Tag: 300-400

Effects of storage temperature on bisdemethoxycurcumin formation in fresh-cut yam (Dioscorea opposita) was written by Guo, Shuang;Ma, Yue;Wang, Yubin;Zhao, Wenting;Zheng, Yanyan;Wang, Pan;Wang, Dan;Zhao, Xiaoyan. And the article was included in Journal of Food Composition and Analysis in 2021.Recommanded Product: 33171-05-0 The following contents are mentioned in the article:

This study investigated the formation of bisdemethoxycurcumin in fresh-cut yam. The effects of storage temperature on the metabolites, expressions of critical genes, and activities of enzymes involved in the bisdemethoxycurcumin pathway in fresh-cut yam were studied by HPLC, qRT-PCR and com. kits. Storage at 25°C increased the contents of bisdemethoxycurcumin and its main intermediates compared to 4°C. It also greatly improved the activities of key enzymes in the phenylpropanoid pathway, including phenylalanine ammonia lyase (PAL), cinnamic acid-4-hydroxylase (C4H), and 4-coumarate-CoA ligase (4CL), and enhanced the gene expressions of PAL, C4H, 4CL, hydroxycinnamoyltransferase, and O-methyltransferase. These changes decreased the content of phenylalanine and increased the contents of p-coumaric acid, cinnamic acid, p-coumaroyl-CoA, and feruloyl-CoA. Importantly, storage at 25°C enhanced the expression of curcumin synthase, whereas it had no effect on diketide-CoA synthase, curcumin synthase 1, curcumin synthase 2, and curcumin synthase 3, in agreement with the observed increase in bisdemethoxycurcumin content in fresh-cut yam compared to 4°C. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Recommanded Product: 33171-05-0).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Recommanded Product: 33171-05-0

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A supramolecular complex of hydrazide-pillar[5]arene and bisdemethoxycurcumin with potential anti-cancer activity was written by Guo, Fang;Xia, Tao;Xiao, Ping;Wang, Qingyue;Deng, Zhitong;Zhang, Wang;Diao, Guowang. And the article was included in Bioorganic Chemistry in 2021.Formula: C19H16O4 The following contents are mentioned in the article:

Pillar[5]arene complexes of the naturally occurring compound bisdemethoxycurcumin (BDMC) were acquired for improving the water solubility and stability of BDMC. As a family member of curcuminoid compounds, BDMC has many interesting therapeutic properties. However, its low aqueous solubility and stability resulted in poor availability and restricted the clin. efficacy. Pillar[5]arenes with hydrophilic ends and a hydrophobic cavity could include with BDMC based on size matching. The synthesized hydrazide-pillar[5]arene (HP5A) and BDMC had a strong host-guest interaction with a 1:1 binding stoichiometry. Furthermore, the HP5A ⊃ BDMC complex could self-assemble into well-defined fibers in water/ethanol solution This supramol. complex worked well in vitro for inhibiting the proliferation of hepatoma carcinoma cells HepG2. Remarkably, this method of complexation with pillar[5]arenes visibly reduced the undesirable side effects on normal cells without weakening the anti-cancer activity of the drugs. We expected that the obtained host-guest complex and fibrous assembly would provide a promising platform for delivering drugs with low water solubility This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Formula: C19H16O4).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Formula: C19H16O4

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Phytochemical properties and functional characteristics of wild turmeric (Curcuma aromatica) fermented with Rhizopus oligosporus was written by Lim, Juho;Nguyen, Thi Thanh Hanh;Pal, Kunal;Gil Kang, Choon;Park, Chanho;Kim, Seung Wook;Kim, Doman. And the article was included in Food Chemistry: X in 2022.Reference of 33171-05-0 The following contents are mentioned in the article:

