Tag: 100-200

Viscosity of 2-ethylhexan-1-amine (EHA)-diglyme, EHA-triglyme and EHA-tetraglyme non-aqueous solutions and its effect on initial absorption rate was written by Fu, Kun;Zhang, Pan;Wang, Lemeng;Huang, Xiayu;Fu, Dong. And the article was included in Journal of Molecular Liquids in 2020.Product Details of 112-49-2 This article mentions the following:

The viscosities (鐣? of 2-ethylhexan-1-amine (EHA), diglyme, triglyme, tetraglyme and EHA-diglyme/triglyme/tetraglyme non-aqueous solutions were measured by using the NDJ-5S rotational viscometer at 101 kPa. The temperatures (T) ranged from 303.2 K to 323.2 K. The mass fractions of EHA (w_EHA) ranged from 0.100 to 0.900. The viscosity was modeled and the calculated results agreed well with the experiments The effects of w_EHA and T on viscosity were demonstrated on the basis of experiments and calculations The initial absorption rates of CO₂ (r) in EHA-diglyme/triglyme/tetraglyme non-aqueous solutions were measured, and the effects of viscosity, absorbent concentration and absorption rate constant of CO₂ (k) on initial absorption rates were demonstrated. Our research shows that in the temperature range of 303.2 K to 323.2 K, the proposed three non-aqueous absorbents have small solution viscosities (<3 mPa.s), which is beneficial to the mass transfer of CO₂ absorption and the initial absorption rate. Thus the proposed non-aqueous absorbents have good application potential in the field of CO₂ capture process. In the experiment, the researchers used many compounds, for example, 2,5,8,11-Tetraoxadodecane (cas: 112-49-2Product Details of 112-49-2).

2,5,8,11-Tetraoxadodecane (cas: 112-49-2) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Product Details of 112-49-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Systematic assessment of working fluid mixtures for absorption refrigeration based on techno-economic, environmental, health and safety performance was written by Papadopoulos, Athanasios I.;Gkouletsos, Dimitris;Champilomatis, Vassilis;Giannakakis, Alexandros;Kousidis, Vergis;Hassan, Ibrahim;Seferlis, Panos. And the article was included in Energy Conversion and Management in 2020.Application In Synthesis of 2,5,8,11-Tetraoxadodecane This article mentions the following:

Absorption refrigeration is a promising technol. for the replacement of vapor compression systems. Few, conventional mixtures of organic components have been evaluated to date as working fluids using mainly operating performance indicators. The aim of this work is to evaluate 75 working fluid mixtures, including 18 novel options as candidates for single-effect absorption refrigeration processes. Multiple performance indicators are considered such as coefficient of performance, exergy efficiency, high cycle pressure, distillate-to-feed ratio and number of stages in the rectifier, mass flowrates, process economics and safety, health and environmental properties of fluids. The evaluation is performed within a systematic, stage-wise approach, which employs multi-criteria anal. It is observed that mixtures of acetaldehyde with DMF or methylpyrolidone exhibit up to 40% and 22% lower costs per ton of cooling compared to ammonia-water and water-lithium bromide. The same mixtures also outperform or match the coefficient of performance of ammonia-water. Propionaldehyde and Me formate with the same absorbents are also competitive options in smaller scale processes, while they exhibit better health, safety and environmental properties than acetaldehyde. The new mixtures are of equivalent or better safety, health and environmental performance than other well-known refrigerants. In the experiment, the researchers used many compounds, for example, 2,5,8,11-Tetraoxadodecane (cas: 112-49-2Application In Synthesis of 2,5,8,11-Tetraoxadodecane).

2,5,8,11-Tetraoxadodecane (cas: 112-49-2) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O閳ユ椊 or N閳ユ椊 bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Application In Synthesis of 2,5,8,11-Tetraoxadodecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Assessing the mixture effects in in vitro bioassays of chemicals occurring in small agricultural streams during rain events was written by Neale, Peta A.;Braun, Georg;Brack, Werner;Carmona, Eric;Gunold, Roman;Konig, Maria;Krauss, Martin;Liebmann, Liana;Liess, Matthias;Link, Moritz;Schafer, Ralf B.;Schlichting, Rita;Schreiner, Verena C.;Schulze, Tobias;Vormeier, Philipp;Weisner, Oliver;Escher, Beate I.. And the article was included in Environmental Science & Technology in 2020.Name: 2,5,8,11-Tetraoxadodecane This article mentions the following:

Rain events may impact the chem. pollution burden in rivers. Forty-four small streams in Germany were profiled during several rain events for the presence of 395 chems. and five types of mixture effects in in vitro bioassays (cytotoxicity; activation of the estrogen, aryl hydrocarbon, and peroxisome proliferator-activated receptors; and oxidative stress response). While these streams were selected to cover a wide range of agricultural impacts, in addition to the expected pesticides, wastewater-derived chems. and chems. typical for street runoff were detected. The unexpectedly high estrogenic effects in many samples indicated the impact by wastewater or overflow of combined sewer systems. The 128 water samples exhibited a high diversity of chem. and effect patterns, even for different rain events at the same site. The detected 290 chems. explained only a small fraction (<8%) of the measured effects. The exptl. effects of the designed mixtures of detected chems. that were expected to dominate the mixture effects of detected chems. were consistent with predictions for concentration addition within a factor of two for 94% of the mixtures Overall, the burden of chems. and effects was much higher than that previously detected in surface water during dry weather, with the effects often exceeding proposed effect-based trigger values. In the experiment, the researchers used many compounds, for example, 2,5,8,11-Tetraoxadodecane (cas: 112-49-2Name: 2,5,8,11-Tetraoxadodecane).

2,5,8,11-Tetraoxadodecane (cas: 112-49-2) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Name: 2,5,8,11-Tetraoxadodecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Analytical pyrolysis of lignin: products stemming from 灏?5 substructures was written by Kuroda, Ken-ichi;Nakagawa-Izumi, Akiko. And the article was included in Organic Geochemistry in 2006.Related Products of 3929-47-3 This article mentions the following:

Five phenolic 2-arylcoumarans containing a 灏?5 linkage: I (R = CH₂OH, R’ = CH:CHCH₂OH) (II), I (R = CH₂OH, R’ = CH:CHCHO) (III), I (R = Me, R’ = CH:CHCH₂OH) (IV), I (R = Me, R’ = CH:CHCHO) (V), I (R = Me, R’ = CH:CHMe) (VI), and diazomethane-methylated II (VII), were pyrolyzed at 500鎺?for 4 s. The products were analyzed by gas chromatog. and gas chromatog./mass spectrometry. The major products of II–V and VII were 4-methylguaiacol (VIII) and 1,2-dimethoxy-4-methylbenzene, resp., stemming from the A moiety of the 2-arylcoumarans. I–V having the ring B with a CH:CHCH₂OH or CH:CHCHO side chain provided VIII in a larger yield than dehydrodiisoeugenol VI having the ring B with a CH=CHCH₃ side chain; the yields of 4 were 閳?.6, 5.7-4.6, and 0.9 mol% from II, III–V and VI, resp. Characterization of the dimeric products of II showed the 浼?aryl ether opened-dimers with the hydrogenated C浼?C灏?bond being the precursors of VIII. Based on these results, guaiacyl and syringyl 灏?5 substructures were proposed as potential pyrolytic origins for VIII and 3,5-dimethoxy-4-methylphenol in anal. pyrolysis of soft- and hardwood lignins. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Related Products of 3929-47-3).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Related Products of 3929-47-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Design, synthesis, and antitumor activity evaluation of novel acyl sulfonamide spirodienones was written by Chen, Chen;Luo, Yang;Yin, Honglu;Zhong, Qiu;Zheng, Shilong;Liu, Rui;Zhao, Chong;Wang, Guangdi;He, Ling. And the article was included in Bioorganic & Medicinal Chemistry in 2022.HPLC of Formula: 1877-75-4 This article mentions the following:

Based on the promising results of benzenesulfonamide spirodienones as antineoplastic agents, a series of novel acyl sulfonamide spirodienones I [R = Me, C₆H₅, 4-MeC₆H₄, etc.; R¹ = H, Me] were designed and synthesized for antineoplastic evaluation. Of these, compound I [R = 4-MeC₆H₄, R¹ = H] exhibited remarkable in-vitro antiproliferative activity by arresting the cell cycle and inducing apoptosis of MDA-MB-231 cells. Acute toxicity study demonstrated that compound I [R = 4-MeC₆H₄, R¹ = H] at 100 mg/kg dose caused no obvious toxicity to the major organs of mice. Moreover, compound I [R = 4-MeC₆H₄, R¹ = H] suppressed the growth of murine 4T1 tumor in-vivo. Preliminary enzyme assay showed that I [R = 4-MeC₆H₄, R¹ = H] was a potential MMP2 inhibitor for cancer therapy. In all, these results indicated that compound I [R = 4-MeC₆H₄, R¹ = H] may be a lead compound for the development of anticancer agents. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4HPLC of Formula: 1877-75-4).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.HPLC of Formula: 1877-75-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Green, versatile, and scale-up synthesis of amides by aerobic oxidative amination over Ag₂O/P-C₃N₄ photocatalyst was written by Deng, Lanqing;Chen, Lang;Zhu, Liangdi;Li, Yang;Ou-Yang, Jie;Wu, Shaofeng;Chen, Peng;Shen, Sheng;Guo, Junkang;Zhou, Yongbo;Au, Chak-Tong;Yin, Shuang-Feng. And the article was included in Chemical Engineering Science in 2022.Quality Control of (4-Methoxyphenyl)methanol This article mentions the following:

Being extensively applied in various fields of chem. and chem. industry, the development of a green and versatile method for the synthesis of amides is in line with the demand of sustainable chem. Herein, a direct, highly selective, and scale-up (5-20 mmol) method for photocatalytic synthesis of amides through aerobic oxidative amination of alcs. with amines was developed under visible light, room temperature, using air as the oxidant. Benefiting from the adsorption of sodium hemiaminal on catalyst lengthens the C-H bond (1.148 鑴?, this novel process is feasible for a broad range of functionlized amides (69 examples), especially those for drug manufacture (e.g., moclobemide and pipobroman). Imines was almost prevented with excellent amide selectivity up to 99% could be ascribed to the low energy barrier for hemiaminal dehydrogenation while that for dehydration is high (2.13 eV). This green and efficient protocol represents an ideal alternative to the currently known methods. In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5Quality Control of (4-Methoxyphenyl)methanol).

(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O閳ユ椊 or N閳ユ椊 bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Quality Control of (4-Methoxyphenyl)methanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Impregnated Platinum on Magnetite as an Efficient, Fast, and Recyclable Catalyst for the Hydrosilylation of Alkynes was written by Cano, Rafael;Yus, Miguel;Ramon, Diego J.. And the article was included in ACS Catalysis in 2012.Recommanded Product: 16356-02-8 This article mentions the following:

New impregnated platinum on magnetite catalyst has been prepared, characterized and used for the hydrosilylation of different alkynes. The catalyst showed a wide reaction scope, allowing its use for different functionalized alkynes, localized triple bonds, and silane reagents. The reaction is selective for the case of diynes, obtaining the desired mono- or dihydrosilylation processes. The reaction with disilane reagents lead to the incorporation of two alkyne units to the final product. The catalyst is easily prepared and handled, avoiding the use of expensive and difficult to handle organic ligands, and it could be removed from the reaction medium just by sequestering by a magnet. The catalyst could be reused up to ten times with exactly the same activity. In the experiment, the researchers used many compounds, for example, 1,4-Dimethoxy-2-butyne (cas: 16356-02-8Recommanded Product: 16356-02-8).

1,4-Dimethoxy-2-butyne (cas: 16356-02-8) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Recommanded Product: 16356-02-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Total Synthesis and Cytotoxic Activity of 7-O-Methylnigrosporolide and Pestalotioprolide D was written by Thiraporn, Aticha;Iawsipo, Panata;Tadpetch, Kwanruthai. And the article was included in Synlett in 2022.Recommanded Product: 105-13-5 This article mentions the following:

A convergent total synthesis of 7- O-methylnigrosporolide and pestalotioprolide D has been accomplished in 17 linear steps and overall yields of 1.7% and 2.6%, resp., starting from ( S)-propylene oxide and ( S)-benzyl glycidyl ether. Our synthesis exploited an acetylide addition and a Shiina macrolactonization to assemble the macrocycle, a Lindlar reduction, and Wittig and Still-Gennari olefinations to construct the three alkene groups, as well as a Jacobsen hydrolytic kinetic resolution to install the stereogenic center. The selection of the silyl protecting group of the C-4 alc. was crucial for the final deprotection step. Our synthesis also led to a hypothesis that pestalotioprolide D might be an artifact of 7- O-methylnigrosporolide. The cytotoxic activities of the two synthetic compounds against six human cancer cell lines were evaluated. Synthetic pestalotioprolide D showed more potent cytotoxic activity than 7-O-methylnigrosporolide against all the cancer cell lines tested, and the SiHa cervical cancer cell line was the most sensitive to both synthetic compounds In the experiment, the researchers used many compounds, for example, (4-Methoxyphenyl)methanol (cas: 105-13-5Recommanded Product: 105-13-5).

(4-Methoxyphenyl)methanol (cas: 105-13-5) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Recommanded Product: 105-13-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis and biological activities of novel 2,5-disubstituted-1,3,4-thiadiazole derivatives was written by Li, Yingjun;Yu, Yang;Jin, Kun;Gao, Lixin;Luo, Tongchuan;Sheng, Li;Shao, Xin;Li, Jia. And the article was included in Youji Huaxue in 2015.Computed Properties of C9H10O4 This article mentions the following:

Sixteen novel 2,5-disubstituted-1,3,4-thiadiazole derivatives containing benzisoselenazolone moiety were synthesized by the reaction of 2-amino-5-substituted-1,3,4-thiadiazoles with ortho-(chloroseleno)benzoyl chloride. The structures were characterized by IR, ¹H NMR spectra and elemental anal. Their biol. activities were evaluated. The exptl. results indicate that some compounds exhibit inhibitory activity against cell division cycle 25B phosphatase (Cdc25B)(IC₅₀=1.67-6.66 娓璵ol璺疞^-1). All the target compounds showed good inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) (IC₅₀=0.73-4.50 娓璵ol璺疞^-1), and some compounds exhibited higher inhibitory activity than pos. control oleanolic acid (IC₅₀=1.90 娓璵ol璺疞^-1). Compound I displayed antitumor activity in vitro for human colon cancer (HCT-8) cell (IC₅₀=12.54 娓璵ol璺疞^-1). Some compounds showed the medium scavenging ability for hydroxyl radical (HO璺? and superoxide anion (O₂^璺?). Some compounds showed the medium scavenging ability for hydroxyl radical (HO璺? and superoxide anion (O₂^璺?), but no scavenging ability for DPPH 璺? In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4Computed Properties of C9H10O4).

2-(4-Methoxyphenoxy)acetic acid (cas: 1877-75-4) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Computed Properties of C9H10O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis, in vivo occupancy, and radiolabeling of potent phosphodiesterase subtype-10 inhibitors as candidates for positron emission tomography imaging was written by Andres, Jose-Ignacio;De Angelis, Meri;Alcazar, Jesus;Iturrino, Laura;Langlois, Xavier;Dedeurwaerdere, Stefanie;Lenaerts, Ilse;Vanhoof, Greet;Celen, Sofie;Bormans, Guy. And the article was included in Journal of Medicinal Chemistry in 2011.Related Products of 63071-12-5 This article mentions the following:

We have recently reported the phosphodiesterase 10A (PDE10A) inhibitor 2-[4-[1-(2-[¹⁸F]fluoroethyl)-4-pyridin-4-yl-1H-pyrazol-3-yl]-phenoxymethyl]-quinoline (I) as a promising candidate for in vivo imaging using positron emission tomog. (PET). We now describe the synthesis and biol. evaluation of a series of related pyridinyl analogs II (R¹ = FCH₂CH₂, FCH₂CH₂CH₂, F₃CCH₂; R² = 3,5-di-Me, 5-methoxy, 6-bromo, etc.) that exhibit high potency and selectivity as PDE10A inhibitors. The most interesting compounds were injected in rats to measure their levels of PDE10A occupancy through an in vivo occupancy assay. The 3,5-dimethylpyridine derivative II (R¹ = FCH₂CH₂, R² = 3,5-di-Me) and the 5-methoxypyridine derivative II (R¹ = FCH₂CH₂, R² = 5-methoxy) showed a comparable level of occupancy to that of I. Because these derivatives showed lower in vitro activity and are slightly less lipophilic than I, we hypothesized that they could behave as better PET imaging ligands. Compounds II (R¹ = ¹⁸FCH₂CH₂, R² = 3,5-dimethyl; R¹ = ¹⁸FCH₂CH₂, R² = 5-methoxy; R¹ = FCH₂CH₂, R² = 5-¹¹CH₃O) were radio synthesized and subjected to biodistribution studies in rats for a preliminary evaluation as candidate PET radioligands for in vivo imaging of PDE10A in the brain. In the experiment, the researchers used many compounds, for example, (6-Methoxypyridin-2-yl)methanol (cas: 63071-12-5Related Products of 63071-12-5).

(6-Methoxypyridin-2-yl)methanol (cas: 63071-12-5) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Ethers feature bent C閳ユ彊閳ユ弲 linkages. In dimethyl ether, the bond angle is 111鎺?and C閳ユ彊 distances are 141 pm. The barrier to rotation about the C閳ユ彊 bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Related Products of 63071-12-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem