Tag: 400-500

HPLC of Formula: 106685-40-9In 2020 ,《Solid lipid microparticles for hair follicle targeting of adapalene and benzoyl peroxide – Release through targeted erosion》 was published in Journal of Drug Delivery Science and Technology. The article was written by Brammann, Christoph; Bornemann, Christel; Kannewurf, Ramon; Mueller-Goymann, Christel C.. The article contains the following contents:

Sebum-dependent targeting of the upper hair follicle by solid lipid microparticles has been demonstrated for retinoids using adapalene as an example. An extension of this formulation principle to the combination of adapalene/benzoyl peroxide was achieved on the basis of congealed solid-in-oil dispersions of nanoparticulate benzoyl peroxide, which were incorporated into the solid lipid microparticles. To investigate the dermal distribution and release behavior of the solid lipid microparticles after application, fluorescence microscopic ex vivo studies on porcine ear skin samples treated with the exptl. vehicle were supplemented by calorimetric skin lipid interaction studies and release experiments on lipid-coated membranes, investigating the influence of sebum and stratum corneum lipids on the solid lipid microparticle matrix. Fluorescent microscopic images of the treated skin confirm the observation of preferential deposition in the upper hair follicle. In addition, the release experiments show a sebum-dependent release of the active ingredients, with no detectable release in the presence of stratum corneum lipids. The observed discrepancy is probably a result of the rapid disintegration of the particles on contact with sebum, as calorimetric investigations suggest. This behavior, which is based on the similarity between the sebum components and the lipid matrix, allows a targeted release into sebum and thus increased follicular penetration. In addition to this study using 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid, there are many other studies that have used 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9HPLC of Formula: 106685-40-9) was used in this study.

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.HPLC of Formula: 106685-40-9

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The author of 《Multi-drug hybrid delivery systems with distinct release profiles based on gelatin/collagen containing vesicles derived from block copolymers》 were Brey Gil, Viviane S.; Brey Gil, Camila S.; Goulart, Gisele Assis Castro; Orefice, Rodrigo L.. And the article was published in International Journal of Biological Macromolecules in 2019. Synthetic Route of C28H28O3 The author mentioned the following in the article:

Hybrid delivery systems can release multiple drugs with different profiles and have several applications, including skin dressing. In this work, the co-solvent technique was used for the preparation of nanometric vesicles based on poly(styrene-b-ethylene oxide) block copolymer (BCPVs) containing adapalene (AD). The BCPVs were incorporated into collagen and gelatin matrixes together with free AD and silver sulfadiazine (SSD). The AD content of BCPVs and their release capacity were analyzed by using UV-visible spectroscopy (UV-Vis). The gelatin and collagen matrixes were evaluated for their ability to release AD and SSD through an in vitro release study. The obtained results confirmed that the production of empty and AD-loaded BCPVs was viable. The degree of AD encapsulation in BCPVs was 9.0% and the in vitro test revealed a constant, slow, and prolonged release of AD content from AD-loaded BCPVs. The combination of free and encapsulated multiple drugs in hybrid delivery systems based on gelatin and collagen matrixes was shown to act as a skin dressing that combined the progressive release of large amounts of drugs within the first hours of use (to restrict infection) with a more prolonged and slow release of AD to enhance skin healing. The experimental process involved the reaction of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Synthetic Route of C28H28O3)

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.Synthetic Route of C28H28O3

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Ether – Wikipedia,
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《An investigation on the effect of drug physicochemical properties on the enhancement strength of enhancer: The role of drug-skin-enhancer interactions》 was written by Xu, Wenwen; Liu, Chao; Zhang, Yang; Quan, Peng; Yang, Degong; Fang, Liang. Application of 106685-40-9This research focused ontransdermal drug physicochem enhancement strength permeation enhancer solubility POCC; Chemical permeation enhancers; Permeation-enhancing mechanism; Physicochemical parameter of drugs; Polar surface area; Polarizability. The article conveys some information:

The aim of present work was to investigate the influence of drug physicochem. properties on the enhancement effect of enhancers, which guided the application of enhancers in different drug transdermal prescriptions. Firstly, Polyglyceryl-3 dioleate (POCC) was selected as a model enhancer and its enhancement effect on ten drugs was assessed by in vitro skin permeation experiment Secondly, the correlation anal. of physicochem. properties of drugs was carried out from the aspects of partition and permeation. The interactions of drug-skin-POCC were elucidated by FT-IR, mol. docking, solubility parameters calculation, ATR-FTIR, Raman study, mol. dynamics simulation and confocal laser scanning microscopy (CLSM). The results showed that the enhancement ratio (ER) of drugs was ranging from 2.23 to 7.45. On one hand, the miscibility between drugs with low polar surface area (P.S.A) and donor solution was decreased more pronounced by the addition of POCC because of the drug was difficult to form hydrogen-bond with POCC, facilitating the vehicle/SC partition of drugs. On the other hand, the permeation of drugs with low P. S. A and polarizability was enhanced more significantly by POCC because the drug was less likely to interact with skin lipids compared to others, causing that POCC had more chance to interact with skin lipids to improve permeation drugs across the SC more easily. In conclusion, the different strength of drug-skin-POCC interactions was the main reason for the discrepancy in the enhancement effect of the POCC on ten drugs, which laid a basis for the research on the drug-specific mol. mechanisms of enhancers. In the experiment, the researchers used 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Application of 106685-40-9)