This study investigated the effect of solid-state fermentation of wild turmeric (Curcuma aromatica) with Rhizopus oligosporus, a common fungus found in fermented soy tempeh, on phytochem. and biol. properties. Ultra-performance liquid chromatog.-tandem mass spectrometry showed that fermented wild turmeric has higher concentrations of curcumin, demethoxycurcumin, bisdemethoxycurcumin, phenolic compounds and total flavonoid-curcuminoid after fermentation for 1-, 3-, and 5-day relative to non-fermented turmeric. The L-carnitine content reached 242μg g-1 extract after fermentation for 7-day. Wild turmeric had 1.47- and 2.25-fold increases in ORAC and FRAP, resp., after 3-day fermentation The inhibitory effects of fermented wild turmeric on lipid accumulation from 3T3-L1 cells, nitric oxide production from lipopolysaccharide-stimulated RAW264.7 murine macrophages, and melanin formation by B16F10 mouse melanoma cells with α-MSH increased 1.08-, 1.44-, and 1.52-fold, resp., after 3-day fermentation Based on these results, fermented wild turmeric product can be used as a functional ingredient in the cosmeceutical and nutraceutical industries. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Reference of 33171-05-0).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Reference of 33171-05-0

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The functional potential of nine Allium species related to their untargeted phytochemical characterization, antioxidant capacity and enzyme inhibitory ability was written by Rocchetti, Gabriele;Zhang, Leilei;Bocchi, Serena;Giuberti, Gianluca;Ak, Gunes;Elbasan, Fevzi;Yildiztugay, Evren;Ceylan, Ramazan;Picot-Allain, Marie Carene Nancy;Mahomoodally, Mohamad Fawzi;Lucini, Luigi;Zengin, Gokhan. And the article was included in Food Chemistry in 2022.Reference of 33171-05-0 The following contents are mentioned in the article:

In this study, the aerial parts and bulbs of nine Allium species were investigated for their functional phytochem. profile, in vitro antioxidant activities, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), α-amylase, α-glucosidase, and tyrosinase inhibitory properties. Phenolics, alkaloids, glucosinolates and other sulfur-containing compounds were distinctively profiled in the different species. Maceration in methanol allowed recovering the highest cumulative phenolic content in A. scabrifolium (42.31 mg/g), followed by A. goekyigiti (33.15 mg/g) and A. atroviolaceum (28.35 mg/g). The aerial parts of all Allium species showed high in vitro antioxidant activity whereas methanolic extract of A. cappadocicum bulb showed the highest inhibition against AChE (2.44 mg galantamine equivalent/g) and the water extracts of A. isauricum aerial part were the best BChE inhibitors (4.31 mg galantamine equivalent/g). Bulbs were the richer source of oligosaccharides, and in vitro digestion determined an increase of oligosaccharides bioaccessibility. A promising nutraceutical potential could be highlighted in our understudied Allium species. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Reference of 33171-05-0).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Reference of 33171-05-0

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Ether – Wikipedia,
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A High-Performance Thin-Layer Chromatographic Method for the Simultaneous Determination of Curcumin I, Curcumin II and Curcumin III in Curcuma longa and Herbal Formulation was written by Abdel-Kader, Maged S.;Salkini, Ayman A.;Alam, Prawez;Alshahrani, Khaled A.;Foudah, Ahmed I.;Alqarni, Mohammed H.. And the article was included in Separations in 2022.Electric Literature of C19H16O4 The following contents are mentioned in the article:

Curcuma longa (turmeric) has traditionally been used in Ayurvedic, Unani and herbal drugs to cure numerous ailments. Due to the high demand, the quant. standardization of herbal products is challenging to maintain their quality. We aim to develop a rapid, sensitive and validated high-performance thin-layer chromatog. (HPTLC) method for the simultaneous determination and quantification of curcumin I, curcumin II and curcumin III in C. longa and herbal formulation. The three standards were separated using centrifugal preparative thin-layer chromatog. (CPTLC) silica gel and identified by different spectroscopic methods. The developed HPTLC method was validated by following ICH guidelines (linearity; limit of detection, LOD; limit of quantitation; accuracy; precision; and robustness). The calibration curves of both the compounds were linear (50-500 ng/spot), with a correlation coefficient (r2) of >999. The developed HPTLC method was effectively applied to the concurrent detection and quantification of curcumins I-III in fresh, dry rhizomes and the herbal formulation of C. longa extracts was obtained by hot and cold extraction methods. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Electric Literature of C19H16O4).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Electric Literature of C19H16O4

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Ether – Wikipedia,
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A simple approach to the determination of three curcuminoids with similar chemical structures in different substrates was written by Li, Sha Sha;Lu, Shao Hua;Zhai, Hong Lin;Yin, Bo;Mi, Jia Ying. And the article was included in Journal of Food Science and Technology in 2021.Recommanded Product: 33171-05-0 The following contents are mentioned in the article:

Abstract: The determination of curcuminoids in mixtures is more difficult due to their similar chem. structures as well as serious interferences, thus the complex pretreatments of samples and the optimization of exptl. conditions are often required. Here, owing to the math. separation of chem. signals by Tchebichef image moments, a simple and effective approach to the simultaneous quant. anal. was proposed, and applied to the determination of the three curcuminoids in turmeric and curry based on their raw fluorescence 3D spectra. For the established linear models, the leave-one-out correlation coefficients (Rloo-cv) were more than 0.9816 within the linear ranges, and the predictive correlation coefficients (Rp) for the external independent samples were more than 0.9897. The intra- and inter-day precision (less than 6.82%, RSD), average spiked recovery (89.9% ∼ 100.8%), LOD (less than 0.07μg/mL) and LOQ (less than 0.23μg/mL) suggest that the proposed approach is accurate and reliable. Compared with N-PLS and MCR-ALS methods, our method can obtain more satisfactory results. This study provides a convenient pathway for the rapid anal. of multi-target components with similar chem. structures in mixture of different substrates. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Recommanded Product: 33171-05-0).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Recommanded Product: 33171-05-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Study of concentration dependent curcumin interaction with serum biomolecules using ATR-FTIR spectroscopy combined with Principal Component Analysis (PCA) and Partial Least Square Regression (PLS-R) was written by Perera, Kalindu D. C.;Weragoda, Geethika K.;Haputhanthri, Rukshani;Rodrigo, Sanjeewa K.. And the article was included in Vibrational Spectroscopy in 2021.Product Details of 33171-05-0 The following contents are mentioned in the article:

The binding of curcumin with biomols. in biol. fluids can affect the activity, distribution, rate of excretion, and toxicity of pharmaceutical agents in the body. It is said that interaction of curcumin with bio mols. such as protein can increase its bioavailability. A simpler alternative to current methods for study of curcumin interaction with biomols. in biol. fluids and the quantification of the interacted curcumin is therefore useful. Herein we demonstrated a method based on ATR-FTIR spectroscopy combined with multivariate anal. for concentration dependent curcumin interaction with serum biomols. as a model. ATR-FTIR spectra of curcumin-spiked serum samples were acquired and data were processed with two different multivariate methods namely, Principal Component Anal. (PCA) and Partial Least-Squares Regression (PLS-R). PCA of the protein region (1701-1304 cm-1) shows a separation into groups based on the concentration of curcumin with no overlaps indicating the curcumin interaction is highest with serum proteins other than lipids and carbohydrates. PLS-R was employed to construct a calibration plot in carbohydrate, protein and lipid regions. The limit of detection of the interaction for all three regions was 10 ppm. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Product Details of 33171-05-0).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Product Details of 33171-05-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

TOF-SIMS analysis of curcuminoids and curcumin crystals crystallized from their pure and impure solutions was written by Kumar, K. Vasanth;Heffernan, Claire;Ramisetty, Kiran A.;Howard, Christopher A.;Beloshapkin, Sergey. And the article was included in CrystEngComm in 2022.Synthetic Route of C19H16O4 The following contents are mentioned in the article:

Impurities are frequently encountered during the crystallization of active pharmaceutical compounds Impurities can either adsorb onto active sites or replace atoms of the crystal lattice. Locating the impurities, especially structurally-similar impurities, on the crystal surface is challenging. In this work, we showed that time-of-flight secondary ion mass spectrometry (TOF-SIMS) can be successfully used to simultaneously quantify the composition of the two structurally-similar impurities, demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC), on the surface of the curcumin (CUR) crystals obtained from crystal growth and cooling crystallization experiments The distribution of the three curcuminoids on the crystal surface was evaluated through imaging of the specific ions that correspond to intact mols. of the curcuminoids. In terms of location, both BDMC and DMC were evenly distributed on the surfaces of the facets of the curcumin crystals. Addnl., we found that BDMC and DMC occupy their own sites or they are located on the same site on the crystal surface providing evidence for lattice replacement of these mols. Thus our results demonstrate the potential of TOF-SIMS to provide new information that can help to understand crystallization This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Synthetic Route of C19H16O4).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Synthetic Route of C19H16O4

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Demethoxycurcumin induces apoptosis in HER2 overexpressing bladder cancer cells through degradation of HER2 and inhibiting the PI3K /Akt pathway was written by Kao, Chien-Chang;Cheng, Yi-Ching;Yang, Ming-Hsin;Cha, Tai-Lung;Sun, Guang-Huan;Ho, Chi-Tang;Lin, Ying-Chao;Wang, Hao-Kuang;Wu, Sheng-Tang;Way, Tzong-Der. And the article was included in Environmental Toxicology in 2021.Quality Control of Bisdemethoxycurcumin The following contents are mentioned in the article:

Bladder cancer is the most common malignancy of the urinary tract and arising from the epithelial lining of the urinary bladder. Resistance to cytotoxic therapies is associated with overexpression of oncogenic proteins; including HER2, and Akt in chemotherapy resistance of bladder cancer. Various studies demonstrated that curcuminoids, the most important active phenolic compounds of turmeric (Curcuma longa), have anti-tumor activities in a wide range of human malignant cell lines. The aim of this study is to evaluate whether curcuminoids (curcumin, demethoxycurcumin (DMC), and bisdemethoxycurcumin) could repress the expression of HER2 in HER2-overexpressing bladder cancer cells. Among the test compounds, DMC significantly suppressed the expression of HER2, and preferentially inhibited cell proliferation and induced apoptosis in HER2-overexpressing bladder cancer cells. DMC decreases HER2 level through inhibiting the interaction of HER2 and Hsp90. Our study also indicated that DMC showed additive activity in combination with chemotherapeutic agents, including paclitaxel and cisplatin. These findings show that DMC should be developed further as a new antitumor drug candidate for treatment of HER2-overexpressing bladder cancer. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Quality Control of Bisdemethoxycurcumin).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Quality Control of Bisdemethoxycurcumin

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Curcuma zedoaria extract as a novel corrosion inhibitor for mild steel in 0.5 M H₂SO₄ was written by Soltani, Nasrin;Tavakkoli, Nahid;Khayatkashani, Maryam;Eslami, Elham. And the article was included in Iranian Journal of Analytical Chemistry in 2022.Reference of 33171-05-0 The following contents are mentioned in the article:

In this study, curcuma zedoaria extract was investigated as a mild steel (MS) corrosion inhibitor in 0.5 M H₂SO₄ solution by conventional methods of weight loss (WL), electrochem. impedance spectroscopy (EIS) and polarization at 25°C. The highest percentage of inhibition was obtained for the concentration of 0.5 g/l of curcuma zedoaria extract The results of polarization method showed that curcuma zedoaria extract acts as a mixed inhibitor. Examination of MS immersion time by weight loss method showed that with increasing immersion time, the inhibitory effect decreases in low concentrations of curcuma zedoaria extract but in higher concentrations of curcuma zedoaria extract (concentration 1.0 g/L), the inhibitory effect remains almost constant over time. The effect of temperature on the performance of curcuma zedoaria extract by electrochem. polarization method in the temperature range of 35-65°C shows a decrease in inhibition percentage with increasing temperature Adsorption of curcuma zedoaria extract mols. on the surface of MS at all studied temperatures follows the Langmuir adsorption isotherm. Using the results of kinetic and thermodn. calculations, the adsorption of mols. of curcuma zedoaria extract on the surface of MS phys. adsorption type was observed This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Reference of 33171-05-0).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Reference of 33171-05-0

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Ether – Wikipedia,
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