Tag: M.W=0-100

Reference of 109-85-3, The chemical industry reduces the impact on the environment during synthesis 109-85-3, name is 2-Methoxyethylamine, I believe this compound will play a more active role in future production and life.

Step 1 2-Chloro-5-nitropyridine (4.0 g) was stirred with 2-methoxyethylamine (20 mL) at room temperature for 1 h. The reaction mixture was diluted with water (30 mL) and extracted with ethyl acetate (2*50 mL), washed with brine (20 mL), dried over sodium sulfate and evaporated under vacuum. The residue was washed with n-pentane (25 mL) to get N-(2-methoxyethyl)-5-nitropyridin-2-amine (4.8 g, 87%) as yellow solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Methoxyethylamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Gruenenthal GmbH; FRANK, Robert; BAHRENBERG, Gregor; CHRISTOPH, Thomas; LESCH, Bernhard; LEE, Jeewoo; US2013/29962; (2013); A1;,
Ether – Wikipedia,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 109-85-3, name is 2-Methoxyethylamine, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 2-Methoxyethylamine

[00580] To a solution of Example 116a (528 mg, 3.0 mmol) and Example 116b (450 mg, 6.0 mmol) in DMSO (4 mL) was added NN-diisopropylethylamine (780 mg, 6.0 mmol). The mixture was heated at 135C for 4 h. The reaction mixture was cooled to r.t., diluted with H20 (20 mL), and then extracted with EtOAc (100 mL). The organic layer was dried over Na2S04, filtered and concentrated under reduced pressure to give the desired product Example 116c (620 mg, yield 90%) as a white solid. LCMS [M+l] + = 230.9/232.9.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 109-85-3.

Reference:
Patent; FRONTHERA U.S. PHARMACEUTICALS LLC; JIN, Bohan; DONG, Qing; HUNG, Gene; (214 pag.)WO2019/51265; (2019); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 109-85-3, name is 2-Methoxyethylamine, A new synthetic method of this compound is introduced below., SDS of cas: 109-85-3

4-Amino-N-hydroxy-1,2,5-oxadiazole-3-carbimidoyl chloride (2.13 kg, 13.15 mol) was mixed with EtOAc(13 L). At 0-5C, 2-methoxyethylamine (1.1 kg, 14.46 mol) was added in one portionwhile stirring. The reaction temperature rose to 41C. The reaction was cooled to 0-5C. TEA (2.0kg, 19.73 mol) was added. After stirring 5 mm, the reaction was washed with water (5 L), brine (5 L),dried over sodium sulfate, and concentrated to give the desired product (1.61 kg, 61%) as a brownoil. LCMS (M+H): m/z = 202.1. 1H NMR (400MHz, DMSO-d6): 6 10.65 (s, 1H), 6.27 (s, 2H), 6.10 (t, J = 6.5Hz, 1H), 3.50 (m, 2H), 3.35 (d, J = 5. 8Hz, 2H), 3.08 (s, 3H).

The synthetic route of 109-85-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; KAZMIERSKI, Wieslaw Mieczyslaw; DE LA ROSA, Martha; SAMANO, Vincent; (70 pag.)WO2017/2078; (2017); A1;,
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Some common heterocyclic compound, 109-85-3, name is 2-Methoxyethylamine, molecular formula is C3H9NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C3H9NO

To an ice-cooled solution of 2-methoxyethylamine (623 mg, 8.29 mmol) and triethylamine (1.50 mL, 10.8 mmol) in anhydrous DCM (50 mL) under argon was added dropwise chloroacetyl chloride (795 muL, 10.0 mmol). After 4 h the mixture was flushed through a Strata SI-1 silica cartridge (20 g Giga Tube), eluting with DCM. Fractions containing the target material (Rf 0.65, 100% EtOAc) were combined and evaporated to afford 2-chloro-N-(2-methoxyethyl)acetamide (1.14 g, 7.50 mmol; 90%) as a brown oil: deltaEta (300 MHz, CDCI3): 6.92 (1 H, br s), 4.02 (2 H, s), 3.44-3.49 (4 H, m), 3.34 (3 H, s).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 109-85-3, its application will become more common.

Reference:
Patent; UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW; HERIOT-WATT UNIVERSITY; MOUNTFORD, Joanne; MILLIGAN, Graeme; ADAMS, Dave; (95 pag.)WO2016/92327; (2016); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 109-85-3, name is 2-Methoxyethylamine, This compound has unique chemical properties. The synthetic route is as follows., name: 2-Methoxyethylamine

Intermediate 8: 6-amino-4-((2-methoxyethyl)amino)nicotinonitrile. A solution of 6-amino-4-fluoronicotinonitrile (intermediate 10, 1 .10 g, 8.02 mmol) in DMA (20 ml) was treated with 2-methoxyethylamine (2.07 ml, 24.1 mmol) and DIPEA (4.20 ml_, 24.1 mmol), heated to 50 C and stirred for 15 h. The reaction mixture was cooled to room temperature and concentrated. The crude material was purified by normal phase chromatography (24 g silica gel cartridge, heptanes/EtOAc 100:0 to 0:100). The product containing fractions were concentrated and dried under vacuum to give the title compound as an off-white solid. 1H NMR (400 MHz, DMSO-d6) delta 7.92 (s, 1 H), 6.39 (s, 2H), 6.15 (t, 1 H), 5.61 (s, 1 H), 3.46 (t, 2H), 3.27 (s, 3H), 3.24 (q, 2H). (UPLC-MS 3) tR 0.62; ESI-MS 193.1 [M+H]+.

According to the analysis of related databases, 109-85-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NOVARTIS AG; BUSCHMANN, Nicole; FAIRHURST, Robin Alec; FURET, Pascal; KNOEPFEL, Thomas; LEBLANC, Catherine; MAH, Robert; (124 pag.)WO2016/151499; (2016); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of 109-85-3,Some common heterocyclic compound, 109-85-3, name is 2-Methoxyethylamine, molecular formula is C3H9NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To 2,3-dichloro-1,4-naphthoquinone (0.341g, 1.50mmol) in 1.5mlof ethanol was added 2-methoxyethylamine (0.124g, 1.65mmol) and triethylamine (0.227g,2.25mmol) and the mixture stirred at r. t. for 18h. The red precipitate formedwas filtered under suction, washed with distilled water and dried to afford (4) as a dark red solid, 87.8%.1H (CDCl3) delta 8.15 (dd, 1H, J=0.94, 7.68Hz), 8.03 (dd, 1H, J=0.99, 7.67Hz), 7.72 (dt, 1H, J=1.31, 7.59Hz), 7.62 (dt, 1H, J=1.28, 7.55Hz), 6.36 (br s, 1H), 4.06(dd, 2H, J=5.60, 10.62Hz), 3.63(t, 2H, J=5.17Hz), 3.42 (s, 3H); 13C(CDCl3) delta 180.42, 176.84, 144.37, 134.85, 132.67, 132.44, 129.88,126.80, 77.20, 71.22, 58.95, 44.50.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Methoxyethylamine, its application will become more common.

Reference:
Article; Ho, Si-Han Sherman; Sim, Mei-Yi; Yee, Wei-Loong Sherman; Yang, Tianming; Yuen, Shyi-Peng John; Go, Mei-Lin; European Journal of Medicinal Chemistry; vol. 104; (2015); p. 42 – 56;,
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