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.Application of 106685-40-9

Referemce:
Ether – Wikipedia,
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《Simultaneous estimation of dapsone and adapalene in gel formulation by UV- spectroscopy》 was published in International Journal of Pharmaceutical Sciences and Research in 2020. These research results belong to Vichare, V. S.; Handargule, P. V.. Reference of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid The article mentions the following:

A new, simple, sensitive, and economical UV spectro-photometric method was developed for the simultaneous anal. of Adapalene and Dapsone in pharmaceutical formulation. This UV method was developed with THF and Distilled water as solvents. The wavelengths selected for anal. in the present method were 237 nm and 293 nm. The method was validated as per ICH guidelines. The method was validated for linearity, accuracy, precision, specificity and robustness. Linearity was found to be within the concentration range of 0.05-0.25μg/mL for Adapalene and 2.5-12.5μg/mL for Dapsone. Accuracy for the method was determined by recovery studies. The % drug recovered was found to be 99-102% weight/weight The % RSD values of repeatability and intermediate precision were found to be less than 2, providing method was precise in nature. From all these studies it was observed that there was no interference of excipients from the formulation during the anal. The advantages of this method for anal. purposes lie in the rapid determination, its cost-effectiveness, easy preparation of the sample and good reproducibility. In addition to this, the present method can be recommended for the simultaneous determination of Adapalene and Dapsone in routine quality control anal. in combined drug formulations. In addition to this study using 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid, there are many other studies that have used 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Reference of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid) was used in this study.

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.Reference of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid

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Ether – Wikipedia,
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《Establishment of a Monoclonal Antibody That Recognizes Cysteine-Rich Domain 1 of Human CD271》 was written by Morita, Shinkichi; Mochizuki, Mai; Shibuya-Takahashi, Rie; Nakamura-Shima, Mao; Yamazaki, Tomoko; Imai, Takayuki; Asada, Yukinori; Matsuura, Kazuto; Kawamura, Sadafumi; Yamaguchi, Kazunori; Yasuda, Jun; Sugamura, Kazuo; Katori, Yukio; Satoh, Kennichi; Tamai, Keiichi. Category: ethers-buliding-blocks And the article was included in Monoclonal Antibodies in Immunodiagnosis and Immunotherapy in 2020. The article conveys some information:

CD271 is a common receptor for all neurotrophins that is localized to neurons, endothelial cells, and the basal layer of the epithelium in normal tissue. Recently, we and others reported that CD271 plays essential roles in the development of squamous cell carcinoma, especially in tumor-initiating cells. Since little is known about how CD271 regulates cancer cell initiation and proliferation, antibodies that recognize different domains of CD271 are needed to enable investigation. Therefore, this study aimed to develop an antihuman CD271 antibody by immunizing mice with a CD271 antigen produced by a baculovirus. The antibody was named hCD271mAb#13, and it recognized cysteine-rich domain 1 with a higher affinity than the com. available antibody ME20.4. We determined that hCD271mAb#13 is suitable for flow cytometry, Western blotting, immunocytochem., and immunohistochem. of formalin-fixed paraffin-embedded tissue. Use of hCD271mAb#13 for CD271 labeling could enable detailed analyses of cancer cell regulation and other biol. processes.6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Category: ethers-buliding-blocks) was used in this study.

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.Category: ethers-buliding-blocks

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Related Products of 106685-40-9In 2020 ,《Vitamin A derivatives use in the treatment of skin conditions》 appeared in International Journal of Current Pharmaceutical Research. The author of the article were Al-Abadie, Mohammed; Oumeish, Faris; Al-Rubaye, Mohammed; Rafiq, Shahid; Ball, Patrick Anthony; Morrissey, Hana. The article conveys some information:

A review. This paper aims to develop prescribers’ knowledge about their benefits, to improve their usability and aids in alleviating patient concerns to improve therapeutic outcomes in dermatol. conditions. In acne vulgaris, adapalene gel and tretinoin cream showed equal efficacy. In psoriasis the combination of acitretin and PUVA was superior to PUVA alone. Acitretin showed a reduction of 41% in the Nail Psoriasis Severity Index and similar efficacy to potent steroids and calcipotriol. In chronic hand eczema, alitretinoin showed 50% improvement in patient’s refractory to steroid treatment. In photoaging and aging, retinoids were shown to increase the synthesis and decrease the degradation rate of collagen and hyaluronate, reducing the impact of aging. In rosacea, topical and systemic isotretinoin showed complete remission in 24% of the patients compared to only 14% with antibiotics (metronidazole and doxycycline). In lichen planus, isotretinoin demonstrated clin. and histopathol. efficacy. In cutaneous T-cell lymphoma, bexarotene used alone or with PUVA or narrow band UVB, showed a response between 80.0% to 84.0%. Lastly in Kaposi sarcoma alitretinoin gel showed superiority to all other agents and better tolerance. This review highlights the benefit of timely use of vitamin A derivatives to encourage wider use. In the part of experimental materials, we found many familiar compounds, such as 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Related Products of 106685-40-9)

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.Related Products of 106685-40-9

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《Subclinical effects of adapalene-benzoyl peroxide: a prospective in vivo imaging study on acne micromorphology and transfollicular delivery》 was written by Fuchs, C. S. K.; Ortner, V. K.; Hansen, F. S.; Philipsen, P. A.; Haedersdal, M.. Formula: C28H28O3 And the article was included in Journal of the European Academy of Dermatology and Venereology in 2021. The article conveys some information:

Adapalene-benzoyl peroxide (A-BPO) is a first-line topical treatment for acne vulgaris. In vivo reflectance confocal microscopy (RCM) and optical coherence tomog. (OCT) detect micromorphol. changes over time and visualize transfollicular delivery. To visualize temporal, subclin. effects of A-BPO on acne micromorphol. using RCM and OCT, and evaluate their impact on transfollicular delivery of microparticulate carrier systems. Fifteen patients with mild to moderate acne received a 6-wk course of A-BPO. Micromorphol. changes were evaluated at time 0, 3 and 6 wk with RCM (n = 1190 images) and OCT (n = 210 scans). Transfollicular delivery of microparticles was assessed at baseline and week 6. In vivo imaging visualized steady normalization of skin micromorphol. in response to A-BPO over 6 wk, including decreased hyperkeratinization of follicular borders (RCM median decrease -71.2%, P < 0.05), reduced intrafollicular keratinous content (RCM median decrease -47.7%, P < 0.05) and increased epidermal thickness (OCT median increase of 25.25%, P < 0.05). Imaging visualized microparticles in the follicular unit. Despite a visible reduction in keratin and sebum, transfollicular microparticle delivery appeared unaffected. Reflectance confocal microscopy and OCT detect A-BPO-induced changes in micromorphol. and visualize transfollicular microparticle delivery. Keratolysis and sebolysis did not have a measurable effect on transfollicular delivery of microparticles. The experimental part of the paper was very detailed, including the reaction process of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Formula: C28H28O3)

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) may be used as a pharmaceutical reference standard for the quantification of the analyte in topical gel formulations using high-performance liquid chromatography technique.Formula: C28H28O3

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《A pharmacovigilance study of topical acne monotherapy with 0.1% adapalene, and a molecular analytical review of adapalene in evidence-based dermatopharmacological treatment》 was written by Hazra, Moumita. Application In Synthesis of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid And the article was included in International Journal of Pharmaceutical Sciences Review and Research in 2021. The article conveys some information:

Acne vulgaris causes cosmetic impairment. User-friendly anti-acne monotherapy with adapalene has activity against the acne pathophysiol., with very minimal adverse effects. Retinoids, like adapalene, are comedolytic and anti-inflammatory. This study was conducted as a pharmacovigilance study of topical acne monotherapy with 0.1% adapalene, and a mol. anal. review of adapalene in evidence-based dermatopharmacol. treatment. A prospective, open- labeled study was done, on 75 patients, with mild to moderate acne. Patients applied 0.1% adapalene topical monotherapy, once daily in the evening, over affected areas on the face, and left overnight. Efficacy was measured by percentage reduction in non-inflammatory, inflammatory and total lesion counts on 0, 15, 30, 60 and 90 days; and severity of lesions was assessed by Investigator’s Global Evaluation Scale and the occurrence of adverse effects like erythyma, dryness, scaling, burning and pruritus, were assessed by the Local Irritation Scale, among the patients receiving the monotherapy. An anal. review of the mol. pharmacol. of adapalene in evidence-based dermatopharmacol. treatment was thoroughly performed. The patients showed highly significant reduction in total lesion counts from baseline. No serious adverse effects were observed; and the observations were statistically non-significant. The mol. anal. review described significantly effective evidence-based dermatopharmacol. response mechanisms of adapalene therapeutics. Topical 0.1% adapalene monotherapy was effective and safe, with significant evidence-based mol. dermatopharmacol. efficacy. The results came from multiple reactions, including the reaction of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Application In Synthesis of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid)

