Tag: 200-300

Formula: C12H12N2O《Synthesis of novel mono- and bis-Schiff bases of morpholine derivatives and the investigation of their antimalarial and antiproliferative activities》 was published in 2015. The authors were Jarrahpour, Aliasghar;Shirvani, Pouria;Sharghi, Hashem;Aberi, Mahdi;Sinou, Veronique;Latour, Christine;Brunel, Jean Michel, and the article was included in《Medicinal Chemistry Research》. The author mentioned the following in the article:

A series of new Schiff bases of morpholine were prepared by the reaction of 2-hydroxy-3-(morpholinomethyl)benzaldehyde with several mono- and bis-aromatic amines. All these new compounds were characterized by ¹H-NMR, ¹³C-NMR and IR spectroscopy. They were evaluated as antimalarial agents against P. falciparum K14 strain demonstrating moderate to excellent activities. The IC₅₀ of 6,6′-((1,2-Phenylenebis(azanylylidene))bis(methanylylidene))bis(2-(morpholinomethyl)phenol) was 2.28 μM. Moreover, derivatives present potent antiproliferative activities against U937 leukemia-derived cell line with EC₅₀ values varying from 3 to 8 μM. Finally, due to its quite low cytotoxicity up to 10 μM against normal fibroblast cells, derivative 6,6′-((1,2-Phenylenebis(azanylylidene))bis(methanylylidene))bis(2-(morpholinomethyl)phenol) appeared as a good compromising biol. active product. To complete the study, the researchers used 3-(4-Aminophenoxy)aniline (cas: 2657-87-6) .

3-(4-Aminophenoxy)aniline is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. Formula: C12H12N2O The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Choi, Young Chul;Kim, Min Su;Ryu, Kyoung Moon;Lee, Sang Hoon;Jeong, Young Gyu published 《Microstructures and electrothermal characterization of aromatic poly(azomethine ether)-derived carbon films》 in 2020. The article was appeared in 《Journal of Applied Polymer Science》. They have made some progress in their research.Application of 2657-87-6 The article mentions the following:

The authors report the microstructural evolution and electrothermal properties of aromatic poly(azomethine ether) (PAME)-derived C films, which were fabricated by a facile spin-coating and following carbonization at different temperatures of 300-1000°. For the purpose, poly[3-(4-nitrilophenoxy)phenylenenitrilomethine-1,3-phenylenemethine] (mPAME) with a high residue of ∼56.4% after carbonization at 1000° was synthesized for a polymeric precursor for C films. The XPS, Raman spectroscopy, and x-ray diffraction analyses revealed that the mol. structures of mPAME films changed into an intrinsically N-doped graphitic structure, dominantly at the carbonization temperatures of 800-1000°. The elec. conductivity increased considerably from ∼10^-7 S/cm, for mPAME-derived films fabricated at 300-700°, to ∼10⁰ S/cm for the film carbonized at 800° to ∼10¹ S/cm for the films carbonized at 900-1000°. Accordingly, mPAME-derived C films, which were carbonized at 900-1000°, exhibited excellent electrothermal performance, such as rapid temperature responsiveness, high maximum temperatures, and high elec. power efficiency to relatively low applied voltages of 5-13 V. The experimental procedure involved many compounds, such as 3-(4-Aminophenoxy)aniline (cas: 2657-87-6) .

3-(4-Aminophenoxy)aniline is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. Application of 2657-87-6 The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Recommanded Product: 2657-87-6《Novel polycondensation method of improving high-temperature properties of microheterogeneous rolivsan copolymers modified by inserting epoxy and imide bridges between spherical microdomains》 was published in 2017. The authors were Zaitsev, Boris A.;Shvabskaya, Irina D.;Kleptsova, Larisa G., and the article was included in《High Performance Polymers》. The author mentioned the following in the article:

Rolivsan thermosetting resins (ROLs) (low-viscosity solvent-free compositions including (di)vinylarom. ethers and thermosensitive (di)methacrylates) were modified by low amounts of polyfunctional compounds (epoxy resins (ERs) and aromatic diamines (DAs)). Thermochem. transformations in modified ROLs give novel glassy densely cross-linked copolymers with increased high-temperature strength and thermo-oxidative stability. It was revealed that copolymers obtained at different ROLs/ERs and ROLs/DA mixing ratios (which were varied over a wide range) and different heat treatment regimes have various compositions, cross-link densities, chem., topol., and morphol. structures. Structural features of these copolymers were studied by IR spectroscopy, dynamic mech., thermal, and elemental analyses; the temperature dependences of flexural strength were also obtained. Morphol. pattern of the cured ROLs is typical of microheterogeneous polymers where spherical highly cross-linked microdomains (polymer grains) with high T_g are weakly bound by less densely cross-linked defective (intergrain) polymer layers with lower T_g. On the basis of the data obtained in the studies of thermochem. transformations in ROLs/ERs and ROLs/DA blends, the new approach to improving thermal stability and heat resistance of thermosetting resins was developed. We suggest using intergrain layers in microheterogeneous cross-linked polymers as “microreactors” which include target polyfunctional compounds for various high-temperature polymerization and polycondensation reactions. To complete the study, the researchers used 3-(4-Aminophenoxy)aniline (cas: 2657-87-6) .

3-(4-Aminophenoxy)aniline is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. Recommanded Product: 2657-87-6 The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Aepkers, Marion;Wuensch, Bernhard published 《Synthesis and NMDA-receptor affinity of ring and side chain homologous dexoxadrol derivatives》. The research results were published in《Archiv der Pharmazie (Weinheim, Germany)》 in 2004.Computed Properties of C15H16O2 The article conveys some information:

The regioselectivity during transacetalization of benzophenone di-Me acetal with butane-1,2,4-triol is controlled by the reaction conditions. Thermodn. control leads predominantly to the 1,3-dioxolanes whereas kinetic control favors the six-membered acetals. The amines were investigated in receptor binding studies with radioligands for their affinity to the phencyclidine binding site of the NMDA-receptor. In both series the primary amines show the highest NMDA-receptor affinity (K_i = 3.38-1.45 μM). Surprisingly, the piperidine derivative (I) binds with high affinity at σ₁-receptors and, therefore, represents a novel lead compound for high affinity σ₁-receptor ligands. To complete the study, the researchers used Dimethoxydiphenylmethane (cas: 2235-01-0) .

Dimethoxydiphenylmethane is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. Computed Properties of C15H16O2 The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ye, Baihua;Cramer, Nicolai published 《Chiral Cyclopentadienyl Ligands as Stereocontrolling Element in Asymmetric C-H Functionalization》. The research results were published in《Science (Washington, DC, United States)》 in 2012.Product Details of 2235-01-0 The article conveys some information:

Metal complexes coordinated by a single cyclopentadienyl (Cp) ligand are widely used, versatile catalysts, but their application to asym. reactions has been hindered by the difficulty of designing Cp substituents that effectively bias the coordination sphere. Here, we report on a class of simple C₂-sym. Cp derivatives that finely control the spatial arrangement of the transiently coordinated reactants around the central metal atom. Rhodium(III) complexes bearing these ligands proved to be highly enantioselective catalysts for directed carbon-hydrogen (C-H) bond functionalizations of hydroxamic acid derivatives To complete the study, the researchers used Dimethoxydiphenylmethane (cas: 2235-01-0) .

The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom.Product Details of 2235-01-0

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Etayo, Pablo;Badorrey, Ramon;Diaz-de-Villegas, Maria D.;Galvez, Jose A. published 《Chiral Amino Diol Derivatives as New Modular Organocatalysts for the Enantioselective α-Chlorination of Cyclic β-Keto Esters》. The research results were published in《Advanced Synthesis & Catalysis》 in 2010.Reference of Dimethoxydiphenylmethane The article conveys some information:

Highly modular chiral amino diol derivatives, e.g. I, have been used as organocatalysts in the enantioselective α-chlorination of cyclic β-keto esters. Optimization of the catalyst structure and the reaction conditions has allowed the synthesis of optically active α-chlorinated products with high enantioselectivities (up to 96% ee) using inexpensive com. available N-chlorosuccinimide (NCS) as the chlorine source under mild conditions.Dimethoxydiphenylmethane (cas: 2235-01-0) were involved in the experimental procedure.

For example, the most common synthesis of ethers involves the attack of an alkoxide ion on an alkyl halide. This method is called Williamson ether synthesis.Reference of Dimethoxydiphenylmethane

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Jin, Ke;Huang, Yuhui;Feng, Yudi;Guo, Jia;Xu, Jiangtao;Wang, Changchun published 《Soluble, Thermally Stable, and Low Thermal Expansion Polyarylamides Enabled by a Seven-Membered Carbocycle》. The research results were published in《ACS Applied Polymer Materials》 in 2020.Computed Properties of C12H12N2O The article conveys some information:

Soluble, thermally, and dimensionally stable polyarylamides have been a long-standing challenge for polymer chemists and materials scientists. Herein, we designed and synthesized a series of polyarylamides with various contents of the seven-membered carbocycle unit of 1,2:4,5-dibenzocycloheptadiene (DBCHD) as the linkage in the polymer backbones. In comparison to their analog with an ether linkage, these advanced polyarylamides showed improved thermal stability (5% weight loss temperature, 413-480°) and elevated glass transition temperatures (218-243°) depending on the content of the DBCHD unit. Given the good solubility in polar aprotic solvents, the polyarylamide films were prepared by simple and straightforward solution casting, which presented excellent optical transparency and low coefficient of thermal expansion (CTE). The polyarylamide with the highest content of DBCHD (43.5 wt %) showed a CTE value of 41.0 ppm/K in the temperature range of 0-150°, which is 43% lower than that of the corresponding ether-linked polyarylamide film. Variable-temperature ¹H NMR demonstrated that the nonplanar and moderately rigid structural features of DBCHD units in polymer backbones are the key influence factors that contribute to thermal stability and reduced thermal expansion. To complete the study, the researchers used 3-(4-Aminophenoxy)aniline (cas: 2657-87-6) .

3-(4-Aminophenoxy)aniline is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. Computed Properties of C12H12N2O The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Category: ethers-buliding-blocksIn 2010, Jung, Misuk;Yoon, Jieun;Kim, Hak Sung;Ryu, Jae-Sang published 《Mild and chemoselective synthesis and deprotection of geminal diacetates catalyzed by titanium(IV) halides》. 《Synthesis》published the findings. The article contains the following contents:

A novel, mild, and chemoselective method was developed for the preparation of gem-diacetates from aldehydes and Ac₂O in the presence of TiF₄ (1-5 mol%) under solvent-free conditions at room temperature The reaction showed a high chemoselectivity toward aldehydes in the presence of ketones. Moreover, TiF₄ also catalyzed the deprotection of gem-diacetates to the corresponding aldehydes in water. .This efficient and simple method has several benefits, including the use of an inexpensive catalyst, solvent-free conditions, mild reaction temperatures, and high yields, which make it both cost-effective and environmentally friendly. And Dimethoxydiphenylmethane (cas: 2235-01-0) was used in the research process.

Dimethoxydiphenylmethane is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. Category: ethers-buliding-blocks The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Wang, Kai;Yuan, Xiaojie;Zhan, Maosheng published 《Comparison between microwave and thermal curing of a polyimide adhesive end-capped with phenylethynyl groups》 in 2017. The article was appeared in 《International Journal of Adhesion and Adhesives》. They have made some progress in their research.COA of Formula: C12H12N2O The article mentions the following:

Microwave energy was investigated to cure phenylethynyl-end-capped polyimide adhesive using an industrial microwave oven at a frequency of 2.45 GHz and the adhesive properties, thermal performance and curing mechanism for bonding stainless steel were evaluated. The results are compared with those of thermal cured samples. It was demonstrated that while the lap shear strength properties and thermal performance of microwave cured samples were almost as good as those cured via a thermal process, the microwave curing process resulted in a significant reduction in the process cycle time and power consumption. The Fourier transform IR (FTIR) spectroscopy and XPS anal. of the cured resin structures suggested that there was no obvious difference in the chem. reactions taking place during the microwave and the thermal cure processes.3-(4-Aminophenoxy)aniline (cas: 2657-87-6) were involved in the experimental procedure.

3-(4-Aminophenoxy)aniline is one of ethers-buliding-blocks. Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. COA of Formula: C12H12N2OEthers do have nonbonding electron pairs on their oxygen atoms, however, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem