Tag: 300-400

Bisdemethoxycurcumin suppresses human brain glioblastoma multiforme GBM 8401 cell migration and invasion via affecting NF-κB and MMP -2 and MMP -9 signaling pathway in vitro was written by Chen, Chiung-Ju;Shang, Hung-Sheng;Huang, Yuan-Li;Tien, Ni;Chen, Yung-Liang;Hsu, Sheng-Yao;Wu, Rick Sai-Chuen;Tang, Chien-Lun;Lien, Jin-Cherng;Lee, Mei-Hui;Lu, Hsu-Feng;Hsia, Te-Chun. And the article was included in Environmental Toxicology in 2022.Name: Bisdemethoxycurcumin The following contents are mentioned in the article:

Human glioblastoma (GBM) is one of the common cancer death in adults worldwide, and its metastasis will lead to difficult treatment. Finding compounds for future to develop treatment is urgent. Bisdemethoxycurcumin (BDMC), a natural product, was isolated from the rhizome of turmeric (Curcuma longa), which has been shown to against many human cancer cells. In the present study, we evaluated the antimetastasis activity of BDMC in human GBM cells. Cell proliferation, cell viability, cellular uptake, wound healing, migration and invasion, and western blotting were analyzed. Results indicated that BDMC at 1.5-3μM significantly decreased the cell proliferation by MTT assay. BDMC showed the highest uptake by cells at 3 h. After treatment of BDMC at 12-48 h significantly inhibited cell motility in GBM 8401 cells by wound healing assay. BDMC suppressed cell migration and invasion at 24 and 48 h treatment by transwell chamber assay. BDMC significantly decreased the levels of proteins associated with PI3K/Akt, Ras/MEK/ERK pathways and resulted in the decrease in the expressions of NF-κB, MMP-2, MMP-9, and N-cadherin, leading to the inhibition of cell migration and invasion. These findings suggest that BDMC may be a potential candidate for the antimetastasis of human GBM cells in the future. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Name: Bisdemethoxycurcumin).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Name: Bisdemethoxycurcumin

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The effect of diphenyliodonium iodide treatment on bisdemethoxycurcumin accumulation in fresh-cut yam was written by Guo, Shuang;Ma, Yue;Liang, Hao;Zhao, Xiaoyan;Wang, Dan. And the article was included in International Journal of Food Science and Technology in 2022.Safety of Bisdemethoxycurcumin The following contents are mentioned in the article:

Yellowing is a main discoloration in fresh-cut yam, which reduces consumer acceptance and, hence, the commodity value. Bisdemethoxycurcumin has been demonstrated to play important roles in fresh-cut yam yellowing. Considering the pharmacol. properties and application in fruits and vegetables of diphenyliodonium iodide (DPI), the effects and mechanism of DPI treatment on bisdemethoxycurcumin accumulation in fresh-cut yam were analyzed. The results showed that total bisdemethoxycurcumin in fresh-cut yam treated with DPI was markedly inhibited due to the significantly weakened phenylpropanoid pathway and bisdemethoxycurcumin biosynthesis. DPI was found to suppress the activities of major enzymes (phenylalanine ammonia lyase, PAL, cinnamate-4 hydroxylase, C4H; 4-coumarate CoA ligase, 4CL), limit the levels of PAL, C4H and 4CL transcription and lower the contents of related metabolites in fresh-cut yam. Moreover, treatment with DPI inhibitor restrained the downstream transcription level of curcumin synthase (CURS), which had a significant impact on bisdemethoxycurcumin synthesis. Thus, our results confirmed that DPI was essential for inhibiting bisdemethoxycurcumin accumulation in fresh-cut yam through suppressed phenylpropanoid pathway and bisdemethoxycurcumin biosynthesis. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Safety of Bisdemethoxycurcumin).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Safety of Bisdemethoxycurcumin

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Impact of light-activated curcumin and curcuminoids films for catheters decontamination was written by Zangirolami, Amanda Cristina;Carbinatto, Fernanda;Filho, Jose Dirceu Vollet;Bagnato, Vanderlei Salvador;Blanco, Kate Cristina. And the article was included in Colloids and Surfaces, B: Biointerfaces in 2022.Electric Literature of C19H16O4 The following contents are mentioned in the article:

Biofilms are microbial communities protected by an extra polymeric matrix, which promotes a defense against antimicrobial agents. Cells attached in surfaces and promote infections. Photodynamic inactivation (PDI) is one of the strategies to eliminate infections due to the facility of use and the absence of resistance by bacteria. The study combines formulation with curcuminoids and with Photogem(R), illuminating them with 450 nm and 630 nm, resp. Films were prepared with pectin, glycerin, Sodium Lauryl Sulfate, curcumin, curcuminoids, or Photogem(R) (0.75; 0.75 mg/mL and 0.03 mg/mL resp.). Bacterial biofilms were formed during 3, 4, or 7 days on catheters and illumination with LED devices at 450 nm and 630 nm.The best PDI applied in S. aureus 7-days biofilm with curcuminoid film. Photogem film was the best strategy for PDI in E. coli 7-day biofilm. Curcumin film promoted similar results with S. aureus and E. coli. Light penetration demonstrated a similar decreased exponential curve along the increase of thickness of biofilm. Curcuminoids, curcumin and Photogem show efficient solubilization and availability in formulation with relevant results in PDI. S aureus biofilms were more susceptible to curcuminoid film. E coli biofilms were more susceptible to Photogem film. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Electric Literature of C19H16O4).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Electric Literature of C19H16O4

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Cardiotoxicity induced by Cochinchina momordica seed extract in zebrafish was written by Du, Zheng-Cai;Xia, Zhong-Shang;Huang, Yan-Feng;Peng, Yi;Cao, Bing-Bing;Li, Chun-Qi;Liang, Yun-Fei;Zhao, Fang-Hui;Zhang, Ming-Zhe;Chen, Zhang-Mei;Hou, Xiao-Tao;Hao, Er-Wei;Deng, Jia-Gang. And the article was included in Journal of Applied Toxicology in 2021.SDS of cas: 33171-05-0 The following contents are mentioned in the article:

Momordica cochinchinensis (Lour.) Spreng is an indigenous South Asian edible fruit, and seeds of Momordica cochinchinensis have been used therapeutically in traditional Chinese medicine. Previous studies have shown that M. cochinchinensis seed (Momordicae Semen) has various pharmaceutical properties such as antioxidant and anti-ulcer effects as well as contains secondary metabolites with potential anticancer activities such as triterpenoids and saponins. Recent studies reported that water extract and ethanol extract of M. cochinchinensi seed were tested on mammals using an acute toxic classic method as OECD guidelines 420. No matter injected i.v. or i.m., animals died within several days. In this study, zebrafish embryos were exposed to various doses of Cochinchina momordica seed extract (CMSE) from 2 dpf (days post fertilization, dpf) to 3 dpf. CMSE-induced cardiotoxicity such as pericardial edema, cardiac apoptosis, increased ROS production, cardiac neutrophil infiltration, decreased blood flow velocity, and reduced expression of three marker genes of cardiac functions were found in zebrafish roughly in a dose-dependent manner. These results suggest that CMSE may induce cardiotoxicity through pathways involved in inflammation, oxidative stress, and apoptosis. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0SDS of cas: 33171-05-0).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.SDS of cas: 33171-05-0

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Impact of cooking and drying operations on color, curcuminoids, and aroma of Curcuma longa L. was written by Yin, Molika;Weil, Mathieu;Avallone, Sylvie;Lebrun, Marc;Conejero, Genevieve;In, Sokneang;Bohuon, Philippe. And the article was included in Journal of Food Processing and Preservation in 2022.Electric Literature of C19H16O4 The following contents are mentioned in the article:

Effects of cooking and drying on color, curcuminoids, essential oil, and aroma compounds of Curcuma longa L. were assessed. Sliced fresh turmeric rhizomes were air-dried at 60°C directly or after cooking at 95°C for 3 or 90 min. Microscopic observations showed that curcuminoids and essential oil are located in different dedicated cells. Curcuminoids and essential oil of dried turmeric were both around 10% db. After processing, curcuminoids were dispersed throughout the matrix. Drastic cooking and drying operations decreased chromatic values more than smooth cooking. Cooking had no impact on curcuminoid and essential oil contents and slightly modified the aromatic profile of essential oils. Drying decreased the curcuminoid (<38%) and essential oil (<13%) contents. Turmeric starchy matrix preserves the curcuminoids and essential oil during the process. We recommend a preliminary smooth cooking step to reduce the drying time, save energy consumption and preserve turmeric quality. Our study brings us to propose better practices for turmeric processing. A smooth cooking (95°C/3 min) before drying is recommended to preserve the quality of the turmeric as the curcuminoids and essential oil are preserved during cooking. This protection could be linked to the starchy structure of the turmeric matrix. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Electric Literature of C19H16O4).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Electric Literature of C19H16O4

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Starch isolation from turmeric dye extraction residue and its application in active film production was written by Maniglia, Bianca Chieregato;Silveira, Thamiris Maria Garcia;Tapia-Blacido, Delia Rita. And the article was included in International Journal of Biological Macromolecules in 2022.HPLC of Formula: 33171-05-0 The following contents are mentioned in the article:

In this study, we have isolated starch from turmeric dye extraction residue by steeping in acid medium (AS), steeping in water (WS), or steeping in alk. medium (KS) and assessed the filmogenic capacity of the resulting starches. We have also characterized the chem. composition, morphol., swelling power, solubility, crystallinity, and active properties of the AS, WS, and KS starches and investigated the mech., functional, antioxidant, and antimicrobial properties of the corresponding films. The AS and KS starches showed lower apparent amylose content and higher purity, relative crystallinity, swelling power, and solubility than the WS starch. All the starches retained phenolic compounds and curcuminoids; their phenolic and curcuminoid contents were higher than the contents in the residue, especially in the case of the AS starch, which yielded films with the best antioxidant and antimicrobial activities. The AS and KS starches yielded films that were more resistant at break, less soluble in water, and less hydrophilic than the film obtained from the WS starch. Thus, submitting turmeric dye extraction residue to AS in ascorbic acid yielded a starch that resulted in films with good mech. properties and better antioxidant and antimicrobial properties, to ensure safe and prolonged food shelf life. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0HPLC of Formula: 33171-05-0).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.HPLC of Formula: 33171-05-0

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Quality assessment and RP-HPLC method development for estimation of curcuminoids in Curcuma longa: A Quality by Design approach was written by Parab Gaonkar, Vishakha;Hullatti, Kirankumar. And the article was included in Journal of Liquid Chromatography & Related Technologies in 2021.Application In Synthesis of Bisdemethoxycurcumin The following contents are mentioned in the article:

The present work aims at developing a QbD assisted RP-HPLC method for the estimation of individual curcuminoids in Curcuma longa rhizomes along with its quality assessment. The quality of crude C. longa sample was evaluated with respect to physicochem., phytochem. and toxic contaminant anal. The ATP and CQA’s were identified followed by the optimization of the method by employing 22 factorial design. The concentration of orthophosphoric acid in aqueous phase (X1) and mobile phase ratio (X2) were selected as independent variable whereas, Tailing factor CUR (R1), peak width CUR (R2), Tailing factor DMC (R3), peak width DMC (R4), Tailing factor BDC (R5), and peak width BDC (R6) selected as dependent variables. The optimized chromatog. conditions were identified with mobile phase, Acetonitrile and Water (0.02%OPA) in the ratio of 55:44 with flow rate of 1 mL/min and detection wavelength of 425 nm. Further, the amount of curcumin, demethoxycurcumin and bis-demethoxycurcumin in crude C. longa sample was found to be 13.86±0.28, 10.98±0.23 and 9.32±0.20 mg/g resp. From the results obtained it can be concluded that the application of the QbD approach ensured the development of a more precise method that can engender consistent, reliable, and quality data throughout the process and also save time. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Application In Synthesis of Bisdemethoxycurcumin).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Application In Synthesis of Bisdemethoxycurcumin

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Bisdemethoxycurcumin Reduces Methicillin-Resistant Staphylococcus aureus Expression of Virulence-Related Exoproteins and Inhibits the Biofilm Formation was written by Wang, Shu;Kang, Ok-Hwa;Kwon, Dong-Yeul. And the article was included in Toxins in 2021.Related Products of 33171-05-0 The following contents are mentioned in the article:

Methicillin-resistant Staphylococcus aureus (MRSA) is a major pathogen of nosocomial infection, which is resistant to most antibiotics. Presently, anti-virulence therapy and anti-biofilm therapy are considered to be promising alternatives. In the current work, we investigated the influence of bisdemethoxycurcumin (BDMC) on the virulence-related exoproteins and the biofilm formation using a reference strain and clinic isolated strains. Western blotting, quant. RT-PCR, and tumor necrosis factor (TNF) release assay were performed to assess the efficacy of BDMC in reducing the expression of Staphylococcus enterotoxin-related exoproteins (enterotoxin A, enterotoxin B) and α-toxin in MRSA. The anti-biofilm activity of BDMC was evaluated through a biofilm inhibition assay. The study suggests that sub-inhibitory concentrations of BDMC significantly inhibited the expression of sea, seb, and hla at the mRNA level in MRSA. Moreover, the expression of virulence-related exoproteins was significantly decreased by down-regulating accessory gene regulator agr, and the inhibition of biofilms formation was demonstrated by BDMC at sub-inhibitory concentrations Consequently, the study suggests that BDMC may be a potential natural antibacterial agent to release the pressure brought by antibiotic resistance. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Related Products of 33171-05-0).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Related Products of 33171-05-0

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Therapeutic deep eutectic solvent-based microemulsion enhances anti-inflammatory efficacy of curcuminoids and aromatic-turmerone extracted from Curcuma longa L. was written by Supaweera, Nassareen;Chulrik, Wanatsanan;Jansakun, Chutima;Bhoopong, Phuangthip;Yusakul, Gorawit;Chunglok, Warangkana. And the article was included in RSC Advances in 2022.Reference of 33171-05-0 The following contents are mentioned in the article:

To diminish chem. waste and improve the delivery of Curcuma longa L. (CL) constituents, microemulsions based on hydrophobic deep eutectic solvents (HDESs) were designed as ready-to-use solvents for CL extraction The microemulsion (ME) of the ME-23 formulation (HDES/Tween 80 : propylene glycol (1 : 1)/water, 25/70/5) displayed CL extraction yields of 1.69, 3.04, 7.36, and 1.39 wt% of bisdemethoxycurcumin, demethoxycurcumin, curcumin, and aromatic-turmerone, resp. The ME-23 without CL chem. constituents and ME-23-based CL extract inhibited NO production with an IC50 value of 0.0136 ± 0.0023%volume/volume and a curcumin IC50 value of 75.2 ± 6.7 nM, resp., and simultaneously lowered inflammatory cytokines tumor necrosis factor-α, interleukin (IL)-6, and IL-1β production in lipopolysaccharide-activated murine macrophages. Authentic curcumin in ME-23 possessed superior NO inhibitory activity, which was 103-fold more effective than curcumin prepared in the conventional solvent DMSO. ME-23 was also capable of delivering curcumin into murine macrophages. After 30 days of storage in HDES and HDES-based ME, curcumin remained more than 90%. ME-23 provides advantages for CL extraction, constituent delivery, and anti-inflammatory functions that can be applied to pharmaceutical and cosmetic products. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Reference of 33171-05-0).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Reference of 33171-05-0

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Design of Turmeric Rhizome Extract Nano-Formula for Delivery to Cancer Cells was written by Auychaipornlert, Sakchai;Lawanprasert, Pojawon Prayurnprohm;Piriyaprasarth, Suchada;Sithisarn, Pongtip;Mangmool, Supachoke. And the article was included in Molecules in 2022.Category: ethers-buliding-blocks The following contents are mentioned in the article:

Novel turmeric rhizome extract nanoparticles (TE-NPs) were developed from fractions of dried turmeric (Curcuma longa Linn.) rhizome. Phytochem. studies, by using HPLC and TLC, of the fractions obtained from ethanol extraction and solvent-solvent extraction showed that turmeric rhizome ethanol extract (EV) and chloroform fraction (CF) were composed mainly of three curcuminoids and turmeric oil. Hexane fraction (HE) was composed mainly of turmeric oil while Et acetate fraction (EA) was composed mainly of three curcuminoids. The optimal TE-NPs formulation with particle size of 159.6 ± 1.7 nm and curcumin content of 357.48 ± 8.39μM was successfully developed from 47-run D-optimal mixture-process variables exptl. design. Three regression models of z-average, d50, and d90 could be developed with a reasonable accuracy of prediction (predicted r2 values were in the range of 0.9120-0.9992). An in vitro cytotoxicity study using MTT assay demonstrated that the optimal TE-NPs remarkably exhibited the higher cytotoxic effect on human hepatoma cells, HepG2, when compared with free curcumin. This study is the first to report nanoparticles prepared from turmeric rhizome extract and their cytotoxic activity to hepatic cancer cells compared with pure curcumin. These nanoparticles might serve as a potential delivery system for cancer therapy. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Category: ethers-buliding-blocks).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Category: ethers-buliding-blocks

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