Tag: 200-300

Synthesis and crystal structure of 2′,4”-O-bis(trimethylsilyl)erythromycin a 9-O-(1-isopropoxycyclohexyl) oxime was written by Liang, Jian-Hua;Yao, Guo-Wei. And the article was included in Heterocycles in 2003.Safety of 1,1-Diisopropoxycyclohexane This article mentions the following:

The ratio of E/Z of 2′-,4”-O-bis(trimethylsilyl)erythromycin A 9-O-(1-isopropoxycyclohexyl) oxime were much higher prepared in CH₃CN than those in CH₂Cl₂. And the ratio would increase with elevation of temperature Compared with 2′-OH, 4”-OH was liable to be silylated in the presence of 1,1,1,3,3,3-hexamethyldisilizane and an NH₄⁺. The crystal structure of E-title compound was determined by single-crystal X-Ray structure anal. to elucidate the origin of regioselectivity occurring at 6-hydroxyl group in the O-methylation of erythromycin A. In the experiment, the researchers used many compounds, for example, 1,1-Diisopropoxycyclohexane (cas: 1132-95-2Safety of 1,1-Diisopropoxycyclohexane).

1,1-Diisopropoxycyclohexane (cas: 1132-95-2) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Safety of 1,1-Diisopropoxycyclohexane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On the molecular structure, packing coefficients and thermal stabilities of the homologous series p-methoxy-XY-p’-alkyl tolanes was written by Prasad, J. Shashidhara. And the article was included in Molecular Crystals and Liquid Crystals in 1978.Category: ethers-buliding-blocks This article mentions the following:

The thermal stability in the p-methoxy-p‘-alkyltolan homologous series was studied by mol. packing coefficients (ratio of geometric volume of a mol. to the volume per mol. in the crystal) without actual conformation of the mols. in the crystalline state. The packing coefficient decreases for the nonmesogenic members (Me and Et) accounting for the decrease in stability and suddenly increases when the mesogenic state is encountered and then again decreases accounting for the thermal stability decrease within the mesogenic materials. In the experiment, the researchers used many compounds, for example, 1-Methoxy-4-((4-propylphenyl)ethynyl)benzene (cas: 39969-26-1Category: ethers-buliding-blocks).

1-Methoxy-4-((4-propylphenyl)ethynyl)benzene (cas: 39969-26-1) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Ethers feature bent C閳ユ彊閳ユ弲 linkages. In dimethyl ether, the bond angle is 111鎺?and C閳ユ彊 distances are 141 pm. The barrier to rotation about the C閳ユ彊 bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Category: ethers-buliding-blocks

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis and photophysical properties of 2,2′-binaphthalene-based receptor bearing trimethylsilyl groups to improve the solubility was written by Kondo, Shin-ichi;Watanabe, Naoya;Takahashi, Fubuki;Takeda, Nobuhiro;Unno, Masafumi. And the article was included in Journal of Inclusion Phenomena and Macrocyclic Chemistry in 2013.Synthetic Route of C10H21NO4 This article mentions the following:

Two trimethylsilyl groups were introduced at 5- and 5′-positions of 2,2′-binaphthalene to improve the solubility of 2,2′-binaphthalene-based receptors. The x-ray crystallog. anal. revealed the twisted structure of 2 in the solid state. The solubility of 2 was moderately improved by 3.1-fold comparing with mother skeleton 1. As a practical example of 2, receptor 8 bearing two aza-15-crown-5 moieties was prepared and the selective binding of 8 with Ba²⁺ can be observed by the formation of sandwich-like complex, which shows no prevention of binding ability of the receptor by introduction of the bulky substituents. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Synthetic Route of C10H21NO4).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Synthetic Route of C10H21NO4

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Spin crossover in polymeric and heterometallic Fe^II species containing polytopic dipyridylamino-substituted-triazine ligands was written by Ross, Tamsyn M.;Moubaraki, Boujemaa;Batten, Stuart R.;Murray, Keith S.. And the article was included in Dalton Transactions in 2012.Formula: C10H21NO4 This article mentions the following:

The authors report the synthesis and characterization of the new polytopic ligands, ddta (N,N-di(pyridin-2-yl)-4,6-di(1,4,7,10-tetraoxa-13-azacyclopentadecan-13-yl)-1,3,5-triazin-2-amine) and tptd (N²,N²,N⁴,N⁴-tetra(pyridin-2-yl)-6-(1,4,7,10-tetraoxa-13-azacyclopentadecan-13-yl)-1,3,5-triazine-2,4-diamine). Each contains N-donor dipyridylamino binding sites as well as sep. and distinct mono-aza-15-crown-5 binding sites. The ligand ddta was used to synthesize the polymeric heterometallic spin crossover (SCO) compound trans-[Fe(II)(NCS)₂(ddta)₂Na₂](ClO₄)₂.4MeCH₂CH₂OH, (I), and tptd was used to synthesize the polymeric SCO compound trans-[Fe(II)(NCS)₂(tptd)].MeOH, (II), and the dinuclear compound cis-[(Fe(II))₂(NCS)₄(tptd)₂], (III). Magnetic susceptibility measurements show that I and a desolvated sample of III each undergo a gradual, 1-step spin transition with T₁/2 values of 閳?40 K and 閳?10 K, resp. The paucity of inter-chain intermol. interactions, as well as the flexible, covalent bridges between Fe(II) spin crossover sites, are likely to contribute to the gradual nature of the spin transition observed in each case. Variable temperature powder x-ray diffraction studies on I show the anisotropic behavior of the unit cell parameters, where c and the b-c plane are most affected by structural changes occurring as the temperature is lowered. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Formula: C10H21NO4).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O閳ユ椊 or N閳ユ椊 bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Formula: C10H21NO4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Metal-free halogenation of arylboronate with N-halosuccinimide was written by Kamei, Toshiyuki;Ishibashi, Aoi;Shimada, Toyoshi. And the article was included in Tetrahedron Letters in 2014.Reference of 365564-07-4 This article mentions the following:

Efficient bromination and chlorination of aryl pinacol boronates were accomplished without the addition of metal reagent. The reaction proceeded efficiently with electron-rich arylboronates or heteroarylboronates in DMF or acetonitrile, to afford mono-, di-, or trihalogenated aryl pinacol boronates. In the experiment, the researchers used many compounds, for example, 2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 365564-07-4Reference of 365564-07-4).

2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 365564-07-4) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Reference of 365564-07-4

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Natural Gas Residual Fluids: Sources, Endpoints, and Organic Chemical Composition after Centralized Waste Treatment in Pennsylvania was written by Getzinger, Gordon J.;O’Connor, Megan P.;Hoelzer, Kathrin;Drollette, Brian D.;Karatum, Osman;Deshusses, Marc A.;Ferguson, P. Lee;Elsner, Martin;Plata, Desiree L.. And the article was included in Environmental Science & Technology in 2015.Recommanded Product: 1-((1-((1-Methoxypropan-2-yl)oxy)propan-2-yl)oxy)propan-2-ol This article mentions the following:

Volumes of natural gas extraction-derived wastewaters have increased sharply over the past decade, but the ultimate fate of those waste streams is poorly characterized. We sought to (a) quantify natural gas residual fluid sources and endpoints to bound the scope of potential waste stream impacts and (b) describe the organic pollutants discharged to surface waters following treatment, a route of likely ecol. exposure. Our findings indicate that centralized waste treatment facilities (CWTF) received 9.5% (8.5 鑴?10⁸ L) of natural gas residual fluids in 2013, with some facilities discharging all effluent to surface waters. In dry months, discharged water volumes were on the order of the receiving body flows for some plants, indicating that surface waters can become waste-dominated in summer. As disclosed organics used in high volume hydraulic fracturing (HVHF) vary greatly in physicochem. properties, we deployed a suite of anal. techniques to characterize CWTF effluents, covering 90.5% of disclosed compounds Results revealed that, of 閳?000 disclosed organics used in HVHF, only petroleum distillates and alc. polyethoxylates were present. Few analytes targeted by regulatory agencies (e.g., benzene or toluene) were observed, highlighting the need for expanded and improved monitoring efforts at CWTFs. In the experiment, the researchers used many compounds, for example, 1-((1-((1-Methoxypropan-2-yl)oxy)propan-2-yl)oxy)propan-2-ol (cas: 20324-33-8Recommanded Product: 1-((1-((1-Methoxypropan-2-yl)oxy)propan-2-yl)oxy)propan-2-ol).

1-((1-((1-Methoxypropan-2-yl)oxy)propan-2-yl)oxy)propan-2-ol (cas: 20324-33-8) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Recommanded Product: 1-((1-((1-Methoxypropan-2-yl)oxy)propan-2-yl)oxy)propan-2-ol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

p-tert-Butylcalix[4]arenes containing azacrown ether substituents at the lower rim as potential polytopic receptors was written by Alekseeva, E. A.;Basok, S. S.;Mazepa, A. V.;Luk’yanenko, A. P.;Snurnikova, O. V.;Gren, A. I.. And the article was included in Russian Journal of General Chemistry in 2013.COA of Formula: C10H21NO4 This article mentions the following:

A series of disubstituted p-tert-butylcalix[4]arenes with N-methoxycarbonylmonoazacrown ether and N-ethoxymonoazacrown ether residues at the lower rim has been prepared via the reaction of di(carboxymethoxy)-p-tert-butylcalix[4]arene with azacrown ethers and subsequent reduction of the resulting amide derivatives Using UV titration and ¹H NMR spectroscopy we have demonstrated the ability of the calixarene with two N-carbonylmonoaza-18-crown-6-ether substituents to form the 1:3 complexes with K⁺ and Na⁺ and the 1:2 complexes with Cs⁺, Sr²⁺, Cu²⁺, and Zn²⁺. The calixarene with two fragments of N-ethoxymonoaza-18-crown ether has formed binuclear complexes with alkali metals cations and mononuclear complexes with transition metals cations. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3COA of Formula: C10H21NO4).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers feature bent C閳ユ彊閳ユ弲 linkages. In dimethyl ether, the bond angle is 111鎺?and C閳ユ彊 distances are 141 pm. The barrier to rotation about the C閳ユ彊 bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.COA of Formula: C10H21NO4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Microwave-Assisted Cross-Coupling and Hydrogenation Chemistry by Using Heterogeneous Transition-Metal Catalysts: An Evaluation of the Role of Selective Catalyst Heating was written by Irfan, Muhammed;Fuchs, Michael;Glasnov, Toma N.;Kappe, C. Oliver. And the article was included in Chemistry – A European Journal in 2009.Formula: C15H14O3 This article mentions the following:

The concept of specific microwave effects in solid/liquid catalytic processes resulting from the selective heating of a microwave-absorbing heterogeneous transition-metal catalyst by using 2.45 GHz microwave irradiation was evaluated. As model transformations Ni/C-, Cu/C-, Pd/C-, and Pd/Al₂O₃-catalyzed carbon-carbon/carbon-heteroatom cross-couplings and hydrogenation reactions were studied. To probe the existence of specific microwave effects by selective catalyst heating in these transformations, control experiments comparing microwave dielec. heating and conventional thermal heating at the same reaction temperature were performed. Although the supported metal catalysts were exptl. found to be strongly microwave absorbing, for all chem. examples studied herein no differences in reaction rate or selectivity between microwave and conventional heating experiments under carefully controlled conditions were observed This was true also for reactions that use low-absorbing or microwave transparent solvents, and was independent of the microwave absorptivity of the catalyst support material. In the case of hydrogenation reactions, the stirring speed is a critical factor on the mass transfer between gas and liquid phase, influencing the rate of the hydrogenation in both microwave and conventionally heated experiments In the experiment, the researchers used many compounds, for example, 1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8Formula: C15H14O3).

1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O閳ユ椊 or N閳ユ椊 bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Formula: C15H14O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Crystal structure of bis[4′-(1,4,7,10-tetraoxa-13- azacyclopentadecan-13-yl)-2,2′:6′,2”-terpyridine]cobalt(III) tris(perchlorate) methanol monosolvate monohydrate was written by Ohmagari, Hitomi;Nakaya, Manabu;Ohtani, Ryo;Nakamura, Masaaki;Hayami, Shinya. And the article was included in Acta Crystallographica, Section E: Crystallographic Communications in 2015.Recommanded Product: 1,4,7,10-Tetraoxa-13-azacyclopentadecane This article mentions the following:

In the title compound, [Co(C₂₅H₃₀N₄O₄)₂](ClO₄)₃璺疌H₃OH璺疕₂O, the metal atom is coordinated by two tridentate crown ether terpyridine ligands, forming a distorted CoN₆ octahedron. The three pyridine rings in each crown-terpyridine ligand are approx. coplanar [maximum deviations = 0.088 (12) and 0.102 (15) 鑴淽 and the mean planes through the three pyridine rings are perpendicular to each other, making a dihedral angle of 89.95 (17)鎺? An intramol. C-H璺矾璺熀 interaction is observed between the two terpyridine ligands. In the crystal, O-H璺矾璺疧 and C-H璺矾璺疧 hydrogen bonds, a 锜?锜?stacking interaction [centroid-centroid distance = 3.923 (7) 鑴淽 and a C-H璺矾璺熀 interaction connect the complex cation, the perchlorate anions and the two types of solvent mols., forming a three-dimensional network. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Recommanded Product: 1,4,7,10-Tetraoxa-13-azacyclopentadecane).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Recommanded Product: 1,4,7,10-Tetraoxa-13-azacyclopentadecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Regioselective iodination of aromatic compounds with potassium iodide in the presence of benzyltriphenylphosphonium perchlorate was written by Albadi, Jalal;Abedini, Masoumeh;Iravani, Nasir. And the article was included in Chinese Chemical Letters in 2012.SDS of cas: 75581-11-2 This article mentions the following:

A simple and efficient method for the selective iodination of various aromatic compounds by using potassium iodide in the presence of benzyltriphenylphosphonium perchlorate, is reported. This method provides several advantages such as good selectivity between ortho and para positions of aromatic compounds and high yields of the products. In the experiment, the researchers used many compounds, for example, 4-Iodo-1-methoxy-2-methylbenzene (cas: 75581-11-2SDS of cas: 75581-11-2).

4-Iodo-1-methoxy-2-methylbenzene (cas: 75581-11-2) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).SDS of cas: 75581-11-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem