Tag: 100-200

Shakunthala, Kinche; Srivastava, Ankit Kumar; Babu, G. Narendra; Keesara, Srinivas; Pal, Samudranil published an article in 2021. The article was titled 《Nickel(II) complexes with N,O-donor thiopseudourea ligands: Syntheses, structures and catalytic applications in Kumada-Corriu cross-coupling reactions》, and you may find the article in Applied Organometallic Chemistry.Related Products of 2398-37-0 The information in the text is summarized as follows:

Synthesis, characterization and phys. properties of benzyl-N’-(4-R-benzoyl)-N-(2,6-diisopropylphenyl)carbamimidothioates, HL1 (R = H) and HL2 (R = Cl) and their nickel(II) complexes having the general mol. formula [Ni(L1/2)2] were reported. Elemental anal., magnetic susceptibility, solution elec. conductivity and various spectroscopic (IR, UV-Vis, and 1H NMR) measurements were used to characterize HL1, HL2 and the two complexes ([Ni(L1)2] and [Ni(L2)2]). The mol. structures of all four compounds were determined by single-crystal X-ray crystallog. studies. The structures of HL1 and HL2 showed the imino-ketone form of both compounds In each of [Ni(L1)2] and [Ni(L2)2], the six-membered chelate ring forming iminolate-O and azomethine-N donor two (L1/2)- ligands form a square-planar trans-N2O2 coordination environment around the metal center. The spectroscopic characteristics of HL1, HL2, [Ni(L1)2] and [Ni(L2)2] were consistent with their mol. structures. Both complexes were successfully employed as efficient catalysts in Kumada-Corriu C-C cross-coupling reactions of aryl bromides with phenylmagnesium bromide. The reactions provided biaryl products in good to excellent yields with a good substrate scope. In addition to this study using 1-Bromo-3-methoxybenzene, there are many other studies that have used 1-Bromo-3-methoxybenzene(cas: 2398-37-0Related Products of 2398-37-0) was used in this study.

1-Bromo-3-methoxybenzene(cas: 2398-37-0) can be used in chemical reaction as intermediates to obtain target materials such as dyes, pharmaceuticals, perfumes, photoinitiators and agrochemicals.Related Products of 2398-37-0

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Ether | (C2H5)2O – PubChem

Recommanded Product: 4637-24-5In 2019 ,《Rational Design and Optimization of a Novel Class of Macrocyclic Apoptosis Signal-Regulating Kinase 1 Inhibitors》 appeared in Journal of Medicinal Chemistry. The author of the article were Himmelbauer, Martin K.; Xin, Zhili; Jones, J. Howard; Enyedy, Istvan; King, Kristopher; Marcotte, Douglas J.; Murugan, Paramasivam; Santoro, Joseph C.; Hesson, Thomas; Spilker, Kerri; Johnson, Joshua L.; Luzzio, Michael J.; Gilfillan, Rab; de Turiso, Felix Gonzalez-Lopez. The article conveys some information:

Structural anal. of a known ASK1 inhibitor bound to its kinase domain led to the design and synthesis of the novel macrocyclic inhibitor I (cell IC50 = 1.2μM). The profile of this compound was optimized for CNS penetration following two independent strategies: a rational design approach leading to II and a parallel synthesis approach leading to III. Both analogs are potent ASK1 inhibitors in biochem. and cellular assays (II, cell IC50 = 95 nM; III, cell IC50 = 123 nM) and have moderate to low efflux ratio (ER) in an MDR1-MDCK assay (II, ER = 5.2; III, ER = 1.5). In vivo PK studies revealed that inhibitor II had moderate CNS penetration (Kp,uu = 0.17) and analog III had high CNS penetration (Kp,uu = 1.0).N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Recommanded Product: 4637-24-5) was used in this study.

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Recommanded Product: 4637-24-5

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Ether – Wikipedia,
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Li, Sanliang; Chen, Qiaoyu; Yang, Junfeng; Zhang, Junliang published an article in 2022. The article was titled 《Palladium-Catalyzed Enantioselective γ-Arylation of β,γ-Unsaturated Butenolides》, and you may find the article in Angewandte Chemie, International Edition.Formula: C7H7BrO The information in the text is summarized as follows:

An efficient Pd-catalyzed enantioselective γ-arylation of β,γ-unsaturated butenolides with aryl bromides R1Br (R1 = Ph, naphthalen-1-yl, thiophen-2-yl, etc.), which shows high γ-selectivity, good functional group tolerance and excellent enantioselectivity, to give I (R2 = Me, Bn, cyclohexyl, etc.) was reported. Notably, this protocol also allows for facile construction of tricyclic tetrahydroindolines and tetrahydroisoquinolinones, e.g., II, in one step. DFT calculations are consistent with the exptl. results, suggesting that the γ-arylation is favored over the α-arylation. Finally, this method is applied to the rapid synthesis of natural product (R)-(+)-boivinianin A. In addition to this study using 1-Bromo-3-methoxybenzene, there are many other studies that have used 1-Bromo-3-methoxybenzene(cas: 2398-37-0Formula: C7H7BrO) was used in this study.

1-Bromo-3-methoxybenzene(cas: 2398-37-0) is a compound useful in organic synthesis and other chemical processes. It is an intermediate used for pharmaceuticals, perfumes and agrochemicals.Formula: C7H7BrO

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Xu, Chaofan; Tassone, Joseph P.; Mercado, Brandon Q.; Ellman, Jonathan A. published an article in 2022. The article was titled 《Stereoselective Synthesis of Allenyl Alcohols by Cobalt(III)-Catalyzed Sequential C-H Bond Addition to 1,3-Enynes and Aldehydes》, and you may find the article in Angewandte Chemie, International Edition.Product Details of 60656-87-3 The information in the text is summarized as follows:

An efficient and stereoselective CoIII-catalyzed sequential C-H bond addition to 1,3-enynes RCCCH=CH2 (R = t-Bu, tert-butyldimethylsilyl, 2-(benzyloxy)propan-2-yl, etc.) and aldehydes R1CHO (R1 = ethoxycarbonyl, (benzyloxy)methyl, OH, etc.) is disclosed. This transformation represents the first example of sequential C-H bond additions to 1,3-enynes and a second coupling partner and provides the first example of preparing allenes I (R2 = 4-methyl-3-[(pyrrolidin-1-yl)carbonyl]thiophen-2-yl, 3-(methylcarbamoyl)-1-benzothiophen-2-yl, 2-(pyridin-2-yl)benzen-1-yl, etc.) by C-H bond addition to 1,3-enynes. A wide range of aldehydes, C-H bond substrates and 1,3-enynes with large substituents on the alkynes are effective substrates. The allenyl alc. products I can be further converted to dihydrofurans II (R3 = H, Cl, F) with high stereoselectivity either in situ or under Ag-mediated cyclization conditions. The allenyl silyl group can also be transferred to the adjacent alc. by a Brook rearrangement. Moreover, a mechanism for the transformation is proposed and supported by X-ray structural characterization of a cobaltacycle intermediate. The experimental process involved the reaction of 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Product Details of 60656-87-3)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) may be used in the following syntheses: (3S,5S)-methyl 6-benzyloxy-3,5-dihydroxyhexanoate ,(S)-5-benzyloxy-4-hydroxypentan-2-one, myxothiazols.Product Details of 60656-87-3

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Ether – Wikipedia,
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Dong, Zhenhua; Pan, Hongguo; Liu, Mengmeng published an article in 2021. The article was titled 《Catalyst-free rapid conversion of arylboronic acids to phenols under green condition》, and you may find the article in ARKIVOC (Gainesville, FL, United States).HPLC of Formula: 150-19-6 The information in the text is summarized as follows:

A catalyst-free and solvent-free method for the oxidative hydroxylation of aryl boronic acids to corresponding phenols with hydrogen peroxide as the oxidizing agent was developed. The reactions could be performed under green condition at room temperature within very short reaction time. 99% yield of phenol could be achieved in only 1 min. A series of different arenes substituted aryl boronic acids were further carried out in the hydroxylation reaction with excellent yield. It was worth nothing that the reaction could completed within 1 min in all cases in the presence of ethanol as co-solvent. In the experiment, the researchers used many compounds, for example, m-Methoxyphenol(cas: 150-19-6HPLC of Formula: 150-19-6)

m-Methoxyphenol(cas: 150-19-6) may be used as an analytical standard for the determination of the analyte in wine, coffee beans, wood samples, and mainstream smoke by gas chromatography (GC) based techniques.HPLC of Formula: 150-19-6

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Ether – Wikipedia,
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Magre, Marc; Cornella, Josep published an article in 2021. The article was titled 《Redox-Neutral Organometallic Elementary Steps at Bismuth: Catalytic Synthesis of Aryl Sulfonyl Fluorides》, and you may find the article in Journal of the American Chemical Society.Reference of 3-Methoxyphenylboronic acid The information in the text is summarized as follows:

A Bi-catalyzed synthesis of sulfonyl fluorides from the corresponding (hetero)aryl boronic acids is presented. Authors demonstrate that the organobismuth(III) catalysts bearing a bis-aryl sulfone ligand backbone revolve through different canonical organometallic steps within the catalytic cycle without modifying the oxidation state. All steps have been validated, including the catalytic insertion of SO2 into Bi-C bonds, leading to a structurally unique O-bound bismuth sulfinate complex. The catalytic protocol affords excellent yields for a wide range of aryl and heteroaryl boronic acids, displaying a wide functional group tolerance. The results came from multiple reactions, including the reaction of 3-Methoxyphenylboronic acid(cas: 10365-98-7Reference of 3-Methoxyphenylboronic acid)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Reference of 3-Methoxyphenylboronic acid

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AlMarzouq, Douaa Salman published their research in European Journal of Chemistry in 2021. The article was titled 《Reactions under increased pressure: the reactivity of functionally substituted 3-oxo-2-arylhydrazones toward active methylene reagents in Q-tube》.Electric Literature of C5H13NO2 The article contains the following contents:

A one-pot two-component reaction of 3-oxo-2-arylhydrazones 4-XC6H4C(O)C(C(O)R)=NNH(4-R1C6H4) (X = H, Cl; R = H, OEt; R1 = H, Me) with active methylene nitriles such as malononitrile and benzoylacetonitrile under high pressure in a Q-tube safe reactor was reported. Comparison between conventional and Q-tube safe reactor-assisted synthesis of organic compounds was done by comparing total reaction time and percentage yield. The results show that the compound 5-cyano-6-oxo-1,4-diphenyl-1,6-dihydro-pyridazine-3-carboxylic acid Et ester was synthesized within 2 h in a yield of 97%. In addition, the pyrazolo[3,4-c]pyridines I were obtained in yields of 93 and 95% within 1 h reaction time, resp. The obtained results suggest that Q-tube safe reactor-assisted syntheses were led to higher product yields within very short reaction times.N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Electric Literature of C5H13NO2) was used in this study.

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Electric Literature of C5H13NO2

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Ether – Wikipedia,
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《Synthesis and Anti-Microbial Activity of Benzylidenhydrazides of Glycyrrhetic Acid》 was written by Baltina, L. A.; Kondratenko, R. M.; Bulgakov, A. K.. COA of Formula: C8H8O2 And the article was included in Russian Journal of Bioorganic Chemistry in 2020. The article conveys some information:

New derivatives of glycyrrhetic acid with hydrazide pharmacophore groups I (R = C6H5, 4-HOC6H4, 4-MeOC6H4, 2-MeOC6H4, 4-(Me)2NC6H3) were synthesized and their antimicrobial activity was evaluated. Compound I (R = 4-HOC6H4) exhibited the highest antimicrobial activity. This compound had both an antibacterial effect against Escherichia coli, Proteus vulgaris, Klebsiella pneumonia, Staphylococcus aureus, Citrobacter diversus, Enterobacter aerogenes, Pseudomonas aeruginosa, and Enterobacter cloacae and antifungal activity against the Candida albicans fungus. The min. inhibitory concentrations of this compound and pimafucin were similar for Candida albicans. In the part of experimental materials, we found many familiar compounds, such as 2-Methoxybenzaldehyde(cas: 135-02-4COA of Formula: C8H8O2)

2-Methoxybenzaldehyde(cas: 135-02-4) is used as a flavor agent in foods including nonalcoholic/alcoholic beverages, baked goods, chewing gum, confections, frozen dairy, fruit ices, hard/soft candy, instant coffee, tea, Jams, jellies, and milk products. It also has been used to obtain good enantioselectivities using Cu(OAc)(2)-bis(oxazolines) via hydrogen bonding in asymmetric Henry reaction.COA of Formula: C8H8O2

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Ether – Wikipedia,
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《Ultrasound assisted eco-friendly synthesis of 3-cinnamoyl coumarins using N,N’-(1,2-phenylene)bis(2-aminobenzamide)dichloro cobalt immobilized on mesoporous Al-SBA-15 as a new and recyclable catalyst》 was published in Green Chemistry Letters and Reviews in 2020. These research results belong to Akbarzadeh, Zeinab; Safaei-Ghomi, Javad. Safety of 2-Hydroxy-4-methoxybenzaldehyde The article mentions the following:

A novel mesoporous Al-SBA-15 modified by N,N’-(1,2-phenylene)bis(2-aminobenzamide) dichloro cobalt has been prepared and applied as a reusable catalyst in the 3-cinnamoyl coumarins I (R = 4-Br, 2-OH, 4-F, etc.; R1 = H, 7-OMe, 6-OMe, 6-Br) synthesis via three-component reaction between benzaldehydes RC6H4CHO, salicylaldehydes like salicylaldehyde, 2-hydroxy-4-methoxybenzaldehyde, 2-hydroxy-5-methoxybenzaldehyde, 5-bromo-2-hydroxybenzaldehyde and Et acetoacetate by the assist of ultrasonic irradiation By using the nanocatalyst and also ultrasound irradiation, the facility and velocity of the above mentioned reaction were enhanced and an environment friendly condition was provided to synthesis of various 3-cinnamoyl coumarin compounds I. The properties and structure of nanocatalyst have been specified by methods including powder X-ray diffraction (XRD), energy dispersive spectroscopy (EDS), Fourier transform IR spectroscopy (FT-IR), transmission electron microscopy (TEM), nitrogen adsorption-desorption anal. and scanning electronic microscopy (SEM). Superiority of this novel and viable method is due to mild reaction condition, short reaction times, high yields of 3-cinnamoyl coumarins I, environmentally benign, recoverability of the CoCl2N,N’-(1,2-phenylene)bis (2-aminobenzamide)/Al-SBA-15 catalyst and reusability with important preservation in its catalytic activity. The experimental process involved the reaction of 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Safety of 2-Hydroxy-4-methoxybenzaldehyde)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Safety of 2-Hydroxy-4-methoxybenzaldehyde

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Introduction of a new bis-derivative of succinimide (Bis-Su) as a sustainable and efficient basic organo-catalyst for the synthesis of arylidene malononitrile and tetrahydrobenzo[b]pyran derivatives under green conditions》 was published in Research on Chemical Intermediates in 2020. These research results belong to Hassanzadeh, Fariba; Daneshvar, Nader; Shirini, Farhad; Mamaghani, Manouchehr. Product Details of 135-02-4 The article mentions the following:

In this work, a new bis-succinimide (Bis-Su) compound 1-[4-(2,5-dioxopyrrolidin-1-yl)butyl]pyrrolidine-2,5-dione is prepared, identified and used as a green and efficient basic organo-catalyst for the promotion of the synthesis of arylidene malononitriles ArCH=C(CN)2 (Ar = C6H5, 4-ClC6H4, (E)-4-NO2C6H4CH=CH, etc.) and tetrahydrobenzo[b]pyrans I. Using this method, both of the reactions were performed under mild conditions, during short reaction times in high yields. The catalyst can also be recycled and reused several times without a considerable decrease in its activity. In the experiment, the researchers used 2-Methoxybenzaldehyde(cas: 135-02-4Product Details of 135-02-4)

2-Methoxybenzaldehyde(cas: 135-02-4) is used as a flavor agent in foods including nonalcoholic/alcoholic beverages, baked goods, chewing gum, confections, frozen dairy, fruit ices, hard/soft candy, instant coffee, tea, Jams, jellies, and milk products. It also has been used to obtain good enantioselectivities using Cu(OAc)(2)-bis(oxazolines) via hydrogen bonding in asymmetric Henry reaction.Product Details of 135-02-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem