Tag: 300-400

Enhancing the water-solubility of curcuminoids-rich extract using a ternary inclusion complex system: Preparation, characterization, and anti-cancer activity was written by Lateh, Likit;Kaewnopparat, Nattha;Yuenyongsawad, Supreeya;Panichayupakaranant, Pharkphoom. And the article was included in Food Chemistry in 2022.Quality Control of Bisdemethoxycurcumin The following contents are mentioned in the article:

Curcuminoids are known to exert diverse pharmacol. effects and used in some pharmaceutical formulations. This study describes the preparation, characterization, and enhancement in the solubility and anticancer activity of a curcuminoids-rich extract (CRE) using a ternary inclusion complex system. CRE containing 88.9% weight/weight curcuminoids was prepared using a ‘green’ microwave extraction coupled with fractionation on a column of hydrophobic adsorbent resin. The ternary complex consisting of CRE, hydroxylpropyl-β-cyclodextrin and polyvinylpyrrolidone K30 was prepared using the solvent evaporation method and thoroughly characterized using Fourier-transform IR spectroscopy, powder X-ray diffractograms, differential scanning calorimetry and SEM. The ternary complex of CRE improved the water-solubility of curcuminoids (up to 70.3μg/mL) as well as the dissolution rate when compared to those of CRE (0μg/mL). In addition, the ternary complex exhibited significantly stronger anticancer activity against human lung adenocarcinoma (A-549), human cervical adenocarcinoma (HeLa) and human colon adenocarcinoma (HT-29) cell lines than CRE. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Quality Control of Bisdemethoxycurcumin).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Quality Control of Bisdemethoxycurcumin

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Targeting Alzheimer’s disease with multimodal polypeptide-based nanoconjugates was written by Duro-castano, A.;Borras, C.;Herranz-perez, V.;Blanco-gandia, M. c.;Conejos-sanchez, I.;Arminan, A.;Mas-bargues, C.;Ingles, M.;Minarro, J.;Rodriguez-arias, M.;Garcia-verdugo, J. m.;Vina, J.;Vicent, M. j.. And the article was included in Science Advances in 2021.Application In Synthesis of Bisdemethoxycurcumin The following contents are mentioned in the article:

Alzheimer’s disease (AD), the most prevalent form of dementia, remains incurable mainly due to our failings in the search for effective pharmacol. strategies. Here, we describe the development of targeted multimodal polypeptide-based nanoconjugates as potential AD treatments. Treatment with polypeptide nanoconjugates bearing propargylamine moieties and bisdemethoxycurcumin or genistein afforded neuroprotection and displayed neurotrophic effects, as evidenced by an increase in dendritic d. of pyramidal neurons in organotypic hippocampal culture. The addnl. conjugation of the Angiopep-2 targeting moiety enhanced nanoconjugate passage through the blood-brain barrier and modulated brain distribution with nanoconjugate accumulation in neurogenic areas, including the olfactory bulb. Nanoconjugate treatment effectively reduced neurotoxic β amyloid aggregate levels and rescued impairments to olfactory memory and object recognition in APP/PS1 transgenic AD model mice. Overall, this study provides a description of a targeted multimodal polyglutamate-based nanoconjugate with neuroprotective and neurotrophic potential for AD treatment. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Application In Synthesis of Bisdemethoxycurcumin).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Application In Synthesis of Bisdemethoxycurcumin

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Multiple health benefits of curcumin and its therapeutic potential was written by Shah, Muddaser;Murad, Waheed;Mubin, Sidra;Ullah, Obaid;Rehman, Najeeb Ur;Rahman, Habibur Md.. And the article was included in Environmental Science and Pollution Research in 2022.Reference of 33171-05-0 The following contents are mentioned in the article:

A review. Turmeric, or Curcuma longa as it is formally named, is a multifunctional plant with numerous names. It was dubbed “the golden spice” and “Indian saffron” not only for its magnificent yellow color, but also for its culinary use. Turmeric has been utilized in traditional medicine since the dawn of mankind. Curcumin, demethoxycurcumin, and bisdemethoxycurcumin, which are all curcuminoids, make up turmeric. Although there have been significant advancements in cancer treatment, cancer death and incidence rates remain high. As a result, there is an increasing interest in discovering more effective and less hazardous cancer treatments. Curcumin is being researched for its anti-inflammatory, anti-cancer, anti-metabolic syndrome, neuroprotective, and antibacterial properties. Turmeric has long been used as a home remedy for coughs, sore throats, and other respiratory problems. As a result, turmeric and its compounds have the potential to be used in modern medicine to cure a variety of diseases. In this current review, we highlighted therapeutic potential of curcumin and its multiple health benefits on various diseases. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Reference of 33171-05-0).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Reference of 33171-05-0

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Ruthenium(II) 1,4,7-trithiacyclononane complexes of curcumin and bisdemethoxycurcumin: Synthesis, characterization, and biological activity was written by Pettinari, Riccardo;Marchetti, Fabio;Tombesi, Alessia;Duan, Fenghe;Zhou, Liming;Messori, Luigi;Giacomelli, Chiara;Marchetti, Laura;Trincavelli, Maria Letizia;Marzo, Tiziano;La Mendola, Diego;Balducci, Gabriele;Alessio, Enzo. And the article was included in Journal of Inorganic Biochemistry in 2021.Computed Properties of C19H16O4 The following contents are mentioned in the article:

Two cationic ruthenium(II) 1,4,7-trithiacyclononane ([9]aneS₃) complexes of curcumin (curcH) and bisdemethoxycurcumin (bdcurcH), namely [Ru(curc)(DMSO-S)([9]aneS₃)]Cl (1) and [Ru(bdcurc)(DMSO-S)([9]aneS₃)]Cl (2) were prepared from the [RuCl₂(DMSO-S)([9]-aneS₃)] precursor and structurally characterized, both in solution and in the solid state by x-ray crystallog. The corresponding PTA complexes [Ru(curc)(PTA)([9]aneS₃)]Cl (3) and [Ru(bdcurc)(PTA)([9]aneS₃)]Cl (4) were also synthesized and characterized (PTA = 1,3,5-triaza-7-phosphaadamantane). Bioinorganic studies relying on mass spectrometry were performed on complexes 1–4 to assess their interactions with the model protein lysozyme. Overall, a rather limited reactivity with lysozyme was highlighted accompanied by a modest cytotoxic potency against three representative cancer cell lines. The moderate pharmacol. activity is likely connected to the relatively high stability of these complexes. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Computed Properties of C19H16O4).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Computed Properties of C19H16O4

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Evaluation of plant extracts as an efficient source of additives for active food packaging was written by Vieira, Dalila M.;Pereira, Carla;Calhelha, Ricardo C.;Barros, Lillian;Petrovic, Jovana;Sokovic, Marina;Barreiro, Maria Filomena;Ferreira, Isabel C. F. R.;Castro, Maria Cidalia R.;Rodrigues, Pedro V.;Machado, Ana Vera. And the article was included in Food Frontiers in 2022.Formula: C19H16O4 The following contents are mentioned in the article:

Natural extracts have been used in several traditional medicine applications and culinary purposes. Their biol. properties (antioxidant and antimicrobial) are due to the presence of several active aromatic compounds Herein, different natural extracts were evaluated, namely structural and thermal characterization and biol. activity, in its natural form and incorporated into a polymeric matrix, to assess their effective potential as additives for active food packaging. While rosemary presented the highest thermal stability with a degradation starting at 327°C, lemon balm extract was the less stable (180°C). Regarding the thiobarbituric acid assay, all extracts presented antioxidant activity, in oxidative hemolysis inhibition; anise, cinnamon, and clove extract did not present any action. Overall, the results demonstrated that leaves (rosemary and green tea) and the rhizome (curcumin) are the plant parts with the best performance. Therefore, extracts from aromatic plants are promising natural additives that can be incorporated into polymeric matrixes to produce active food packaging film, increasing products shelf-life. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Formula: C19H16O4).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Formula: C19H16O4

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Empowering Students with Multidisciplinary Research Experience was written by Waghe, Anil B.;Waghe, Aparna A.. And the article was included in ACS Symposium Series in 2021.COA of Formula: C19H16O4 The following contents are mentioned in the article:

Chem. courses can be trailblazers for breaking the traditional instructional mold for college students. Involving students in course-based undergraduate research experience (CUR) in Organic Chem. helps in developing conceptual understanding and skill development for future careers. The direct impact of our undergraduate research program is improved retention of concepts and intellectual independence. Discovery and collaboration have been a foundation for cluster-based pedagogy at Plymouth State University. The Organic Chem. mini-research project described herein incorporates core concepts and competencies that allow students to work on a challenging problem while experiencing the excitement of scientific discovery. In this chapter, we present how the introduction of a multidisciplinary group research project helped us to demonstrate the relationship between the course materials with core disciplines and enhanced the interest and performance of our students. Assessment of learning and end-of-the-course surveys indicate an increase in the retention of principles taught in the Organic Chem. laboratory course. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0COA of Formula: C19H16O4).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.COA of Formula: C19H16O4

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Promising iron(II) complexes of curcumins: designing, density functional theory, and molecular docking was written by Kumar, Ajay;Kumar, Vinod;Kumari, Kamlesh;Jain, Pallavi;Kaushik, Nagendra Kumar;Singh, Prashant. And the article was included in Journal of Physical Organic Chemistry in 2021.Related Products of 33171-05-0 The following contents are mentioned in the article:

Curcumin is the key compound of turmeric and was identified as diferuloylmethane. It can be administered through various routes like orally and inhalation. It is hydrophobic, and the bioavailability for oral administration of curcumin is low. It is an important biol. promising compound and used for the treatment of patients’ suffering from atherosclerosis, colon cancer, hypercholesteremia, inflammatory bowel disease, pancreatic cancer, and so forth. The work aims to design the iron(II) complexes of curcumin and its derivatives The designed complexes were studied by the d. functional theory (DFT) approach for their stability and were investigated based on IR spectra using Gaussian 9.0. Further, curcumin and the iron (II) complexes were explored for their biol. potency as inhibitors against the main protease of SARS-CoV-2, as well as for antimicrobial and antioxidant activities using mol. docking with the iGemDock. Based on the results, it has been observed that among the iron(II) complexes of curcumin, C1 showed promising biol. activities against tyrosinase kinase and the main protease of SARS-CoV-2 as well as satisfactory action against Escherichia coli. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Related Products of 33171-05-0).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Related Products of 33171-05-0

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One-Way Intestinal Perfusion of PVP/VA-Poloxamer 188-Curcuma longa L. Extract Solid Dispersion in Rats In Vivo and Its Effect on HSC-T6 Cell Proliferation was written by Gao, Jie;Shi, Yi;Han, Yunfeng;Tang, Xi;Bi, Ruohong;Pan, Lin;Lai, Xianrong. And the article was included in AAPS PharmSciTech in 2022.Recommanded Product: 33171-05-0 The following contents are mentioned in the article:

Turmeric was the dried rhizome of Curcuma longa L., and its extract had important pharmacol. effects such as anti-tumor, cholagogic, and antioxidant. However, curcuma extract had poor water solubility and low bioavailability, which had become the main limiting factor for its clin. application. The purpose of this study was to prepare PVP/VA-Poloxamer-188-curcuma extract solid dispersion (PAP-CSD) to improve the solubility and bioavailability of the curcuma extract The intestinal absorption mechanism of solid dispersion of this extract was studied by one-way intestinal perfusion in rats. PAP-CSD,PVP/VA-curcuma extract solid dispersion (PA-CSD) and Poloxamer-188-curcuma extract solid dispersion (P-CSD) was able to improve the intestinal absorption of the curcuma extract (P < 0.05), and PAP-CSD (combined use of two carriers) was better than that of PA-CSD and P-CSD. CCK8 method was used to investigate the effects of the curcuma extract and PAP-CSD on the proliferation of hepatic stellate cells (HSC)-T6 cells. The inhibitory effect of PAP-CSD on the proliferation of HSC-T6 cells, related to the p38 MAPK pathway, was better than that of the curcuma extract This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Recommanded Product: 33171-05-0).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Recommanded Product: 33171-05-0

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A multicolor fluorescent sensor array based on curcumin and its analogs as a shrimp freshness indicator was written by Cai, Shaoyong;Song, Guangjie;Zhang, Guofan;Wang, Lei;Jian, Tianlan;Xu, Jiatong;Su, Fengyu;Tian, Yanqing. And the article was included in Sensors and Actuators, B: Chemical in 2022.Category: ethers-buliding-blocks The following contents are mentioned in the article:

The colorimetric sensing label is a simple, cost-effective, and user-friendly tool for monitoring ammonia vapor (NH3) concentrations in food packaging. Numerous natural dyes present excellent NH3-sensitivity, but their low solubility in water limits their food-related applications. Herein, a special cellulose-based ink system with an EtOH/water mixture as solvent was proposed to improve the dispersion of non-aqueous dyes (curcumin and its analogs (indexed as Bur and Bur-BF2)). Subsequently, three sensing labels containing different dyes were prepared by simple screen-printing after optimizing the inks′ rheol. properties. Benefiting from the different intramol. charge-transfer (ICT) behaviors of dyes, each sensing label exhibited various characteristics in terms of the optical property, NH3-sensitivity, and fluorescent color-changing routes upon exposure to 0-50 ppm NH3. Importantly, all sensing labels showed excellent stability in environments with various relative humidity and temperature Therefore, three sensing labels were used to construct a multicolor fluorescent sensor array, which aimed to visually monitor the freshness of shrimp for consumers. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Category: ethers-buliding-blocks).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Category: ethers-buliding-blocks

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The effect of Epichloe endophyte on phyllosphere microbes and leaf metabolites in Achnatherum inebrians was written by Liu, Bowen;Ju, Yawen;Xia, Chao;Zhong, Rui;Christensen, Michael J.;Zhang, Xingxu;Nan, Zhibiao. And the article was included in iScience in 2022.Synthetic Route of C19H16O4 The following contents are mentioned in the article:

Upon exposure to the prevailing environment, leaves become increasingly colonized by fungi and bacteria located on the surface (epiphytic) or within (endophytic) the leaves. Many cool season grasses, including Achnatherum inebrians, host a seed-borne, intercellular, mutualistic Epichloe fungal endophyte, the growth of which is synchronized with the host grass. A study utilizing illumina sequencing was used to examine the epiphytic and endophytic microbial communities in Epichloe endophyte-infected and endophyte-free A. inebrians plants growing under hot dry field conditions. The presence of Epichloe endophyte increased the Shannon and decreased Simpson diversity of bacterial and fungal communities. Sphingomonas and Hymenobacter bacteria and Filobasidium and Mycosphaerella fungi were growing largely epiphytically, whereas Methylobacterium, Escherichia-Shigella, and the fungus Blumeria were mostly found within leaves with the location of colonization influenced by the Epichloe endophyte. In addition, leaf metabolites in Epichloe-infected and Epichloe-free leaves were examined using LC/MS. Epichloe was significantly correlated with 132 metabolites. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Synthetic Route of C19H16O4).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Synthetic Route of C19H16O4

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Ether – Wikipedia,
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