Tag: 100-200

Name: N,N-Dimethylformamide Dimethyl AcetalIn 2022 ,《New Synthesis of Tetrahydroisoquinolines》 was published in Russian Journal of Organic Chemistry. The article was written by Dyachenko, I. V.; Dyachenko, V. D.; Dorovatovskii, P. V.; Khrustalev, V. N.; Nenajdenko, V. G.. The article contains the following contents:

The reaction of cyclohexylidenecyanothioacetamide with N,N-dimethylformamide di-Me acetal was studied. This transformation, depending on the reaction conditions, leads to different results: when the starting reagents are refluxed without a solvent, 3-(methylsulfanyl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile is formed, and refluxing in benzene leads to 2-cyano-3-(dimethylamino)prop-2-enethioamide. The structure of these products was studied by XRD analysts. The experimental part of the paper was very detailed, including the reaction process of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Name: N,N-Dimethylformamide Dimethyl Acetal)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Name: N,N-Dimethylformamide Dimethyl Acetal

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Computed Properties of C5H13NO2In 2020 ,《Controllable Soil Degradation Rate of 5-Substituted Sulfonylurea Herbicides as Novel AHAS Inhibitors》 was published in Journal of Agricultural and Food Chemistry. The article was written by Zhou, Shaa; Meng, Fan-Fei; Hua, Xue-Wen; Li, Yong-Hong; Liu, Bin; Wang, Bao-Lei; Chen, Jie; Chen, An-Liang; Li, Zheng-Ming. The article contains the following contents:

Chlorsulfuron has been applied in wheat fields as a recognized herbicide worldwide, yet it was officially banned in China since 2014 for its soil persistence problem. On the basis of our previous research that 5-dimethylamino distinctively accelerated degradation rate in soils, a modified amino moiety (Ia-c) and monosubstituted amino group (Id-e) were introduced onto the fifth position of the benzene ring in sulfonylurea structures, as well as heterocyclic amino substituents (If-g) to seek a suitable soil degradation rate during such an in situ crop rotation system. Referring to the biol. data and ScAHAS inhibition and ScAHAS docking results, they turned out to be AHAS inhibitors with high potent herbicidal activities. The various influence on soil degradation rate along with crop safety indicated that different substituents on the fifth position have exerted an apparent impact. Their united study of structure-activity-safety-degradation relationship has great potential to provide valuable information for further development of eco-friendly agrochems. The experimental part of the paper was very detailed, including the reaction process of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Computed Properties of C5H13NO2)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Computed Properties of C5H13NO2

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Recommanded Product: 60656-87-3In 2022 ,《α,β-Unsaturated β-Methyl-δ-lactones in Nitrile Oxide Cycloaddition Reactions. Synthesis of Saturated Lactones and Lactams》 was published in Russian Journal of Organic Chemistry. The article was written by Mineyeva, I. V.. The article contains the following contents:

New isoxazoline derivatives have been synthesized in high yields by cycloaddition of acetonitrile oxide to α,β-unsaturated β-methyl-δ-lactones. These unsaturated lactones have been used to obtain β-Me branched saturated lactones and lactams, as well as lactones with an inverted configuration of hydroxy group, following the divergent approach. The experimental part of the paper was very detailed, including the reaction process of 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Recommanded Product: 60656-87-3)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).Recommanded Product: 60656-87-3

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COA of Formula: C8H8O2In 2019 ,《CuO nanoparticles as a reusable catalyst for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives under solvent-free conditions》 appeared in Journal of the Iranian Chemical Society. The author of the article were Patil, Sonatai; Mane, Ananda; Dhongade-Desai, Savita. The article conveys some information:

Nanostructured CuO was successfully utilized for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives I (R = H, 4-Cl, 4-NO2, etc.) via one-pot multicomponent reaction using phthalhydrazide, malononitrile and aromatic aldehydes under solvent-free conditions. Utilization of non-toxic and inexpensive catalyst, improved yields in short reaction times, wide substrate scope and easy purification of products are the important features of the developed protocol. The CuO nanocatalyst presents good reusability over five catalytic cycles. The experimental process involved the reaction of 2-Methoxybenzaldehyde(cas: 135-02-4COA of Formula: C8H8O2)

2-Methoxybenzaldehyde(cas: 135-02-4) is found in cassia oil, cinnamon bark, and cinnamon bark oil. It is a clear colorless liquid with a strong aroma. It has been used to examine the acaricidal activity of Periploca sepium oil and its active component against Tyrophagus putrescentiae.COA of Formula: C8H8O2

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Category: ethers-buliding-blocksIn 2019 ,《Design, synthesis, and antifibrosis evaluation of 4-(benzo-[c][1,2,5]thiadiazol-5-yl)-3(5)-(6-methyl- pyridin-2-yl)pyrazole and 3(5)-(6-methylpyridin- 2-yl)-4-(thieno-[3,2,-c]pyridin-2-yl)pyrazole derivatives》 appeared in European Journal of Medicinal Chemistry. The author of the article were Zhu, Wen-Jing; Cui, Ben-Wen; Wang, Hui Min; Nan, Ji-Xing; Piao, Hu-Ri; Lian, Li-Hua; Jin, Cheng Hua. The article conveys some information:

Six series of 4-(benzo[c][1,2,5]thiadiazol-5-yl)-3(5)-(6-methylpyridin-2-yl)- pyrazoles and 3(5)-(6-methylpyridin-2-yl)-4-(thieno[3,2,-c]- pyridin-2-yl)pyrazoles have been synthesized and evaluated for their activin receptor-like kinase 5 (ALK5) and p38α mitogen activated protein (MAP) kinase inhibitory activities in enzymic assays. Among these compounds, the most active compound, I, inhibited ALK5 phosphorylation with an IC50 value of 0.030 μM in the enzymic assay. Compound I showed four-fold more potent activity against ALK5 kinase than the clin. candidate, compound LY-2157299. The selectivity index of I against p38α MAP kinase is 235, which is much higher than that of LY-2157299 (II) and equally selective to that of EW-7197 (III). Compound I effectively suppressed protein and mRNA expression of collagen I and α-SMA in TGF-β-induced LX-2 human hepatic stellate cell (HSC), this result shows that compound I has the ability to inhibit the activation of HSC. Compound I is expected to be a preclin. candidate for the treatment of hepatic fibrosis. The experimental part of the paper was very detailed, including the reaction process of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Category: ethers-buliding-blocks)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Category: ethers-buliding-blocks

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Quality Control of N,N-Dimethylformamide Dimethyl AcetalIn 2020 ,《Discovery of novel heat shock protein (Hsp90) inhibitors based on luminespib with potent antitumor activity》 appeared in Bioorganic & Medicinal Chemistry Letters. The author of the article were Jung, Juyoung; Kwon, Jinsun; Hong, Soojung; Moon, An-Na; Jeong, Jinah; Kwon, Sungwook; Kim, Jeong-ah; Lee, Myoungjae; Lee, Hongsub; Lee, Jin Hee; Lee, Jeewoo. The article conveys some information:

A series of isosteric surrogates of the 4-Ph group in luminespib were investigated as new scaffolds of the Hsp90 inhibitor for the discovery of novel antitumor agents. Among the synthesized surrogates of isoxazole and pyrazole, compounds 4a, 5e and 12b exhibited potent Hsp90 inhibition in ATPase activity and Her2 degradation assays and significant antitumor activity in A2780 and HCT116 cell lines. Animal studies indicated that compared to luminespib, their activities were superior in A2780 or NCI-H1975 tumor xenograft models. A mol. modeling study demonstrated that compound 4a could fit nicely into the N-terminal ATP binding pocket. In the experiment, the researchers used N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Quality Control of N,N-Dimethylformamide Dimethyl Acetal)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Quality Control of N,N-Dimethylformamide Dimethyl Acetal

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In 2022,Su, Xiao-Xuan; Chen, Yue-Ru; Wu, Jia-Qiang; Wu, Xiong-Zhi; Li, Kun-Tao; Wang, Xiao-Na; Sun, Jia-Wei; Wang, Honggen; Ou, Tian-Miao published an article in European Journal of Medicinal Chemistry. The title of the article was 《Design, synthesis, and evaluation of 9-(pyrimidin-2-yl)-9H-carbazole derivatives disrupting mitochondrial homeostasis in human lung adenocarcinoma》.Recommanded Product: 60656-87-3 The author mentioned the following in the article:

Since more than 85% of lung cancer cases are non-small cell lung cancer (NSCLC), finding novel agents with anti-tumor activities is meaningful for NSCLC patients. Mitochondria is essential for cellular energy metabolism in cancer, and regulating mitochondrial bioenergetics is emerging as a practical approach for cancer treatment and prevention. The carbazole scaffold is an active structure showing anti-cancer biol. activity, and the structural diversity has been expanded through the improvement and optimization of synthesizing methods. To find novel carbazole derivatives with great anti-tumor potential and explore structures variety, we designed and synthesized a series of 9-(pyrimidin-2-yl)-9H-carbazole derivatives based on the previously reported Cp*Rh(III)/H+ tandem catalytic system. With thoroughly bioactivity exploration, we found benzo[d] [1,3]dioxol-5-yl(9-(pyrimidin-2-yl)-9H-carbazol-1-yl)methanone (compound 5n) showed notable activity in disrupting the mitochondrial homeostasis, induced cell cycle arrest and apoptosis in human adenocarcinoma cells, and finally showed anti-tumor activity in an NSCLC-xenograft mice model. In addition to this study using 2-(Benzyloxy)acetaldehyde, there are many other studies that have used 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Recommanded Product: 60656-87-3) was used in this study.

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).Recommanded Product: 60656-87-3

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In 2022,Bhat, Mashooq A.; Al-Omar, Mohamed A.; Naglah, Ahmed M.; Al-Dhfyan, Abdullah published an article in Polish Journal of Chemical Technology. The title of the article was 《Facile synthesis and anticancer activity of novel dihydropyrimidinone derivatives》.Application of 4637-24-5 The author mentioned the following in the article:

The enaminone, (2E)-3-(dimethylamino)-1-(3,4,5-trimethoxyphenyl) prop-2-en-1-one was prepared by refluxing 3,4,5-trimethoxy acetophenone with DMF dimethylacetal (DMF-DMA) without solvent for 12 h. The dihydropyrimidinone derivatives (1-9) were prepared by reacting enaminone, substituted benzaldehydes and urea in glacial acetic acid. The compounds (1-9) were synthesized in significant yield using one step multicomponent reaction. Structures of all the novel synthesized compounds were characterized and confirmed by various spectroscopic methods. The compounds were evaluated for their anti-cancer activity against HepG2 cancer cell line. Compound 9 displayed significant anti-cancer activity. During the apoptotic assay, it showed a significant increase in necrosis from 1.97% to 12.18% as compared to the control. Mechanism of anti-proliferation was performed by cell cycle distribution assay, which showed a decrease in G2+M from 12.90 to 8.13 as compared to control. The experimental process involved the reaction of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Application of 4637-24-5)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Application of 4637-24-5

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Yue, Wen-Jun; Day, Craig S.; Martin, Ruben published their research in Journal of the American Chemical Society in 2021. The article was titled 《Site-Selective Defluorinative sp3 C-H Alkylation of Secondary Amides》.Computed Properties of C7H9BO3 The article contains the following contents:

A site-selective defluorinative sp3 C-H alkylation of secondary amides that rapidly and reliably incorporates gem-difluoroalkene motifs into previously unfunctionalized sp3 sites was disclosed. This protocol was distinguished by its mild conditions, wide scope and exquisite site-selectivity, thus unlocking a new platform to introduce carbonyl isosteres at saturated hydrocarbon sites. In the experimental materials used by the author, we found 3-Methoxyphenylboronic acid(cas: 10365-98-7Computed Properties of C7H9BO3)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Computed Properties of C7H9BO3

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《Development of a Robust Protocol for the Synthesis of 6-Hydroxybenzofuran-3-carboxylic Acid》 was written by Gallou, Isabelle; Erb, Bernhard; Marti, Michael; Nuzzo, Gian-Luca; Jager, Andreas; Seeger, Manuela; Chassagne, Pierre; Aronow, Jonas; Cortes-Clerget, Margery; Gallou, Fabrice. Recommanded Product: m-Methoxyphenol And the article was included in Organic Process Research & Development in 2020. The article conveys some information:

Benzofuran scaffolds are fundamental moieties found in a variety of biol. active natural products and synthetic drugs. In the course of one of our development programs, we needed to develop a practical and cost-effective manufacturing approach to such a benzofuran scaffold. Here we report a highly robust four-step, one-pot process that provides access to a 6-hydroxybenzofuran-3-carboxylic acid structure. An 1H NMR monitoring study allowed a better understanding of the overall sequence of events and the nature of the detected intermediates. After six steps, including the optimized tandem process, the desired hydroxylated benzofuran was obtained in 40% yield with a purity above 99%. In the experimental materials used by the author, we found m-Methoxyphenol(cas: 150-19-6Recommanded Product: m-Methoxyphenol)

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneRecommanded Product: m-Methoxyphenol

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