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) may be used as a pharmaceutical reference standard for the quantification of the analyte in topical gel formulations using high-performance liquid chromatography technique.Application In Synthesis of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid

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In 2019,International Journal of Pharmaceutics (Amsterdam, Netherlands) included an article by Brammann, Christoph; Mueller-Goymann, Christel C.. HPLC of Formula: 106685-40-9. The article was titled 《Incorporation of benzoyl peroxide nanocrystals into adapalene-loaded solid lipid microparticles: Part II – Solid-in-Oil dispersion of nanoparticulate benzoyl peroxide》. The information in the text is summarized as follows:

Benzoyl peroxide as a monotherapeutic and in combination with adapalene is a cornerstone of current acne therapy, but its unfavorable side effect profile reduces the therapeutic value of this compound The incorporation into an adapalene-loaded microparticulate lipid matrix, which – via the principle of targeted erosion – allows the targeted release of active substances in the hair follicles, is a promising approach to reduce side effects such as skin redness, increased scaling and allergic reactions. However, there are challenges to the production of such a vehicle which require a galenic solution That is in particular the redispersion of nanoparticulate benzoyl peroxide in lipids while maintaining its nanodisperse character. In the present work, the lamellar liquid crystalline phase of a binary water/phospholipid system is used to stabilize a nanosuspension during freeze-drying. Both after redispersing in water and after dispersing in nonpolar fat phases, the initial size of the nanosuspension was recovered with only minor deviations. The found cryoprotective effect of purified phospholipid allows the generation of highly concentrated solid-in-oil systems both in fat phases liquid at room temperature and in lipid melts, which after solidification can serve as starting material for the preparation of lipid microparticles loaded with benzoyl peroxide nanocrystals. The experimental part of the paper was very detailed, including the reaction process of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9HPLC of Formula: 106685-40-9)

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) may be used as a pharmaceutical reference standard for the quantification of the analyte in topical gel formulations using high-performance liquid chromatography technique.HPLC of Formula: 106685-40-9

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The author of 《Anatomy, immunohistochemistry, and numerical distribution of human splenic microvessels.》 were Almenar, S; Rios-Navarro, C; Ortega, M; Molina, P; Ferrandez-Izquierdo, A; Ruiz-Sauri, A. And the article was published in Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft in 2019. Application of 106685-40-9 The author mentioned the following in the article:

The microvascular architecture of the spleen plays an important role in the immunological function of this organ. The different types of vessels are related to different reticular cells each with their own immunomodulatory functions. The present study describes an immunohistochemical and morphometric analysis of the various types of vessels in 21 human autopsy non-pathological splenic samples. On an area of 785,656.37 μm2 for each sample, we classified and quantified the type and number of vascular structures, each according to their morphology and immunohistochemical profile, and obtained the ratios between them. The distribution of trabecular vessels and the characteristics of the venules are reviewed. In our material the so-called “”cavernous perimarginal sinus”” (anatomical structure previously described by Schmidt et al., 1988) was observed and interpreted as a curvilinear venule shaped by the follicle in contact with the trabecular vein. Our material comprised 261 trabeculae (containing 269 arterial sections and 508 venous sections), 30,621 CD34+ capillaries, 7739 CD271+ sheathed capillaries, 2588 CD169+ sheathed capillaries, and 31,124 CD8+ sinusoids. The total area (TA) (14,765,714.88 μm2) occupied by the sinusoidal sections of the 21 cases was much higher than the TA of the capillary sections (1,700,269.83 μm2). Similarly, the TA (651,985 μm2) occupied by the sections of the trabecular veins was much higher than the TA of the trabecular arteries (88,594 μm2). The total number of CD34+ capillaries and of sinusoids CD8+ was similar for the sum of the 21 cases, nevertheless there were large differences in each case. Statistically the hypothesis that the number of capillaries and sinusoids are present with the same frequency is discarded. In view of the absence of a numerical correlation between capillaries and sinusoids, we postulate that very possibly the arterial and the venous vascular trees are two anatomically independent structures separated by the splenic cords. We believe that this is the first work where splenic microvascularization is simultaneously approached from a morphometric and immunohistochemical point of view. The experimental part of the paper was very detailed, including the reaction process of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Application of 106685-40-9)

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.Application of 106685-40-9

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem