Tag: 100-200

《The crystal structure of (5-chloro-2-hydroxy-N-(4-methoxy-2-oxidobenzylidene)benzohydrazonato-κ3N,O,O′)-(pyridine-κ1N)copper(II), C20H16ClCuN3O4》 was published in Zeitschrift fuer Kristallographie – New Crystal Structures in 2020. These research results belong to Xin, Wang; Li, Shuli; Yang, Liguo; Song, Haixiang; Niu, Yongsheng. Safety of 2-Hydroxy-4-methoxybenzaldehyde The article mentions the following:

C20H16ClCuN3O4, triclinic, P1[n.772] (number 2), a = 7.629(4) Å, b = 8.893(5) Å, c = 14.193(8) Å, α = 88.603(6)°, β = 81.093(6)°, γ = 83.715(6)°, V = 945.6(9) Å3, Z = 2, Rgt(F) = 0.0245, wRref(F2) = 0.0709, T = 296(2) K. CCDC number: 1964895. 2-Hydroxy-4-methoxybenzaldehyde 5-chlorosalicylhydrazide (0.32 g, 1 mmol) in 10 mL methanol and 1 mL pyridine was stirred at room temperature for 1 h. The mixture was filtered, and left at room temperature After a few days, colorless block crystals formed. Yield (0.22 g, 50%). In the experiment, the researchers used many compounds, for example, 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Safety of 2-Hydroxy-4-methoxybenzaldehyde)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Safety of 2-Hydroxy-4-methoxybenzaldehyde

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Shao, Chenwen; Hedberg, Christian; Qian, Yong published an article in 2021. The article was titled 《In Vivo Imaging of the Macrophage Migration Inhibitory Factor in Liver Cancer with an Activity-Based Probe》, and you may find the article in Analytical Chemistry (Washington, DC, United States).Application of 4637-24-5 The information in the text is summarized as follows:

The macrophage migration inhibitory factor (MIF), a vital cytokine and biomarker, has been suggested to closely associate with the pathogenesis of liver cancer. However, a simple and effective approach for monitoring the change and distribution of cellular MIF is currently lacking and urgently needed, which could be helpful for a better understanding of its role in the progression of cancer. Herein, we report a novel activity-based probe, TPP2 (I), which allows for direct labeling and imaging of endogenous MIF activity within live cells, clin. tissues, and in vivo in a mouse model of liver cancer. With this probe, we have intuitively observed the dynamic change of intracellular MIF activity by both flow cytometry and confocal imaging. We further found that TPP2 permits the identification and distinguishing of liver cancer in vitro and in vivo with high sensitivity and selectivity toward MIF. Our observations indicate that TPP2 could provide a promising new imaging approach for elucidating the MIF-related biol. functions in liver cancer. In the experiment, the researchers used N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Application of 4637-24-5)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Application of 4637-24-5

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《Synthesis of coumarin derivatives in a microfluidic flow system employing the Pechmann condensation: A case study》 was written by Liu, Ling-Kang; Deng, Jhao-Hong; Guo, Yang-Ming. COA of Formula: C7H8O2 And the article was included in Journal of the Chinese Chemical Society (Weinheim, Germany) in 2020. The article conveys some information:

For the synthesis of coumarin derivatives using the Pechmann condensation scheme, an acidic ionic liquid catalyst, abbreviated as [EBsImH][HSO4], was prepared from the ring opening of 1,4-butanesultone by 1-ethylimidazole, followed by the addition of 1 equivalent H2SO4(c). The [EBsImH][HSO4]-catalyzed Pechmann condensation reactions proceeded smoothly in a batch setup, with recyclable [EBsImH][HSO4] showing great catalytic activity. The acidic ionic liquid catalyst [EBsImH][HSO4] was recovered from EtOAc/H2O extraction of the product mixture, where the H2O layer was worked up and dried for reuse in consecutive runs of the Pechmann condensation reactions, maintaining >85% conversion for four times. The catalytic reactions were also carried out in a microfluidic flow setup. The flow parameters, the reactant molar amounts, and the addnl. H2SO4 as a modifying acid catalyst were optimized in the current case study. A min. conversion rate of 2.8 g/h of coumarin derivatives was demonstrated. The results came from multiple reactions, including the reaction of m-Methoxyphenol(cas: 150-19-6COA of Formula: C7H8O2)

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneCOA of Formula: C7H8O2

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Maritz, Marius; Hosten, Eric C.; Betz, Richard published an article in 2021. The article was titled 《Crystal structure of ortho-methoxy benzaldehyde, C8H8O2 – a second polymorph and deposition of 3D coordinates》, and you may find the article in Zeitschrift fuer Kristallographie – New Crystal Structures.Application In Synthesis of 2-Methoxybenzaldehyde The information in the text is summarized as follows:

C8H8O2, tetragonal, P43212 (number 96), a = 10.9521(5) Å, c = 23.3014(17) Å, V = 2795.0(3) Å3, Z = 16, R gt(F) = 0.0317, wR ref(F 2) = 0.0883, T = 200 K. The experimental process involved the reaction of 2-Methoxybenzaldehyde(cas: 135-02-4Application In Synthesis of 2-Methoxybenzaldehyde)

2-Methoxybenzaldehyde(cas: 135-02-4) is found in cassia oil, cinnamon bark, and cinnamon bark oil. It is a clear colorless liquid with a strong aroma. It has been used to examine the acaricidal activity of Periploca sepium oil and its active component against Tyrophagus putrescentiae.Application In Synthesis of 2-Methoxybenzaldehyde

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《Development of a method to measure laccase activity on methoxyphenolic food ingredients and isomers》 was written by Manzano-Nicolas, Jesus; Marin-Iniesta, Fulgencio; Taboada-Rodriguez, Amaury; Garcia-Canovas, Francisco; Tudela-Serrano, Jose; Munoz-Munoz, Jose Luis. Product Details of 150-19-6 And the article was included in International Journal of Biological Macromolecules in 2020. The article conveys some information:

We studied the laccase-catalyzed oxygenation of methoxyphenolic food ingredients, such as 2-methoxyphenol (guaiacol) and 2,6-dimethoxyphenol (syringol), isomers such as 3- and 4-methoxyphenol, and 2,3-, 3,4- and 3,5-dimethoxyphenol. These methoxyphenolic substrates generate unstable free radicals, which leads to the erroneous determination of steady state rates. The addition of small quantities of ascorbic acid as coupling reagent generates a lag period because it reduces free radicals to methoxyphenols. Measurement of the length of the lag period provides the reliable determination of true steady state rates. We describe the application of this chronometric method to the kinetic characterization of the oxidation of the above methoxyphenolic substrates by Trametes versicolor laccase. The experimental part of the paper was very detailed, including the reaction process of m-Methoxyphenol(cas: 150-19-6Product Details of 150-19-6)

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneProduct Details of 150-19-6

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Gharpure, Santosh J.; Jegadeesan, S.; Vishwakarma, Dharmendra S. published an article in 2021. The article was titled 《Acid-catalysed iterative generation of o-quinone methides for the synthesis of dioxabicyclo[3.3.1]nonanes: total synthesis of myristicyclins A-B》, and you may find the article in Chemical Communications (Cambridge, United Kingdom).Recommanded Product: 673-22-3 The information in the text is summarized as follows:

A practical and efficient method for the synthesis of bioactive flavanoids relying on the strategic use of o-quinine methide (o-QM) intermediates was reported. This involved Bronsted acid-catalyzed iterative generation of o-QMs/[4+2] cycloaddition/intermol. Michael addition/cyclative acetalization in a cascade sequence for the synthesis of dioxabicyclo[3.3.1]nonanes I [R1 = H, 7-OMe, 8-OMe; R2 = H, CO2Me, CO2Et; R3 = H, Me, Ph, etc.]. The ‘one-pot’, controlled cascade sequence successfully provided the shortest route amenable for gram scale synthesis of natural products (±)-myristicyclins A-B II and III. In the experimental materials used by the author, we found 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Recommanded Product: 673-22-3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Recommanded Product: 673-22-3

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Alnaja, Alaa M. A.; Farghaly, Thoraya A.; El-zahabi, Heba S. A.; Shaaban, Mohamed R. published an article in 2021. The article was titled 《Cytotoxicity, Docking Study of New Fluorinated Fused Pyrimidine Scaffold: Thermal and Microwave Irradiation Synthesis》, and you may find the article in Medicinal Chemistry (Sharjah, United Arab Emirates).Synthetic Route of C5H13NO2 The information in the text is summarized as follows:

Azolopyrimidines are imposed on the arena of drugs treated for cancer. The urgent need to discover new selective anticancer agents, paved the way to explore the antitumor significance of such fused systems. From the synthetic point of view, Microwave facilitated technique for synthesis is very strongly associated with green method in chem. field. Our aim is to synthesize bioactive compounds using docking simulation run by MOE program to explore the binding mode of the most active enzyme inhibitor among the target compounds In addition to the use of conventional heating, the MARS system of CEM utilized for Microwave irradiation that is equipped with a multi-mode platform with a magnetic stirring plate and a rotor that allows the parallel processing of many vessels per batch. All the synthesized compounds were tested for their anticancer activity against hepatic cancer (HepG-2), breast cancer (MCF-7) and colon cancer (HCT-116). Screening against the cancer cell lines was performed, using doxorubicin as a reference drug. Docking studies were conducted using MOE software. A novel series of fluorinated fused-pyrimidine namely, pyrazolopyrimidine, triazolopyrimidine and pyrimidobenzimidazole were designed and synthesized conventionally and under microwave irradiations. The mechanistic pathways as well as the structure of all products were debated and demonstrated based on all possible spectral data. In-vitro examination of the novel prepared derivatives vs. the three different human cancer cell lines [hepatic cancer (HepG-2), breast cancer (MCF-7) and colon cancer (HCT-116)] was evaluated to estimate their actual activity. We have developed a simple, facile, and efficient procedure for the formation of new series of azolopyrimidines. All spectra of all products were investigated deliberately to confirm their structures. The anti-cancer activity has been examined against three cancer cell lines e.g. HepG-2, MCF-7 and HCT116. Mol. modeling study was carried out in order to rationalize the in vitro anti-tumor results. In addition to this study using N,N-Dimethylformamide Dimethyl Acetal, there are many other studies that have used N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Synthetic Route of C5H13NO2) was used in this study.

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Synthetic Route of C5H13NO2

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The author of 《Evaluation of phytochemical compounds and antimicrobial activities of Hemidesmus indicus》 were Ashalatha, K. S.; Raja, Shantha Reddy A.; Raveesha, H. R.. And the article was published in Asian Journal of Pharmaceutical and Clinical Research in 2019. Category: ethers-buliding-blocks The author mentioned the following in the article:

The present study was aimed to investigate the phytochem. screening, antibacterial activities, and identification of bioactive compounds by gas chromatog.-mass spectrometry (GC-MS) and high-performance liquid chromatog. (HPLC) in Hemidesmus indicus root extracts The qual. and quant. phytochem. anal. was carried out using standard methods. Bioactive compounds were identified by GC-MS and HPLC anal. Antibacterial activity of different solvent extracts was carried out using the agar well diffusion method. Preliminary phytochem. anal. showed the presence of phenols, tannins, alkaloids, flavonoids, proteins, reducing sugar, glycosides, amino acids, steroids, terpenoids, resins, volatile oil, emodols, and coumarins. Total phenolic and flavonoid contents were higher in the methanolic extracts compared to other solvent extracts 2-hydroxy 4-methoxy benzaldehyde was identified as the major compound The maximum zone of inhibition was observed in the methanolic extracts of root against Klebsiella pneumoniae, Staphylococcus aureus, and Escherichia coli. Our results suggest that H. indicus plant contains many chem. compounds and its root exhibits the wide range of antimicrobial activity. Further studies have to be carried out regarding the in vitro multiplication of plant and to enhance the root flavoring compounds for medicinal, food, and beverage industries. In the part of experimental materials, we found many familiar compounds, such as 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Category: ethers-buliding-blocks)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Category: ethers-buliding-blocks

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In 2019,Journal of Polymer Science, Part A: Polymer Chemistry included an article by Yamauchi, Akira; Sudo, Atsushi; Endo, Takeshi. COA of Formula: C5H13NO2. The article was titled 《Polymer with Zwitterionic Structure in Main Chain via Polyaddition of Bifunctional Cyclic Amidine and Diisothiocyanate》. The information in the text is summarized as follows:

Another mode of application for the addition reaction of cyclic amidine and isothiocyanate to the construction of polymers with zwitterionic moieties, i.e., polyaddition of a bifunctional cyclic amidine monomer and diisothiocyanate. The thermal properties and ionic conductivity of the resulting polymer were investigated. In addition to this study using N,N-Dimethylformamide Dimethyl Acetal, there are many other studies that have used N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5COA of Formula: C5H13NO2) was used in this study.

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.COA of Formula: C5H13NO2

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Nakamura, Kento; Kondo, Masaru; Krishnan, Chandu G.; Takizawa, Shinobu; Sasai, Hiroaki published their research in Chemical Communications (Cambridge, United Kingdom) in 2021. The article was titled 《Azopyridine-based chiral oxazolines with rare-earth metals for photoswitchable catalysis》.Product Details of 60656-87-3 The article contains the following contents:

An azopyridine-based oxazolines I [R = H, Me] was developed for utilizing azo group coordination and isomerization as a photoswitchable ligand. The ligand coordinated to rare-earth metal (RE) catalyst underwent efficient E/Z photoisomerization, suggesting tri- and bidentate coordination switching. The photoisomerization of the ligand enabled modulation of the enantioselectivity of an RE-catalyzed aminal forming reaction. The results came from multiple reactions, including the reaction of 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Product Details of 60656-87-3)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) may be used in the following syntheses: (3S,5S)-methyl 6-benzyloxy-3,5-dihydroxyhexanoate ,(S)-5-benzyloxy-4-hydroxypentan-2-one, myxothiazols.Product Details of 60656-87-3

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