Tag: 100-200

《MnSb2O6-chitosan nanocomposite: An efficient catalyst for the synthesis of coumarins via Pechmann reaction》 was published in Journal of Heterocyclic Chemistry in 2020. These research results belong to Bahramnezhad, Baharak; Ghazanfari, Dadkhoda; Sheikhhosseini, Enayatollah; Akhgar, Mohammad Reza; Ahmadi, Sayed Ali. HPLC of Formula: 150-19-6 The article mentions the following:

In this work, MnSb2O6-chitosan nanocomposites were synthesized and have been employed in Pechmann condensation for the synthesis of coumarin derivatives e.g., I. MnSb2O6-chitosan nanocomposites were characterized by Fourier transform IR (FTIR), X-ray powder diffraction (XRD), scanning electron microscope (SEM), and energy-dispersive X-ray spectroscopy (EDX) techniques. The particles of MnSb2O6-chitosan have uniform spheres with sizes that are less than 100 nm. Simplicity, easy work-up, and short reaction times are advantages of this reaction. Also, the antibacterial activity for some of the products was evaluated, and the result showed significant pharmaceutical activities as antibacterial reagents against Staphylococcus aureus and Escherichia coli. In the experiment, the researchers used m-Methoxyphenol(cas: 150-19-6HPLC of Formula: 150-19-6)

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneHPLC of Formula: 150-19-6

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Quality Control of 2-(Benzyloxy)acetaldehydeIn 2021 ,《Catalytic Regioselective Olefin Hydroarylation(alkenylation) by Sequential Carbonickelation-Hydride Transfer》 was published in Journal of the American Chemical Society. The article was written by Liu, Chen-Fei; Luo, Xiaohua; Wang, Hongyu; Koh, Ming Joo. The article contains the following contents:

Catalytic amounts of a dimeric Ni(I) complex and an exogenous alkoxide base promoted Markovnikov-selective hydroarylation(alkenylation) of unactivated and activated olefins using organo bromides or triflates derived from widely available phenols and ketones was reported for the synthesis of substituted alkanes. Products bearing aryl- and alkenyl-substituted tertiary and quaternary centers could be isolated in up to 95% yield and >99:1 regioisomeric ratios. Contrary to previous dual-catalytic methods that rely on metal-hydride atom transfer (MHAT) to the olefin prior to carbofunctionalization with a cocatalyst, mechanistic evidence points toward a nonradical reaction pathway that begins with site-selective carbonickelation across the C=C bond followed by hydride transfer using alkoxide as the hydride source. Utility of the single-catalyst protocol is highlighted through the synthesis of medicinally relevant scaffolds. In the experiment, the researchers used 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Quality Control of 2-(Benzyloxy)acetaldehyde)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).Quality Control of 2-(Benzyloxy)acetaldehyde

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Recommanded Product: 4637-24-5In 2022 ,《Regio- and stereoselective synthesis of spiro-heterocycles bearing the pyrazole scaffold via [3+2] cycloaddition reaction》 was published in Journal of Molecular Structure. The article was written by Islam, Mohammad Shahidul; Haukka, Matti; Soliman, Saied M.; Al-Majid, Abdullah Mohammed; Rahman, A. F. M. Motiur; Bari, Ahmed; Barakat, Assem. The article contains the following contents:

The utility of one-pot multicomponent based [3+2] cycloaddition reaction transformation to prepare a new two hybrids of spirooxindoles engrafted with pyrazole skeleton I (R1 = H and Cl; R2 = F and Cl) was reported. Upon treatment of the electron-deficient olefins based pyrazole motif with in situ the generated azomethine ylides (AY) of sarcosine with the 6-chloro-isatin afforded spiroadducts. To enlighten the regio- and diastereo-selectivity of these spiroheterocycles, single crystal X-ray diffraction anal. was presented. Using Hirshfeld calculations, many short distance contacts such as O…H, Cl…H, N…H, H…C, C…C and Cl…S have a great impact on the mol. packing and the crystal stability of I (R1 = H; R2 = F) and I (R1 = Cl; R2 = Cl). The latter showed some Cl…Cl inter halogen interactions (Cl1…Cl3; 3.358 Å ). Both compounds are polar where I (R1 = Cl; R2 = Cl) (3.995 Debye) has higher dipole moment than I (R1 = H; R2 = F) (3.414 Debye). The NMR chem. shifts were calculated and found in excellent correlations between the calculated and exptl. data were obtained (R2 = 0.94-0.98). In the experiment, the researchers used many compounds, for example, N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Recommanded Product: 4637-24-5)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Recommanded Product: 4637-24-5

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Product Details of 673-22-3In 2020 ,《Indian sarsaparilla, Hemidesmus indicus (L.) R. Br. ex Schult: tissue culture studies》 appeared in Applied Microbiology and Biotechnology. The author of the article were Kher, Mafatlal M.; Shekhawat, Mahipal S.; Nataraj, M.; Teixeira da Silva, Jaime A.. The article conveys some information:

A review. Abstract: Hemidesmus indicus (L.) R. Br. ex Schult is commonly known as anantmul or Indian sarsaparilla. The roots of this plant, which display a wide range of medicinal, biol., and phytopharmaceutical properties, are used in the pharmaceutical and food industries. Conventionally, the plant is propagated by seed germination or vegetatively, but the efficacy of traditional methods has some limitations: plants derived from seed germination are prone to seed-borne diseases, or plantlet production using vegetative propagation is limited. In contrast, plant tissue culture allows for large-scale propagation and secondary metabolite production in vitro without sacrificing plants from their natural habitats. Many efforts have been made over 40 years of research to establish efficient micropropagation protocols to speed up cultivation of this plant, including callus-mediated in vitro propagation, somatic embryogenesis, and shoot multiplication using cotyledenory nodes, stem segments, shoot tips, and nodal explants. Among these explants, nodal explants are the most commonly used for H. indicus micropropagation. The application of adenine sulfate, citric acid, ascorbic acid, and arginine may be useful in preventing explant browning, premature leaf senescence, and shoot tip abscission during in vitro culture. This review provides insight into micropropagation, use of synthetic seeds for short-term germplasm preservation, and in vitro production of secondary metabolites such as 2-hydroxy-4-methoxybenzaldehyde, lupeol, vanillin, and rutin, from in vitro root and callus cultures. Furthermore, unexplored and possible innovative areas of research in Hemidesmus biotechnol. are also discussed. Key Points: • Hemidesmus indicus has multiple therapeutic applications. • H. indicus roots are used in confectionary and pharmacy. • This review comprehensively assesses H. indicus tissue culture. • Challenges and future research of H. indicus biotechnol. are discussed. In the experiment, the researchers used many compounds, for example, 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Product Details of 673-22-3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Product Details of 673-22-3

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Product Details of 673-22-3In 2021 ,《Unsymmetrical Pyridoxal-Based Bisazomethines》 appeared in Russian Journal of General Chemistry. The author of the article were Bagautdinova, R. H.; Kibardina, L. K.; Burilov, A. R.; Pudovik, M. A.. The article conveys some information:

The reaction of equimolar amounts of pyridoxal and 1,2-propylenediamine led to the formation of monoimine I, which exists as cyclic imidazolidine tautomer II. The latter reacts with aromatic aldehydes ArCHO to form unsym. bisazomethines, e.g., III. The reaction of II with Ph isocyanate produces a compound containing a carbamate group, IV, and the reaction with hydrochloric acid leads to the formation of a salt-based furopyridine. After reading the article, we found that the author used 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Product Details of 673-22-3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Product Details of 673-22-3

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Category: ethers-buliding-blocksIn 2020 ,《Highly functionalized N-1-(2-pyridinylmethyl)-3,5-bis[(E)-arylmethylidene]tetrahydro-4(1H)-pyridinones: Synthesis, characterization, crystal structure and DFT studies》 appeared in Journal of Molecular Structure. The author of the article were Al-thamili, Dhaifallah M.; Almansour, Abdulrahman I.; Arumugam, Natarajan; Kansiz, Sevgi; Dege, Necmi; Soliman, Saied M.; Azam, Mohammad; Kumar, Raju Suresh. The article conveys some information:

Highly functionalized N-1-(2-pyridinylmethyl)-3,5-bis[(E)-2-methoxy/fluorophenylmethylidene]-tetrahydro-4(1H)-pyridinone have been synthesized in good yields. The mol. structure of the synthesized compounds was elucidated by NMR spectroscopy and further confirmed by single crystal X-ray crystallog. studies. The Hirshfeld anal. reveals that the mol. packing of N-1-(2-Pyridinylmethyl)-3,5-bis[(E)-(2-methoxylphenyl)methylidene]tetrahydro-4(1H)-pyridinone is mainly controlled by N…H (4.9%), C…H (30.6%) and H…H (52.4%) contacts, whereas the mols. are packed by strong F…H (16.8-16.9%), N…H (5.4%) and O…H (5.2-5.4%) as well as weak C…C (3.9-4.5%), H…H (39.7-39.9%) and C…H (24.8-25.8%) contacts in N-1-(2-Pyridinylmethyl)-3,5-bis[(E)-(4-fluorophenyl)methylidene]tetrahydro-4(1H)-pyridinone. DFT calculations are used in order to predict the electronic properties of studied compounds The NMR data obtained exptl. correlated well with the calculated findings. In the experimental materials used by the author, we found 2-Methoxybenzaldehyde(cas: 135-02-4Category: ethers-buliding-blocks)

2-Methoxybenzaldehyde(cas: 135-02-4) is found in cassia oil, cinnamon bark, and cinnamon bark oil. It is a clear colorless liquid with a strong aroma. It has been used to examine the acaricidal activity of Periploca sepium oil and its active component against Tyrophagus putrescentiae.Category: ethers-buliding-blocks

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In 2022,AL-Shammri, Khairiah Nasser; Elkanzi, Nadia A. A.; Arafa, Wael A. A.; Althobaiti, Ibrahim O.; Bakr, Rania B.; Moustafa, Shaima Mohamed Nabil published an article in Arabian Journal of Chemistry. The title of the article was 《Novel indan-1,3-dione derivatives: Design, green synthesis, effect against tomato damping-off disease caused by Fusarium oxysporum and in silico molecular docking study》.Category: ethers-buliding-blocks The author mentioned the following in the article:

An effective method for synthesizing series of twenty-two new compounds was performed starting from reaction of 1,2,3-indenetrione thiourea, and Et cyanoacetate under microwave irradiation and / or 2-(1,3-dioxo-1H-inden-2(3H)-ylidene) hydrazine carbothioamide with acetic anhydride. The designed new compounds have been successfully examined in-vitro for their antifungal activities. The relation between the structure of the synthesized compounds and their activity against tomato damping-off disease caused by Fusarium oxysporum fungi was studied and favorable results were obtained. The antifungal studies indicated that few compounds exerted the highest antifungal activities, while 7′-thioxo-7′,8′-dihydrospiro[indene-2,5′-pyrimido[4,5-d][1,3]oxazine]-1,3,4′(6’H)-trione and Et 6′-(4-hydroxybenzylideneamino)-1,3-dioxo-2′-thioxo-1,2′,3,3′-tetrahydro-1’H-spiro [indene-2,4′-pyrimidine]-5′-carboxylate recorded the lowest effect. The obtained results confirmed the possibility of the application of Et 6′-amino-1,3-dioxo-2′-thioxo-1,2′,3,3′-tetrahydro-1’H-spiro[indene-2,4′-pyrimidine]-5′-carboxylate as a new effective regulator of the vegetative growth of tomatoes. The mol. docking anal. was performed within succinate dehydrogenase (SDH) as a target enzyme in order to rationalize the promising findings obtained for the active compounds In the experiment, the researchers used many compounds, for example, 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Category: ethers-buliding-blocks)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

De Smet, Gilles; Bai, Xingfeng; Mensch, Carl; Sergeyev, Sergey; Evano, Gwilherm; Maes, Bert U. W. published an article in 2022. The article was titled 《Selective Nickel-Catalyzed Hydrodeacetoxylation of Aryl Acetates》, and you may find the article in Angewandte Chemie, International Edition.Recommanded Product: m-Methoxyphenol The information in the text is summarized as follows:

Ni-catalyzed hydrodeacetoxylation of aryl acetates (Ar-OAc) with HBpin in a green carbonate solvent selectively delivered the corresponding deoxygenated arenes (ArH). The method was also applicable to highly challenging guaiacyl and syringyl acetates, leaving -OMe groups intact without arene reduction Renewable 4-propylguaiacol obtained from pine could also be transformed without significant loss in yield vs. oil derived feedstock. The observed chemoselectivity for Ar-OAc vs. ArO-Ac bond cleavage was rationalized based on mechanistic experiments and DFT calculations ArOH side-product formation was attributed to direct competitive Ni-catalyzed reduction of the C=O bond. Hydrodeacyloxylation of a set of aryl alkanoates featured interesting chemoselectivity with a dramatic influence of the length and structure of the alkyl chain on catalysis. After reading the article, we found that the author used m-Methoxyphenol(cas: 150-19-6Recommanded Product: m-Methoxyphenol)

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneRecommanded Product: m-Methoxyphenol

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Ether – Wikipedia,
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《One-pot enzymatic synthesis of enantiopure 1,3-oxathiolanes using Trichosporon laibachii lipase and the kinetic model》 was written by Zhang, Yuanyuan; Sun, Yangjian; Tang, Hui; Zhao, Qiuxiang; Ren, Wenjie; Lv, Kuiying; Yang, Fengke; Wang, Fanye; Liu, Junhong. SDS of cas: 60656-87-3 And the article was included in Organic Process Research & Development in 2020. The article conveys some information:

The dynamic covalent kinetic resolution protocol was efficiently used for the synthesis of the enantiopure ((R)-5-acetoxy-1,3-oxathiolan-2-yl)ethyl benzoate (PR) from substrates 2-(phenylmethoxy)acetaldehyde (A), 1,4-dithiane-2,5-diol (B), and Ph acetate (D) by a one-pot process with 99.6% conversion, 97.3% yield, and 96.5% ee through the combination of reversible hemithioacetal transformation and enantiomer-selective lactonization catalyzed by immobilized lipase from Trichosporon laibachii. A proposed kinetic model consisting of transformation and lactonization was developed herein for the first time, fitting the exptl. data very well. It was concluded that (1) the transformation in a chem. fashion may follow a power law. (2) The enzymic lactonization may follow a sequential mechanism with product inhibition. The reaction kinetic data reveal that phenol (P1) would have strong product inhibition, while noncompetitive inhibition, product inhibition of PR, and substrate inhibition were not recognized. The model suggests that there is a common limitation of both enzyme and chem. in the chemo-enzymic system, and thus the amount of lipase was increased to accelerate the enzymic lactonization and to reduce the limitation caused by the enzymic reaction, resulting in the increase of the yield of PR significantly. The exptl. results demonstrate that both the internal and external mass diffusion resistance could be negligible, and thus the kinetic model developed is the inherent kinetic one. In the part of experimental materials, we found many familiar compounds, such as 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3SDS of cas: 60656-87-3)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).SDS of cas: 60656-87-3

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《Bismuth-Catalyzed Oxidative Coupling of Arylboronic Acids with Triflate and Nonaflate Salts》 was published in Journal of the American Chemical Society in 2020. These research results belong to Planas, Oriol; Peciukenas, Vytautas; Cornella, Josep. Reference of 3-Methoxyphenylboronic acid The article mentions the following:

Herein, a Bi-catalyzed cross-coupling of arylboronic acids with perfluoroalkyl sulfonate salts based on a Bi(III)/Bi(V) redox cycle is presented. An electron-deficient sulfone ligand proved to be key for the successful implementation of this protocol, which allows the unusual construction of C(sp2)-O bonds using com. available NaOTf and KONf as coupling partners. Preliminary mechanistic studies as well as theor. investigations reveal the intermediacy of a highly electrophilic Bi(V) species, which rapidly eliminates Ph triflate. In the experimental materials used by the author, we found 3-Methoxyphenylboronic acid(cas: 10365-98-7Reference of 3-Methoxyphenylboronic acid)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Reference of 3-Methoxyphenylboronic acid

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Ether – Wikipedia,
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