Tag: M.W=100-150

Sabat, Nazarii published the artcileUnbiased C3-Electrophilic Indoles: Triflic Acid Mediated C3-Regioselective Hydroarylation of N-H Indoles, Product Details of C8H10O2, the publication is Angewandte Chemie, International Edition (2022), 61(30), e202204400, database is CAplus and MEDLINE.

The direct dearomative addition of arenes to the C3 position of unprotected indoles is reported under operationally simple conditions, using triflic acid at room temperature The present regioselective hydroarylation is a straightforward manner to generate an electrophilic indole at the C3 position from unbiased indoles in sharp contrast to previous strategies. This atom-economical method delivers biol. relevant 3-arylindolines and 3,3-spiroindolines in high yields and regioselectivities from both intra- and intermol. processes. DFT computations suggest the stabilization of cationic or dicationic intermediates with H-bonded (TfOH)n clusters.

Angewandte Chemie, International Edition published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Product Details of C8H10O2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhang, Huan-Huan published the artcilePhotocatalytic Hydrogen Evolution Coupled with Production of Highly Value-Added Organic Chemicals by a Composite Photocatalyst CdIn₂S₄@MIL-53-SO₃Ni_1/2, Synthetic Route of 6850-57-3, the publication is Chemistry – An Asian Journal (2021), 16(11), 1499-1506, database is CAplus and MEDLINE.

Photocatalytic water splitting coupled with the production of highly value-added organic chems. is of significant importance, which represents a very promising pathway for transforming green solar energy into chem. energy. Herein, we report a composite photocatalyst CdIn₂S₄@MIL-53-SO₃Ni_1/2, which is highly efficient on prompting water splitting for the production of H₂ in the reduction half-reaction and selective oxidation of organic mols. for the production of highly value-added organic chems. in the oxidation half-reaction under visible light irradiation The superior photocatalytic properties of the composite photocatalyst CdIn₂S₄@MIL-53-SO₃Ni_1/2 should be ascribed to coating suspended ion catalyst (SIC), consisting of redox-active Ni^II ions in the anionic pores of coordination network MIL-53-SO₃^–, on the surface of photoactive CdIn₂S₄, which endows photogenerated electron-hole pairs sep. more efficiently for high rate production of H₂ and selective production of highly value-added organic products, demonstrating great potential for practical applications.

Chemistry – An Asian Journal published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C5H10Cl3O3P, Synthetic Route of 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Wei, Yanze published the artcileCdSe 1D/2D Mixed-Dimensional Heterostructures: Curvature-Complementary Self-Assembly for Enhanced Visible-Light Photocatalysis, SDS of cas: 6850-57-3, the publication is Small (2021), 17(33), 2102047, database is CAplus and MEDLINE.

Mixed-dimensional heterostructures (MDHs), which combine nanomaterials of different dimensionalities deliver on the promise to bypass intrinsic limitations of a given low-dimensional material. Here, a strategy to engineer MDHs between two low-dimensional materials by curvature-complementary self-assembly is described. CdSe nanotubes rolled from 2D nanosheets and 1D CdSe nanorods, with neg. and pos. curvatures, resp., are selected to illustrate complementary curvature self-assembly. The assembly process, optical, and photoelec. properties of the CdSe MDHs are thoroughly investigated. Several remarkable features of CdSe MDHs, including increased light absorption, efficient charge separation, and appropriate bandgap structure are confirmed. The MDHs significantly alleviate the sluggish kinetics of electron transfer in the quantum sized CdSe subunits (onset potential of 0.21 V vs RHE for MDHs; 0.4 V lower than their low-dimensional building blocks), while the spatial nano-confinement effect in the CdSe MDHs also assists the interfacial reaction kinetics to render them ideal photocatalysts for benzylamine oxidation (conversion > 99% in 4 h with a two times higher rate than simple mixtures). The results highlight opportunities for building MDHs from low-dimensional building blocks with curvature-complementary features and expand the application spectrum of low dimensional materials in artificial photosynthesis.

Small published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is Al2H32O28S3, SDS of cas: 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Li, Xia published the artcileExtending the 2D conjugated microporous polymers linked by thiazolo[5,4-d]thiazole for green light-driven selective aerobic oxidation of amines, Safety of (2-Methoxyphenyl)methanamine, the publication is Journal of Materials Chemistry A: Materials for Energy and Sustainability (2022), 10(28), 14965-14975, database is CAplus.

Donor-π-acceptor (D-π-A) type CMPs linked by the electron-deficient thiazolo[5,4-d]thiazole (TzTz, i.e. the acceptor) were designed by extending the donor from benzene to pyrene to broaden the visible light activity. Subsequently, two-dimensional (2D) CMPs, TzTz-CMP-Be and TzTz-CMP-Py, were constructed via a solvothermal process. The more extended π-conjugation and planar pyrene bestow upon TzTz-CMP-Py with broader absorption of visible light and higher efficiency of charge transfer than TzTz-CMP-Be. Significantly, TzTz-CMP-Py outperformed TzTz-CMP-Be in the green light-driven selective aerobic oxidation of amines RCH₂NHR¹ [R = Ph, pyridin-2-yl, thiophen-2-yl, etc.; R¹ = H, t-Bu, Bn, 4-fluorobenzyl, etc.]. Remarkable photocatalytic performance was observed in converting a wealth of primary and secondary amines to corresponding imines RCH=NR¹ with mol. oxygen (O₂) over TzTz-CMP-Py. This work suggests that CMPs can be rationally designed for extensive visible light-driven selective organic transformations.

Journal of Materials Chemistry A: Materials for Energy and Sustainability published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Safety of (2-Methoxyphenyl)methanamine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Cheng, Xiuyan published the artcilePeriodically nanoporous hydrogen-bonded organic frameworks for high performance photocatalysis, Recommanded Product: (2-Methoxyphenyl)methanamine, the publication is Nanoscale (2022), 14(27), 9762-9770, database is CAplus and MEDLINE.

The development of highly catalytic hydrogen-bonded organic frameworks (HOFs) is of great importance, but remains challenging. Herein, we demonstrate the fabrication of a periodically nanoporous HOF for high performance photocatalysis. Compared with the conventional microporous HOFs, the nanoporous HOF architecture has a larger number of free carboxyl groups on the surface and presents greatly improved photoelectrochem. properties. It exhibits high catalytic activity for the photo-oxidative coupling of amines under mild conditions such as air atm. and room temperature and without any co-catalysts, sacrificial reagents or photosensitizers. The relationship between the structure, properties and catalytic performance of the nanoporous HOF was studied by exptl. and theor. investigations. It shows that such a HOF structure facilitates reactant adsorption and O₂ dissociation, thus promoting the oxidative coupling reaction. This work provides a new way for improving the catalytic performance of a single HOF.

Nanoscale published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Recommanded Product: (2-Methoxyphenyl)methanamine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Xie, Hong-Xu published the artcileNovel tetrahydrobenzo[b](thiophen-2-yl)urea derivatives as novel α-glucosidase inhibitors: Synthesis, kinetics study, molecular docking, and in vivo anti-hyperglycemic evaluation, Application In Synthesis of 6850-57-3, the publication is Bioorganic Chemistry (2021), 105236, database is CAplus and MEDLINE.

α-Glucosidase inhibitors, which can inhibit the digestion of carbohydrates into glucose, are one of important groups of anti-type 2 diabetic drugs. In the present study, we report our effort on the discovery and optimization of α-glucosidase inhibitors with tetrahydrobenzo[b](thiophen-2-yl)urea core. Screening of an inhouse library revealed a moderated α-glucosidase inhibitors, 5a, and then the following structural optimization was performed to obtain more efficient derivatives Most of these derivatives showed increased inhibitory activity against α-glucosidase than the parental compound 5a (IC₅₀ of 26.71 ± 1.80 μM) and the pos. control acarbose (IC₅₀ of 258.53 ± 1.27 μM). Among them, compounds 8r (IC₅₀ = 0.59 ± 0.02 μM) and 8s (IC₅₀ = 0.65 ± 0.03 μM) were the most potent inhibitors, and showed selectivity over α-amylase. The direct binding of both compounds with α-glucosidase was confirmed by fluorescence quenching experiments Kinetics study revealed that these compounds were non-competitive inhibitors, which was consistent with the mol. docking results that compounds 8r and 8s showed high preference to bind to the allosteric site instead of the active site of α-glucosidase. In addition, compounds 8r and 8s were not toxic (IC₅₀ > 100 μM) towards LO2 and HepG2 cells. Finally, the in vivo anti-hyperglycemic activity assay results indicated that compounds 8r could significantly decrease the level of plasma glucose and improve glucose tolerance in SD rats treated with sucrose. The present study provided the (tetrahydrobenzo[b]thiophen-2-yl)urea chemotype for developing novel α-glucosidase inhibitors against type 2 diabetes.

Bioorganic Chemistry published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C9H6N2O2, Application In Synthesis of 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhang, Xiaoying published the artcileNickel Complexes Bearing N,N,O-Tridentate Salicylaldiminato Ligand: Efficient Catalysts for Imines Formation via Dehydrogenative Coupling of Primary Alcohols with Amines, Product Details of C8H11NO, the publication is Organometallics (2021), 40(22), 3843-3853, database is CAplus.

Treatment of salicylaldiminato ligand L1H-L2H (L1H = 2,4-di-tert-butyl-6-((quinolin-8-ylimino)methyl)phenol; L2H = 2,4-di-tert-butyl-6-(((2-(diethylamino)ethyl)imino)methyl)phenol) with Ni(OAc)₂·4H₂O in refluxing EtOH afforded Ni complexes [(L1)Ni(OAc)] (1) and [(L2)Ni(OAc)] (2), resp. Reaction of L3H (L3H = (2,4-di-tert-butyl-6-(((2-(pyridin-2-yl)ethyl)imino)methyl)phenol)) with Ni(OAc)₂·4H₂O in the presence of excess triethylanmine gave the dual ligands coordinated Ni complex [(L2)₂Ni] (3). Complexes 1–3 were well characterized by high-resolution mass spectrometry, IR spectroscopy, elemental anal., and x-ray diffraction anal. All the three Ni(II) complexes exhibited efficient activity and good selectivity in the acceptorless dehydrogenative coupling of alcs. and amines to produce imines and diimines. The present protocol provides an atom-economical and sustainable route for the synthesis of various imine derivatives by employing an earth-abundant Ni salt and easily prepared salicylaldiminato ligands.

Organometallics published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H19NO2, Product Details of C8H11NO.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Wang, Shan published the artcileDesign, synthesis, and biological evaluation of 2,4-diamino pyrimidine derivatives as potent FAK inhibitors with anti-cancer and anti-angiogenesis activities, Category: ethers-buliding-blocks, the publication is European Journal of Medicinal Chemistry (2021), 113573, database is CAplus and MEDLINE.

A series of 2,4-diamino pyrimidine (DAPY) derivatives I (R¹ = 2-ClC₆H₄, 4-MeOC₆H₄, 4-BrC₆H₄, etc.), II (R² = 4-H₂NC₆H₄, 4-MeOC₆H₄, 2-O₂NC₆H₄, etc.) were designed, synthesized, and evaluated as inhibitors of focal adhesion kinase (FAK) with antitumor and anti-angiogenesis activities. Most compounds effectively suppressed the enzymic activities of FAK, and the IC₅₀s of I (R¹ = 2-ClC₆H₄) and II (R² = 2-MeOC₆H₄) were 2.75 and 1.87 nM, resp. They exhibited strong antiproliferative effects against seven human cancer cells, with IC₅₀ values against two FAK-overexpressing pancreatic cancer cells (PANC-1 and BxPC-3) of 0.98μM, 0.55μM, and 0.11μM, 0.15μM, resp. Moreover, the above two compounds obviously suppressed the colony formation, migration, and invasion of PANC-1 cells in a dose-dependent manner. Meanwhile, these two compounds could induce the apoptosis of PANC-1 cells and arrest the cell cycle in G2/M phase according to the flow cytometry assay. Western blot revealed that these compounds effectively inhibited the FAK/PI3K/Akt signal pathway and significantly decreased the expression of cyclin D1 and Bcl-2. In addition, the above compounds potently inhibited the antiproliferative of HUVECs and obviously altered the cell morphol and also significantly inhibited the migration, tube formation of HUVECs and severely impaired the angiogenesis in the zebrafish model. Overall, these results revealed the potential of these compounds as promising candidates for further preclin. studies.

European Journal of Medicinal Chemistry published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C10H9NO4S, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

He, Ben published the artcileortho-Terphenylene Viologens with Through-Space Conjugation for Enhanced Photocatalytic Oxidative Coupling and Hydrogen Evolution, Application In Synthesis of 6850-57-3, the publication is Journal of the American Chemical Society (2022), 144(10), 4422-4430, database is CAplus and MEDLINE.

A series of novel ortho-terphenylene viologen derivatives (o-TPV²⁺) with through-space conjugation (TSC) via the combination of ortho-terphenylene skeletons with viologen structure is reported. Their optoelectronic properties can be adjusted by N-arylation or N-alkylation reactions. Compared with other viologen derivatives, o-TPV²⁺ not only exhibits strong photoluminescence, but also retards the charge recombination process and stabilizes diradicals state without forming a quinoid structure due to the special TSC effect. Based on their special redox characteristics, o-TPV²⁺ were applied to the photocatalytic oxidative coupling of benzylamine with 96% yield. In addition, pTA-o-TPV²⁺ (tethered with p-toluic acid) modified g-C₃N₄ was used for visible-light-driven hydrogen production for the first time, exceeding 15 times the rate over unmodified g-C₃N₄.

Journal of the American Chemical Society published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Application In Synthesis of 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Mi, Si published the artcileGeographical discrimination and authentication of Chinese garlic based on multi-element, volatile and metabolomics profiling combined with chemometrics, Application In Synthesis of 91-16-7, the publication is Food Control (2021), 108328, database is CAplus.

This study aims to discriminate the garlics collected from four different geog. locations of China. The multi-element (12 samples), volatile (12 samples) and metabolome (24 samples) composition of the garlics were analyzed and compared. A total of 34 chem. elements, 68 volatiles and 854 metabolites were detected in the garlic samples. Significant differences were observed in the chem. element, volatile and metabolomics profiles of the four groups of garlic. Multivariate statistics indicate that 10 chem. elements, 6 volatiles and 225 metabolites could be used as candidate markers for the separation of garlics obtained from Langfang, Jining, Kaifeng and Dali of China. The current work provides a chem. fingerprint of the selected Chinese garlics. Our results demonstrate that chem. profiling in combination with chemometrics has the potential to be used as feasible approaches for the authentication of the geog. origin of garlic.

Food Control published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Application In Synthesis of 91-16-7.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem