Tag: 400-500

《Increased flare of acne caused by long-time mask wearing during COVID-19 pandemic among general population》 was written by Han, Changxu; Shi, Jialiang; Chen, Yan; Zhang, Zhenying. Application In Synthesis of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid And the article was included in Dermatologic Therapy in 2020. The article conveys some information:

Wearing a mask is encouraged for preventing dispersal of droplets during talking, sneezing and coughing. Therefore, it is thought to reduce the risk of environmental contamination by SARS-CoV-2 (COVID-19) based on the precautionary principles. However, longtime mask wearing could increase the flare of acne due to higher temperature and humidity on the surface of facial skin caused by expired air and the perspiration. Higher temperature has a close correlation with the flare of acne,which can be explained by the effect of higher temperature on the sebum excretion rate. Increased flare of acne caused by long-time mask wearing during COVID-19 pandemic among general population were noted here. Although wearing mask is extremely important to our fight against COVID-19, general public should be aware of proper and rational mask wearing. In the experimental materials used by the author, we found 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Application In Synthesis of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid)

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.Application In Synthesis of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Category: ethers-buliding-blocksIn 2020 ,《Advanced development of a non-ionic surfactant and cholesterol material based niosomal gel formulation for the topical delivery of anti-acne drugs》 was published in Materials Advances. The article was written by Shah, Akhilesh; Boldhane, Sanjay; Pawar, Atmaram; Bothiraja, Chellampillai. The article contains the following contents:

The aim of the present investigation was to develop adapalene (ADP), a high lipophilicity and low solubility anti-acne drug-loaded niosomal topical gel formulation, in order to improve its therapeutic efficacy. ADP niosomes were prepared using Span 60 and cholesterol using a modified ethanol injection method. A design of experiments (DOE) study was conducted to optimize ADP loaded niosomes. The potential of ADP niosomes was investigated for in vitro release and ex vivo skin permeation studies. Addnl., ADP niosomes were loaded into the Carbopol 934 gel and studied for its skin irritation, skin deposition and ex vivo skin permeation potential. The developed ADP niosomes showed the mean particle size, zeta potential, and entrapment efficiency of 278 nm, -17.99 mV, and 86%, resp. The optimized ADP niosomes showed controlled drug release up to 12 h. Nevertheless, the niosomal gel displayed controlled drug release up to 24 h with a reduction in skin irritation in Wistar rats. An in vivo skin deposition study showed 2.5-fold higher ADP retention in the stratum corneum layer as compared to the com. ADP formulation. The ADP niosomal gel would be a safe and valuable alternative to the conventional delivery systems for the treatment of acne. The experimental part of the paper was very detailed, including the reaction process of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Category: ethers-buliding-blocks)

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Development and Investigation of Vitamin C-Enriched Adapalene-Loaded Transfersome Gel: a Collegial Approach for the Treatment of Acne Vulgaris》 was written by Vasanth, Sandhya; Dubey, Akhilesh; Ravi, G. S.; Lewis, Shaila A.; Ghate, Vivek M.; El-Zahaby, Sally A.; Hebbar, Srinivas. Application In Synthesis of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acidThis research focused onvitamin C adapalene transfersome gel delivery acne vulgaris; Transfersomes; adapalene; cosmetics; topical; vitamin C. The article conveys some information:

Adapalene-loaded transfersome gel containing vitamin C as a combination therapy for the management of acne vulgaris was developed in the present study. The transfersome was prepared by reverse-phase evaporation, and the effect of various process parameters were investigated by the Design of Experiment (DOE) approach and optimized based on the particle size (PS), polydispersity index (PDI), zeta potential (ZP), and entrapment efficiency (EE). The selected tranfersomes were further evaluated for their thermal behavior and morphol. by transmission electron microscopy and turbidity measurements and incorporated into a gel with/without vitamin C. The gel was evaluated and compared with the marketed product (Adiff gel) for various physicochem. parameters, and in vivo studies in testosterone-induced rat models of acne. The prepared transfersomes had PS in the range of 280 to 400 nm, PDI values of 0.416 to 0.8, ZP of – 38 to – 20 mV, and % EE of 32 to 70%. DSC studies confirmed a pos. interaction of the components in the transfersome. Surface morphol. confirmed that the vesicles were spherical, unilamellar, and discrete. A relative deformability study showed higher elasticity of the transfersomes compared with Adiff aqs gel. Ascorbyl-6-palmitate in adapalene-loaded transfersome gel containing vitamin C (ADVTG) was found to have a good antioxidant free radical-scavenging activity. An in vitro drug release study showed that the sustained release of the transfersomal formulations was attributed to the flexibility of the vesicles by which penetration was increased. ADVTG was found to be promising in treating acne compared with the marketed product. The experimental part of the paper was very detailed, including the reaction process of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Application In Synthesis of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid)

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.Application In Synthesis of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Liu, Zhenfeng; Ai, Jing; Zhu, Zhenlai; Huang, Lixia; Yi, Zhen; Wu, Linshan; Xu, Yunjing; Zhu, Dingheng; Li, Huizhong; Yan, Yunling; Zhang, Lichun; Zhong, Xinyi; Yang, Bin published an article in Dermatologic Therapy. The title of the article was 《Chemical peeling with 35% glycolic acid for the treatment of disseminated facial verruca plana: A randomized, split-face, evaluator-blinded trial》.Recommanded Product: 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid The author mentioned the following in the article:

Disseminated facial verruca plana is a chronic disorder that causes significant psychol. distress. However, safe and effective treatment is lacking. This study aimed to explore the efficacy and safety of 35% glycolic acid (GA) for the treatment of disseminated facial verruca plana. A split-face clin. trial was conducted to explore the efficacy and safety of using chem. peeling with 35% GA for the treatment of disseminated facial verruca plana. One side of the face was applied with 35% GA once every fortnight for a total of three times. Adapalene gel was applied every night to the other side of the face as the control. The clearance rate of lesions was evaluated at different time points. Between June 2020 and Dec. 2020, 30 patients with disseminated verruca plana who visited the Dermatol. Hospital of Southern Medical University were enrolled. After three chem. peelings with 35% GA that was applied at 2-wk intervals, 15 (50%) patients achieved >70% lesion reduction The same effective rate in the adapalene gel-treated side of the face was documented in eight patients. Subgroup anal. showed a higher clearance rate in patients with a shorter disease duration. Moreover, concurrent improvements in facial roughness were observed in the 35% GA-treated group. Adverse effects including mild erythema and desquamation were observed during chem. peeling with 35% GA. In conclusion, chem. peeling with 35% GA could be a safe and effective option for treating disseminated facial verruca plana, especially for those who desire skin improvement.6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Recommanded Product: 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid) was used in this study.

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.Recommanded Product: 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Efficacy of topical ichthammol 10% for hidradenitis suppurativa: Case series and systematic review of its use in dermatology》 was written by Fisher, Shani; Ziv, Michael. Formula: C28H28O3 And the article was included in Dermatologic Therapy in 2020. The article conveys some information:

Hidradenitis suppurativa (HS) is a chronic, inflammatory, autoimmune, and persistent skin disease. It is representing in adolescence with painful, secreting, odorous lesions in apocrine gland-bearing areas, causing significantly decreased quality of life, depression, and low functioning. Ichthammol 10% ointment is a mixture of soft yellow paraffin with ichthammol 10%. It is prepared by distilling bituminous shale with ammonium sulfate. and has a strong smell reminiscent of fuel, and it colors the skin, and fabrics with greasy black stains that are difficult to remove. HS patients frequently suffer from abscesses despite systemic treatment. Prodromal symptoms to HS lesion development include fatigue, malaise, headache, and nausea. Local symptoms include erythema, paresthesia, itching and usually occurs 12 to 24 h before the outburst. Topical treatments mentioned in European guideline for the treatment of HS/acne inversa are resorcinol and clindamycin. Adapalene or azelaic acid are mentioned as exptl. The experimental process involved the reaction of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Formula: C28H28O3)

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.Formula: C28H28O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Yadav, Preeti; Bhatt, Bharat; Balaji, Kithiganahalli Narayanaswamy published an article in 2021. The article was titled 《Selective activation of MST1/2 kinases by retinoid agonist adapalene abrogates AURKA-regulated septic arthritis》, and you may find the article in Journal of Immunology.Safety of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid The information in the text is summarized as follows:

Septic arthritis is a chronic inflammatory disorder caused by Staphylococcus aureus invasion of host synovium, which often progresses to impairment of joint functions. Although it is known that disease progression is intricately dependent on dysregulated inflammation of the knee joint, identification of mol. events mediating such imbalance during S. aureus-induced septic arthritis still requires detailed investigation. In this article, we report that Aurora kinase A (AURKA) responsive WNT signaling activates S. aureus infection-triggered septic arthritis, which results in inflammation of the synovium. In this context, treatment with adapalene, a synthetic retinoid derivative, in a mouse model for septic arthritis shows significant reduction of proinflammatory mediators with a simultaneous decrease in bacterial burden and prevents cartilage loss. Mechanistically, adapalene treatment inhibits WNT signaling with concomitant activation of HIPPO signaling, generating alternatively activated macrophages. Collectively, we establish adapalene as a promising strategy to suppress S. aureus-induced irreversible joint damage. In the experiment, the researchers used many compounds, for example, 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Safety of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid)

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.Safety of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Drug Delivery Letters included an article by Jain, Divya D.; Desai, Namita D.. SDS of cas: 106685-40-9. The article was titled 《Development and Evaluation of Particulate Microcarriers of Adapalene as a Topical Delivery System》. The information in the text is summarized as follows:

Microparticulate drug delivery can play a major role in reducing side effects and providing better patient compliance due to targeted delivery. Methods: Adapalene microparticles were prepared using quasi emulsion solvent diffusion method. The effects of formulation variables including polymer ratios, amounts of emulsifier, drug loading and process variables such as stirring time and speed on the phys. characteristics of microparticles were investigated. The developed microparticles were characterized by DSC and SEM. Adapalene microparticles were incorporated into Carbopol 971 NF gel for ease of topical delivery. Results: Adapalene microparticulate topical gel showed sustained drug release over 8 h in in vitro studies. The amount of drug retained in the rat skin during ex vivo studies was higher in the microparticulate topical gel (227.43 ± 0.83 μg/cm2) as compared to the marketed formulation (81.4 ± 1.11 μg/cm2) after 8 h indicating localized and sustained drug action that can be useful in treating acne vulgaris. The safety of optimized Adapalene gel determined by skin irritation studies performed on Sprague Dawley rats showed no irritation potential. Conclusion: Microparticles can provide promising carrier systems to deliver Adapalene, improving patient compliance due to enhanced skin deposition, localized and sustained action with reduced associated irritant effects. The experimental part of the paper was very detailed, including the reaction process of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9SDS of cas: 106685-40-9)

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) may be used as a pharmaceutical reference standard for the quantification of the analyte in topical gel formulations using high-performance liquid chromatography technique.SDS of cas: 106685-40-9

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Tressler, Caitlin M.; Zondlo, Neal J. published their research in Organic Letters on December 16 ,2016. The article was titled 《Synthesis of Perfluoro-tert-butyl Tyrosine, for Application in 19F NMR, via a Diazonium-Coupling Reaction》.Formula: C24H22N2O4 The article contains the following contents:

A practical synthesis of the novel highly fluorinated amino acid Fmoc-perfluoro-tert-Bu tyrosine was developed. The sequence proceeds in two steps from com. available Fmoc-4-NH2-phenylalanine via diazotization followed by diazonium coupling reaction with perfluoro-tert-butanol. In peptides, perfluoro-tert-Bu tyrosine was detected in 30 s by NMR spectroscopy at 500 nM peptide concentration due to nine chem. equivalent fluorines that are a sharp singlet by 19F NMR. Perfluoro-tert-Bu ether has an estimated σp Hammett substituent constant of +0.30. In addition to this study using Fmoc-D-Phe(4-NH2)-OH, there are many other studies that have used Fmoc-D-Phe(4-NH2)-OH(cas: 324017-21-2Formula: C24H22N2O4) was used in this study.

Fmoc-D-Phe(4-NH2)-OH(cas: 324017-21-2) belongs to ethers.The C-O bonds that comprise simple ethers are strong. They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes. Formula: C24H22N2O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Miyazaki, Akira; Taki, Tomoki; Takeichi, Takuya; Kono, Michihiro; Yagi, Hiroaki; Akiyama, Masashi published an article in Journal of Dermatology. The title of the article was 《Darier disease successfully treated with a topical agent containing vitamin A (retinyl palmitate), vitamin E, and urea》.Product Details of 106685-40-9 The author mentioned the following in the article:

Darier disease (DD), also called keratosis follicularis, is an autosomal dominant hereditary keratinization disorder that manifests as keratotic papules with plaques in seborrheic areas. There are no validated curative treatments for DD, with the majority of cases treated symptomatically. We report the efficacy of a topical over-the-counter agent which contains retinyl palmitate, vitamin E, and urea for a patient with DD. A 13-yr-old girl had brown papules on her scalp, neck, shoulders, and axillae since entering elementary school. A skin biopsy revealed hyperkeratosis, suprabasal acantholysis, and dyskeratosis manifested as corps ronds and grains in the epidermis. Sanger sequencing found the previously reported heterozygous mutation c.1484C>T in ATP2A2. The application of an over-the-counter topical agent containing retinyl palmitate 2750 μg/g (5000 IU/g), tocopheryl acetate 20 mg/g, urea 200 mg/g, and monoammonium glycyrrhizinate 5 mg/g twice daily for 2 mo improved the papules without serious adverse events. Oral or topical aromatic vitamin A analogs (retinoids) are often used to treat DD. However, several adverse events are associated with retinoid treatment, and many patients only undergo their intermittent use or discontinue the treatments. Retinyl palmitate is more stable and has a lower irritative profile than other retinoic acids. When applied topically, however, retinyl palmitate cannot penetrate the skin as well as retinol can. Some reports have noted that vitamin E increases the biol. availability of vitamin A and that urea helps mech. percutaneous drug delivery. Our case suggests that retinyl palmitate has a sufficient therapeutic effect when combined with vitamin E and urea. In conclusion, we propose that topical agents containing retinyl palmitate, vitamin E, and urea might have a satisfactory effect on the skin lesions of DD patients, without the serious risks of adverse events. The experimental part of the paper was very detailed, including the reaction process of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Product Details of 106685-40-9)

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.Product Details of 106685-40-9

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Evaluating liver uptake and distribution of different poly(2-methyl-2-oxazoline) modified lysine dendrimers following intravenous administration》 were England, Richard M.; Moss, Jennifer I.; Hill, Kathryn J.; Elvevold, Kjetil; Smedsroed, Bard; Ashford, Marianne B.. And the article was published in Biomaterials Science in 2019. COA of Formula: C28H28O3 The author mentioned the following in the article:

We report on the synthesis of four poly(2-methyl-2-oxazoline) modified lysine dendrimers with different residual groups or modifications on the dendrimer core, including: amino groups (pos. charge), carboxyl groups (neg. charge), and two drug mols., one of which has a high log P. We looked at the in vivo distribution amongst three main liver cell types: hepatocytes, liver sinusoidal endothelial cells (LSECs) and Kupffer cells (KCs) and found differences in cell distribution and uptake concentrations dependent on these residual groups. In particular, the amino-functional polymer showed greater uptake by the hepatocytes while the carboxyl-functionalised polymer exhibited greater uptake by KCs and LSECs. These findings provide insight into which professional scavenger cells of the liver remove these types of nanoparticles from the bloodstream and we describe some of the design criteria to consider when creating novel drug delivery systems. In the experimental materials used by the author, we found 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9COA of Formula: C28H28O3)

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.COA of Formula: C28H28O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem