Tag: M.W=100-150

Kawecki, Robert published the artcileSynthesis of N-sulfenylimines from disulfides and primary methanamines, Formula: C8H11NO, the publication is Journal of Organic Chemistry (2022), 87(11), 7514-7520, database is CAplus and MEDLINE.

N-sulfenylimines (sulfenimines, thiooximes, N-alkylidenesulfenamides) were efficiently synthesized through the reaction of primary amines and disulfides with NBS or bromine. This reaction can be carried out in an open flask at room temperature without the need for any transition metal-containing additives. The use of thiols instead of disulfides gave similar results. A wide range of amines were reacted with aryl and alkyldisulfides, resulting in the formation of sulfenimines in a yield of 44-99%.

Journal of Organic Chemistry published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Formula: C8H11NO.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Muller, Norbert published the artcileFluorine chemical shifts and microheterogeneity in aqueous solutions of 2-(2,2,2-trifluoroethoxy)ethanol, Category: ethers-buliding-blocks, the publication is Journal of Physical Chemistry (1979), 83(15), 2041-4, database is CAplus.

The title compound was prepared in the expectation that its water solutions would show interesting structural effects similar to those suggested by a variety of measurements for aqueous tert-Bu alc. and aqueous 2-n-butoxyethanol and that the nature of these effects might be elucidated by following the fluorine chem. shift as a function of concentration and temperature The material is miscible with water above room temperature, but an upper critical solution temperature was found between 1 and 2°. Chem. shift-composition curves determined at five temperatures spanning the interval from 1 to 61° reveal a change in the nature of the solutions when the mole fraction of the nonaqueous component is about 0.18. It appears that in the dilute region the cosolvent mols. are preferentially solvated by water, especially at the lower temperatures, while the more concentrated solutions are microheterogeneous, with rapid exchange of the organic species between water-rich and cosolvent-rich domains. It is very likely that the properties of aqueous solutions of tert-Bu alc., 2-n-butoxyethanol, and 2-(2,2,2-trifluoroethoxy)ethanol indeed reflect essentially the same type of behavior.

Journal of Physical Chemistry published new progress about 2358-54-5. 2358-54-5 belongs to ethers-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-(2,2,2-Trifluoroethoxy)ethanol, and the molecular formula is C4H7F3O2, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Wu, Jing published the artcileDiscovery of novel paeonol-based derivatives against skin inflammation in vitro and in vivo, COA of Formula: C8H11NO, the publication is Journal of Enzyme Inhibition and Medicinal Chemistry (2022), 37(1), 817-831, database is CAplus and MEDLINE.

In this study, a series of paeonol derivatives I [R = NHMe, PhNH, BnNH, etc.] was designed and synthesized using a fragment growing approach, and their anti-inflammatory activities against lipopolysaccharide (LPS)-induced nitric oxide production in RAW264.7 cells were tested. Among them, compound I [R = 3-CF₃C₆H₄NH] yielded the best results (IC₅₀ = 2.14μM) with low toxicity (IC₅₀ > 50μM). Preliminary mechanistic studies indicated that this compound could inhibit the TOPK-p38/JNK signalling pathway and phosphorylate downstream related proteins. A murine psoriasis-like skin inflammation model was used to determine its therapeutic effect.

Journal of Enzyme Inhibition and Medicinal Chemistry published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, COA of Formula: C8H11NO.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Wu, Shujuan published the artcileHydrazone-linked 2D porphyrinic covalent organic framework photocatalysis for visible light-driven aerobic oxidation of amines to imines, Category: ethers-buliding-blocks, the publication is Journal of Colloid and Interface Science (2022), 446-454, database is CAplus and MEDLINE.

A hydrazone-linked 2D (two-dimensional) porphyrinic COF, Por-DETH-COF, was assembled from 5,10,15,20-tetrakis(4-benzaldehyde)porphyrin (p-Por-CHO) and 2,5-diethoxyterephthalohydrazide (DETH) and its photocatalytic activity was duly appraised with the aerobic oxidation of amines. Thereby, the red light-driven selective oxidation of benzyl amines to imines RCH=NR¹ [R = Ph, 4-FC₆H₄, 2-thienyl, etc.; R¹ = t-Bu, Bn, 4-MeC₆H₄CH₂, etc.]was obtained in very high conversions and selectivities with ambient air as the oxidant. Importantly, the photocatalytic system exhibited remarkable compatibility of functional groups and extensive scope of benzyl amines. Notably, the Por-DETH-COF photocatalyst displayed outstanding recyclability after five successive cycles. This work suggests that 2D COFs could contribute a unique juncture for selective organic transformations by photocatalysis.

Journal of Colloid and Interface Science published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C11H16BNO3, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Guo, Jianan published the artcileN-Propargylamine-hydroxypyridinone hybrids as multitarget agents for the treatment of Alzheimer disease, Category: ethers-buliding-blocks, the publication is Bioorganic Chemistry (2021), 105013, database is CAplus and MEDLINE.

AD is a progressive brain disorder. Because of the lack of remarkable single-target drugs against neurodegenerative disorders, the multitarget-directed ligand strategy has received attention as a promising therapeutic approach. Herein, we rationally designed twenty-nine hybrids of N-propargylamine-hydroxypyridinone. The designed hybrids possessed excellent iron-chelating activity (pFe3+ = 17.09-22.02) and potent monoamine oxidase B inhibitory effects. Various biol. evaluations of the optimal compound 6b were performed step by step, including inhibition screening of monoamine oxidase (hMAO-B IC50 = 0.083 ± 0.001 μM, hMAO-A IC50 = 6.11 ± 0.08 μM; SI = 73.5), prediction of blood-brain barrier permeability and mouse behavioral research. All of these favorable results proved that the N-propargylamine-hydroxypyridinone scaffold is a promising structure for the discovery of multitargeted ligands for AD therapy.

Bioorganic Chemistry published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C8H11NO, Category: ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhang, Guo-Ning published the artcileDiscovery and optimization of 2-((1H-indol-3-yl)thio)-N-benzyl-acetamides as novel SARS-CoV-2 RdRp inhibitors, Application In Synthesis of 6850-57-3, the publication is European Journal of Medicinal Chemistry (2021), 113622, database is CAplus and MEDLINE.

The emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the global pandemic coronavirus disease (COVID-19), but no specific antiviral drug has been proven effective for controlling this pandemic to date. In this study, several 2-((indol-3-yl)thio)-N-benzyl-acetamides were identified as SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitors. After a two-round optimization, a new series of 2-((indol-3-yl)thio)-N-benzyl-acetamides was designed, synthesized, and evaluated for SARS-CoV-2 RdRp inhibitory effect. Compounds 6b2, 6b5, 6c9, 6d2, and 6d5 were identified as potent inhibitors with IC₅₀ values of 3.35 ± 0.21μM, 4.55 ± 0.2μM, 1.65 ± 0.05μM, 3.76 ± 0.79μM, and 1.11 ± 0.05μM, resp.; the IC₅₀ of remdesivir (control) was measured as 1.19 ± 0.36μM. All of the compounds inhibited RNA synthesis by SARS-CoV-2 RdRp. The most potent compound 6d5, which showed a stronger inhibitory activity against the human coronavirus HCoV-OC43 than remdesivir, is a promising candidate for further investigation.

European Journal of Medicinal Chemistry published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C5H10N2OS, Application In Synthesis of 6850-57-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Zhang, Shuxiang published the artcileSynthesis, characterization and properties of a novel fluorinated methacrylate polymer, Product Details of C4H7F3O2, the publication is Journal of Fluorine Chemistry (2011), 132(11), 915-919, database is CAplus.

A fluorinated monomer of 2-(2,2,2-trifluoroethoxy)ethyl methacrylate (FEMA) was prepared by a “one pot” process and then a novel fluorinated methacrylate polymer, poly[2-(2,2,2-trifluoroethoxy)ethyl methacrylate] (PFEMA), was successfully synthesized via miniemulsion polymerization using cetyltrimethyl ammonium bromide (CTAB) as emulsifier, hexadecane (HD) as co-stabilizer and 2,2′-azobisisobutyronitrile (AIBN) as initiator. The chem. structure of PFEMA was characterized by FT-IR, ¹H NMR and ¹⁹F NMR. GPC results show that the number average mol. weight (M_n) of PFEMA was as high as 8.5 × 10⁵ g/mol and the polydispersity index (PDI) was only 1.3. SEM and DLS characterizations showed that the morphol. of PFEMA latex was uniform spheres with the diameter of about 110-125 nm. It was also found that PFEMA has high thermo-stability (T_d > 200 °C), low glass transition temperature (T_g = 13.0 °C), and nice hydrophobicity (θ_water = 99.9°). Comparison studies on PFEMA and poly(2,2,2-trifluoroethyl methacrylate) show that an introduced functional group (-CH₂CH₂O-) has a significant effect on lowering T_g and improving hydrolysis resistance without impairing surface properties.

Journal of Fluorine Chemistry published new progress about 2358-54-5. 2358-54-5 belongs to ethers-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2-(2,2,2-Trifluoroethoxy)ethanol, and the molecular formula is C9H22OSi, Product Details of C4H7F3O2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Al-Dalali, Sam published the artcileTracking volatile flavor changes during two years of aging of Chinese vinegar by HS-SPME-GC-MS and GC-O, Safety of 1,2-Dimethoxybenzene, the publication is Journal of Food Composition and Analysis (2022), 104295, database is CAplus.

Aging is an essential step for enriching the aroma profiles of Chinese vinegar. This study aimed to track the volatile flavor changes in the same batch of Chinese vinegar for the first time during two years of aging with the aid of HS-SPME-GC-MS. The aroma-active compounds were characterized at 0, 6, and 12 mo of aging using GC-O coupled with a modified frequency method. A total of 67 volatile compounds and 30 aroma-active compounds were identified during the different stages of aging. Most alcs., esters, ketones, acids, and phenols decreased during the aging from 628.4, 105.4, 132.1, 22.1, and 21.4μg/L at 0 mo to 228.7, 7.2, 9.69, 17.24, and 11.6μg/L at 24 mo sep., except aldehydes and pyrazines, which showed slight increases. Many aroma-active compounds were generated during the aging, such as methional, trimethylpyrazine, acetophenone, and 2-acetyl-3-ethylpyrazine, while pyrazines were formed during 24 mo of aging. Three aroma-active compounds with high odor activity values (OAVs) showed significant contributions to the aroma profile of vinegar, which included isovaleric acid (2743, 340, and 3139), 4-ethylguaiacol (580, 429, and 516), and γ-nonalactone (324, 640, and 442) at 0, 6, and 12 mo of aging, resp.

Journal of Food Composition and Analysis published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Safety of 1,2-Dimethoxybenzene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Liu, Panpan published the artcileDynamic changes in the aroma profile of Qingzhuan tea during its manufacture, Formula: C8H10O2, the publication is Food Chemistry (2022), 131847, database is CAplus and MEDLINE.

Changes in key odorants and aroma profiles of Qingzhuan tea (QZT) during its manufacture were determined using headspace solid-phase microextraction gas chromatog.-mass spectrometry/olfactometry. An aroma profile was constructed to illustrate sensory changes during manufacture The characteristic aroma of QZT was aged fragrance, which was mostly developed during pile fermentation and was enhanced during the aging and drying stages. Using volatile compounds found in the raw materials, sun-dried green tea and QZT finished product were compared by orthogonal partial least square-discriminant anal. Among 108 detected volatiles, 19 were significantly upregulated and 15 were downregulated. (E)-β-Ionone, (E,Z)-2,6-nonadienal, 1-octen-3-one, (E,E)-2,4-heptadienal, (E,E)-2,4-nonadienal, safranal, (E)-2-nonenal, α-ionone, and 1,2,3-trimethoxybenzene were found to be significant contributors to the aged QZT fragrance, reflecting their high odor-activity values and aroma intensities. Finally, the metabolic transformation of key aroma-active compounds was systematically analyzed. This study provided a theor. basis for improving the processing and quality of QZT.

Food Chemistry published new progress about 91-16-7. 91-16-7 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether,Inhibitor,Inhibitor,Inhibitor, name is 1,2-Dimethoxybenzene, and the molecular formula is C8H10O2, Formula: C8H10O2.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Wang, Yuexin published the artcileCooperative Photocatalysis with 4-Amino-TEMPO for Selective Aerobic Oxidation of Amines over TiO₂ Nanotubes, Formula: C8H11NO, the publication is Chemistry – An Asian Journal (2021), 16(18), 2659-2668, database is CAplus and MEDLINE.

Attaching π-conjugated mols. onto TiO₂ can form surface complexes that could capture visible light. However, to make these TiO₂ surface complexes durable, integrating 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) or its analogs as a redox mediator with photocatalysis is the key to constructing selective chem. transformations. Herein, sodium 6,7-dihydroxynaphthalene-2-sulfonate (DHNS) was obtained by extending the π-conjugated system of catechol by adding a benzene ring and a substituent sodium sulfonate (-SO₃^–Na⁺). The DHNS-TiO₂ showed the best photocatalytic activity towards the blue light-induced selective aerobic oxidation of benzylamine. Compared to TEMPO, 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl (4-amino-TEMPO) could rise above 70% in conversion of benzylamine over the DHNS-TiO₂ photocatalyst. Eventually, a wide range of amines could be selectively oxidized into imines with atm. O₂ by cooperative photocatalysis of DHNS-TiO₂ with 4-amino-TEMPO. Notably, superoxide (O₂^•-) is crucial in coupling the photocatalytic cycle of DHNS-TiO₂ and the redox cycle of 4-amino-TEMPO. This work underscores the design of surface ligands for semiconductors and the selection of a redox mediator in visible light photocatalysis for selective chem. transformations.

Chemistry – An Asian Journal published new progress about 6850-57-3. 6850-57-3 belongs to ethers-buliding-blocks, auxiliary class Amine,Benzene,Ether, name is (2-Methoxyphenyl)methanamine, and the molecular formula is C15H12O8, Formula: C8H11NO.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem