Tag: M.W=100-150

Li, Zhibin published the artcileSelective electrochemical oxidation of aromatic hydrocarbons and preparation of mono/multi-carbonyl compounds, Quality Control of 6850-57-3, the publication is Science China: Chemistry (2021), 64(12), 2134-2141, database is CAplus.

A selective electrochem. oxidation was developed under mild condition. Various mono-carbonyl and multi-carbonyl compounds can be prepared from different aromatic hydrocarbons with moderate to excellent yield and selectivity by virtue of this electrochem. oxidation The produced carbonyl compounds can be further transformed into α-ketoamides, homoallylic alcs. and oximes in a one-pot reaction. In particular, a series of α-ketoamides were prepared in a one-pot continuous electrolysis. Mechanistic studies showed that 2,2,2-trifluoroethan-1-ol (TFE) can interact with catalyst species and generate the corresponding hydrogen-bonding complex to enhance the electrochem. oxidation performance.

Science China: Chemistry published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Quality Control of 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

You, Hongyun published the artcileHydrogenation of Lignin-derived Phenolic Compounds over Ru/C Enhanced by Al₂O₃ Catalyst at Room Temperature, Recommanded Product: 1,2-Dimethoxybenzene, the publication is ChemistrySelect (2022), 7(19), e202200709, database is CAplus.

In this study, an efficient hydrogenation of phenols using Ru/C enhanced Al₂O₃ as catalyst at room temp to obtain cyclohexanols R-OH [R = 2-MeC₆H₁₁, 3-MeC₆H₁₁, 2-MeOC₆H₁₁, etc.] with selectivity close to 100% was reported. The addition of Al₂O₃ could made a significant difference on the phenol adsorption by the introduction of abundant Lewis acid site, which enabled activate aromatic rings by changing the electrophilic substitution reaction of aromatic groups and triggered the occurrence of phenol hydrogenation under the catalysis of Ru/C. The Lewis acid site and metal site cooperated with each other and promoted the conversion of phenols to cyclohexanols as the final products. Moreover, a variety of other phenolic or aromatic compounds were also tested. The steric effects derived from the different substituted groups on aromatic rings had a significant influence on the hydrogenation performances.

ChemistrySelect published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H5F3O3, Recommanded Product: 1,2-Dimethoxybenzene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Li, Zhen published the artcileAn S-scheme α-Fe₂O₃/Cu₂O photocatalyst for an enhanced primary amine oxidative coupling reaction under visible light, Safety of (2-Methoxyphenyl)methanamine, the publication is Dalton Transactions (2022), 51(27), 10578-10586, database is CAplus and MEDLINE.

Here, an S-scheme α-Fe₂O₃/Cu₂O heterojunction photocatalyst was designed and fabricated for the primary amines oxidative coupling reaction to give aryl imines. On account of that, the S-scheme structure effectively separated the photogenerated electron-hole pairs and enhanced the photoredox ability of the photocatalytic system. The α-Fe₂O₃/Cu₂O composite could also enhance the reactivity to a large extent. This work will provide new insight into the design of photocatalysts with a more reasonable structure and higher performance.

Dalton Transactions published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Safety of (2-Methoxyphenyl)methanamine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Kang, Qiaoxiang published the artcileHollow multi-shelled In₂S₃ hierarchical nanotubes for enhanced photocatalytic oxidative coupling of benzylamine, Quality Control of 6850-57-3, the publication is Journal of Solid State Chemistry (2022), 123087, database is CAplus.

The unique structural features of the hollow and hierarchical structures give light to the developing categories of photocatalysts as a promising way to deal with the challenges involved in the process of heterogeneous photocatalysis. Herein, hollow multi-shelled In₂S₃ hierarchical nanotubes have been fabricated using NH₂-MIL-68 (In) as template and TAA. The results demonstrated that hollow multi-shelled In₂S₃ hierarchical nanotubes has been used as an efficient photocatalyst for the coupling of benzylamines under visible light irradiation and aerobic or anaerobic conditions, which burst out of the shackles of the reported reaction conditions. And the conversion and selectivity reached 74% and 99%, resp. The hierarchical structure with nanosheet on the surface of hollow multi-shelled nanotube have effectively promote the mass transfer and photogenerated carrier separation, increasing the number of reactive points. Then, it also has proved that the hole (h⁺), the nitrogen-centered radical cations as well as the carbon-centered radicals were most important in the reaction. This work provides a novel concept for further design of unique structural photocatalyst for boosting the catalytic activity.

Journal of Solid State Chemistry published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Quality Control of 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Xing, Chuanwang published the artcilePerylenetetracarboxylic diimide covalently bonded with mesoporous g-C₃N₄ to construct direct Z-scheme heterojunctions for efficient photocatalytic oxidative coupling of amines, Application In Synthesis of 6850-57-3, the publication is Applied Catalysis, B: Environmental (2021), 120534, database is CAplus.

Photocatalytic oxidative coupling of amines is a promising method for imine synthesis. In this paper, a robust covalently-bonded direct Z-scheme heterostructure (PDI/mpgCN) for photocatalytic oxidative coupling of amine was reported for the first time. Perylenetetracarboxylic diimide (PDI) mols. were covalently connected to the surface of mesoporous carbon nitride (mpgCN) via an in-situ condensation strategy. Compared with the poor conversion efficiency upon pristine g-C₃N₄, PDI/mpgCN heterostructure exhibits a remarkable enhancement on amine oxidation rate (AOR), with the optimal AOR reaches to as high as 20.63 mmol g^-1 h^-1 upon 20 % PDI/mpgCN. As far as we know, it is the highest AOR achieved so far for amine photooxidation coupling with heterojunction materials. Transient absorption studies proved the formation of Z-scheme junction, and efficient interfacial charge transfer. Our study not only makes an insight into the heterojunction design with chem. bond precision, but highlights the great prospects of Z-scheme photocatalyst in photo-chem. synthesis.

Applied Catalysis, B: Environmental published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C10H9IO4, Application In Synthesis of 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Mei, Xinyi published the artcileSynthesis of new fluorine-containing room temperature ionic liquids and their physical and electrochemical properties, HPLC of Formula: 2358-54-5, the publication is Journal of Fluorine Chemistry (2018), 26-37, database is CAplus.

An improved synthesis of fluorine-containing room temperature ionic liquids (FRTILs) is described. Twelve FRTILs are synthesized, in which the fluorinated cations based on N-Me pyrrolidinium (MPy), 1-Me imidazolium (MIm) and diethylsulfide (DES) are associated with anions, such as dicyanamide (DCA) or bis(trifluoromethane sulfonyl)imide (TFSI). The mol. structures of these FRTILs were confirmed by FT-IR, ¹H-NMR, ¹³C-NMR and elemental anal. The FRTILs have been investigated for their potential as electrolyte solvents, especially for lithium-sulfur (Li-S) batteries. Thermal behaviors were also studied by thermogravimetric anal. (TGA) and differential scanning calorimetry (DSC) showing excellent thermal stability, exceeding 150°C, for all FRTILs. Some of their physicochem. properties were determined, including d., flammability, viscosity, and miscibility with polar and nonpolar solvents. Due to the high viscosity of FRTILs, two low viscosity ILs (co-solvent thinners), [MImEt] [DCA] and [MImEt] [TFSI], have been synthesized and used to dilute the FRTILs. The resulting ternary electrolyte systems, LiTFSI in 1:1wt.% FRTILs/thinner, were characterized by their ionic conductivity and electrochem. stability.

Journal of Fluorine Chemistry published new progress about 2358-54-5. 2358-54-5 belongs to ethers-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-(2,2,2-Trifluoroethoxy)ethanol, and the molecular formula is C4H7F3O2, HPLC of Formula: 2358-54-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Taguchi, Hiroyasu published the artcileSynthesis and Tautomerism of Curcumin Derivatives and Related Compounds, Safety of 2-(2,2,2-Trifluoroethoxy)ethanol, the publication is Australian Journal of Chemistry (2015), 68(2), 224-229, database is CAplus.

1,7-Bis(4′-hydroxy-3′-trifluoromethoxyphenyl)-1,6-heptadiene-3,5-dione, related to curcumin, and thirteen 4-substituted derivatives were prepared and their keto/enol ratio in DMSO[D6] was determined by 19F NMR because the enolic form of these related curcumins had been shown to bind to amyloid plaques in the Alzheimer brain. The parent compound and the 4-ethoxycarbonyl derivative were almost 100% in the enolic form that contains a conjugated hepta-1,4,6-trien-3-on-5-ol backbone. Enolisation decreased to varying amounts in the derivatives that had 4-substituted alkyl groups. Attempts to prepare the 4-hydroxypropyl derivative by hydrolysis of O-methoxymethyl or O-tetrahydropyranyloxy protected derivatives led to cyclised products. A related pyrimidine compound that mimicked a fixed enol form was also prepared

Australian Journal of Chemistry published new progress about 2358-54-5. 2358-54-5 belongs to ethers-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-(2,2,2-Trifluoroethoxy)ethanol, and the molecular formula is C5H5BrN2, Safety of 2-(2,2,2-Trifluoroethoxy)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhao, Lingyue published the artcileDesign, synthesis, and biological evaluation of arylmethylpiperidines as Kv1.5 potassium channel inhibitors, Product Details of C8H11NO, the publication is Journal of Enzyme Inhibition and Medicinal Chemistry (2022), 37(1), 462-471, database is CAplus and MEDLINE.

Kv1.5 potassium channel, encoded by KCNA5, is a promising target for the treatment of atrial fibrillation, one of the common arrhythmia. A new series of arylmethylpiperidines derivatives based on were synthesized and evaluated for their ability to inhibit Kv1.5 channel. Among them, compound showed good inhibitory activity (IC50 = 0.72 μM), preferable anti-arrhythmic effects and favored safety. These results indicate that can be a promising Kv1.5 inhibitor for further studies.

Journal of Enzyme Inhibition and Medicinal Chemistry published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C4H5NS2, Product Details of C8H11NO.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Lillich, Felix F. published the artcileStructure-Based Design of Dual Partial Peroxisome Proliferator-Activated Receptor γ Agonists/Soluble Epoxide Hydrolase Inhibitors, Recommanded Product: (2-Methoxyphenyl)methanamine, the publication is Journal of Medicinal Chemistry (2021), 64(23), 17259-17276, database is CAplus and MEDLINE.

A dual partial PPARγ agonist/sEH inhibitor using a structure-guided approach was designed. Exhaustive structure-activity relationship studies lead to the successful optimization of the designed lead. Crystal structures of one representative compound with both targets revealed potential points for optimization. The optimized compounds exhibited favorable metabolic stability, toxicity, selectivity, and desirable activity in adipocytes and macrophages.

Journal of Medicinal Chemistry published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Recommanded Product: (2-Methoxyphenyl)methanamine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Wang, Xuebao published the artcileDiscovery of N-substituted sulfamoylbenzamide derivatives as novel inhibitors of STAT3 signaling pathway based on Niclosamide, Safety of (2-Methoxyphenyl)methanamine, the publication is European Journal of Medicinal Chemistry (2021), 113362, database is CAplus and MEDLINE.

Signal transducer and activator of transcription 3 (STAT3) has been confirmed as an attractive therapeutic target for cancer therapy. Herein, a series of N-substituted sulfamoylbenzamide STAT3 inhibitors I [R¹ = H, OH; R² = H, Cl; R³ = 2-MeOC₆H₄, 3,4,5-(OMe)₃C₆H₂, 3-MeOC₆H₄CH₂, etc.; R⁴ = H, C(O)Me, C(O)Ph, etc.] based on small-mol. STAT3 inhibitor Niclosamide was synthesized. Compound I [R¹ = H, R² = Cl, R³ = 4-CO₂t-BuC₆H₄, R⁴ = H] the best active compound of this series, was identified as an inhibitor of IL-6/STAT3 signaling with an IC₅₀ of 0.61-1.11μM in MDA-MB-231, HCT-116 and SW480 tumor cell lines with STAT3 overexpression, by inhibiting the phosphorylation of STAT3 of Tyr705 residue and the expression of STAT3 downstream genes, inducing apoptosis and inhibiting the migration of cancer cells. Furthermore, in vivo study revealed that compound I [R¹ = H, R² = Cl, R³ = 4-CO₂t-BuC₆H₄, R⁴ = H] suppressed the MDA-MB-231 xenograft tumor growth in nude mice at the dose of 30 mg/kg (i.g.), which has better antitumor activity than the pos. control Niclosamide. More importantly, compound I [R¹ = H, R² = Cl, R³ = 4-CO₂t-BuC₆H₄, R⁴ = H] was an orally bioavailable anticancer agent as a promising candidate for further development.

European Journal of Medicinal Chemistry published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C10H10O2, Safety of (2-Methoxyphenyl)methanamine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem