Tag: 200-300

Unveiling Extreme Photoreduction Potentials of Donor-Acceptor Cyanoarenes to Access Aryl Radicals from Aryl Chlorides was written by Xu, Jinhui;Cao, Jilei;Wu, Xiangyang;Wang, Han;Yang, Xiaona;Tang, Xinxin;Toh, Ren Wei;Zhou, Rong;Yeow, Edwin K. L.;Wu, Jie. And the article was included in Journal of the American Chemical Society in 2021.Quality Control of 2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane This article mentions the following:

Since the seminal work of Zhang in 2016, donor-acceptor cyanoarene-based fluorophores, such as 1,2,3,5-tetrakis(carbazol-9-yl)-4,6-dicyanobenzene (4CzIPN), have been widely applied in photoredox catalysis and used as excellent metal-free alternatives to noble metal Ir- and Ru-based photocatalysts. However, all the reported photoredox reactions involving this chromophore family are based on harnessing the energy from a single visible light photon, with a limited range of redox potentials from -1.92 to +1.79 V vs SCE. Here, we document the unprecedented discovery that this family of fluorophores can undergo consecutive photoinduced electron transfer (ConPET) to achieve very high reduction potentials. One of the newly synthesized catalysts, 2,4,5-tri(9H-carbazol-9-yl)-6-(ethyl(phenyl)amino)isophthalonitrile (3CzEPAIPN), possesses a long-lived (12.95 ns) excited radical anion form, 3CzEPAIPN^閳?*, which can be used to activate reductively recalcitrant aryl chlorides (E_red 閳?-1.9 to -2.9 V vs SCE) under mild conditions. The resultant aryl radicals can be engaged in synthetically valuable aromatic C-B, C-P, and C-C bond formation to furnish arylboronates, arylphosphonium salts, arylphosphonates, and spirocyclic cyclohexadienes. In the experiment, the researchers used many compounds, for example, 2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 365564-07-4Quality Control of 2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane).

2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 365564-07-4) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Quality Control of 2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Divergent synthesis and biological evaluation of 2-(trifluoromethyl)pyridines as virulence-attenuating inverse agonists targeting PqsR was written by Schuetz, Christian;Hodzic, Amir;Hamed, Mostafa;Abdelsamie, Ahmed S.;Kany, Andreas M.;Bauer, Maximilian;Roehrig, Teresa;Schmelz, Stefan;Scrima, Andrea;Blankenfeldt, Wulf;Empting, Martin. And the article was included in European Journal of Medicinal Chemistry in 2021.Reference of 75581-11-2 This article mentions the following:

A short and divergent route towards new derivatives of 2-(trifluoromethyl)pyridines as potent inverse agonists of the bacterial target PqsR against Pseudomonas aeruginosa (PA) infections was described. This Gram-neg. pathogen causes severe nosocomial infections and common antibiotic treatment options were rendered ineffective due to resistance issues. Based on an earlier identified optimized hit, the derivatization and rigidification attempts employing two central building blocks were conducted. The western part of the mol. was built up via a 2-(trifluoromethyl)pyridine head group equipped with a terminal alkyne. The eastern section was then introduced through aryliode motifs exploiting Sonogashira as well as Suzuki-type chem. Subsequent modification provided quick access to an array of compounds, allowed for deep SAR insights, and enabled to optimize the hit scaffold into a lead structure of nanomolar potency combined with favorable in vitro ADME/T features. In the experiment, the researchers used many compounds, for example, 4-Iodo-1-methoxy-2-methylbenzene (cas: 75581-11-2Reference of 75581-11-2).

4-Iodo-1-methoxy-2-methylbenzene (cas: 75581-11-2) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Reference of 75581-11-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Silver-containing microemulsion as a high-efficient and recyclable catalytic system for hydration of alkynes was written by Dong, Qizhi;Li, Ningbo;Qiu, Renhua;Wang, Jinying;Guo, Cancheng;Xu, Xinhua. And the article was included in Journal of Organometallic Chemistry in 2015.Safety of 1-Methoxy-4-((4-propylphenyl)ethynyl)benzene This article mentions the following:

A silver-catalyzed highly efficient and regioselective synthesis of ketones from a wide range of alkynes is described. The reaction is dramatically accelerated by its performance in aqueous emulsion, which is self-assembled by the addition of silver perfluorooctanesulfonate and perfluorooctanesulfonic acid (PFOS) to water. The reaction is conducted under convenient conditions with broad substrate scope, including a variety of aromatic and aliphatic terminal alkynes and internal alkynes. Furthermore, the air- and light-stable silver catalytic microemulsion can be reused for 4 times with minimal change in catalytic efficiency. In the experiment, the researchers used many compounds, for example, 1-Methoxy-4-((4-propylphenyl)ethynyl)benzene (cas: 39969-26-1Safety of 1-Methoxy-4-((4-propylphenyl)ethynyl)benzene).

1-Methoxy-4-((4-propylphenyl)ethynyl)benzene (cas: 39969-26-1) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethers feature bent C閳ユ彊閳ユ弲 linkages. In dimethyl ether, the bond angle is 111鎺?and C閳ユ彊 distances are 141 pm. The barrier to rotation about the C閳ユ彊 bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Safety of 1-Methoxy-4-((4-propylphenyl)ethynyl)benzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Conductometric, spectrophotometric, ¹HNMR and quantum chemical studies of the thermodynamics complexation of some transition metal ions with aza-15-crown-5 ligands in acetonitrile solution was written by Payehghadr, Mahmood;Nourifard, Farzaneh;Taghdiri, Mehdi;Behjatmanesh-Ardakani, Reza. And the article was included in Inorganic Chemistry: An Indian Journal in 2012.Quality Control of 1,4,7,10-Tetraoxa-13-azacyclopentadecane This article mentions the following:

In this paper, the complexation reactions between aza-15-crown-5 (A15C5) ligand with Zn²⁺, Hg²⁺, Co²⁺, Ag⁺ and Cd²⁺ ions has been studied by conductometric and spectrophotometric methods in acetonitrile solution at various temperatures The formation constants of the resulting 1:1 complexes were calculated from the computer fitting of the molar conductance-mole ratio data at different temperatures At 25鎺矯, the order of stability of the 1:1 complexes of the A15C5 ligand with different cations are as Hg²⁺> Co²⁺> Cd²⁺> Zn²⁺> Ag⁺. The enthalpy and entropy changes of the complexation reactions were evaluated from the temperature dependence of formation constants In addition, ¹HNMR study of complexes of nitrate salt of Cd⁺² in acetonitrile with A15C5 ligand at 25鎺矯 has been also undertaken to compare the results with those obtained by conductivity and UV measurements, which have been found to be in good agreement with each other. Finally, ab initio studies of the level of HF/lanl2dz have been done to investigate the binding energies of the ligand with Ag⁺ and Hg²⁺. All theor. data are in line with the exptl. ones. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Quality Control of 1,4,7,10-Tetraoxa-13-azacyclopentadecane).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O閳ユ椊 or N閳ユ椊 bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Quality Control of 1,4,7,10-Tetraoxa-13-azacyclopentadecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Organic pollutants in the effluents of large wastewater treatment plants in Sweden was written by Paxeus, Nicklas. And the article was included in Water Research in 1996.Category: ethers-buliding-blocks This article mentions the following:

Effluent from the 3 largest wastewater treatment plants (WWTP) in Sweden were analyzed for the presence of organic pollutants by gas chromatog.-mass spectrometry. From a total of 137 identified compounds, only 10 were priority pollutants. A broad spectrum of non-regulated organic pollutants in the effluent included aromatic hydrocarbons, food- and household-related compounds, solvents, plasticizers, flame retardants, preservatives, anti-oxidants, and washing- and cleaning-related compounds Individual effluent compound concentrations of all 3 WWTP were 0.5-50 娓璯/L. Few point-discharged pollutants from specific industries were present in the effluent. The majority of pollutants detected in effluent were attributable to overall use and discharge of chem. products. These pollutants originate from diffuse sources and represent a background chem. pollution load to the receiving waters through the discharge from WWTP in large cities. In the experiment, the researchers used many compounds, for example, 1-((1-((1-Methoxypropan-2-yl)oxy)propan-2-yl)oxy)propan-2-ol (cas: 20324-33-8Category: ethers-buliding-blocks).

1-((1-((1-Methoxypropan-2-yl)oxy)propan-2-yl)oxy)propan-2-ol (cas: 20324-33-8) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Ethers feature bent C閳ユ彊閳ユ弲 linkages. In dimethyl ether, the bond angle is 111鎺?and C閳ユ彊 distances are 141 pm. The barrier to rotation about the C閳ユ彊 bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Curcumin Recognizes a Unique Binding Site of Tubulin was written by Chakraborti, Soumyananda;Das, Lalita;Kapoor, Neha;Das, Amlan;Dwivedi, Vishnu;Poddar, Asim;Chakraborti, Gopal;Janik, Mark;Basu, Gautam;Panda, Dulal;Chakrabarti, Pinak;Surolia, Avadhesha;Bhattacharyya, Bhabatarak. And the article was included in Journal of Medicinal Chemistry in 2011.Recommanded Product: 6972-61-8 This article mentions the following:

Although curcumin is known for its anticarcinogenic properties, the exact mechanism of its action or the identity of the target receptor is not completely understood. Studies on a series of curcumin analogs, synthesized to investigate their tubulin binding affinities and tubulin self-assembly inhibition, showed that: (i) curcumin acts as a bifunctional ligand, (ii) analogs with substitution at the diketone and acetylation of the terminal phenolic groups of curcumin are less effective, (iii) a benzylidiene derivative, compound 7, is more effective than curcumin in inhibiting tubulin self-assembly. Cell-based studies also showed compound 7 to be more effective than curcumin. Using fluorescence spectroscopy we show that curcumin binds tubulin 32 鑴?away from the colchicine-binding site. Docking studies also suggests that the curcumin-binding site to be close to the vinblastine-binding site. Structure-activity studies suggest that the tridented nature of compound 7 is responsible for its higher affinity for tubulin compared to curcumin. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8Recommanded Product: 6972-61-8).

3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O閳ユ椊 or N閳ユ椊 bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Recommanded Product: 6972-61-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis and Photophysics of Fully 锜?Conjugated Heterobis-Functionalized Polymeric Molecular Wires via Suzuki Chain-Growth Polymerization was written by Elmalem, Einat;Biedermann, Frank;Johnson, Kerr;Friend, Richard H.;Huck, Wilhelm T. S.. And the article was included in Journal of the American Chemical Society in 2012.Electric Literature of C14H21BO4 This article mentions the following:

Fully 锜?conjugated polymers of 2-bromo-9,9-dioctylfluoren-2-yl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane with with d.p. up to 23 and near quant. (>95%) heterobis-functionalization are prepared by a controlled Suzuki chain-growth polymerization, with control over mol. weight, narrow polydispersity, and ability to define polymer end groups. The first end group is introduced through the initiator metal complex tert-Bu₃PPd(X)Br (X = aryl), while the second end group is added by quenching of the chain-growth polymerization with the desired boronic esters. In all cases, polymers obtained at 50% conversion showed excellent end group fidelity and high purity following a simple workup procedure, as determined by MALDI-TOF, GPC, and ¹H and 2D NMR. End group functionalization altered the optoelectronic properties of the bridge polymer. Building on a common fluorene backbone, and guided by DFT calculations, donor and acceptor end groups introduced to create polymeric mol. wires exhibiting charge transfer and energy transfer as characterized by fluorescence, absorption, and transient absorption spectroscopy as well as by fluorescence lifetime measurements. In the experiment, the researchers used many compounds, for example, 2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 365564-07-4Electric Literature of C14H21BO4).

2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 365564-07-4) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Electric Literature of C14H21BO4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

para-C-H Borylation of benzene derivatives by a bulky iridium catalyst was written by Saito, Yutaro;Segawa, Yasutomo;Itami, Kenichiro. And the article was included in Journal of the American Chemical Society in 2015.Name: 2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane This article mentions the following:

A highly para-selective aromatic C-H borylation has been accomplished. By a new iridium catalyst bearing a bulky diphosphine ligand, Xyl-MeO-BIPHEP, the C-H borylation of monosubstituted benzenes can be affected with para-selectivity up to 91%. This catalytic system is quite different from the usual iridium catalysts that cannot distinguish meta- and para-C-H bonds of monosubstituted benzene derivatives, resulting in the preferred formation of meta-products. The para-selectivity increases with increasing bulkiness of the substituent on the arene, indicating that the regioselectivity of the present reaction is primarily controlled by steric repulsion between substrate and catalyst. Caramiphen, an anticholinergic drug used in the treatment of Parkinson’s disease, was converted into five derivatives via our para-selective borylation. The present [Ir(cod)OH]₂/Xyl-MeO-BIPHEP catalyst represents a unique, sterically controlled, para-selective, aromatic C-H borylation system that should find use in streamlined, predictable chem. synthesis and in the rapid discovery and optimization of pharmaceuticals and materials. In the experiment, the researchers used many compounds, for example, 2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 365564-07-4Name: 2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane).

2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 365564-07-4) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Name: 2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Rapid analysis of brake fluid uses gas-liquid chromatography was written by Esposito, George G.;Jamison, Robert G.. And the article was included in SAE Journal in 1971.Application In Synthesis of 1-((1-((1-Methoxypropan-2-yl)oxy)propan-2-yl)oxy)propan-2-ol This article mentions the following:

The volatile compounds making up 70-80% of most hydraulic brake fluid can be identified and determined by gas chromatog. on a 20 weight % Carbowax 20M/Chromosorb W or a 20 weight % diethylene glycol succinate/Chromosorb W column, by using ethylene glycol monoethyl ether acetate internal standard, a thermal conductivity detector, and He carrier gas. Retention data are given for 36 compounds Anal. of a synthetic composition gave [component, weight % added, weight % found]: ethylene glycol monoethyl ether, 25.0, 24.8; methoxybutanol, 10.0, 12.0; diethylene glycol monoethyl ether, 24.0, 23.5; diethylene glycol monobutyl ether, 11.0, 10.7; base lubricant (by difference), 30.0, 29.0. In the experiment, the researchers used many compounds, for example, 1-((1-((1-Methoxypropan-2-yl)oxy)propan-2-yl)oxy)propan-2-ol (cas: 20324-33-8Application In Synthesis of 1-((1-((1-Methoxypropan-2-yl)oxy)propan-2-yl)oxy)propan-2-ol).

1-((1-((1-Methoxypropan-2-yl)oxy)propan-2-yl)oxy)propan-2-ol (cas: 20324-33-8) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Application In Synthesis of 1-((1-((1-Methoxypropan-2-yl)oxy)propan-2-yl)oxy)propan-2-ol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Selective Reductive Cleavage of Inert Aryl C-O Bonds by an Iron Catalyst was written by Ren, Yunlai;Yan, Mengjie;Wang, Jianji;Zhang, Z. Conrad;Yao, Kaisheng. And the article was included in Angewandte Chemie, International Edition in 2013.Related Products of 75581-11-2 This article mentions the following:

An effective reductive cleavage of inert aryl C-O bonds with an inexpensive Fe catalyst has been developed. During this process, the reduction of the arene rings was not observed This catalytic system also enabled the selective cleavage of the 灏?O-4 linkage of lignin model compounds, thus offering an opportunity for the depolymerization of lignin. Thus, e.g., reductive cleavage of Ph₂O in presence of Fe(acac)₃, LiAlH₄ as reducing agent, and tBuONa at 140鎺?afforded PhOH (81%) and benzene (97%). In the experiment, the researchers used many compounds, for example, 4-Iodo-1-methoxy-2-methylbenzene (cas: 75581-11-2Related Products of 75581-11-2).

4-Iodo-1-methoxy-2-methylbenzene (cas: 75581-11-2) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Related Products of 75581-11-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem