Tag: 300-400

After enjoying curry: urine metabolism analysis of curcuminoids by microemulsion electrokinetic chromatography with laser-induced native fluorescence detection was written by Zang, Kun;Xia, Jingtong;Wu, Chengxin;Yang, Shuping;Wang, Wei;Zeng, Zhi-Cong;Zhou, Lei;Pu, Qiaosheng. And the article was included in Journal of Chromatography A in 2021.Formula: C19H16O4 The following contents are mentioned in the article:

Considering pH-dependent fluorescence of curcuminoids, a microemulsion electrokinetic chromatog. (MEEKC) method was developed under acidic conditions for their separation and detection using laser-induced native fluorescence (LINF), so as to solve the anal. of urine metabolism for curcuminoids. The microemulsion composition was optimized by response surface methodol. (RSM), and the effects of buffer pH and organic modifiers were systematically investigated. The optimal buffer for the separation of curcuminoids was chosen as follows: 2.8% (volume/volume) Et acetate, 80 mM SDS and 2.8% (volume/volume) n-butanol to form microemulsion, 28% (volume/volume) ethanol as organic modifier, and 20 mM phosphoric acid as electrolyte at pH 3.0. Under these conditions, four curcuminoids including curcumin, demethoxy curcumin (DMC), bisdemethoxy curcumin (BDMC) and demethyl curcumin (DEC) could be well separated within 18 min, and the detection limits (LOD, based on S/N=3) were calculated to be 71, 60, 22, and 147 pg mL-1, resp. Combined with solid-phase extraction (SPE), the developed MEEKC-LINF method has been successfully applied to continuously monitor the curcuminoids and related metabolites in human urine collected from a healthy volunteer after oral administration of curry, testifying that this method has potential for evaluating the pharmacol. activity of curcuminoids. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Formula: C19H16O4).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Formula: C19H16O4

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Transcriptomic and Metabolic Analysis of Fruit Development and Identification of Genes Involved in Raffinose and Hydrolysable Tannin Biosynthesis in Walnuts was written by Wang, Hua;Asker, Keysarjan;Zhan, Chang;Wang, Nian. And the article was included in Journal of Agricultural and Food Chemistry in 2021.Application of 33171-05-0 The following contents are mentioned in the article:

Walnut (Juglans regia L.) is an important fruit tree with high nutrition in its nuts. Here, the development of walnut fruits was monitored, and nine biol. samples at five developmental stages were collected and analyzed by transcriptomic and metabolic assays. Many phenolic metabolites accumulated in the peel of mature fruits, while lipids, carbohydrates, and amino acids and their derivatives mainly accumulated in the kernel. Fatty acid biosynthesis occurred at 13 wk after pollination, and photosynthesis might occur in the exocarp of walnuts. By coexpression anal. of the transcriptome and metabolome, genes responsible for some metabolic pathways were predicted. Three genes encoding shikimate dehydrogenases (SDHs) that convert 3-dehydroshikimic acid to gallic acid (GA) and four genes encoding UDP-glycosyltransferase (UGT) that convert GA to β-glucogallin in the biosynthesis of hydrolysable tannins (HTs) were selected for functional confirmation. These three SDH genes were then expressed in Escherichia coli, and their recombinant proteins showed GA formation activity. Moreover, heterologous expression of the three SDH and four UGT genes in poplar hairy roots also showed a significant increase in GA and β-glucogallin accumulation, resp. Taken together, we have provided an overview of walnut fruit development and uncovered genes involved in HT biosynthesis. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Application of 33171-05-0).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Application of 33171-05-0

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Anti-inflammatory and Antioxidant Activity of Nanoencapsulated Curcuminoids Extracted from Curcuma longa L. in a Model of Cutaneous Inflammation was written by Lima, Emanuele P.;Goncalves, Odinei H.;Ames, Franciele Q.;Castro-Hoshino, Lidiane V.;Leimann, Fernanda V.;Cuman, Roberto K. N.;Comar, Jurandir F.;Bersani-Amado, Ciomar A.. And the article was included in Inflammation in 2021.COA of Formula: C19H16O4 The following contents are mentioned in the article:

The present study evaluated the anti-inflammatory effect of nanoencapsulated curcuminoid preparations of poly(vinyl pyrrolidone) (Nano-cur) and free curcuminoids (Cur) in an exptl. model of croton oil-induced cutaneous inflammation. Male Swiss mice, weighing 25-30 g, received oral treatment by gavage 1 h before CO application or topical treatment immediately after CO application (200 Μg diluted in 70% acetone) with a single dose of Cur and Nano-cur. After 6 h, the animals were anesthetized and euthanized. The ears were sectioned into disks (6.0 mm diameter) and used to determine edema, myeloperoxidase (MPO) activity, and oxidative stress. Photoacoustic spectroscopy (PAS) was used to evaluate the percutaneous penetration of Cur and Nano-cur. Topical treatment with both preparations had a similar inhibitory effect on the development of edema, MPO activity, and the oxidative response. The PAS technique showed that the percutaneous permeation of both topically applied preparations was similar. Oral Nano-cur administration exerted a higher anti-inflammatory effect than Cur. Topical Cur and Nano-cur application at the same dose similarly inhibited the inflammatory and oxidative responses. Oral Nano-cur administration inhibited such responses at doses that were eight times lower than Cur, suggesting the better bioavailability of Nano-cur compared with Cur. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0COA of Formula: C19H16O4).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.COA of Formula: C19H16O4

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Comparative Study of Preparation, Evaluation, and Pharmacokinetics in Beagle Dogs of Curcumin β-Cyclodextrin Inclusion Complex, Curcumin Solid Dispersion, and Curcumin Phospholipid Complex was written by Song, Wanrong;Chen, Xizhao;Dai, Chongshan;Lin, Degui;Pang, Xuelin;Zhang, Di;Liu, Gang;Jin, Yipeng;Lin, Jiahao. And the article was included in Molecules in 2022.HPLC of Formula: 33171-05-0 The following contents are mentioned in the article:

Curcumin is a natural acidic polyphenol extracted from turmeric with a wide range of biol. and pharmacol. effects. However, the application of curcumin for animal production and human life is limited by a low oral bioavailability. In this study, natural curcumin was prepared for the curcumin β-cyclodextrin inclusion complex (CUR-β-CD), curcumin solid dispersion (CUR-PEG-6000), and curcumin phospholipid complex (CUR-HSPC) using co-precipitation, melting, and solvent methods, resp. Curcumin complex formations were monitored using SEM (SEM), X-ray diffraction (XRD), and Fourier transform IR (FT-IR) techniques via the shifts in the microscopic structure, mol. structure, and crystalline state. Subsequently, twenty-four female beagle dogs were randomly divided into four groups to receive unmodified curcumin and three other curcumin preparations The validated UPLC-MS assay was successfully applied to pharmacokinetic and bioavailability studies of curcumin in beagle dog plasma, which were collected after dosing at 0 min (predose), 5 min, 15 min, 30 min, 40 min, 50 min, 1.5 h, 3 h, 4.5 h, 5.5 h, 6 h, 6.5 h, 9 h, and 24 h. The relative bioavailabilities of CUR-β-CD, CUR-PEG-6000, and CUR-HSPC were 231.94%, 272.37%, and 196.42%, resp. This confirmed that CUR-β-CD, CUR-HSPC, and especially CUR-PEG-6000 could effectively improve the bioavailability of curcumin. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0HPLC of Formula: 33171-05-0).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.HPLC of Formula: 33171-05-0

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Genome sequencing of turmeric provides evolutionary insights into its medicinal properties was written by Chakraborty, Abhisek;Mahajan, Shruti;Jaiswal, Shubham K.;Sharma, Vineet K.. And the article was included in Communications Biology in 2021.Name: Bisdemethoxycurcumin The following contents are mentioned in the article:

Curcuma longa, or turmeric, is traditionally known for its immense medicinal properties and has diverse therapeutic applications. However, the absence of a reference genome sequence is a limiting factor in understanding the genomic basis of the origin of its medicinal properties. In this study, we present the draft genome sequence of C. longa, belonging to Zingiberaceae plant family, constructed using 10x Genomics linked reads and Oxford Nanopore long reads. For comprehensive gene set prediction and for insights into its gene expression, transcriptome sequencing of leaf tissue was also performed. The draft genome assembly had a size of 1.02 Gbp with ∼70% repetitive sequences, and contained 50,401 coding gene sequences. The phylogenetic position of C. longa was resolved through a comprehensive genome-wide anal. including 16 other plant species. Using 5,388 orthogroups, the comparative evolutionary anal. performed across 17 species including C. longa revealed evolution in genes associated with secondary metabolism, plant phytohormones signaling, and various biotic and abiotic stress tolerance responses. These mechanisms are crucial for perennial and rhizomatous plants such as C. longa for defense and environmental stress tolerance via production of secondary metabolites, which are associated with the wide range of medicinal properties in C. longa. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Name: Bisdemethoxycurcumin).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Name: Bisdemethoxycurcumin

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Interaction of bisdemethoxycurcumin with sodium dodecyl sarcosine + Tween 20/Tween 60 mixed surfactants: Insights from multispectral analysis and solubilization effect was written by Weng, Tianxin;Wang, Lu;Liu, Yinglin;Zhang, Xinpeng;Wu, Yushu;Zhang, Yongfang;Han, Jun;Liu, Min. And the article was included in Colloids and Surfaces, A: Physicochemical and Engineering Aspects in 2022.Related Products of 33171-05-0 The following contents are mentioned in the article:

The low aqueous solubility of curcuminoids, including bisdemethoxycurcumin (BDMC), severely limits their applications in the food and pharmaceutical industries. This improvement is expected to be achieved by encapsulating them with mixed surfactant micellar systems. In this study, the interaction of BDMC with sodium dodecyl sarcosine (SDDS) + Tween 20/Tween 60 mixed micelles was studied at the mol. level. The molar ratio of Tween 20/Tween 60 to SDDS in the mixed micelles was optimized using response surface methodol. The binding parameters of BDMC to the mixed micelles were determined by fluorescence and UV-vis absorption spectroscopy. Thermodn. anal. showed that the hydrophobic interaction was dominant in the binding process. The longer hydrophobic chain of Tween 60 was responsible for the stronger interaction of BDMC with SDDS + Tween 60. The binding site of BDMC in the hydrophobic alkyl chains of the mixed micelles was analyzed by copper ion fluorescence quenching anal., fluorescence polarization anal., ¹H NMR spectroscopy, and time-resolved fluorescence spectroscopy. The solubility of BDMC in the mixed micelles was enhanced and SDDS + Tween 60 had more significant solubilization capacity. Therefore, the mixed micellar systems may provide a feasible solution for the application of BDMC in functional food and medicine fields. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Related Products of 33171-05-0).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Related Products of 33171-05-0

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Trienone analogs of curcuminoids induce fetal hemoglobin synthesis via demethylation at ^Gγ-globin gene promoter was written by Nuamsee, Khanita;Chuprajob, Thipphawan;Pabuprapap, Wachirachai;Jintaridth, Pornrutsami;Munkongdee, Thongperm;Phannasil, Phatchariya;Vadolas, Jim;Chaichompoo, Pornthip;Suksamrarn, Apichart;Svasti, Saovaros. And the article was included in Scientific Reports in 2021.Formula: C19H16O4 The following contents are mentioned in the article:

The reactivation of γ-globin chain synthesis to combine with excess free α-globin chains and form fetal Hb (HbF) is an important alternative treatment for β-thalassemia. We had reported HbF induction property of natural curcuminoids, curcumin (Cur), demethoxycurcumin (DMC) and bis-demethoxycurcumin (BDMC), in erythroid progenitors. Herein, the HbF induction property of trienone analogs of the three curcuminoids in erythroleukemic K562 cell lines and primary human erythroid progenitor cells from β-thalassemia/HbE patients was examined All three trienone analogs could induce HbF synthesis. The most potent HbF inducer in K562 cells was trienone analog of BDMC (T-BDMC) with 2.4 ± 0.2 fold increase. In addition, DNA methylation at CpG – 53, – 50 and + 6 of Gγ-globin gene promoter in K562 cells treated with the compounds including T-BDMC (9.3 ± 1.7%, 7.3 ± 1.7% and 5.3 ± 0.5%, resp.) was significantly lower than those obtained from the control cells (30.7 ± 3.8%, 25.0 ± 2.9% and 7.7 ± 0.9%, resp. P < 0.05). The trienone compounds also significantly induced HbF synthesis in β-thalassemia/HbE erythroid progenitor cells with significantly reduction in DNA methylation at CpG + 6 of Gγ-globin gene promoter. These results suggested that the curcuminoids and their three trienone analogs induced HbF synthesis by decreased DNA methylation at Gγ-globin promoter region, without effect on Aγ-globin promoter region. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Formula: C19H16O4).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Formula: C19H16O4

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

A state of the art of antioxidant properties of curcuminoids in neurodegenerative diseases was written by Silvestro, Serena;Sindona, Cinzia;Bramanti, Placido;Mazzon, Emanuela. And the article was included in International Journal of Molecular Sciences in 2021.Name: Bisdemethoxycurcumin The following contents are mentioned in the article:

A review. Neurodegenerative diseases represent a set of pathologies characterized by an irreversible and progressive, and a loss of neuronal cells in specific areas of the brain. Oxidative phosphorylation is a source of energy production by which many cells, such as the neuronal cells, meet their energy needs. Dysregulations of oxidative phosphorylation induce oxidative stress, which plays a key role in the onset of neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS). To date, for most neurodegenerative diseases, there are no resolute treatments, but only interventions capable of alleviating the symptoms or slowing the course of the disease. Therefore, effective neuroprotection strategies are needed. In recent years, natural products, such as curcuminoids, have been intensively explored and studied for their therapeutic potentials in several neurodegenerative diseases. Curcuminoids are, nutraceutical compouns, that owen several therapeutic properties such as anti-oxidant, anti-inflammatory and neuroprotective effects. In this context, the aim of this review was to provide an overview of preclin. and clin. evidence aimed to illustrate the antioxidant effects of curcuminoids in neurodegenerative diseases. Promising results from preclin. studies encourage the use of curcuminoids for neurodegeneration prevention and treatment. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Name: Bisdemethoxycurcumin).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Name: Bisdemethoxycurcumin

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Molecular docking and molecular dynamics to identify collagenase inhibitors as lead compounds to address osteoarthritis was written by Roy, Himadri Shekhar;Dubey, Gurudutt;Sharma, Vishnu Kumar;Bharatam, Prasad V.;Ghosh, Deepa. And the article was included in Journal of Biomolecular Structure and Dynamics in 2022.Related Products of 33171-05-0 The following contents are mentioned in the article:

Osteoarthritis (OA) is a degenerative disease which affects a large number of individuals. Collagenases, which belong to a class of metalloproteases (MMPs), are responsible for the degradation of cartilage manifested in OA. Inhibition of the catalytic domains of these MMPs is one of the important therapeutic strategies proposed for the prevention of OA. The main objective of this work is to evaluate the binding of curcumin and its metabolites with the active sites of collagenases in comparison to standard inhibitors on the basis of our hypothesis that curcumin/metabolites could exhibit an inhibitory effect on MMPs. Here, we report the mol. docking anal. of curcumin and its metabolites with collagenases (MMP-1, MMP-8, MMP-13). Among the mols. tested, curcumin monoglucuronide (CMG) demonstrated the best binding affinity with MMP-13, which is specifically implicated in OA. The CMG-MMP-complexes were further subjected to mol. dynamic simulations to explore the stability of the complexes and to estimate the free binding energies. The results indicated that CMG preferentially bind to MMP-13 in comparison to that of MMP-1 and MMP-8 with binding free energies (ΔGbind) of (-60.55), (-27.02) and (-46.91) kcal/mol, resp. This is the first study which suggests that curcumin monoglucuronide can be considered as an effective lead compound to prevent the progression of OA.Communicated by Ramaswamy H. Sarma. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Related Products of 33171-05-0).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Related Products of 33171-05-0

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Evaluation of Antiproliferative Palladium(II) Complexes of Synthetic Bisdemethoxycurcumin towards In Vitro Cytotoxicity and Molecular Docking on DNA Sequence was written by Miklasova, Natalia;Herich, Peter;Davila-Becerril, Juan Carlos;Barroso-Flores, Joaquin;Fischer-Fodor, Eva;Valentova, Jindra;Leskovska, Janka;Kozisek, Jozef;Takac, Peter;Mojzis, Jan. And the article was included in Molecules in 2021.Safety of Bisdemethoxycurcumin The following contents are mentioned in the article:

Metallodrugs form a large family of therapeutic agents against cancer, among which is cisplatin, a paradigmatic member. Therapeutic resistance and undesired side effects to Pt(II) related drugs, prompts research on different metal-ligand combinations with potentially enhanced biol. activity. We present the synthesis and biol. tests of novel palladium(II) complexes containing bisdemethoxycurcumin (BDMC) 1 and 2. Complexes were fully characterized and their structures were determined by X-ray diffraction. Their biol. activity was assessed for several selected human tumor cell lines: Jurkat (human leukemic T-cell lymphoma), HCT-116 (human colorectal carcinoma), HeLa (human cervix epitheloid carcinoma), MCF-7 (human breast adenocarcinoma), MDA-MB-231 (human mammary gland adenocarcinoma), A549 (human alveolar adenocarcinoma), Caco-2 (human colorectal carcinoma), and for non-cancerous 3T3 cells (murine fibroblasts). The cytotoxicity of 1 is comparable to that of cisplatin, and superior to that of 2 in all cell lines. It is a correlation between IC₅₀ values of 1 and 2 in the eight studied cell types, promising a potential use as anti-proliferative drugs. Moreover, for Jurkat cell line, complexes 1 and 2, show an enhanced activity. DFT and docking calculations on the NF-κB protein, Human Serum Albumin (HSA), and DNA were performed for 1 and 2 to correlate with their biol. activities. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Safety of Bisdemethoxycurcumin).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Safety of Bisdemethoxycurcumin

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem