Tag: M.W=0-100

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 109-85-3, name is 2-Methoxyethylamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 109-85-3

2-methoxyethaneamine (3 mL) is added to a solution of l-fluoro-2-nitrobenzene (400 mg, 2.84 mmol) in ethanol. The reaction may be stirred at room temperature for an appropriate time period (such as overnight) and concentrated. The residue may be purified by any appropriate method including Biotage column chromatography to give N-(2-methoxyethyl)-2-nitroaniline (477 mg).

The synthetic route of 109-85-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; WANG, Tong; GATELY, Stephen; TRANSLATIONAL GENOMICS RESEARCH INSTITUTE; WO2010/151441; (2010); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 109-85-3, name is 2-Methoxyethylamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 109-85-3

A solution of 6-amino-4-fluoronicotinonitrile (intermediate 21, 1.10 g, 8.02 mmol) in DMA (20 ml)was treated with 2-methoxyethylamine (2.07 ml, 24.1 mmol) and DIPEA (4.20 mL, 24.1 mmol),heated to 50 C and stirred for 15 h. The reaction mixture was cooled to room temperature and concentrated. The crude material was purified by normal phase chromatography (24 g silica gel cartridge, heptanes/EtOAc 100:0 to 0:100). The product containing fractions were concentrated and dried under vacuum to give the title compound as an off-white solid.

The synthetic route of 109-85-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NOVARTIS AG; BUSCHMANN, Nicole; FAIRHURST, Robin Alec; FURET, Pascal; KNOePFEL, Thomas; LEBLANC, Catherine; MAH, Robert; NIMSGERN, Pierre; RIPOCHE, Sebastien; LIAO, Lv; XIONG, Jing; ZHAO, Xianglin; HAN, Bo; WANG, Can; WO2015/59668; (2015); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 109-85-3, name is 2-Methoxyethylamine, A new synthetic method of this compound is introduced below., Product Details of 109-85-3

Example 8: BenzvI-{l-f2-(lH-indoI-4-ylV4-morpholin-4-vI-thieno[3,2- dl py rimidine-6-y Imethyll -piperidin-4-yl) -(2-methoxy-ethyl)-amine; l-BOC-4-piperidone (2.00 g) and 2-methoxyethylamine (872 mul) were stirred together in methanol (20 ml) at room temperature for 12 hours. Sodium borohydride (760 mg) was added in several aliquots over 30 minutes and the reaction mixture stirred for a further 12 hours at ambient temperature. The solvents were removed in vacuo and the residue diluted with dichloromethane (50 ml) and washed with brine, dried (MgSO4). The solvents were removed in vacuo to give a residue which was purified by flash silica chromatography to give 4-(2-methoxy-ethylamino)-piperidine- 1-carboxylic acid tert-butyl ester (1.69 g) as a colourless oil.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; PIRAMED LIMITED; WO2007/122410; (2007); A1;,
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Some common heterocyclic compound, 109-85-3, name is 2-Methoxyethylamine, molecular formula is C3H9NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C3H9NO

[0706] A solution of 6-amino-4-fluoronicotinonitrile (intermediate21, 1.10 g, 8.02 mmol) in DMA (20 ml) wastreated with 2-methoxyethylamine (2.07 ml, 24.1 mmol) andDIPEA ( 4.20 mL, 24.1 mmol), heated to 50 C. and stirred for15 h. The reaction mixture was cooled to room temperatureand concentrated. The crude material was purified by normalphase chromatography (24 g silica gel cartridge, heptanes/EtOAc 100:0 to 0: 100). The product containing fractionswere concentrated and dried under vacuum to give the titlecompound as an off-white solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 109-85-3, its application will become more common.

Synthetic Route of 109-85-3,Some common heterocyclic compound, 109-85-3, name is 2-Methoxyethylamine, molecular formula is C3H9NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

4-Amino-N-hydroxy-1,2,5-oxadiazole-3-carboximidoyl chloride (200.0 g, 1.23 mol) was mixed with ethyl acetate (1.2 L). At 0-5 C. 2-methoxyethylamine [Aldrich, product No.143693] (119.0 mL, 1.35 mol) was added in one portion while stirring. The reaction temperature rose to 41 C. The reaction was cooled to 0-5 C. Triethylamine (258 mL, 1.84 mol) was added. After stirring 5 min, LCMS indicated reaction completion. The reaction solution was washed with water (500 mL) and brine (500 mL), dried over sodium sulfate, and concentrated to give the desired product (294 g, 119%) as a crude dark oil. LCMS for C6H12N5O3 (M+H)+: m/z=202.3. 1H NMR (400 MHz, DMSO-d6): delta 10.65 (s, 1H), 6.27 (s, 2H), 6.10 (t, J=6.5 Hz, 1H), 3.50 (m, 2H), 3.35 (d, J=5.8 Hz, 2H), 3.08 (s, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Methoxyethylamine, its application will become more common.

Reference:
Patent; Incyte Corporation; Incyte Holdings Corporation; Combs, Andrew P.; Yue, Eddy W.; Sparks, Richard B.; Zhu, Wenyu; (63 pag.)US9320732; (2016); B2;,
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Adding a certain compound to certain chemical reactions, such as: 109-85-3, name is 2-Methoxyethylamine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 109-85-3, Application In Synthesis of 2-Methoxyethylamine

To a stirred solution of tert-butyl 4-oxopiperidine-l -carboxylate (2 g, 10.04 acetic acid (0.575 mL, 10.04 mmol) and 2-methoxyethanamine (0.754 g, 10.04 mmol) in MeOH (40 mL) under N2 was cooled to 0 C. Then the mixture was added NaCNBH4 (0.631 g, 10.04 mmol) and stirred at RT for 16 hrs. The reaction mixture was quenched with 50 mL of aqueous 10% NaHC03 solution and extracted with EtOAc (2 x 200 mL). The combined organic layer was dried over sodium sulfate and concentrated under reduced pressure. Purification by flash chromatography gave 103 A (liquid, 1.5 g, 5.81 mmol, 58 % yield). GC-MS Anal.Calc?d for C]3H26N203 258.2, found 157.2 (M- Boc). Tr = 9.43 min (Method AE).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Methoxyethylamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; BALOG, James Aaron; MARKWALDER, Jay A.; SHAN, Weifang; WILLIAMS, David K.; NARA, Susheel Jethanand; ROY, Saumya; THANGAVEL, Soodamani; CHERUKU, Srinivas; SISTLA, Ramesh Kumar; (230 pag.)WO2020/23355; (2020); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 109-85-3, name is 2-Methoxyethylamine, A new synthetic method of this compound is introduced below., category: ethers-buliding-blocks

EXAMPLE 532-[2-(1 ,3-benzothiazol-5-yl)-1 H-imidazol-4-yl]-1 -[2-(methyloxy)ethyl]-1 H-benzimidazole-6- carbonitrile hydrochlorideStep 1 . 5-bromo-N-[2-(methyloxy)ethyl]-2-nitroaniline: 4-bromo-2-fluoro-1 -nitrobenzene (0.3 g, 1.336 mmol), 2-(methyloxy)ethylamine (0.1 17 ml_, 1.336 mmol), and DIEA (0.238 ml_, 1 .336 mmol) in Ethanol (5 mL) were irradiated by microwave at 100C for 30 min. The reaction mixture was partitioned between dichloromethane and brine. The aqueous layer was extracted with DCM twice. The combined DCM layers were dried over sodium sulfate, filtered, and concentrated. The residue was purified via Biotage (SNAP Cartridge KP Sil 25 g, 0-10% EtOAc/Hexane) to yield 5-bromo-N-[2-(methyloxy)ethyl]-2-nitroaniline (0.374 g, 1.286 mmol, 96 % yield). 1H NMR (400 MHz, CDCI3) delta 8.22 (br. s., 1 H), 8.04 (d, J = 9.1 Hz, 1 H), 7.05 (d, J = 1.5 Hz, 1 H), 6.78 (dd, 1 H), 3.69 (t, 2 H), 3.48 (t, 2 H), 3.45 (s, 3 H); MS (m/z) 275.1 (M+H)+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; GLAXO GROUP LIMITED; BODMER, Vera, Q.; CASILLAS, Linda, N.; DEMARTINO, Michael, P.; KING, Bryan, W.; LAKDAWALA SHAH, Ami; LEISTER, Lara, Kathryn; WANG, Gren, Z.; WISNOSKI, David, Duff; HARRIS, Philip, A.; RAMANJULU, Joshi, M.; ROMANO, Joseph, J.; WILSON, Matthew, A.; WO2011/123609; (2011); A1;,
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In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 109-85-3 as follows. Formula: C3H9NO

Ligand 1b was prepared according to the method described for 1a using 2-(methoxy)ethylamine (0.39 mL, 4.54 mmol) and 1- methyl-1H-imidazole-2-carbaldehyde (0.455 g, 4.13 mmol) and isolated as a pale yellow oil in 92% yield. 1H NMR (300 MHz, CD2Cl2): d(ppm) 8.26 (s, 1H), 7.04 (s, 1H), 6.94 (s, 1H), 3.95 (s, 3H), 3.75e3.68 (m, 2H), 3.67e3.60 (m, 2H), 3.33 (s, 3H). 13C{1H} NMR (75 MHz, CD2Cl2): d(ppm) 154.96, 143.59, 129.32, 125.12, 72.53, 61.64, 58.86, 35.46. FT-IR (cm 1): 2875m, 1650s (nC]N), 1518w, 1475m, 1437m, 1366w, 1287m, 1236w, 1191w, 1118s, 1026w, 955w, 919m, 802m, 757m, 708m, 690m, 558w, 473w.

According to the analysis of related databases, 109-85-3, the application of this compound in the production field has become more and more popular.

Reference:
Article; Boudier, Adrien; Breuil, Pierre-Alain R.; Magna, Lionel; Olivier-Bourbigou, Helene; Braunstein, Pierre; Journal of Organometallic Chemistry; vol. 718; (2012); p. 31 – 37,7;; ; Article; Boudier, Adrien; Breuil, Pierre-Alain R.; Magna, Lionel; Olivier-Bourbigou, Helene; Braunstein, Pierre; Journal of Organometallic Chemistry; vol. 718; (2012); p. 31 – 37;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 109-85-3, name is 2-Methoxyethylamine, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 109-85-3

Preparation of 3-Bromo-N-(2-methoxy-ethyl)-benzenesulfonamide. A solution of 3-bromobenzenesulfonyl chloride (1.0 g, 3.72 mmol), 2-methoxyethylamine (0.84 g, 11.15 mmol, 3.0 eq), potassium carbonate (2.57 g, 18.59 mmol, 5.0 eq) in acetone (10.0 mL) was stirred at 40 0C for 4 h. The reaction was diluted with ethyl acetate, washed with water, brine, and dried over magnesium sulfate. The solvent was removed at reduced pressure and purified on the MPLC (Biotage) eluted with 20-25% ethyl acetate – hexane to afford 1.05 g (96 %) of the product. Rf = 0.33 (silica, ethyl acetate:hexanes, 3:7); 1H-NMR (DMSO-d6) 7.94 to 7.76 (m, 4H), 7.54 (t, J = 7.9 Hz, IH), 3.27 (t, J = 5.6 Hz, 2H), 3.13 (s, 3H), 2.93 (q, J = 5.6 Hz, 2H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 109-85-3.

Reference:
Patent; BAYER HEALTHCARE AG; WO2008/25509; (2008); A1;,
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Synthetic Route of 109-85-3, The chemical industry reduces the impact on the environment during synthesis 109-85-3, name is 2-Methoxyethylamine, I believe this compound will play a more active role in future production and life.

To a colorless solution of methyl 3-fluoro-4-nitrobenzoate (50 g, 250 mmol) in THF (400 ml_) was added triethylamine (40.7 g, 402 mmol, 55.8 ml_) followed by addition of 2- methoxyethanamine (30.2 g, 402 mmol) in THF (100 ml_), drop-wise, at room temperature. The resultant yellow solution was stirred at 55 C for 18 hours. The solution was cooled to room temperature and concentrated under reduced pressure to remove THF. The resultant yellow solid was dissolved in EtOAc (800 ml_) and washed with saturated aqueous ammonium chloride solution (250 ml_). The aqueous phase was separated and extracted with EtOAc (200 ml_). The combined organic layers were washed with saturated aqueous sodium chloride solution (3 x 250 ml_), dried over sodium sulfate, filtered, and concentrated under reduced pressure to yield C49 (60.2 g, 94%) as a yellow solid. 1H NMR (CDCb) d 8.23 (d, 1 H), 8.17 (br s, 1 H), 7.58 (d, 1 H), 7.25 (dd, 1 H), 3.95 (s, 3H), 3.69 – 3.73 (m, 2H), 3.56 (m, 2H), 3.45 (s, 3H); LCMS m/z 255.4 [M+H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Methoxyethylamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PFIZER INC.; ASPNES, Gary Erik; BAGLEY, Scott W.; CONN, Edward L.; CURTO, John M.; EDMONDS, David James; FLANAGAN, Mark E.; FUTATSUGI, Kentaro; GRIFFITH, David A.; HUARD, Kim; LIMBERAKIS, Chris; MATHIOWETZ, Alan M.; PIOTROWSKI, David W.; RUGGERI, Roger B.; (149 pag.)WO2019/239371; (2019); A1;,
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