Tag: M.W=100-150

Taglang, Celine published the artcileEnantiospecific C-H activation using ruthenium nanocatalysts, Formula: C4H12ClNO, the publication is Angewandte Chemie, International Edition (2015), 54(36), 10474-10477, database is CAplus and MEDLINE.

The activation of C-H bonds has revolutionized modern synthetic chem. However, no general strategy for enantiospecific C-H activation has been developed to date. We herein report an enantiospecific C-H activation reaction followed by deuterium incorporation at stereogenic centers. Mechanistic studies suggest that the selectivity for the α-position of the directing heteroatom results from a four-membered dimetallacycle as the key intermediate. This work paves the way to novel mol. chem. on nanoparticles.

Angewandte Chemie, International Edition published new progress about 1162054-86-5. 1162054-86-5 belongs to ethers-buliding-blocks, auxiliary class Aliphatic Chain, name is (S)-1-Methoxypropan-2-amine hydrochloride, and the molecular formula is C18H10F3NO3S2, Formula: C4H12ClNO.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Sangjan, Worasit published the artcileIdentification of volatile biomarkers for high-throughput sensing of soft rot and Pythium leak diseases in stored potatoes, Recommanded Product: 1,2-Dimethoxybenzene, the publication is Food Chemistry (2022), 130910, database is CAplus and MEDLINE.

Soft rot and Pythium leak are postharvest storage diseases of potato tubers that can cause substantial crop losses in the US. This study focused on detecting volatile organic compounds (VOCs) associated with rot inoculated tubers during storage (up to 21 days) using headspace solid-phase microextraction (SPME) coupled to gas chromatog. (GC) with mass spectrometry (MS) and flame ionization detector (FID) anal. Russet Burbank and Ranger Russet tubers were inoculated with the rot pathogens. Static sampling with 50 min trapping time followed by GC-MS and GC-FID anal. identified 23 and 30 common VOCs from the pathogen inoculated tubers. Overall, n,n-dimethylmethylamine, acetone, 1-undecene, and styrene, occurred frequently and repeatability in inoculated samples based on GC-MS anal., with the latter two found using GC-FID anal. as well. Identification of such biomarkers can be useful in developing high-throughput VOC sensing systems for early disease detection in potato storage facilities.

Food Chemistry published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Recommanded Product: 1,2-Dimethoxybenzene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Clemente, Francesca published the artcilePiperidine Azasugars Bearing Lipophilic Chains: Stereoselective Synthesis and Biological Activity as Inhibitors of Glucocerebrosidase (GCase), Name: (2-Methoxyphenyl)methanamine, the publication is Journal of Organic Chemistry (2021), 86(18), 12745-12761, database is CAplus and MEDLINE.

We report a straightforward synthetic strategy for the preparation of trihydroxypiperidine azasugars, e.g. I, decorated with lipophilic chains at both the nitrogen and the adjacent carbon as potential inhibitors of the lysosomal enzyme glucocerebrosidase (GCase), which is involved in Gaucher disease. The procedure relies on the preparation of C-erythrosyl N-alkylated nitrones reaction of aldehyde and primary amines followed by oxidation of the imines formed in situ with the methyltrioxorhenium catalyst and urea hydrogen peroxide. The addition of octyl-MgBr to nitrone provided access to both epimeric hydroxylamines with opposite configuration at the newly created stereo-center in a stereo-divergent and completely stereoselective way, depending on the absence or presence of BF₃·Et₂O, and reductive amination. Hydroxypiperidine I was the best ligand for GCase (IC₅₀ = 15μM), in agreement with MD simulations that allowed us to identify the chair conformation corresponding to the best binding affinity.

Journal of Organic Chemistry published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Name: (2-Methoxyphenyl)methanamine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Nambu, Noritoshi published the artcilePhysical and electrochemical properties of fluorinated dialkyl ethers, COA of Formula: C4H7F3O2, the publication is Electrochemistry (Tokyo, Japan) (2016), 84(10), 776-778, database is CAplus.

Dialkyl ethers show high relative permittivities and low viscosities as compared to the corresponding linear carbonates. We have synthesized 1-(2-fluoroethoxy)-2-(2,2,2-trifluoroethoxy)ethane (FETFEE). The relative permittivity and viscosity of FETFEE were higher than those of 1,2-diethoxyethane (DEE, ethylene glycol di-Et ether). The conductivity of 1 mol dm^-3 LiPF₆ solution in FETFEE was higher than that in 1-ethoxy-2-(2,2,2-trifluoroethoxy)ethane (ETFEE). The use of FETFEE as a co-solvent improved the discharge capacity of a Li ‘ LiCoO₂ coin cell.

Electrochemistry (Tokyo, Japan) published new progress about 2358-54-5. 2358-54-5 belongs to ethers-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-(2,2,2-Trifluoroethoxy)ethanol, and the molecular formula is C4H7F3O2, COA of Formula: C4H7F3O2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Yue, Zheng published the artcileSynthesis and physical properties of new fluoroether sulfones, Safety of 2-(2,2,2-Trifluoroethoxy)ethanol, the publication is Journal of Fluorine Chemistry (2018), 118-123, database is CAplus.

Eight new strategically designed fluoroether sulfone solvents have been synthesized through different synthetic pathways for potential applications in lithium-sulfur battery electrolytes. The structures of these compounds have been confirmed by ¹H-NMR, ¹³C-NMR and elemental anal. Several 1,2-dimethoxyethane (DME)-based electrolyte formulations have been prepared with these solvents to derive an electrolyte with good ionic conductivity (>5 mS cm^-1 at 25 °C). The viscosity of these new additives has also been determined as it is directly related to the ionic conductivity Three of these solvents that contain a trifluoromethyl group displayed acceptable ionic conductivity

Journal of Fluorine Chemistry published new progress about 2358-54-5. 2358-54-5 belongs to ethers-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-(2,2,2-Trifluoroethoxy)ethanol, and the molecular formula is C10H10CoF6P, Safety of 2-(2,2,2-Trifluoroethoxy)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Meena, Mahesh published the artcileI₂/FeCl₃ Promoted Cascade Reaction of 4-Quinazolinone, Pyridine, and Chalcone for the Synthesis of Indolizines, Safety of (2-Methoxyphenyl)methanamine, the publication is ChemistrySelect (2022), 7(21), e202201378, database is CAplus.

The indolizines nucleus is an important element of many synthetic mols. with significant biol. activity. An efficient methodol. for the synthesis of a variety of indolizines from quinazolinone, pyridine, and chalcone via I₂/FeCl₃ has been described. The reaction was promoted through zwitterion formation/cyclization/aromatization sequence, affording the desired products in moderate to very good yields. This approach is a highly efficient and convenient way to get derivatives of indolizines from readily accessible substrate under relatively mild reaction conditions.

ChemistrySelect published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Safety of (2-Methoxyphenyl)methanamine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Grishin, Igor Yu. published the artcileA sequence of acylamination and acylation reactions in polyphosphoric acid – a novel approach to the Friedlander synthesis of 2-arylquinolines, Formula: C8H10O2, the publication is Chemistry of Heterocyclic Compounds (New York, NY, United States) (2022), 58(6-7), 313-318, database is CAplus.

A method for the synthesis of 2-(2-acylaminoaryl)quinolines I (R¹ = OMe, -OCH₂CH₂O-, Me; R² = Me, Et) was developed based on a one-pot sequence of direct electrophilic acylamination of arenes with nitroalkanes R²NO₂ in polyphosphoric acid and acylation at the ortho position with respect to the acylamino group.

Chemistry of Heterocyclic Compounds (New York, NY, United States) published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Formula: C8H10O2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Chen, Kang published the artcileCobalt-Mediated Decarboxylative/Desilylative C-H Activation/Annulation Reaction: An Efficient Approach to Natural Alkaloids and New Structural Analogues, SDS of cas: 6850-57-3, the publication is European Journal of Organic Chemistry (2022), 2022(16), e202101355, database is CAplus.

A Co(II)-mediated decarboxylative/desilylative C-H activation/annulation reaction for the efficient synthesis of 3-arylisoquinolines has been developed [e.g., N-benzylpicolinamide + phenylpropiolic acid â†?3-phenylisoquinoline (86%) in presence of Co(OAc)₂ as catalyst, KPF₆ as additive and PEG-400 as solvent; an 80% yield was obtained using 1-phenyl-2-(trimethylsilyl)acetylene instead, under the same optimized conditions.]. Using alkynyl carboxylic acid and alkynyl silane as terminal alkyne precursors provides straightforward routes for the synthesis of natural alkaloids and novel structural analogs.

European Journal of Organic Chemistry published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, SDS of cas: 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Torrens, Aidan A. published the artcileRapid and Mild Cleavage of Aryl-Alkyl Ethers to Liberate Phenols, Recommanded Product: 1,2-Dimethoxybenzene, the publication is European Journal of Organic Chemistry (2022), 2022(27), e202200570, database is CAplus.

The Piers-Rubinsztajn reaction enables rapid deprotection of aryl alkyl ethers under ambient conditions was reported. This chem. leverages tris(pentafluorophenyl)borane and silyl hydrides to convert aryl Me ethers to siloxanes, which can then be cleaved using 1 % HCl in EtOH. Authors examined 26 derivatives and routinely obtained yields >85 %, even in the presence of sterically demanding groups and complex substrate structures. Other alkyl ethers including Et, Pr, iso-Pr, tert-Bu, and benzyl groups were also easily removed.

European Journal of Organic Chemistry published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C25H34N4O2S, Recommanded Product: 1,2-Dimethoxybenzene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Allen, Meredith A. published the artcileA redox-enabled strategy for intramolecular hydroamination, Safety of (2-Methoxyphenyl)methanamine, the publication is Chemical Science (2022), 13(24), 7264-7268, database is CAplus and MEDLINE.

A process for intramol. hydroamination that uses a redox-enabled strategy relying on efficient in situ generation of hydroxylamines by oxidation, followed by Cope-type hydroamination, then reduction of the resulting pyrrolidine N-oxide. The steps were performed sequentially in a single pot, no catalyst was required, the conditions were mild, the process was highly functional group tolerant, and no chromatog. was generally required for isolation.

Chemical Science published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Safety of (2-Methoxyphenyl)methanamine.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem