxic activities and relatively low potency. Modifications of its chem. structure were needed to reduce its cytotoxicity and improve its therapeutic potential against AD. For this purpose, 16 α-M carbamate derivatives were synthesized. An animal model of AD was established, and the effects of AMG-1 on the spatial learning ability and memory ability were evaluated using behavioral tests. The effect on neuropathol. was tested by histopathol. evaluation, Nissl staining, and silver staining. Computational systems pharmacol. anal. using the chemogenomics knowledgebase was applied for network studies. Compound-target, target-pathway, and target-disease networks were constructed, integrating both in silico anal. and reported exptl. data. The results show that AMG-1 can demonstrate its therapeutic effects in a one-mol., multiple-targets manner to remarkably ameliorate neurol. changes and reverse behavioral deficits in AD model rats. The improved cognitive function and alleviated neuronal injury can be observed The ability of AMG-1 to scavenge β-amyloid in the hippocampus was validated in AD model rats.

ACS Omega published new progress about Alzheimer disease. 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Application of C8H11NO.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

McNeice, Peter; Vallana, Federico M. F.; Coles, Simon J.; Horton, Peter N.; Marr, Patricia C.; Seddon, Kenneth R.; Marr, Andrew C. published the artcile< Quinine based ionic liquids: A tonic for base instability>, Formula: C3H7BrO, the main research area is quinine ionic liquid catalyst preparation crystal structure; malononitrile benzaldehyde quinine catalyst Knoevenagel condensation.

Six basic ionic liquids were synthesized from the natural mol. quinine, including one room temperature ionic liquid The thermal properties were studied and the basicity analyzed by Hammett measurements. The properties are discussed in relation to the crystal structure of one of the salts, [C4Qn][NTf2] and electron d. models generated using Spartan. The ionic liquids were shown to catalyze the Knoevenagel condensation of malononitrile and benzaldehyde.

Journal of Molecular Liquids published new progress about Crystal structure. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Formula: C3H7BrO.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Liang, Yuwei; Niu, Linbin; Liang, Xing-An; Wang, Shengchun; Wang, Pengjie; Lei, Aiwen published the artcile< Electrooxidation-Induced C(sp3)-H/C(sp2)-H Radical-Radical Cross-Coupling between Xanthenes and Electron-Rich Arenes>, Safety of 2-Methoxy-N-methylaniline, the main research area is xanthene aryl preparation; arene electrooxidation radical cross coupling xanthene.

Herein, an electrooxidation-induced alkylation of electron-rich arenes, such as anilines, imidazo[1,2-a]pyridines, etc., with xanthenes with H2 evolution under exogenous oxidant-free conditions, avoiding the utilization of metal catalysts, is reported. This protocol is well performed with various electron-rich aniline derivatives and nitrogen-containing heterocyclic compounds This electro-oxidative C(sp3)-H arylation represents an important expansion for the classic arenes alkylation, thereby proving that an attractive strategy for the developments of radical cross-coupling chem. was anticipated.

Chinese Journal of Chemistry published new progress about Alkylation. 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Safety of 2-Methoxy-N-methylaniline.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Katayama, Shin-taro; Nishino, Hiroshi published the artcile< Facile synthesis of spiro[cyclohexane-1,3'-indoline]-2,2'-diones>, Computed Properties of 10541-78-3, the main research area is phenyl methyl oxocyclohexane carboxamide preparation one pot oxidative heterocyclization; methylspiro oxocyclohexane indolinone preparation.

Spiro[cyclohexane-1,3′-indoline]-2,2′-diones were easily prepared in good to high yields by the oxidation of N-aryl-N-methyl-2-oxocyclohexane-1-carboxamides in one-pot with a short reaction time. The spiroindolinediones could be important for the total synthesis of natural products.

Heterocyclic Communications published new progress about Amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Computed Properties of 10541-78-3.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Huang, Shuang; Hong, Xi; Cui, He-Zhen; Zhou, Quan; Lin, Yue-Jian; Hou, Xiu-Feng published the artcile< N-Methylation of ortho-substituted aromatic amines with methanol catalyzed by 2-arylbenzo[d]oxazole NHC-Ir(III) complexes>, Related Products of 10541-78-3, the main research area is arylamine methanol arylbenzoxazole iridium complex catalyst methylation green chem; methyl arylamine preparation.

Seven new chelated cyclometalated Ir complexes of ABON,P, ABON,O and ABON,C(carbene) based on a rigid and tunable 2-arylbenzo[d]oxazole backbone were prepared for the N-methylation of amines. Among these three coordinated modes, ABON,C(carbene)-chelated iridium-based catalysts exhibited good performance in the monomethylation of aromatic amines with methanol (MeOH) as the green methylation reagent. The steric-modified synthesis of ABON,C(carbene) complexes was described. The most active ABON,C(carbene) complex with marginal steric hindrance as a catalyst was obtained from the benzoxazole ring without a substituent and Me group of the benzimidazole ring on the N-heterocyclic carbene (NHC) ligand. A variety of amines including para- and meta-substituted aromatic amines, as well as heterocyclic amines, were formulated as suitable substrates. Importantly, this catalyst considerably promoted the yield of the N-methylation of ortho-substituted aromatic amines. Controlled kinetic experiments and deuterium-labeling reactions of these ortho-substituted amines were conducted under optimized conditions. On the basis of the exptl. results, a plausible mechanism was proposed.

Dalton Transactions published new progress about Benzoxazoles Role: CAT (Catalyst Use), PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), USES (Uses), RACT (Reactant or Reagent), PREP (Preparation). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Related Products of 10541-78-3.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem